中草药调节活性氧抗肿瘤的研究进展
|
摘要
活性氧(ROS)对于肿瘤而言是把双刃剑。一方面,肿瘤细胞内适度升高的ROS有利于肿瘤的生存、发展,并与耐药密切相关,另一方面,过量的ROS又能通过选择性杀死肿瘤细胞达到治疗的目的。基于ROS的肿瘤治疗策略受到了人们的广泛关注。文章从ROS调节角度综述了中草药防治肿瘤的最新进展及应用策略,旨在为中草药抗肿瘤药物的研发提供新的思路和有益的参考。
Reactive oxygen species(ROS) is a double-edged sword for cancer. On one hand, moderately elevated ROS in cancer cells is conducive to the survival and development of tumor and is closely related to the drug resistance. On the other hand, excess ROS can kill cancer cells selectively for the treatment purpose. ROS-based treatment is emerging as an attractive anticancer strategy. This article provides an overview of Chinese herbal medicine in the prevention and treatment of cancer from the perspective of ROS regulation, aiming to provide new ideas and useful references for the research and development of Chinese herbal medicine as anti-cancer agents.
Reactive oxygen species(ROS) is a double-edged sword for cancer. On one hand, moderately elevated ROS in cancer cells is conducive to the survival and development of tumor and is closely related to the drug resistance. On the other hand, excess ROS can kill cancer cells selectively for the treatment purpose. ROS-based treatment is emerging as an attractive anticancer strategy. This article provides an overview of Chinese herbal medicine in the prevention and treatment of cancer from the perspective of ROS regulation, aiming to provide new ideas and useful references for the research and development of Chinese herbal medicine as anti-cancer agents.
引文
[1]PAN J-S,HONG M-Z,REN J-L.Reactive oxygen species:A doubleedged sword in oncogenesis.World Journal of Gastroenterology,2009,15(14):1702
[2]ZOROV D B,JUHASZOVA M,SOLLOTT S J.Mitochondrial reactive oxygen species(ROS)and ROS-induced ROS release.Physiological Reviews,2014,94(3):909-950
[3]RECZEK C R,CHANDEL N S.ROS-dependent signal transduction.Current Opinion in Cell Biology,2015,33:8-13
[4]HANDY D E,LOSCALZO J.Redox regulation of mitochondrial function.Antioxidants&Redox Signaling,2012,16(11):1323-1367
[5]HAN D,WILLIAMS E,CADENAS E.Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space.The Biochemical Journal,2001,353(Pt2):411-416
[6]LIOU G Y,STORZ P.Reactive oxygen species in cancer.Free Radical Research,2010,44(5):479-496
[7]DIZDAROGLU M,JARUGA P.Mechanisms of free radical-induced damage to DNA.Free Radical Research,2012,46(4):382-419
[8]BEDARD K,KRAUSE K H.The NOX family of ROS-generating NADPH oxidases:Physiology and pathophysiology.Physiological Reviews,2007,87(1):245-313
[9]MOLONEY J N,COTTER T G.ROS signalling in the biology of cancer.Seminars in Cell&Developmental Biology,2018,80:50-64
[10]TONG L,CHUANG C C,WU S,et al.Reactive oxygen species in redox cancer therapy.Cancer Letters,2015,367(1):18-25
[11]SABHARWAL S,SCHUMACKER P.Mitochondrial ROS in cancer:Initiators,amplifiers or an Achilles'heel?.Nat Rev Cancer,2014,14(11):709-721
[12]LESLIE N R,BENNETT D,LINDSAY Y E,et al.Redox regulation of PI3-kinase signalling via inactivation of PTEN.The EMBO Journal,2003,22(20):5501-5510
[13]CHIO I I C,TUVESON D A.ROS in cancer:The burning question.Trends in Molecular Medicine,2017,23(5):411-429
[14]PARK J H,KIM T Y,JONG H S,et al.Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells.Clinical Cancer Research:An Official Journal of the American Association for Cancer Research,2003,9(1):433-440
[15]POILLET-PEREZ L,DESPOUY G,DELAGE-MOURROUX R,et al.Interplay between ROS and autophagy in cancer cells,from tumor initiation to cancer therapy.Redox Biology,2015,4:184-192
[16]OKON I S,ZOU M H.Mitochondrial ROS and cancer drug resistance:Implications for therapy.Pharmacological Research,2015,100:170-174
[17]OZBEN T.Oxidative stress and apoptosis:Impact on cancer therapy.Journal of Pharmaceutical Sciences,2007,96(9):2181-2196
[18]WAGNER E F,NEBREDAáR.Signal integration by JNK and p38MAPK pathways in cancer development.Nature Reviews Cancer,2009,9(8):537-549
[19]GROEGER G,QUINEY C,COTTER T G.Hydrogen peroxide as a cell-survival signaling molecule.Antioxidants&Redox Signaling,2009,11(11):2655-2671
[20]D’ALESSIO M,CERELLA C,DE NICOLA M,et al.Apoptotic GSH extrusion is associated with free radical generation.Annals of the New York Academy of Sciences,2003,1010:449-452
[21]SOLBAN N,RIZVI I,HASAN T.Targeted photodynamic therapy.Lasers in Surgery and Medicine,2006,38(5):522-531
[22]GLASAUER A,CHANDEL N S.Targeting antioxidants for cancer therapy.Biochemical Pharmacology,2014,92(1):90-101
[23]TRACHOOTHAM D,ALEXANDRE J,HUANG P.Targeting cancer cells by ROS-mediated mechanisms:A radical therapeutic approach?.Nat Rev Drug Discov,2009,8(7):579-591
[24]HOSSAINMS,DIETZKJ.Tuningofredoxregulatory mechanisms,reactive oxygen species and redox homeostasis under salinity stress.Front Plant Sci,2016,7:548-557
[25]MARTIN-CORDERO C,JOSE LEON-GONZALEZ A,MANUEL CALDERON-MONTANO J,et al.Pro-oxidant natural products as anticancer agents.Current Drug Targets,2012,13(8):1006-1028
[26]RAZA M H,SIRAJ S,ARSHAD A,et al.ROS-modulated therapeutic approaches in cancer treatment.Journal of Cancer Research and Clinical Oncology,2017,143(9):1789-1809
[27]吴建春,李雁.中药抗肺癌转移机制的实验研究进展.辽宁中医药大学学报,2009,11(4):71-74
[28]YE L,JIA Y,JI K,et al.Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis.Oncology Letters,2015,10(3):1240-1250
[29]方雪妮,周天,李泉旺,等.中药对肿瘤微环境各组分的调节作用.中华中医药杂志,2018,33(2):631-634
[30]CABELLO C M,BAIR W B,3RD,WONDRAK G T.Experimental therapeutics:Targeting the redox Achilles heel of cancer.Current Opinion in Investigational Drugs(London,England:2000),2007,8(12):1022-1037
[31]BUCHNER F L,BUENO-DE-MESQUITA H B,LINSEISEN J,et al.Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition(EPIC).Cancer Causes&Control,2010,21(3):357-371
[32]JIAO R,LIU Y,GAO H,et al.The anti-oxidant and antitumor properties of plant polysaccharides.The American Journal of Chinese Medicine,2016,44(3):463-488
[33]LI Y,HU Y,SHI S,et al.Evaluation of antioxidant and immunoenhancing activities of Purslane polysaccharides in gastric cancer rats.International Journal of Biological Macromolecules,2014,68:113-116
[34]YANAKA A.Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro,and demonstrates antiinflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.Current Pharmaceutical Design,2011,17(16):1532-1540
[35]BAO J,DING R,ZOU L,et al.Forsythiae fructus inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidation and anti-inflammation.The American Journal of Chinese Medicine,2016,44(5):1043-1061
[36]ZHANG X,YEUNG E D,WANG J,et al.Isoliquiritigenin,a natural anti-oxidant,selectively inhibits the proliferation of prostate cancer cells.Clinical and Experimental Pharmacology&Physiology,2010,37(8):841-847
[37]KWON G T,CHO H J,CHUNG W Y,et al.Isoliquiritigenin inhibits migration and invasion of prostate cancer cells:Possible mediation by decreased JNK/AP-1 signaling.The Journal of Nutritional Biochemistry,2009,20(9):663-676
[38]LI B,KIM D S,YADAV R K,et al.Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2cells.International Journal of Molecular Medicine,2015,36(1):53-64
[39]GAO Y,CHU S,SHAO Q,et al.Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice.Free Radical Research,2017,51(1):1-13
[40]CHOI M J,ZHENG H M,KIM J M,et al.Protective effects of Centella asiatica leaf extract on dimethylnitrosamineinduced liver injury in rats.Molecular Medicine Reports,2016,14(5):4521-4528
[41]JIN J,LI M,ZHAO Z,et al.Protective effect of Wuzhi tablet(Schisandra sphenanthera extract)against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2015,22(5):528-535
[42]YU W N,SUN L F,YANG H.Inhibitory effects of astragaloside IV on bleomycin-induced pulmonary fibrosis in rats via attenuation of oxidative stress and inflammation.Inflammation,2016,39(5):1835-1841
[43]JI K,CHEN J,HU J,et al.The protective effect of astragaloside IV against benzo[a]pyrene induced endothelial progenitor cell dysfunction.Life Sciences,2015,132:13-19
[44]SUN C,ZHANG H,MA X F,et al.Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status.Cell Biochemistry and Biophysics,2013,65(3):433-444
[45]LAMBERT J D,ELIAS R J.The antioxidant and pro-oxidant activities of green tea polyphenols:A role in cancer prevention.Archives of Biochemistry and Biophysics,2010,501(1):65-72
[46]OZBEN T.Antioxidant supplementation on cancer risk and during cancer therapy:An update.Curr Top Med Chem,2015,15(2):170-178
[47]REN G,LUO W,SUN W,et al.Psoralidin induced reactive oxygen species(ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2016,23(9):939-947
[48]HAO W,ZHANG X,ZHAO W,et al.Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.Peer J,2014,2:e555
[49]CAO S,XIA M,MAO Y,et al.Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma:involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway.International Journal of Oncology,2016,49(5):2075-2087
[50]CHEN G,WANG K,YANG B Y,et al.Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells.International Journal of Oncology,2012,40(1):139-147
[51]GUO P,WANG S,LIANG W,et al.Salvianolic acid B reverses multidrug resistance in HCT8/VCR human colorectal cancer cells by increasing ROS levels.Molecular Medicine Reports,2017,15(2):724-730
[52]WANG Z S,LUO P,DAI S H,et al.Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation.Cellular and Molecular Neurobiology,2013,33(7):921-928
[53]ELING N,REUTER L,HAZIN J,et al.Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.Oncoscience,2015,2(5):517-532
[54]YANG Y,ZHANG Y,WANG L,et al.Levistolide a induces apoptosis via ROS-mediated ER stress pathway in colon cancer cells.Cellular Physiology and Biochemistry:International Journal of Experimental Cellular Physiology,Biochemistry,and Pharmacology,2017,42(3):929-938
[55]FAN C,YANG Y,LIU Y,et al.Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling.Scientific Reports,2016,6:21145
[56]FILIPPOVA M,FILIPPOV V.Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents.2014,2014:574659
[57]HART P C,MAO M,DE ABREU A L P,et al.MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPKdependent signalling in cancer.Nature Communications,2015,6:6053
[58]RAJ L,IDE T,GURKAR A U,et al.Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Nature,2011,475(7355):231-234
[59]ROH J L,KIM E H,PARK J Y,et al.Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer.Oncotarget,2014,5(19):9227-9238
[60]SUN X,WANG W,CHEN J,et al.The natural diterpenoid isoforretin a inhibits thioredoxin-1 and triggers potent ROS-mediated antitumor effects.Cancer Research,2017,77(4):926-936
[61]DUAN D,ZHANG B,YAO J,et al.Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.Free Radical Biology and Medicine,2014,70:182-193
[62]DUAN D,ZHANG J,YAO J,et al.Targeting thioredoxin reductase by parthenolide contributes to inducing apoptosis of HeLa cells.The Journal of Biological Chemistry,2016,291(19):10021-10031
[63]REN D,VILLENEUVE N,JIANG T,et al.Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.Proc Natl Acad Sci USA,2011,108(4):1433-1438
[64]LIU Y,ZHI D,LI M,et al.Shengmai Formula suppressed overactivated Ras/MAPK pathway in C.elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.Scientific Reports,2016,6:38934
[65]BJELAKOVIC G,NIKOLOVA D,GLUUD C.Antioxidant supplements to prevent mortality.JAMA,2013,310(11):1178-1179
[66]PISKOUNOVA E,AGATHOCLEOUS M,MURPHY M M,et al.Oxidative stress inhibits distant metastasis by human melanoma cells.Nature,2015,527(7577):186-191
[67]WANG Y,GUO S H,SHANG X J,et al.Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response.Acta Pharmacol Sin,2018,39(2):311-327
[68]CAI W,ZHANG B,DUAN D,et al.Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells.Toxicology and Applied Pharmacology,2012,262(3):341-348
[2]ZOROV D B,JUHASZOVA M,SOLLOTT S J.Mitochondrial reactive oxygen species(ROS)and ROS-induced ROS release.Physiological Reviews,2014,94(3):909-950
[3]RECZEK C R,CHANDEL N S.ROS-dependent signal transduction.Current Opinion in Cell Biology,2015,33:8-13
[4]HANDY D E,LOSCALZO J.Redox regulation of mitochondrial function.Antioxidants&Redox Signaling,2012,16(11):1323-1367
[5]HAN D,WILLIAMS E,CADENAS E.Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space.The Biochemical Journal,2001,353(Pt2):411-416
[6]LIOU G Y,STORZ P.Reactive oxygen species in cancer.Free Radical Research,2010,44(5):479-496
[7]DIZDAROGLU M,JARUGA P.Mechanisms of free radical-induced damage to DNA.Free Radical Research,2012,46(4):382-419
[8]BEDARD K,KRAUSE K H.The NOX family of ROS-generating NADPH oxidases:Physiology and pathophysiology.Physiological Reviews,2007,87(1):245-313
[9]MOLONEY J N,COTTER T G.ROS signalling in the biology of cancer.Seminars in Cell&Developmental Biology,2018,80:50-64
[10]TONG L,CHUANG C C,WU S,et al.Reactive oxygen species in redox cancer therapy.Cancer Letters,2015,367(1):18-25
[11]SABHARWAL S,SCHUMACKER P.Mitochondrial ROS in cancer:Initiators,amplifiers or an Achilles'heel?.Nat Rev Cancer,2014,14(11):709-721
[12]LESLIE N R,BENNETT D,LINDSAY Y E,et al.Redox regulation of PI3-kinase signalling via inactivation of PTEN.The EMBO Journal,2003,22(20):5501-5510
[13]CHIO I I C,TUVESON D A.ROS in cancer:The burning question.Trends in Molecular Medicine,2017,23(5):411-429
[14]PARK J H,KIM T Y,JONG H S,et al.Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells.Clinical Cancer Research:An Official Journal of the American Association for Cancer Research,2003,9(1):433-440
[15]POILLET-PEREZ L,DESPOUY G,DELAGE-MOURROUX R,et al.Interplay between ROS and autophagy in cancer cells,from tumor initiation to cancer therapy.Redox Biology,2015,4:184-192
[16]OKON I S,ZOU M H.Mitochondrial ROS and cancer drug resistance:Implications for therapy.Pharmacological Research,2015,100:170-174
[17]OZBEN T.Oxidative stress and apoptosis:Impact on cancer therapy.Journal of Pharmaceutical Sciences,2007,96(9):2181-2196
[18]WAGNER E F,NEBREDAáR.Signal integration by JNK and p38MAPK pathways in cancer development.Nature Reviews Cancer,2009,9(8):537-549
[19]GROEGER G,QUINEY C,COTTER T G.Hydrogen peroxide as a cell-survival signaling molecule.Antioxidants&Redox Signaling,2009,11(11):2655-2671
[20]D’ALESSIO M,CERELLA C,DE NICOLA M,et al.Apoptotic GSH extrusion is associated with free radical generation.Annals of the New York Academy of Sciences,2003,1010:449-452
[21]SOLBAN N,RIZVI I,HASAN T.Targeted photodynamic therapy.Lasers in Surgery and Medicine,2006,38(5):522-531
[22]GLASAUER A,CHANDEL N S.Targeting antioxidants for cancer therapy.Biochemical Pharmacology,2014,92(1):90-101
[23]TRACHOOTHAM D,ALEXANDRE J,HUANG P.Targeting cancer cells by ROS-mediated mechanisms:A radical therapeutic approach?.Nat Rev Drug Discov,2009,8(7):579-591
[24]HOSSAINMS,DIETZKJ.Tuningofredoxregulatory mechanisms,reactive oxygen species and redox homeostasis under salinity stress.Front Plant Sci,2016,7:548-557
[25]MARTIN-CORDERO C,JOSE LEON-GONZALEZ A,MANUEL CALDERON-MONTANO J,et al.Pro-oxidant natural products as anticancer agents.Current Drug Targets,2012,13(8):1006-1028
[26]RAZA M H,SIRAJ S,ARSHAD A,et al.ROS-modulated therapeutic approaches in cancer treatment.Journal of Cancer Research and Clinical Oncology,2017,143(9):1789-1809
[27]吴建春,李雁.中药抗肺癌转移机制的实验研究进展.辽宁中医药大学学报,2009,11(4):71-74
[28]YE L,JIA Y,JI K,et al.Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis.Oncology Letters,2015,10(3):1240-1250
[29]方雪妮,周天,李泉旺,等.中药对肿瘤微环境各组分的调节作用.中华中医药杂志,2018,33(2):631-634
[30]CABELLO C M,BAIR W B,3RD,WONDRAK G T.Experimental therapeutics:Targeting the redox Achilles heel of cancer.Current Opinion in Investigational Drugs(London,England:2000),2007,8(12):1022-1037
[31]BUCHNER F L,BUENO-DE-MESQUITA H B,LINSEISEN J,et al.Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition(EPIC).Cancer Causes&Control,2010,21(3):357-371
[32]JIAO R,LIU Y,GAO H,et al.The anti-oxidant and antitumor properties of plant polysaccharides.The American Journal of Chinese Medicine,2016,44(3):463-488
[33]LI Y,HU Y,SHI S,et al.Evaluation of antioxidant and immunoenhancing activities of Purslane polysaccharides in gastric cancer rats.International Journal of Biological Macromolecules,2014,68:113-116
[34]YANAKA A.Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro,and demonstrates antiinflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects.Current Pharmaceutical Design,2011,17(16):1532-1540
[35]BAO J,DING R,ZOU L,et al.Forsythiae fructus inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidation and anti-inflammation.The American Journal of Chinese Medicine,2016,44(5):1043-1061
[36]ZHANG X,YEUNG E D,WANG J,et al.Isoliquiritigenin,a natural anti-oxidant,selectively inhibits the proliferation of prostate cancer cells.Clinical and Experimental Pharmacology&Physiology,2010,37(8):841-847
[37]KWON G T,CHO H J,CHUNG W Y,et al.Isoliquiritigenin inhibits migration and invasion of prostate cancer cells:Possible mediation by decreased JNK/AP-1 signaling.The Journal of Nutritional Biochemistry,2009,20(9):663-676
[38]LI B,KIM D S,YADAV R K,et al.Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2cells.International Journal of Molecular Medicine,2015,36(1):53-64
[39]GAO Y,CHU S,SHAO Q,et al.Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice.Free Radical Research,2017,51(1):1-13
[40]CHOI M J,ZHENG H M,KIM J M,et al.Protective effects of Centella asiatica leaf extract on dimethylnitrosamineinduced liver injury in rats.Molecular Medicine Reports,2016,14(5):4521-4528
[41]JIN J,LI M,ZHAO Z,et al.Protective effect of Wuzhi tablet(Schisandra sphenanthera extract)against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2015,22(5):528-535
[42]YU W N,SUN L F,YANG H.Inhibitory effects of astragaloside IV on bleomycin-induced pulmonary fibrosis in rats via attenuation of oxidative stress and inflammation.Inflammation,2016,39(5):1835-1841
[43]JI K,CHEN J,HU J,et al.The protective effect of astragaloside IV against benzo[a]pyrene induced endothelial progenitor cell dysfunction.Life Sciences,2015,132:13-19
[44]SUN C,ZHANG H,MA X F,et al.Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status.Cell Biochemistry and Biophysics,2013,65(3):433-444
[45]LAMBERT J D,ELIAS R J.The antioxidant and pro-oxidant activities of green tea polyphenols:A role in cancer prevention.Archives of Biochemistry and Biophysics,2010,501(1):65-72
[46]OZBEN T.Antioxidant supplementation on cancer risk and during cancer therapy:An update.Curr Top Med Chem,2015,15(2):170-178
[47]REN G,LUO W,SUN W,et al.Psoralidin induced reactive oxygen species(ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.Phytomedicine:International Journal of Phytotherapy and Phytopharmacology,2016,23(9):939-947
[48]HAO W,ZHANG X,ZHAO W,et al.Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.Peer J,2014,2:e555
[49]CAO S,XIA M,MAO Y,et al.Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma:involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway.International Journal of Oncology,2016,49(5):2075-2087
[50]CHEN G,WANG K,YANG B Y,et al.Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells.International Journal of Oncology,2012,40(1):139-147
[51]GUO P,WANG S,LIANG W,et al.Salvianolic acid B reverses multidrug resistance in HCT8/VCR human colorectal cancer cells by increasing ROS levels.Molecular Medicine Reports,2017,15(2):724-730
[52]WANG Z S,LUO P,DAI S H,et al.Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation.Cellular and Molecular Neurobiology,2013,33(7):921-928
[53]ELING N,REUTER L,HAZIN J,et al.Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells.Oncoscience,2015,2(5):517-532
[54]YANG Y,ZHANG Y,WANG L,et al.Levistolide a induces apoptosis via ROS-mediated ER stress pathway in colon cancer cells.Cellular Physiology and Biochemistry:International Journal of Experimental Cellular Physiology,Biochemistry,and Pharmacology,2017,42(3):929-938
[55]FAN C,YANG Y,LIU Y,et al.Icariin displays anticancer activity against human esophageal cancer cells via regulating endoplasmic reticulum stress-mediated apoptotic signaling.Scientific Reports,2016,6:21145
[56]FILIPPOVA M,FILIPPOV V.Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents.2014,2014:574659
[57]HART P C,MAO M,DE ABREU A L P,et al.MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPKdependent signalling in cancer.Nature Communications,2015,6:6053
[58]RAJ L,IDE T,GURKAR A U,et al.Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Nature,2011,475(7355):231-234
[59]ROH J L,KIM E H,PARK J Y,et al.Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer.Oncotarget,2014,5(19):9227-9238
[60]SUN X,WANG W,CHEN J,et al.The natural diterpenoid isoforretin a inhibits thioredoxin-1 and triggers potent ROS-mediated antitumor effects.Cancer Research,2017,77(4):926-936
[61]DUAN D,ZHANG B,YAO J,et al.Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.Free Radical Biology and Medicine,2014,70:182-193
[62]DUAN D,ZHANG J,YAO J,et al.Targeting thioredoxin reductase by parthenolide contributes to inducing apoptosis of HeLa cells.The Journal of Biological Chemistry,2016,291(19):10021-10031
[63]REN D,VILLENEUVE N,JIANG T,et al.Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.Proc Natl Acad Sci USA,2011,108(4):1433-1438
[64]LIU Y,ZHI D,LI M,et al.Shengmai Formula suppressed overactivated Ras/MAPK pathway in C.elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.Scientific Reports,2016,6:38934
[65]BJELAKOVIC G,NIKOLOVA D,GLUUD C.Antioxidant supplements to prevent mortality.JAMA,2013,310(11):1178-1179
[66]PISKOUNOVA E,AGATHOCLEOUS M,MURPHY M M,et al.Oxidative stress inhibits distant metastasis by human melanoma cells.Nature,2015,527(7577):186-191
[67]WANG Y,GUO S H,SHANG X J,et al.Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response.Acta Pharmacol Sin,2018,39(2):311-327
[68]CAI W,ZHANG B,DUAN D,et al.Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells.Toxicology and Applied Pharmacology,2012,262(3):341-348