基于中医传承辅助平台分析石岩教授治疗甲状腺机能亢进用药规律
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摘要
目的:基于"中医传承辅助平台管理系统(V2. 5)",探讨石岩教授诊治甲状腺机能亢进的临证经验及用药规律,并为进一步挖掘瘿病的用药规律分析及新药研发提供参考。方法:将2017年1月—2018年6月就诊于石岩教授国医堂门诊甲状腺机能亢进患者信息输入系统中,结合传承辅助平台系统的分析功能,采用了包括关联规则法、聚类法的分析法,以及改进的互信息法、复杂系统熵聚类等高级数据挖掘方法,统计得出用药特点和组方规律分析;制定检索式,双人筛选并录入信息,构建石岩教授治疗瘿病的中药数据库,采用软件集成的数据挖掘方法,对数据库进行四气、五味、归经分布及用药频次统计,组方规律、药物组合分析。结果:共纳入103个病例,涉及药物107味。依次通过频数分析、关联规则分析、聚类分析以及可视化分析用药规律,最常使用药物性味为苦、甘,最常使用药物四气是寒性药。归经中最常使用的是肝、肾和肺经。出现频数分析症状最高的为心悸、失眠、乏力和腹泻等。结论:通过中医传承辅助平台管理系统的分析结果,总结出石岩教授对于甲状腺机能亢进疾病治疗的用药规律,为接下来的科学研究提供了数据的支撑。
Objective:To explore the clinical experience and medication rules of professor SHI Yan in the diagnosis and treatment of hyperthyroidism based on the"Traditional Chinese Medicine Aided Platform Management System(V2.5)",and to provide further analysis of drug use patterns and new drug development for rickets. reference. Methods:From January 2017 to June 2018,he was visited in the information input system of the hyperthyroidism patient in the outpatient clinic of professor SHI Yan.Combined with the software analysis system,the association rule analysis method,cluster analysis method and improved mutual information were adopted. Advanced data mining methods such as method,entropy clustering of complex systems and unsupervised entropy hierarchical clustering,statistical analysis of drug characteristics and prescription rules;formulating search,double screening and entering information,constructing professor SHI Yan to treat rickets the Chinese medicine database uses software-integrated data mining methods to perform four-gas,five-flavor,return distribution and frequency statistics,and formulas and drug combinations. Results:A total of 103 cases were included,involving 107 drugs. Through frequency analysis,association rule analysis,cluster analysis and visual analysis of medication rules,the most commonly used drug taste is bitter,sweet,and the most commonly used drugs are cold drugs. The most commonly used in menopause are the liver,kidney and lung. The highest symptoms of frequency analysis were palpitations,insomnia,fatigue and diarrhea. Conclusion:Through the method of data mining,professor SHI Yan's treatment of hyperthyroidism is summarized,which provides data support for further scientific research.
Objective:To explore the clinical experience and medication rules of professor SHI Yan in the diagnosis and treatment of hyperthyroidism based on the"Traditional Chinese Medicine Aided Platform Management System(V2.5)",and to provide further analysis of drug use patterns and new drug development for rickets. reference. Methods:From January 2017 to June 2018,he was visited in the information input system of the hyperthyroidism patient in the outpatient clinic of professor SHI Yan.Combined with the software analysis system,the association rule analysis method,cluster analysis method and improved mutual information were adopted. Advanced data mining methods such as method,entropy clustering of complex systems and unsupervised entropy hierarchical clustering,statistical analysis of drug characteristics and prescription rules;formulating search,double screening and entering information,constructing professor SHI Yan to treat rickets the Chinese medicine database uses software-integrated data mining methods to perform four-gas,five-flavor,return distribution and frequency statistics,and formulas and drug combinations. Results:A total of 103 cases were included,involving 107 drugs. Through frequency analysis,association rule analysis,cluster analysis and visual analysis of medication rules,the most commonly used drug taste is bitter,sweet,and the most commonly used drugs are cold drugs. The most commonly used in menopause are the liver,kidney and lung. The highest symptoms of frequency analysis were palpitations,insomnia,fatigue and diarrhea. Conclusion:Through the method of data mining,professor SHI Yan's treatment of hyperthyroidism is summarized,which provides data support for further scientific research.
引文
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[11]程相稳,张广德,魏子孝.含碘中药在甲状腺功能亢进症中的应用评述[J].中华中医药杂志,2017(9):3901-3904.
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[13]姜德友,曲晓雪.瘿病的中医证治[J].河南中医,2016(7):1237-1239.
[14]嶲洪岳,王耀山.消瘿汤治疗甲状腺机能亢进症的体会[J].辽宁中医杂志,1960(4):19-20.
[15]刘晓汉,张韬玉.治疗甲状腺机能亢进症20例疗效观察[J].中医杂志,1980(1):40-41.
[16]张曾譻.甲Ⅱ号丸剂治疗甲亢50例[J].北京中医,1983(2):51.
[17]张淑芝.甲亢丸治疗甲状腺机能亢进152例[J].黑龙江中医药,1987(1):43.
[18]崔鹏,高天舒,李贺.富碘中药治疗瘿病的研究进展[J].中华中医药学刊,2007,25(10):2090-2092.
[19]时杨,高天舒,杨柳.富碘中药复方对甲亢大鼠甲状腺功能和形态的影响[J].辽宁中医药大学学报,2009,10(9):186-188.
[2]周林.于世家教授中西医结合治疗甲状腺功能亢进症经验[J].中华中医药学刊,2007,25(8):1557.
[2]李健,卢朋,唐仕欢,等.基于中医传承辅助系统的治疗肺痈方剂组方规律分析[J].中国实验方剂学杂志,2012(2):254-257.
[3]田黎.黄仰模教授治疗甲状腺功能亢进症经验[J].河南中医,2010,30(10):961-963.
[4]卢朋,李健,唐仕欢,等.中医传承辅助系统软件开发与应用[J].中国实验方剂学杂志,2012(9):1-4.
[5]唐仕欢,申丹,卢朋,等.中医传承辅助平台应用评述[J].中华中医药杂志,2015(2):329-331.
[6]中华医学会.中国甲状腺疾病诊疗指南一甲状腺功能亢进症[M].北京:人民卫生出版社,2007.
[7]巢元方.诸病源候论[M].沈阳:沈阳科技出版社,1997:143.
[8]李梴.医学入门[M].金嫣莉,校注.北京:中国中医药出版社,1995:472.
[9]柳长凤,刘洪毓,苗晶囡,等.国家已公开专利中治疗甲亢的中药用药规律探讨[J].中医药信息,2013,30(2):61-64.
[10]周玉,吕萌,王芷乔,等.基于中医传承辅助系统探讨瘿病方剂组方规律[J].中医学报,2016(11):1758-1762.
[11]程相稳,张广德,魏子孝.含碘中药在甲状腺功能亢进症中的应用评述[J].中华中医药杂志,2017(9):3901-3904.
[12]柳红芳,王倩.含碘中药在甲状腺机能亢进症中的应用[J].中医杂志,2009(S1):23-24.
[13]姜德友,曲晓雪.瘿病的中医证治[J].河南中医,2016(7):1237-1239.
[14]嶲洪岳,王耀山.消瘿汤治疗甲状腺机能亢进症的体会[J].辽宁中医杂志,1960(4):19-20.
[15]刘晓汉,张韬玉.治疗甲状腺机能亢进症20例疗效观察[J].中医杂志,1980(1):40-41.
[16]张曾譻.甲Ⅱ号丸剂治疗甲亢50例[J].北京中医,1983(2):51.
[17]张淑芝.甲亢丸治疗甲状腺机能亢进152例[J].黑龙江中医药,1987(1):43.
[18]崔鹏,高天舒,李贺.富碘中药治疗瘿病的研究进展[J].中华中医药学刊,2007,25(10):2090-2092.
[19]时杨,高天舒,杨柳.富碘中药复方对甲亢大鼠甲状腺功能和形态的影响[J].辽宁中医药大学学报,2009,10(9):186-188.