活血痹痛膏治疗血瘀寒湿阻络型腰椎骨性关节炎临床研究
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摘要
目的观察活血痹痛膏治疗血瘀寒湿阻络型腰椎骨性关节炎的临床疗效。方法将120例纳入患者采用抽签法分为试验组60例和对照组60例。试验组采用活血痹痛膏贴敷,对照组予狗皮膏贴敷,每日1次,均治疗2周,观察治疗前后中医症状和体征评分、疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)及起效时间,评价临床疗效。结果试验组总有效率为86.67%(52/60),对照组总有效率为85.00%(51/60),差异无统计学意义(P>0.05)。与治疗前比较,2组治疗后中医各症状和体征评分及总分均降低(P<0.05),试验组腰痛及晨僵积分低于对照组(P<0.05),对照组腰部沉重评分低于试验组(P<0.05)。2组治疗后VAS、ODI均有不同程度降低,试验组优于对照组(P<0.05)。试验组对腰痛、晨僵的起效时间快于对照组(P<0.05),对照组对腰部沉重的起效时间快于试验组(P<0.05)。结论活血痹痛膏治疗血瘀寒湿阻络型腰椎骨性关节炎具有较好疗效。
Objective To observe the clinical efficacy of Huoxue Bitong Plaster on lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome. Methods Totally 120 patients were randomly divided into treatment group(60 cases) and control group(60 cases). Huoxue Bitong Plaster was applied externally in the treatment group, while Goupigao Plaster was used externally in the control group, once a day, for two weeks. The clinical efficacy was evaluated by observing TCM symptom scores, VAS, Oswestry dability index(ODI), and onset time in both groups before and after treatment. Results The total effective rate was 86.67%(52/60) in treatment group, and 85.00%(51/60) in the control group, with no statistical significance(P >0.05). TCM symptom scores of both groups decreased after treatment(P <0.05). For the effect of relieving back pain and morning stiffness, the treatment group was superior to control group(P <0.05). For the effect of relieving waist heaviness, the control group was better than the treatment group(P <0.05). Besides, VAS and ODI of the treatment group were lower than the control group after treatment(P <0.05). The onset time of lightening back pain, morning stiffness in the treatment group was quicker than control group(P <0.05). For waist heaviness, the onset time in control group was quicker than treatment group(P <0.05). Conclusion Huoxue Bitong Plaster has good efficacy for lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome.
Objective To observe the clinical efficacy of Huoxue Bitong Plaster on lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome. Methods Totally 120 patients were randomly divided into treatment group(60 cases) and control group(60 cases). Huoxue Bitong Plaster was applied externally in the treatment group, while Goupigao Plaster was used externally in the control group, once a day, for two weeks. The clinical efficacy was evaluated by observing TCM symptom scores, VAS, Oswestry dability index(ODI), and onset time in both groups before and after treatment. Results The total effective rate was 86.67%(52/60) in treatment group, and 85.00%(51/60) in the control group, with no statistical significance(P >0.05). TCM symptom scores of both groups decreased after treatment(P <0.05). For the effect of relieving back pain and morning stiffness, the treatment group was superior to control group(P <0.05). For the effect of relieving waist heaviness, the control group was better than the treatment group(P <0.05). Besides, VAS and ODI of the treatment group were lower than the control group after treatment(P <0.05). The onset time of lightening back pain, morning stiffness in the treatment group was quicker than control group(P <0.05). For waist heaviness, the onset time in control group was quicker than treatment group(P <0.05). Conclusion Huoxue Bitong Plaster has good efficacy for lumbar osteoarthritis with blood stasis and cold-dampness blocking collaterals syndrome.
引文
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[11]戎利民,冯丰.腰椎骨关节炎源性腰痛的诊断和治疗[J].新医学,2009,40(9):569-570.
[12]吕尧,于芳.小针刀松解术治疗腰椎骨性关节炎的临床观察[J].中国社区医师,2013,15(21):66.
[13]赵贵琴,李帆帆,李纯刚,等.狗皮膏抗炎镇痛作用试验研究[J].中药与临床,2011,2(4):27-29.
[14]曾勇,赵贵琴,陈怀斌,等.狗皮膏皮肤用药安全性实验研究[J].时珍国医国药,2012,23(2):375-376.
[2]孙树椿,孙之镐.临床骨伤科学[M].北京:人民卫生出版社,2006:897-898.
[3]中华人民共和国卫生部.中药新药临床研究指导原则:第一辑[M].1993:210.
[4]Lee CK,Vessa P,Lee JK.Chronic disabling low back pain syndrome caused by internal disc derangements:the results of disc excision and posterior lumbar interbody fusion[J].Spine,1995,20(3):356-361.
[5]Fairbank JC,Pynsent PB.The Oswestry disability index[J].Spine,2000,25(22):2940-2952.
[6]李文庆,廉春光,王定,等.骨性关节炎的基础研究进展[J].中医正骨,2009,21(5):67-70.
[7]张超,杨少锋.补肾活血汤综合治疗腰椎骨性关节炎60例疗效观察[J].湖南中医杂志,2014,30(10):69-70.
[8]郑皓.新止骨增生丸治疗腰椎骨性关节炎疗效观察[J].临床合理用药,2014,7(5):26-27.
[9]文宏修.补肾益肝汤治疗骨性关节炎63例报告[J].中医正骨,2000,12(9):51-52.
[10]李霞.独活寄生汤加减治疗腰椎骨性关节炎的疗效观察[J].长治医学院学报,2013,27(4):300-302.
[11]戎利民,冯丰.腰椎骨关节炎源性腰痛的诊断和治疗[J].新医学,2009,40(9):569-570.
[12]吕尧,于芳.小针刀松解术治疗腰椎骨性关节炎的临床观察[J].中国社区医师,2013,15(21):66.
[13]赵贵琴,李帆帆,李纯刚,等.狗皮膏抗炎镇痛作用试验研究[J].中药与临床,2011,2(4):27-29.
[14]曾勇,赵贵琴,陈怀斌,等.狗皮膏皮肤用药安全性实验研究[J].时珍国医国药,2012,23(2):375-376.