丁苯酞治疗高危性短暂性脑缺血发作的临床分析
|
摘要
目的:探讨丁苯酞治疗高危性短暂性脑缺血发作的临床应用效果。方法:选取在我院接受治疗的94例高危性短暂性脑缺血发作患者,其中47例患者作为对照组采用前列地尔治疗,47例患者作为观察组采用丁苯酞治疗,比较两组患者临床治疗效果。结果:观察组患者临床治疗总有效率为97.87%,显著高于对照组(P<0.05);在接受治疗前,两组患者血液流变学指标、血清三酰甘油水平、颈动脉内膜中层厚度及斑块面积均差异无统计学意义(P>0.05),在接受治疗后,观察组患者血液流变学指标、血清三酰甘油水平、颈动脉内膜中层厚度及斑块面积等各项指标均显著优于对照组(P<0.05);观察组患者颈动脉内膜中层厚度和斑块面积分别为(0.76±0.21)mm~2、(19.01±4.36)mm~2,均显著低于对照组(P<0.05);观察组患者不良反应发生率为4.26%,对照组为17.02%,两组之间差异有统计学意义(P<0.05)。结论:采用丁苯酞治疗高危性短暂性脑缺血发作,可明显改善患者临床病症,降低其发作频率,对于脑梗死疾病的发生具有积极预防作用。
Objective: To investigate the clinical application effects of butylphthalide in the treatment of high-risk transient ischemic attack. Methods: A total of 94 patients with high-risk transient ischemic attack were treated in our hospital. Among them, 47 patients in the control group were treated with alprostadil, while another 47 patients in the observation group were treated with butylphthalide, then the clinical effects of patients in the two groups were compared. Results: The total effective rate of the observation group was 97.87%, which was significantly higher than that in the control group(P< 0.05). Before the treatment, there were no significant differences of the hemorheology index, serum triglyceride level and carotid intima media thickness(CIMT)and area of carotid artery plaque in patients in both groups(P>0.05). After treatment, the hemorheology index, serum triglyceride level and CIMT and area of carotid artery plaque in patients in the observation group were obviously better than those of the control group(P<0.05). The CIMT and plaque area of patients in the observation group were(0.76±0.21)mm and(19.01±4.36)mm~2, respectively, which were significantly lower than those of the control group(P<0.05). The incidence of adverse reactions was 4.26% for patients in the observation group and 17.02% in the control group, which was of significant difference(P<0.05). Conclusion: The use of butylphthalide in the treatment of high-risk transient ischemic attack can significantly improve the clinical symptoms of patients and reduce the frequency of attacks. It has a positive preventive effect on the occurrence of cerebral infarction disease.
Objective: To investigate the clinical application effects of butylphthalide in the treatment of high-risk transient ischemic attack. Methods: A total of 94 patients with high-risk transient ischemic attack were treated in our hospital. Among them, 47 patients in the control group were treated with alprostadil, while another 47 patients in the observation group were treated with butylphthalide, then the clinical effects of patients in the two groups were compared. Results: The total effective rate of the observation group was 97.87%, which was significantly higher than that in the control group(P< 0.05). Before the treatment, there were no significant differences of the hemorheology index, serum triglyceride level and carotid intima media thickness(CIMT)and area of carotid artery plaque in patients in both groups(P>0.05). After treatment, the hemorheology index, serum triglyceride level and CIMT and area of carotid artery plaque in patients in the observation group were obviously better than those of the control group(P<0.05). The CIMT and plaque area of patients in the observation group were(0.76±0.21)mm and(19.01±4.36)mm~2, respectively, which were significantly lower than those of the control group(P<0.05). The incidence of adverse reactions was 4.26% for patients in the observation group and 17.02% in the control group, which was of significant difference(P<0.05). Conclusion: The use of butylphthalide in the treatment of high-risk transient ischemic attack can significantly improve the clinical symptoms of patients and reduce the frequency of attacks. It has a positive preventive effect on the occurrence of cerebral infarction disease.
引文
[1] 瞿砚舟,吕锦,蓝丽康,等.丁苯酞治疗高危性短暂性脑缺血发作的临床疗效与安全性[J].中国临床药理学杂志,2016,32(5):406-408.
[2] 杨照玲.丁苯酞对高危性短暂性脑缺血发作患者血脂和血液流变学的影响[J].中国药业,2016,25(14):68-71.
[3] 李春生.丁苯酞治疗高危性短暂性脑缺血发作的疗效及安全性分析[J].中国实用神经疾病杂志,2017,20(7):122-123.
[4] 韩亚杰.丁苯酞治疗高危性短暂性脑缺血发作的近期疗效[J].临床医学研究与实践,2017,2(29):25-26.
[5] 牛慧艳,张占强,王海,等.丁笨酞氯化钠注射液联合尿激酶治疗急性卒中疗效观察[J].中国现代神经疾病杂志,2014,14(9):820-823.
[6] 高雪武.脑苷肌肽与丁苯酚治疗急性缺血性脑血管病的疗效比较[J].医学理论与实践,2016,29(8):1024-1025.
[7] 王永会.双抗加他汀联合丁苯酞治疗短暂性脑缺血发作[J].中西医结合心脑血管病杂志,2014,12(1):57-58.
[8] 高青华,刘水策,郭凤,等.壬基苯酚对H9c2心肌细胞钙信号和细胞增殖的影响及其作用机制[J].中国医科大学学报,2015,44(2):109-113.
[9] 刘宏顺.丁苯酞氯化钠注射液防治高风险TIA患者进展为脑梗死的疗效观察[J].心理医生,2016,22(27):111-112.
[2] 杨照玲.丁苯酞对高危性短暂性脑缺血发作患者血脂和血液流变学的影响[J].中国药业,2016,25(14):68-71.
[3] 李春生.丁苯酞治疗高危性短暂性脑缺血发作的疗效及安全性分析[J].中国实用神经疾病杂志,2017,20(7):122-123.
[4] 韩亚杰.丁苯酞治疗高危性短暂性脑缺血发作的近期疗效[J].临床医学研究与实践,2017,2(29):25-26.
[5] 牛慧艳,张占强,王海,等.丁笨酞氯化钠注射液联合尿激酶治疗急性卒中疗效观察[J].中国现代神经疾病杂志,2014,14(9):820-823.
[6] 高雪武.脑苷肌肽与丁苯酚治疗急性缺血性脑血管病的疗效比较[J].医学理论与实践,2016,29(8):1024-1025.
[7] 王永会.双抗加他汀联合丁苯酞治疗短暂性脑缺血发作[J].中西医结合心脑血管病杂志,2014,12(1):57-58.
[8] 高青华,刘水策,郭凤,等.壬基苯酚对H9c2心肌细胞钙信号和细胞增殖的影响及其作用机制[J].中国医科大学学报,2015,44(2):109-113.
[9] 刘宏顺.丁苯酞氯化钠注射液防治高风险TIA患者进展为脑梗死的疗效观察[J].心理医生,2016,22(27):111-112.