静息态脑电分析在精神分裂症研究中的应用(综述)
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摘要
本文从功率谱、协调性和脑电微状态3个指标的改变综述了精神分裂症患者静息态脑电的特征,比较一致的发现是,患者低频δ和θ功率增强,而这种改变似乎未出现在其一级亲属中;γ协调性的降低,且这一改变在患者的局部脑区和全脑均有发现;患者脑电微状态中注意相关的D类微状态覆盖率降低,而其他微状态增加。这些静息态脑电指标的特异性改变,能够帮助我们寻求可能的精神分裂症内表型,为疾病的早期筛查和识别提供可能性。
This paper critically reviews spectral power,coherence,and microstates of resting-state electroencephalography(EEG) findings in patients with schizophrenia.This review indicates that,power of slow wave,such as delta and theta bands,is decreased,while first-degree relatives of patients may be free from such change.Gamma coherence and synchronization are decreased in both local and whole brain regions of the patients.The brain microstates of patients with schizophrenia are different from healthy controls,with decreasing coverage of microstate D(related to attentional function) and increasing coverage of other 3 microstates.Taken together,these specific changes in resting EEG parameters could help us to look for possible endophenotype for schizophrenia and provide possibilities for early screening and identification of this clinical group.
This paper critically reviews spectral power,coherence,and microstates of resting-state electroencephalography(EEG) findings in patients with schizophrenia.This review indicates that,power of slow wave,such as delta and theta bands,is decreased,while first-degree relatives of patients may be free from such change.Gamma coherence and synchronization are decreased in both local and whole brain regions of the patients.The brain microstates of patients with schizophrenia are different from healthy controls,with decreasing coverage of microstate D(related to attentional function) and increasing coverage of other 3 microstates.Taken together,these specific changes in resting EEG parameters could help us to look for possible endophenotype for schizophrenia and provide possibilities for early screening and identification of this clinical group.
引文
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[8] Hanslmayr S,Backes H,Straub S,et al.Enhanced resting-state oscillations in schizophrenia are associated with decreased synchronization during inattentional blindness [J].Hum Brain Mapp,2013,34 (9):2266-2275.
[9] Kindler J,Hubl D,Strik WK,et al.Resting-state EEG in schizophrenia:auditory verbal hallucinations are related to shortening of specific microstates [J].Clin Neurophysiol,2011,122 (6):1179-1182.
[10]Roth JK,Johnson MK,Tokoglu F,et al.Modulating intrinsic connectivity:adjacent subregions within supplementary motor cortex,dorsolateral prefrontal cortex,and parietal cortex connect to separate functional networks during task and also connect during rest [J].PLoS One,2014,9 (3):e90672.doi:10.1371/journal.pone.0090672.
[11]Grin-Yatsenko VA,Ponomarev VA,Pronina MV,et al.Local and widely distributed EEG activity in schizophrenia with prevalence of negative symptoms [J].Clin EEG Neurosci,2017,48 (5):307-315.
[12]李颖洁,邱意宏,朱贻盛.脑电信号分析方法及其应用[M].北京:科学出版社,2009.
[13]Imani E,Pourmohammad A,Mahsa B,et al.ICA-based imagined conceptual words classification on EEG signals [J].J Med Signals Sens,2017,7 (3):130-144.
[14]Karan S,Amit KA.Quality,Reliability,security and robustness in heterogeneous networks [M].London:Springer Heidelberg Dordrecht,2013.
[15]Gabor D.Theory of communication [J].IEEE.1946,93:429-457.
[16]Akar SA,Kara S,Latifo?lu F,et al.Estimation of nonlinear measures of schizophrenia patients' EEG in emotional states [J].IRBM,2015,36 (4):250-258.
[17]Thilakvathi B,Devi SS,Bhanu K,et al.EEG signal complexity analysis for schizophrenia during rest and mental activity [J].Biomed Res,2017,28 (1):1-9.
[18]Boutros NN,Arfken C,Galderisi S,et al.The status of spectral EEG abnormality as a diagnostic test for schizophrenia [J].Schizophr Res,2008,99 (1-3):225-237.
[19]Mitra S,Nizamie SH,Goyal N,et al.Electroencephalogram alpha-to-theta ratio over left fronto-temporal region correlates with negative symptoms in schizophrenia [J].Asian J Psychiatr,2017,26:70-76.doi:10.1016/j.ajp.2017.01.013.
[20]Muller HF,Achim A,Laur A,et al.Topography and possible physiological significance of EEG amplitude variability in psychosis [J].Acta Psychiatr Scand,1986,73 (6):665-675.
[21]Takahashi T,Goto T,Nobukawa S,et al.Abnormal functional connectivity of high-frequency rhythms in drug-naive schizophrenia [J].Clin Neurophysiol,2018,129 (1):222-231.
[22]Narayanan B,O' Neil K,Berwise C,et al.Resting state electroencephalogram oscillatory abnormalities in schizophrenia and psychotic bipolar patients and their relatives from the bipolar and schizophrenia network on intermediate phenotypes study [J].Biol Psychiatry,2014,76 (6):456-465.
[23]Venables NC,Bernat EM,Sponheim SR.Genetic and disorder-specific aspects of resting state EEG abnormalities in schizophrenia [J].Schizophr Bull,2009,35 (4):826-839.
[24]Sullivan PF,Kendler KS,Neale MC.Schizophrenia as a complex trait:evidence from a meta-analysis of twin studies [J].Arch Gen Psychiatry,2003,60 (12):1187-1192.
[25]Rossini PM,Rossi S,Babiloni C,et al.Clinical neurophysiology of aging brain:from normal aging to neurodegeneration [J].Prog Neurobiol,2007,83 (6):375-400.
[26]Fuggetta G,Bennett MA,Duke PA,et al.Quantitative electroencephalography as a biomarker for proneness toward developing psychosis [J].Schizophr Res,2014,153 (1-3):68-77.
[27]Baenninger A,Diaz Hernandez L,Rieger K,et al.Inefficient preparatory fMRI-BOLD network activations predict working memory dysfunctions in patients with schizophrenia [J].Front Psychiatry,2016,7:29.doi:10.3389/fpsyt.2016.00029.
[28]Guevara MA,Cruz Paniagua EI,Hernández González M,et al.EEG activity during the spatial span task in young men:differences between short-term and working memory [J].Brain Res,2018,1683:86-94.doi:10.1016/j.brainres.2018.02.004.
[29]Wisniewski MG,Iyer N,Thompson ER,et al.Sustained frontal midline theta enhancements during effortful listening track working memory demands [J].Hear Res,2017,pii:S0378-5955(17)30368-4.doi:10.1016/j.heares.2017.11.009.
[30]Euler MJ,Wiltshire TJ,Niermeyer MA,et al.Working memory performance inversely predicts spontaneous delta and theta-band scaling relations [J].Brain Res,2016,1637:22-33.doi:10.1016/j.brainres.2016.02.008.
[31]Dickson H,Cullen AE,Jones R,et al.Trajectories of cognitive development during adolescence among youth at-risk for schizophrenia [J].J Child Psychol and Psychiatry,2018,59(11):1215-1224.doi:10.1111/jcpp.12912.
[32]St?blein M,Storchak H,Ghinea D,et al.Visual working memory encoding in schizophrenia and first-degree relatives:neurofunctional abnormalities and impaired consolidation [J].Psychol Med,2018,9:1-9.doi:10.1017/S003329171800051X.
[33]Schmiedt C,Brand A,Hildebrandt H,et al.Event-related theta oscillations during working memory tasks in patients with schizophrenia and healthy controls [J].Brain Res Cogn Brain Res,2005,25 (3):936-947.
[34]Steffen-Allen F.Increased Delta as a compensatory strategy during working memory in high-performing patients with schizophrenia [D].St.Louis,:University of Connecticut Graduate School,2016,961.https://opencommons.uconn.edu/gs_theses/961
[35]Kang SS,MacDonald AW 3rd,Chafee MV,et al.Abnormal cortical neural synchrony during working memory in schizophrenia [J].Clin Neurophysiol,2018,129 (1):210-221.
[36]Wichniak A,Okruszek L,Linke M,et al.Electroencephalographic theta activity and cognition in schizophrenia:preliminary results [J].World J Biol Psychiatry,2015,16 (3):206-210.
[37]Raichle ME.The brain' s default mode network[J].Annu Rev Neurosci,2015,38:433-447.doi:10.1146/annurev-neuro-071013-014030.
[38]Galindo L,Berge D,Murray GK,et al.Default mode network aberrant connectivity associated with neurological soft signs in schizophrenia patients and unaffected relatives [J].Front Psychiatry,2018,8:298.doi:10.3389/fpsyt.2017.00298.
[39]Whitfield-Gabrieli S,Thermenos HW,Milanovic S,et al.Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia [J].Proc Natl Acad Sci U S A,2009,106 (4):1279-1284.
[40]Jann K,Kottlow M,Dierks T,et al.Topographic electrophysiological signatures of fMRI resting state networks [J].PLoS One,2010,5 (9):e12945.doi:10.1371/journal.pone.0012945.
[41]Pettersson-Yeo W,Allen P,Benetti S,et al.Dysconnectivity in schizophrenia:where are we now [J].Neurosci Biobehav Rev,2011,35 (5):1110-1124.
[42]Stephan KE,Baldeweg T,Friston KJ.Synaptic plasticity and dysconnection in schizophrenia [J].Biol Psychiatry,2006,59 (10):929-939.
[43]Engel AK,Fries P,Singer W.Dynamic predictions:oscillations and synchrony in top-down processing [J].Nat Rev Neurosci,2001,2 (10):704-716.
[44]Kikuchi M,Hashimoto T,Nagasawa T,et al.Frontal areas contribute to reduced global coordination of resting-state gamma activities in drug-na?ve patients with schizophrenia [J].Schizophr Res,2011,130 (1):187-194.
[45]Blum J,Lutz K,J?ncke L.Coherence and phase locking of intracerebral activation during visuo-and audio-motor learning of continuous tracking movements [J].Exp Brain Res,2007,182 (1):59-69.
[46]Bandyopadhyaya D,Nizamie SH,Pradhan N,et al.Spontaneous gamma coherence as a possible trait marker of schizophrenia:an explorative study [J].Asian J Psychiatr,2011,4 (3):172-177.
[47]Yeragani VK,Cashmere D,Miewald J,et al.Decreased coherence in higher frequency ranges (beta and gamma) between central and frontal EEG in patients with schizophrenia:a preliminary report [J].Psychiatry Res,2006,141 (1):53-60.
[48]Kim JS,Shin KS,Jung WH,et al.Power spectral aspects of the default mode network in schizophrenia:an MEG study [J].BMC Neurosci,2014,15:104.doi:10.1186/1471-2202-15-104..
[49]Rutter L,Nadar SR,Holroyd T,et al.Graph theoretical analysis of resting magnetoencephalographic functional connectivity networks [J].Front Comput Neurosci,2013,7:93.doi:10.3389/fncom.2013.00093
[50]Umesh S,Nizamie SH,Goyal N,et al.Social anhedonia and gamma band abnormalities as a composite/multivariate endophenotype for schizophrenia:a dense array EEG study [J].Early Interv Psychiatry,2018,12 (3):362-371.
[51]Fries P.Neuronal gamma-band synchronization as a fundamental process in cortical computation [J].Annu Rev Neurosci,2009,32:209-224.doi:10.1146/annurev.neuro.051508.135603.
[52]Bosman CA,Lansink CS,Pennartz CM.Functions of gamma-band synchronization in cognition:from single circuits to functional diversity across cortical and subcortical systems [J].Eur J Neurosci,2014,39 (11):1982-1999.
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