杞参膏联合角膜吸氧治疗干眼症的临床研究
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摘要
目的杞参膏联合角膜吸氧治疗干眼症的临床疗效。方法选取我科室就诊的干眼患者共40例(80眼),采用随机数字表进行分组,对照组和试验组。对照组用0.1%的玻璃酸钠滴眼液滴眼进行常规治疗,4次/日,试验组口服杞参膏,2次/日,5 mL/次,加上角膜局部吸氧,1次/日,20 min/次,治疗时间均为30 d。结果治疗结束后,试验组效果优于对照组,且分别进行组间比较和组内比较,差异有统计学意义,P<0.05。试验组有效率为90%大于对照组有效率60%,泪膜破裂时间,泪液分泌实验,角膜荧光素钠染色和患者自觉症状试验组均优于对照组,且差异有统计学意义(P<0.05)。结论角膜吸氧疗法联合玻璃酸钠滴眼液治疗干眼症效果优于单纯玻璃酸钠治疗效果,对于临床干眼症治疗有一定的指导意义。
Objective To study of the clinical effect of Qishen ointment combined with corneal oxygenation in the treatment of dry eyes. Methods Collecting cases of dry eye patients from ophthalmology department of the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. A total of 40 patients(80 eyes) were divided into control group and experimental group according to the random number table. The control group was treated with 0.1 % sodium hyaluronate eye drops, four times a day. The experimental group was given oral administration of Qishen ointment, 10ml/two times a day, in addition, experimental group was given local oxygen inhalation, one times a day, 20 minutes each time. Both groups were treated for 30 days. Group comparison and intra group comparison were conducted respectively. Results The experimental group had better effect(P<0.05), and the difference was statistically significant. The effective rate of the experimental group was 90 %, which was higher than that of the control group(60%). The time of tear film rupture, tear secretion, the corneal fluorescein sodium staining and the conscious symptoms and the curative effect of the experimental group was better than that of the control group. The difference was statistically significant( P<0.05).Conclusion The corneal local oxygen therapy combined with sodium hyaluronate drops is effective in the treatment of dry eyes, and has a definite effect on the clinical treatment of dry eyes.
Objective To study of the clinical effect of Qishen ointment combined with corneal oxygenation in the treatment of dry eyes. Methods Collecting cases of dry eye patients from ophthalmology department of the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. A total of 40 patients(80 eyes) were divided into control group and experimental group according to the random number table. The control group was treated with 0.1 % sodium hyaluronate eye drops, four times a day. The experimental group was given oral administration of Qishen ointment, 10ml/two times a day, in addition, experimental group was given local oxygen inhalation, one times a day, 20 minutes each time. Both groups were treated for 30 days. Group comparison and intra group comparison were conducted respectively. Results The experimental group had better effect(P<0.05), and the difference was statistically significant. The effective rate of the experimental group was 90 %, which was higher than that of the control group(60%). The time of tear film rupture, tear secretion, the corneal fluorescein sodium staining and the conscious symptoms and the curative effect of the experimental group was better than that of the control group. The difference was statistically significant( P<0.05).Conclusion The corneal local oxygen therapy combined with sodium hyaluronate drops is effective in the treatment of dry eyes, and has a definite effect on the clinical treatment of dry eyes.
引文
[1]刘祖国,杨文照.加强干眼的临床研究[J].中华眼科杂志,2013,49(10):865-868.
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[8]沈乎醒,高卫萍. 2型糖尿病发生干眼的相关因素分析[J].国际眼科杂志,2018,18(1):126-129.
[9]谯雁彬,易虹,聂昕. 620例眼科门诊干眼病的流行病学调查[J].重庆医学,2013,42(14):1623-1625.
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[11]Li J,Zheng K,Deng Z,et al. Prevalence and risk factors of dryeye disease among ahospital-based population in southeast China[J]. Eye Contac Lens,2015,41(1):44-50.
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[14]King-Smith P E,Hinel E A,Nichols J J. Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning[J]. Invest Ophthalmol Vis Sci,2010,51(5):2418-2423.
[15]Hodges RR,Dartt D A. Tear film mucins:front line defenders of the ocular surface;comparison with airway and gastrointestinaltract mucins[J]. Exp Eye Res,2013,117(12):62-78.
[16]Vanathi M,Kashyap S,Khan R,et al. Ocular surfaceevaluation in allogenic hematopoietic stem cell transplantationpatients[J]. Eur J Ophthalmol,2014,7:530.
[17]刘丹,郭纯刚,李秀惠,等.性激素在干眼发病中作用的研究概述[J].中国中医眼科杂志,2013,23(4):306-308.
[18]袁媛.干眼危险因素的研究[J].眼科新进展,2017,37(12):1173-1177.
[19]Bigdeli M R. Preconditioning with prolonged normobaric hyperoxia induces ischemic tolerance partly by upregulation of antioxidant enzymes in rat brain tissue[J].Brain Res,2009(1260):47-54.
[20]Bigdeli M R,Rasoulian B,Meratan A A. In vivo normobaric hyperoxiapreconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue[J]. Eur J Pharmaco,2009,611(1-3):22-29.
[21]GOTTRUP F. Oxygen in wound healing ang infection[J]. World Jsurg,2004,28(3):312-315.
[22]GORDILLO G M,SEN C K. Revisiting the essential role of oxygen in wound healing[J]. The Am J of Surgery,2003,186(3):259-263.
[2]杨智,李若溪.若干环境因素对干眼症发病的影响[J].国际眼科杂志,2013,13(3):632-633.
[3]中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识(2013年)[J].中华眼科杂志,2013,49(1):73-75.
[4]杨雯,田琪,左韬.视频显示终端工作人员干眼症病因与防治[J].中国工业医学杂志,2013,26(4):261-263.
[5]黄桦,邹文进.视频显示终端使用时间及睡眠时间与儿童干眼的关系[J].广东医学,2018,39(5):701-704,709.
[6] Messmer E M. The pathophysiology,diagnosis,and treatmeng of dry eye disese[J]. Deutsches Arzteblatt international,2015,112(5):71.
[7]李娟,丁小艳,王亚虹,等. PM2.5对小鼠泪膜功能和角膜上皮组织结构的影响[J].眼科新进展,2017,37(3):201-204.
[8]沈乎醒,高卫萍. 2型糖尿病发生干眼的相关因素分析[J].国际眼科杂志,2018,18(1):126-129.
[9]谯雁彬,易虹,聂昕. 620例眼科门诊干眼病的流行病学调查[J].重庆医学,2013,42(14):1623-1625.
[10]蒋凯婷,谢亚男,叶宇峰.杭州某校大学生干眼病患病及相关因素分析[J].中国学校卫生,2015,36(10):1570-1571.
[11]Li J,Zheng K,Deng Z,et al. Prevalence and risk factors of dryeye disease among ahospital-based population in southeast China[J]. Eye Contac Lens,2015,41(1):44-50.
[12]赵堪兴,杨培增.眼科学[M].北京:人民卫生出版社,2013:92.
[13]King-Smith P E,Reuter K S,Braun R J,et al. Tear film breakup and structure studied by si multaneous video recording of fluorescence and tear film lipid layer images[J]. Invest Ophthalmol Vis Sci,2013,54(7):4900-4909.
[14]King-Smith P E,Hinel E A,Nichols J J. Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning[J]. Invest Ophthalmol Vis Sci,2010,51(5):2418-2423.
[15]Hodges RR,Dartt D A. Tear film mucins:front line defenders of the ocular surface;comparison with airway and gastrointestinaltract mucins[J]. Exp Eye Res,2013,117(12):62-78.
[16]Vanathi M,Kashyap S,Khan R,et al. Ocular surfaceevaluation in allogenic hematopoietic stem cell transplantationpatients[J]. Eur J Ophthalmol,2014,7:530.
[17]刘丹,郭纯刚,李秀惠,等.性激素在干眼发病中作用的研究概述[J].中国中医眼科杂志,2013,23(4):306-308.
[18]袁媛.干眼危险因素的研究[J].眼科新进展,2017,37(12):1173-1177.
[19]Bigdeli M R. Preconditioning with prolonged normobaric hyperoxia induces ischemic tolerance partly by upregulation of antioxidant enzymes in rat brain tissue[J].Brain Res,2009(1260):47-54.
[20]Bigdeli M R,Rasoulian B,Meratan A A. In vivo normobaric hyperoxiapreconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue[J]. Eur J Pharmaco,2009,611(1-3):22-29.
[21]GOTTRUP F. Oxygen in wound healing ang infection[J]. World Jsurg,2004,28(3):312-315.
[22]GORDILLO G M,SEN C K. Revisiting the essential role of oxygen in wound healing[J]. The Am J of Surgery,2003,186(3):259-263.