中医“肾阴肾阳失常”与肠屏障功能损伤的机制
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摘要
肾阴肾阳是中医藏象学说中两个重要的基本概念,肾阴,又称为元阴、真阴,为一身阴液的根本,起到濡养滋润的作用;肾阳,又称为元阳、真火,为一身阳气的根本,起到温煦推动的作用。肾阴肾阳和脾胃及大肠小肠之间有着源与流、本与末的密切关系,肠屏障功能与"肾主二便"功能密切相关,试从肾阴肾阳角度论述肠屏障功能损伤的机制,并用温补肾阳和滋补肾阴的方法治疗肠屏障损伤时出现的大便失常症状。
Kidney Yin and kidney Yang are two important basic concepts in the theory of visceral manifestations in traditional Chinese medicine. Kidney Yin, also known as the Yuanyin, the true Yin, as a fundamental one of Yin fluid to moisten and moist. Kidney Yang,also known as Yuanyang, the true fire, as the root of Yangqi in the whole body to warm and promote. There is a close relationship between kidney Yin and kidney Yang, spleen and stomach and large intestine and small intestine. The gut barrier function is closely related to the function of "kidney controlling urination and defecation". This paper discusses the mechanism of intestinal barrier dysfunction from the perspective of kidney Yin and kidney Yang, and uses the method of warming kidney Yang and nourishing kidney Yin to treat the symptoms of fecal disorders occurring when intestinal barrier is injured.
Kidney Yin and kidney Yang are two important basic concepts in the theory of visceral manifestations in traditional Chinese medicine. Kidney Yin, also known as the Yuanyin, the true Yin, as a fundamental one of Yin fluid to moisten and moist. Kidney Yang,also known as Yuanyang, the true fire, as the root of Yangqi in the whole body to warm and promote. There is a close relationship between kidney Yin and kidney Yang, spleen and stomach and large intestine and small intestine. The gut barrier function is closely related to the function of "kidney controlling urination and defecation". This paper discusses the mechanism of intestinal barrier dysfunction from the perspective of kidney Yin and kidney Yang, and uses the method of warming kidney Yang and nourishing kidney Yin to treat the symptoms of fecal disorders occurring when intestinal barrier is injured.
引文
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[17] 张宁, 李鲜.从“肾为胃之关”论治泄泻[J].中医临床研究,2017,9(7):50-51.
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[2] 方东行,何立群,娄国菁.中医肾与其他四脏关系的研究与思考[J].上海中医药大学学报,2011,25(4):23-27.
[3] 张冰冰,朱爱松,石岩.对于“五脏相关”理论的科学内涵探讨[J].中华中医药杂志,2017,32(7):3259-3263.
[4] 刘征堂,韦云,吴斌龙.脾肾相关理论及其应用[J].中医杂志,2012,53(16):1351-1355.
[5] 杜晓泉,刘力,惠建萍,等.基于肾与肠相关理论与溃疡性结肠炎抗复发治疗[J].辽宁中医杂志,2012,39(11):2158-2159.
[6] 王朝阳.《黄帝内经》肾脏理论探微[J].中医研究,2010,23(2):72-73.
[7] 李娅妮,姜维,姜华琴.尿毒症便秘的中医病机及证治探析[J].上海中医药杂志,2013,47(12):63-64.
[8] 李琪毅,舒建昌.肠粘膜屏障损伤机制研究进展[J].临床荟萃,2006,21(6):447-449.
[9] 吕永德,舒建昌,宋卫兵.肠粘膜屏障与肠内营养[M].西安:第四军医大学出版社,2008.
[10] Allison Cabinian,Daniel Sinsimer,May Tang,et al.Gut symbiotic microbes imprint intestinal immune cells with the innate receptor SLAMF4 which contributes to gut immune protection against enteric pathogens[J].Gut microbiota, 2018,67:847-859.
[11] 杨武,肖桦,黄永坤.肠屏障功能障碍发生机制与诊断治疗[J].实用儿科临床杂志,2007,22(19):1514-1518.
[12] Antza C,Stabouli S,Kotsis V.Gut microbiota in kidney disease and hypertension[J].Pharmacological Research, 2018(130):198-203.
[13] 郭庆捷.肠黏膜屏障功能的研究进展[J].河北医药,2005,27(8):627-628.
[14] 侯维,孟庆华.肠黏膜屏障功能的损伤与修复[J].中国全科医学杂志,2010,13(7B):2295-2297.
[15] Tao Zuo,Sunny H Wong,Kelvin Lam,et al.Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome[J].Gut microbiota, 2018,67:634-643.
[16] 徐春霞,李慧.从肾阴虚论治泄泻[J].河南中医,2013,33(4):617-618.
[17] 张宁, 李鲜.从“肾为胃之关”论治泄泻[J].中医临床研究,2017,9(7):50-51.
[18] 李莉,张广业.中老年功能性便秘从肾阴虚论治理论探析[J].中医临床研究,2012,4(5):53.
[19] 刘丽,吴杞纳,梁民联,等.泄泻从肾论治刍议[J].新中医,2013,45(9):9-10.
[20] 周永学,闫曙光,谢培.功能性便秘从肾论治机理探讨[J].陕西中医学院学报,2015,38(2):6-18.