氧化应激对断奶仔猪的影响及营养的调控作用
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摘要
氧化应激与仔猪健康关系密切,营养物质影响仔猪机体的氧化还原水平和健康。仔猪出生后遭遇断奶、疾病、免疫等应激,损伤机体健康,其在一定程度上体现机体抗氧化能力的改变。本文从断奶对仔猪氧化还原系统的影响、氧化应激对断奶仔猪的影响以及营养缓解氧化应激的作用进行综述,初步探讨氧化应激作为判断仔猪健康的生物标识的可行性。
Oxidative stress is closely related to the health of piglets. The redox status of piglets is affected by nutrients. Piglets suffer from weaning,disease,immunity and other stresses from birth,which damages the health of the body. To some extent,it is reflected in the changes of antioxidant capacity in the body. In this paper,the effect of weaning on redox system in piglets,the effects of oxidative stress on weaned piglets and nutrientrelieving oxidative stress were reviewed. The feasibility of oxidative stress as a biomarker for health in weaned piglets was discussed.[Chinese Journal of Animal Nutrition,2019,31( 5) : 2022-2029]
Oxidative stress is closely related to the health of piglets. The redox status of piglets is affected by nutrients. Piglets suffer from weaning,disease,immunity and other stresses from birth,which damages the health of the body. To some extent,it is reflected in the changes of antioxidant capacity in the body. In this paper,the effect of weaning on redox system in piglets,the effects of oxidative stress on weaned piglets and nutrientrelieving oxidative stress were reviewed. The feasibility of oxidative stress as a biomarker for health in weaned piglets was discussed.[Chinese Journal of Animal Nutrition,2019,31( 5) : 2022-2029]
引文
[1] SOHAL R S,ALLEN R G.Oxidative stress as a causal factor in differentiation and aging:a unifying hypothesis[J].Experimental Gerontology,1990,25(6):499-522.
[2] LALLES J P,BOSI P,SMIDT H,et al. Nutritional management of gut health in pigs around w eaning[J].Proceedings of the Nutrition Society,2007,66(2):260-268.
[3] YIN J,REN W K,WU X,et al.Oxidative stress-mediated signaling pathw ays:a review[J]. Journal of Food Agriculture and Environment,2013,11(2):132-139.
[4] PI J B,ZHANG Q,FU J Q,et al.ROS signaling,oxidative stress and Nrf2 in pancreatic beta-cell function[J]. Toxicology and Applied Pharmacology,2010,244(1):77-83.
[5] REUTER S,GUPTA S C,CHATURVEDI M M,et al.Oxidative stress,inflammation,and cancer:how are they linked?[J].Free Radical Biology and M edicine,2010,49(11):1603-1616.
[6] PIRINCCIOGLU A G,GOKALP D,PIRINCCIOGLU M,et al. M alondialdehyde(M DA)and protein carbonyl(PCO)levels as biomarkers of oxidative stress in subjects w ith familial hypercholesterolemia[J].Clinical Biochemistry,2010,43(15):1220-1224.
[7]蔡旋.基于自由基理论的仔猪肠道屏障断奶应激损伤机理研究[D].博士学位论文.上海:上海交通大学,2015.
[8] SHEN H M,LIU Z G.JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species[J]. Free Radical Biology and M edicine,2006,40(6):928-939.
[9]徐建雄.不同断奶日龄仔猪的氧化应激损伤及其机理研究[D].博士学位论文.南京:南京农业大学,2014.
[10] MINELLI A,BELLEZZA I C,CONTE C,et al.Oxidative stress-related aging:a role for prostate cancer?[J]. Biochimica et Biophysica Acta:Reviews on Cancer,2009,1795(2):83-91.
[11]陈刚.止痢草油缓解断奶仔猪肠道氧化应激的作用及机制[D].博士学位论文.武汉:华中农业大学,2015.
[12]田刚,黄琳惠,宋晓华,等.壳寡糖对氧化应激仔猪生长性能、抗氧化能力及空肠养分消化和转运能力的影响[J].动物营养学报,2018,30(7):2652-2661.
[13] KICK A R,TOMPKINS M B,FLOWERS W L,et al.Effects of stress associated w ith w eaning on the adaptive immune system in pigs[J]. Journal of Animal Science,2012,90(2):649-656.
[14] WIJTTEN P J,VAN DER MEULEN J,VERSTEGEN M W.Intestinal barrier function and absorption in pigs after w eaning:a review[J]. British Journal of Nutrition,2011,105(7):967-981.
[15] ZHU L H,ZHAO K L,CHEN X L,et al. Impact of w eaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J]. Journal of Animal Science,2012,90(8):2581-2589.
[16] YIN J,WU M M,XIAO H,et al.Development of an antioxidant system after early w eaning in piglets[J].Journal of Animal Science,2014,92(2):612-619.
[17] JIANG X R,ZHANG H J,MANTOVANI G,et al.The effect of plant polyphenols on the antioxidant defence system of w eaned piglets subjected to an Escherichia coli challenge[J]. Journal of Animal&Feed Sciences,2014,23(4):324-330.
[18] LI L A,YANG J J,XIE J J,et al.Growth performance and antioxidant capacities in piglets w ith different w eaning age[J]. The Journal of Animal&Plant Sciences,2016,26(2):360-365.
[19] MATTIASSON G,SULLIVAN P G. The emerging functions of UCP2 in health,disease,and therapeutics[J].Antioxidants&Redox Signaling,2006,8(1/2):1-38.
[20] LEE J Y,JANG K S,KANG S C,et al.699 Risk of p53 expression in upper urinary tract urothelial carcinoma:a systematic review and meta-analysis[J]. The Journal of Urology,2013,189(4):e287-e288.
[21] TAKADA Y,AGGARWAL B B.Flavopiridol inhibits NF-κB activation induced by various carcinogens and inflammatory agents through inhibition of IκBαkinase and p65 phosphorylation abrogation of cyclin D1,cyclooxygenase-2,and matrix metalloprotease-9[J].Journal of Biological Chemistry,2004,279(6):4750-4759.
[22] ZHANG T,WANG F,XU H X,et al. Activation of nuclear factor erythroid 2-related factor 2 and PPARγplays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury[J].British Journal of Nutrition,2013,109(2):223-235.
[23]田刚,陈代文,郑萍,等.氧化应激与仔猪健康及其营养调控[J].饲料工业,2012,33(14):58-61.
[24] HIGUCHI M,OSHIDA J,ORINO K,et al. Wheat bran protects Fischer-344 rats from diquat-induced oxidative stress by activating antioxidant system:selenium as an antioxidant[J]. Journal of the Agricultural Chemical Society of Japan,2011,75(3):496-499.
[25]马文涛,杨来启,林玉梅,等.应激对大鼠血清皮质醇及白细胞介素2、6、8水平的影响[J].中国心理卫生杂志,2002,16(1):14-15.
[26]刘通,李泽青,闫峻,等.构建Diquat诱导断奶仔猪氧化应激模型的研究[J].畜牧兽医杂志,2016,35(6):61-63.
[27]袁施彬,陈代文,余冰,等.氧化应激对断奶仔猪生产性能和养分利用率的影响[J].中国饲料,2007(8):19-22.
[28]张海文,施平伟,洪枫,等.抗菌肽对脂多糖导致的仔猪肝脏氧化应激的影响[J].饲料工业,2017,38(10):5-8.
[29]辛向荣.Ala-Gln对断奶仔猪氧化应激的调节作用及其机制初步研究[D].硕士学位论文.南昌:江西农业大学,2014.
[30]张建龙,丘富安,董星,等.猴头菇多糖对氧化应激状态下仔猪回肠形态结构及通透性的影响[J].畜牧兽医学报,2018,49(1):203-210.
[31]袁施彬,陈代文.氧化应激对断奶仔猪组织抗氧化酶活性和病理学变化的影响[J].中国兽医学报,2009,29(1):74-78.
[32]李欢,黄牛,何流琴,等.谷氨酰胺对脂多糖诱导的断奶仔猪氧化应激的影响[J].动物营养学报,2017,29(4):1350-1358.
[33]徐静.猪氧化应激模型构建以及茶多酚的抗应激效应的研究[D].硕士学位论文.雅安:四川农业大学,2009.
[34] ZHENG P,YU B,LV M,et al. Effects of oxidative stress induced by Diquat on arginine metabolism of postw eaning pigs[J]. Asian Australasian Journal of Animal Sciences,2010,23(1):98-105.
[35]李永义,段绪东,赵娇,等.茶多酚对氧化应激仔猪生长性能和免疫功能的影响[J].中国畜牧杂志,2011,47(15):53-57.
[36] LV M,YU B,MAO X B,et al.Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in w eaned pigs[J]. Animal,2012,6(6):928-934.
[37] ZHENG P,YU B,HE J,et al.Protective effects of dietary arginine supplementation against oxidative stress in w eaned piglets[J]. British Journal of Nutrition,2013,109(12):2253-2260.
[38]郑萍.氧化应激对仔猪精氨酸代谢和需求特点的影响及机制研究[D].博士学位论文.雅安:四川农业大学,2010.
[39] ZHENG P,YU B,HE J,et al. Arginine metabolism and its protective effects on intestinal health and functions in w eaned piglets under oxidative stress induced by diquat[J]. The British Journal of Nutrition,2017,117(11):1495-1502.
[40]吕美,余冰,郑萍,等.氧化应激对断奶仔猪色氨酸分解代谢的影响[J].畜牧兽医学报,2010,41(7):823-828.
[41] GRATTAGLIANO I,PALMIERI V O,PORTINCASA P,et al. Oxidative stress-induced risk factors associated w ith the metabolic syndrome:a unifying hypothesis[J]. The Journal of Nutritional Biochemistry,2008,19(8):491-504.
[42] FINKEL T.Reactive oxygen species and signal transduction[J].IUBM B Life,2010,52(1):3-6.
[43] FALOWO A B,FAYEMI P O,MUCHENJE V.Natural antioxidants against lipid-protein oxidative deterioration in meat and meat products:a review[J]. Food Research International,2014,64:171-181.
[44]李利平.探讨肝功能中ALT、AST及血脂中TG、TC在脂肪肝诊断中意义[J].世界最新医学信息文摘,2015,15(66):107,34.
[45]赵娇,周招洪,梁小芳,等.葡萄籽原花青素及维生素E对氧化应激仔猪生长性能、血清氧化还原状态和肝脏氧化损伤的影响[J].中国农业科学,2013,46(19):4157-4164.
[46]刘通.日粮添加L-茶氨酸对断奶仔猪的抗应激效果研究[D].硕士学位论文.杨凌:西北农林科技大学,2016.
[47]蔡文丽,张慧,唐选,等.有氧运动对酒精性肝损伤小鼠ALT、AST、IL-10和IL-6等的影响[J].沈阳体育学院学报,2013,32(3):89-92.
[48]袁施彬,陈代文.不同氧化应激模式下仔猪血细胞参数变化的比较研究[J].动物营养学报,2008,20(6):617-623.
[49]袁施彬,余冰,陈代文.硒添加水平对氧化应激仔猪生产性能和免疫功能影响的研究[C]//2009'微量元素与饲料安全(长沙)国际论坛论文集.长沙:长沙兴嘉生物工程股份有限公司,2009.
[50]高运苓,吴信,周锡红,等.精氨酸和精氨酸生素对断奶仔猪氧化应激的影响[J].农业现代化研究,2010,31(4):484-487.
[51]吕美,余冰,郑萍,等.氧化应激对断奶仔猪色氨酸分解代谢的影响[C]//中国畜牧兽医学会2009学术年会论文集.石家庄:中国畜牧兽医学会,2009.
[52] KOOPMANS S A,TERWEE T,GLASSER A,et al.Accommodative lens refilling in rhesus monkeys[J].Investigative Ophthalmology&Visual Science,2006,47(7):2976-2984.
[53] MAHAN D C,PARRETT N A.Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grow er and finisher sw ine[J]. Journal of Animal Science,1996,74(12):2967-2974.
[54] BUCKLEY D J,MORRISSEY P A,GRAY J I.Influence of dietary vitamin E on the oxidative stability and quality of pig meat[J]. Journal of Animal Science,1995,73(10):3122-3130.
[55] XIONG Q Y,WEI Y N,XIE H D,et al.Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation[J].Vaccine,2014,32(27):3445-3451.
[56]徐元庆,王哲奇,史彬林,等.壳聚糖对断奶仔猪生长性能、粪便评分及血清激素和T淋巴细胞亚群的影响[J].动物营养学报,2017,29(5):1678-1686.
[57] TAO Y,ZHANG H L,HU Y M,et al.Preparation of chitosan and w ater-soluble chitosan microspheres via spray-drying method to low er blood lipids in rats fed w ith high-fat diets[J]. International Journal of M olecular Sciences,2013,14(2):4174-4184.
[58] XU Y Q,XING Y Y,WANG Z Q,et al. Pre-protective effects of dietary chitosan supplementation against oxidative stress induced by diquat in w eaned piglets[J].Cell Stress and Chaperones,2018,23(4):703-710.
[59] DENG Q L,XU J,YU B,et al. Effect of dietary tea polyphenols on grow th performance and cell-mediated immune response of post-w eaning piglets under oxidative stress[J].Archives of Animal Nutrition,2010,64(1):12-21.
[60]陈丰,蒋宗勇,林映才,等.大豆异黄酮对哺乳母猪生产性能及抗氧化性能的影响[J].饲料博览,2010(8):1-5.
[2] LALLES J P,BOSI P,SMIDT H,et al. Nutritional management of gut health in pigs around w eaning[J].Proceedings of the Nutrition Society,2007,66(2):260-268.
[3] YIN J,REN W K,WU X,et al.Oxidative stress-mediated signaling pathw ays:a review[J]. Journal of Food Agriculture and Environment,2013,11(2):132-139.
[4] PI J B,ZHANG Q,FU J Q,et al.ROS signaling,oxidative stress and Nrf2 in pancreatic beta-cell function[J]. Toxicology and Applied Pharmacology,2010,244(1):77-83.
[5] REUTER S,GUPTA S C,CHATURVEDI M M,et al.Oxidative stress,inflammation,and cancer:how are they linked?[J].Free Radical Biology and M edicine,2010,49(11):1603-1616.
[6] PIRINCCIOGLU A G,GOKALP D,PIRINCCIOGLU M,et al. M alondialdehyde(M DA)and protein carbonyl(PCO)levels as biomarkers of oxidative stress in subjects w ith familial hypercholesterolemia[J].Clinical Biochemistry,2010,43(15):1220-1224.
[7]蔡旋.基于自由基理论的仔猪肠道屏障断奶应激损伤机理研究[D].博士学位论文.上海:上海交通大学,2015.
[8] SHEN H M,LIU Z G.JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species[J]. Free Radical Biology and M edicine,2006,40(6):928-939.
[9]徐建雄.不同断奶日龄仔猪的氧化应激损伤及其机理研究[D].博士学位论文.南京:南京农业大学,2014.
[10] MINELLI A,BELLEZZA I C,CONTE C,et al.Oxidative stress-related aging:a role for prostate cancer?[J]. Biochimica et Biophysica Acta:Reviews on Cancer,2009,1795(2):83-91.
[11]陈刚.止痢草油缓解断奶仔猪肠道氧化应激的作用及机制[D].博士学位论文.武汉:华中农业大学,2015.
[12]田刚,黄琳惠,宋晓华,等.壳寡糖对氧化应激仔猪生长性能、抗氧化能力及空肠养分消化和转运能力的影响[J].动物营养学报,2018,30(7):2652-2661.
[13] KICK A R,TOMPKINS M B,FLOWERS W L,et al.Effects of stress associated w ith w eaning on the adaptive immune system in pigs[J]. Journal of Animal Science,2012,90(2):649-656.
[14] WIJTTEN P J,VAN DER MEULEN J,VERSTEGEN M W.Intestinal barrier function and absorption in pigs after w eaning:a review[J]. British Journal of Nutrition,2011,105(7):967-981.
[15] ZHU L H,ZHAO K L,CHEN X L,et al. Impact of w eaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs[J]. Journal of Animal Science,2012,90(8):2581-2589.
[16] YIN J,WU M M,XIAO H,et al.Development of an antioxidant system after early w eaning in piglets[J].Journal of Animal Science,2014,92(2):612-619.
[17] JIANG X R,ZHANG H J,MANTOVANI G,et al.The effect of plant polyphenols on the antioxidant defence system of w eaned piglets subjected to an Escherichia coli challenge[J]. Journal of Animal&Feed Sciences,2014,23(4):324-330.
[18] LI L A,YANG J J,XIE J J,et al.Growth performance and antioxidant capacities in piglets w ith different w eaning age[J]. The Journal of Animal&Plant Sciences,2016,26(2):360-365.
[19] MATTIASSON G,SULLIVAN P G. The emerging functions of UCP2 in health,disease,and therapeutics[J].Antioxidants&Redox Signaling,2006,8(1/2):1-38.
[20] LEE J Y,JANG K S,KANG S C,et al.699 Risk of p53 expression in upper urinary tract urothelial carcinoma:a systematic review and meta-analysis[J]. The Journal of Urology,2013,189(4):e287-e288.
[21] TAKADA Y,AGGARWAL B B.Flavopiridol inhibits NF-κB activation induced by various carcinogens and inflammatory agents through inhibition of IκBαkinase and p65 phosphorylation abrogation of cyclin D1,cyclooxygenase-2,and matrix metalloprotease-9[J].Journal of Biological Chemistry,2004,279(6):4750-4759.
[22] ZHANG T,WANG F,XU H X,et al. Activation of nuclear factor erythroid 2-related factor 2 and PPARγplays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury[J].British Journal of Nutrition,2013,109(2):223-235.
[23]田刚,陈代文,郑萍,等.氧化应激与仔猪健康及其营养调控[J].饲料工业,2012,33(14):58-61.
[24] HIGUCHI M,OSHIDA J,ORINO K,et al. Wheat bran protects Fischer-344 rats from diquat-induced oxidative stress by activating antioxidant system:selenium as an antioxidant[J]. Journal of the Agricultural Chemical Society of Japan,2011,75(3):496-499.
[25]马文涛,杨来启,林玉梅,等.应激对大鼠血清皮质醇及白细胞介素2、6、8水平的影响[J].中国心理卫生杂志,2002,16(1):14-15.
[26]刘通,李泽青,闫峻,等.构建Diquat诱导断奶仔猪氧化应激模型的研究[J].畜牧兽医杂志,2016,35(6):61-63.
[27]袁施彬,陈代文,余冰,等.氧化应激对断奶仔猪生产性能和养分利用率的影响[J].中国饲料,2007(8):19-22.
[28]张海文,施平伟,洪枫,等.抗菌肽对脂多糖导致的仔猪肝脏氧化应激的影响[J].饲料工业,2017,38(10):5-8.
[29]辛向荣.Ala-Gln对断奶仔猪氧化应激的调节作用及其机制初步研究[D].硕士学位论文.南昌:江西农业大学,2014.
[30]张建龙,丘富安,董星,等.猴头菇多糖对氧化应激状态下仔猪回肠形态结构及通透性的影响[J].畜牧兽医学报,2018,49(1):203-210.
[31]袁施彬,陈代文.氧化应激对断奶仔猪组织抗氧化酶活性和病理学变化的影响[J].中国兽医学报,2009,29(1):74-78.
[32]李欢,黄牛,何流琴,等.谷氨酰胺对脂多糖诱导的断奶仔猪氧化应激的影响[J].动物营养学报,2017,29(4):1350-1358.
[33]徐静.猪氧化应激模型构建以及茶多酚的抗应激效应的研究[D].硕士学位论文.雅安:四川农业大学,2009.
[34] ZHENG P,YU B,LV M,et al. Effects of oxidative stress induced by Diquat on arginine metabolism of postw eaning pigs[J]. Asian Australasian Journal of Animal Sciences,2010,23(1):98-105.
[35]李永义,段绪东,赵娇,等.茶多酚对氧化应激仔猪生长性能和免疫功能的影响[J].中国畜牧杂志,2011,47(15):53-57.
[36] LV M,YU B,MAO X B,et al.Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in w eaned pigs[J]. Animal,2012,6(6):928-934.
[37] ZHENG P,YU B,HE J,et al.Protective effects of dietary arginine supplementation against oxidative stress in w eaned piglets[J]. British Journal of Nutrition,2013,109(12):2253-2260.
[38]郑萍.氧化应激对仔猪精氨酸代谢和需求特点的影响及机制研究[D].博士学位论文.雅安:四川农业大学,2010.
[39] ZHENG P,YU B,HE J,et al. Arginine metabolism and its protective effects on intestinal health and functions in w eaned piglets under oxidative stress induced by diquat[J]. The British Journal of Nutrition,2017,117(11):1495-1502.
[40]吕美,余冰,郑萍,等.氧化应激对断奶仔猪色氨酸分解代谢的影响[J].畜牧兽医学报,2010,41(7):823-828.
[41] GRATTAGLIANO I,PALMIERI V O,PORTINCASA P,et al. Oxidative stress-induced risk factors associated w ith the metabolic syndrome:a unifying hypothesis[J]. The Journal of Nutritional Biochemistry,2008,19(8):491-504.
[42] FINKEL T.Reactive oxygen species and signal transduction[J].IUBM B Life,2010,52(1):3-6.
[43] FALOWO A B,FAYEMI P O,MUCHENJE V.Natural antioxidants against lipid-protein oxidative deterioration in meat and meat products:a review[J]. Food Research International,2014,64:171-181.
[44]李利平.探讨肝功能中ALT、AST及血脂中TG、TC在脂肪肝诊断中意义[J].世界最新医学信息文摘,2015,15(66):107,34.
[45]赵娇,周招洪,梁小芳,等.葡萄籽原花青素及维生素E对氧化应激仔猪生长性能、血清氧化还原状态和肝脏氧化损伤的影响[J].中国农业科学,2013,46(19):4157-4164.
[46]刘通.日粮添加L-茶氨酸对断奶仔猪的抗应激效果研究[D].硕士学位论文.杨凌:西北农林科技大学,2016.
[47]蔡文丽,张慧,唐选,等.有氧运动对酒精性肝损伤小鼠ALT、AST、IL-10和IL-6等的影响[J].沈阳体育学院学报,2013,32(3):89-92.
[48]袁施彬,陈代文.不同氧化应激模式下仔猪血细胞参数变化的比较研究[J].动物营养学报,2008,20(6):617-623.
[49]袁施彬,余冰,陈代文.硒添加水平对氧化应激仔猪生产性能和免疫功能影响的研究[C]//2009'微量元素与饲料安全(长沙)国际论坛论文集.长沙:长沙兴嘉生物工程股份有限公司,2009.
[50]高运苓,吴信,周锡红,等.精氨酸和精氨酸生素对断奶仔猪氧化应激的影响[J].农业现代化研究,2010,31(4):484-487.
[51]吕美,余冰,郑萍,等.氧化应激对断奶仔猪色氨酸分解代谢的影响[C]//中国畜牧兽医学会2009学术年会论文集.石家庄:中国畜牧兽医学会,2009.
[52] KOOPMANS S A,TERWEE T,GLASSER A,et al.Accommodative lens refilling in rhesus monkeys[J].Investigative Ophthalmology&Visual Science,2006,47(7):2976-2984.
[53] MAHAN D C,PARRETT N A.Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grow er and finisher sw ine[J]. Journal of Animal Science,1996,74(12):2967-2974.
[54] BUCKLEY D J,MORRISSEY P A,GRAY J I.Influence of dietary vitamin E on the oxidative stability and quality of pig meat[J]. Journal of Animal Science,1995,73(10):3122-3130.
[55] XIONG Q Y,WEI Y N,XIE H D,et al.Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation[J].Vaccine,2014,32(27):3445-3451.
[56]徐元庆,王哲奇,史彬林,等.壳聚糖对断奶仔猪生长性能、粪便评分及血清激素和T淋巴细胞亚群的影响[J].动物营养学报,2017,29(5):1678-1686.
[57] TAO Y,ZHANG H L,HU Y M,et al.Preparation of chitosan and w ater-soluble chitosan microspheres via spray-drying method to low er blood lipids in rats fed w ith high-fat diets[J]. International Journal of M olecular Sciences,2013,14(2):4174-4184.
[58] XU Y Q,XING Y Y,WANG Z Q,et al. Pre-protective effects of dietary chitosan supplementation against oxidative stress induced by diquat in w eaned piglets[J].Cell Stress and Chaperones,2018,23(4):703-710.
[59] DENG Q L,XU J,YU B,et al. Effect of dietary tea polyphenols on grow th performance and cell-mediated immune response of post-w eaning piglets under oxidative stress[J].Archives of Animal Nutrition,2010,64(1):12-21.
[60]陈丰,蒋宗勇,林映才,等.大豆异黄酮对哺乳母猪生产性能及抗氧化性能的影响[J].饲料博览,2010(8):1-5.