拉莫三嗪联合醒脑静对创伤性颅脑损伤继发癫痫患者神经功能、认知能力的影响
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摘要
目的探讨拉莫三嗪联合醒脑静治疗创伤性颅脑损伤继发癫痫的疗效及对患者神经功能、认知能力的影响。方法随机抽取2015年9月至2017年4月入院治疗的创伤性颅脑损伤继发癫痫患者60例,依据治疗措施不同分为两组,各30例。对照组患者予拉莫三嗪治疗,观察组患者予拉莫三嗪联合醒脑静治疗。结果观察组患者总有效率为96. 67%,显著高于对照组的73. 33%(P <0. 05);治疗后,观察组神经功能评分、认知能力评分均显著优于对照组(P <0. 05);两组不良反应发生率无显著差异(P> 0. 05)。结论拉莫三嗪联合醒脑静治疗创伤性颅脑损伤继发癫痫可改善神经功能、认知能力,并提高疗效,不良反应少,值得临床推广。
Objective To investigate lamotrigine combined with Xingnaojing in the treatment of secondary epilepsy after traumatic brain injury( TBI) and its effect on nerve function and cognitive function. Methods Totally 60 patients with secondary epilepsy after TBI admitted to our hospital from September 2015 to April 2017 were selected and divided into two groups according to the different treatment measures,30 cases in each group. The patients in the control group were treated with lamotrigine,while the patients in the observation group were treated with lamotrigine combined with Xingnaojing. Results The total effective rate of the observation group was96. 67%,which was significantly higher than 73. 33% of the control group( P < 0. 05). After treatment,the neurological function score and cognitive ability score in the observation group were significantly better than those of the control group( P < 0. 05). There was no significant difference in the incidence rate of adverse reactions between the two groups( P > 0. 05). Conclusion Lamotrigine combined with Xingnaojing in the treatment of secondary epilepsy after TBI can improve neurological function and cognitive ability, and improve the curative effect,it has fewer adverse reactions,which is worthy of clinical promotion.
Objective To investigate lamotrigine combined with Xingnaojing in the treatment of secondary epilepsy after traumatic brain injury( TBI) and its effect on nerve function and cognitive function. Methods Totally 60 patients with secondary epilepsy after TBI admitted to our hospital from September 2015 to April 2017 were selected and divided into two groups according to the different treatment measures,30 cases in each group. The patients in the control group were treated with lamotrigine,while the patients in the observation group were treated with lamotrigine combined with Xingnaojing. Results The total effective rate of the observation group was96. 67%,which was significantly higher than 73. 33% of the control group( P < 0. 05). After treatment,the neurological function score and cognitive ability score in the observation group were significantly better than those of the control group( P < 0. 05). There was no significant difference in the incidence rate of adverse reactions between the two groups( P > 0. 05). Conclusion Lamotrigine combined with Xingnaojing in the treatment of secondary epilepsy after TBI can improve neurological function and cognitive ability, and improve the curative effect,it has fewer adverse reactions,which is worthy of clinical promotion.
引文
[1]黄亿平,陈文延,吴植念.神经节苷脂联合高压氧治疗对颅脑损伤患者预后的影响[J].中国药业,2017,26(10):75-77.
[2]焦保华,赵宗茂.《第4版美国重型颅脑损伤诊疗指南》解读[J].河北医科大学学报,2018,39(2):125-128.
[3]王福顺.加强对创伤性脑损伤后早期癫痫机理的研究[J].中华神经外科疾病研究杂志,2016,15(4):289-292.
[4] ZAMAN A,DUBIEL R,DRIVER S,et al. Seizure Prophylaxis Guidelines Following Traumatic Brain Injury:An Evaluation of Compliance[J]. Journal of Head Trauma Rehabilitation,2016,30(3):95.
[5]朱永山,张玉龙,程海云,等.创伤性脑损伤后脑白质损伤与认知功能障碍的相关性研究[J].中华创伤杂志,2016,32(1):69-73.
[6]中华医学会神经外科学分会神经创伤专业组.颅脑创伤后癫痫防治中国专家共识[J].中华神经外科杂志,2017,33(7):652-654.
[7] REID AY,BRAGIN A,GIZA CC,et al. The progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injury[J]. Epilepsia,2016,57(10):1558-1567.
[8]关晨霞,郭钢花,李哲.不同频率低频重复经颅磁刺激对有癫痫发作史的颅脑损伤患者认知功能的影响[J].中华物理医学与康复杂志,2016,38(5):349-352.
[9]殷春立,张丹,王兆伟.颅脑外伤患者并发癫痫47例救治的探讨[J].中国医药导刊,2016,18(11):1095-1096.
[10]张颖.特殊类型癫痫患者120例应用拉莫三嗪的疗效分析[J].中南医学科学杂志,2016,44(3):341-344.
[11] ZHANG ZB,JI SM,HAN Y,et al. Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy[J]. European Journal of Clinical Pharmacology,2017,73(4):1-9.
[12]屈文英,解建国.拉莫三嗪与丙戊酸钠治疗癫痫患者的疗效比较[J].实用临床医药杂志,2017,21(19):163-164.
[13]王志刚,李春永,刘浩然,等.微创血肿清除术联合醒脑静注射液治疗高血压脑出血60例[J].中国药业,2015,24(2):86-87.
[14]赵美刚,李钊,郭德江.醒脑静联合高压氧治疗重型颅脑损伤34例[J].中国药业,2015,24(22):217.
[2]焦保华,赵宗茂.《第4版美国重型颅脑损伤诊疗指南》解读[J].河北医科大学学报,2018,39(2):125-128.
[3]王福顺.加强对创伤性脑损伤后早期癫痫机理的研究[J].中华神经外科疾病研究杂志,2016,15(4):289-292.
[4] ZAMAN A,DUBIEL R,DRIVER S,et al. Seizure Prophylaxis Guidelines Following Traumatic Brain Injury:An Evaluation of Compliance[J]. Journal of Head Trauma Rehabilitation,2016,30(3):95.
[5]朱永山,张玉龙,程海云,等.创伤性脑损伤后脑白质损伤与认知功能障碍的相关性研究[J].中华创伤杂志,2016,32(1):69-73.
[6]中华医学会神经外科学分会神经创伤专业组.颅脑创伤后癫痫防治中国专家共识[J].中华神经外科杂志,2017,33(7):652-654.
[7] REID AY,BRAGIN A,GIZA CC,et al. The progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injury[J]. Epilepsia,2016,57(10):1558-1567.
[8]关晨霞,郭钢花,李哲.不同频率低频重复经颅磁刺激对有癫痫发作史的颅脑损伤患者认知功能的影响[J].中华物理医学与康复杂志,2016,38(5):349-352.
[9]殷春立,张丹,王兆伟.颅脑外伤患者并发癫痫47例救治的探讨[J].中国医药导刊,2016,18(11):1095-1096.
[10]张颖.特殊类型癫痫患者120例应用拉莫三嗪的疗效分析[J].中南医学科学杂志,2016,44(3):341-344.
[11] ZHANG ZB,JI SM,HAN Y,et al. Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy[J]. European Journal of Clinical Pharmacology,2017,73(4):1-9.
[12]屈文英,解建国.拉莫三嗪与丙戊酸钠治疗癫痫患者的疗效比较[J].实用临床医药杂志,2017,21(19):163-164.
[13]王志刚,李春永,刘浩然,等.微创血肿清除术联合醒脑静注射液治疗高血压脑出血60例[J].中国药业,2015,24(2):86-87.
[14]赵美刚,李钊,郭德江.醒脑静联合高压氧治疗重型颅脑损伤34例[J].中国药业,2015,24(22):217.