积雪草主要化学成分及治疗消化系统疾病的研究进展
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摘要
积雪草为伞形科积雪草属植物积雪草(Centella asiatica L. Urban)的干燥全草,主要含三萜类、挥发油类、多炔烯类、黄酮类、甾醇类等多种成分,具有抗癌、抑制瘢痕增生、抗溃疡及抗菌、消炎等生物活性。随着对积雪草化学成分及药理作用研究的不断深入,积雪草在消化系统疾病方面的作用引起了国内外越来越多学者的关注。本文就积雪草的主要化学成分及其治疗消化系统疾病作用的研究进展作简要阐述,为该药的后续研究提供参考。
Centella asiatica L. is a dried whole herb of Centella asiatica L. in Umbelliferae,which mainly contains triterpenoids,volatile oils,polyacetylenes,flavonoids,sterols and other components. It has anti-cancer,anti-scarring hyperplasia,anti-ulcer,antibacterial,anti-inflammatory and other biological activities. With the deepening of the research on the chemical constituents and pharmacological effects of Centella asiatica,the role of Centella asiatica in digestive system diseases has attracted more and more attention from scholars at home and abroad. The research progress of Centella asiatica L. was briefly described from the aspects of chemical constituents and it,s therapeutic effects on digestive system diseases,to provide a reference for the further development and utilization of the drug.
Centella asiatica L. is a dried whole herb of Centella asiatica L. in Umbelliferae,which mainly contains triterpenoids,volatile oils,polyacetylenes,flavonoids,sterols and other components. It has anti-cancer,anti-scarring hyperplasia,anti-ulcer,antibacterial,anti-inflammatory and other biological activities. With the deepening of the research on the chemical constituents and pharmacological effects of Centella asiatica,the role of Centella asiatica in digestive system diseases has attracted more and more attention from scholars at home and abroad. The research progress of Centella asiatica L. was briefly described from the aspects of chemical constituents and it,s therapeutic effects on digestive system diseases,to provide a reference for the further development and utilization of the drug.
引文
[1]项佳媚,肖伟,许利嘉,等.积雪草的研究进展[J].中国现代中药,2016,18(2):233-238,258.
[2]闫凯,徐艳梅,徐敬朴,等.UPLC-MS/MS法测定积雪草中7种有效成分的含量[J].中国临床药理学杂志,2017,33(19):1949-1953.
[3]王阳阳.积雪草中活性成分的提取分离[D].杭州:浙江大学,2011.
[4]彭倩,陈有权,曹梓珍,等.溶解介质的性质对积雪草苷溶解度的影响[J].中国新药杂志,2017,26(17):2082-2086.
[5]Weng X X,Shao Y,Chen Y Y,et al. Two new dammarane monodesmosides from Centella asiatica[J].J Asian Nat Prod Res,2011,13(8):749-755.
[6]张伟,张娟娟,尹震花,等.HS-SPME-GC-MS法快速检测积雪草挥发性成分[J].中国药房,2016,27(33):4710-4711.
[7]秦路平,丁如贤,张卫东,等.积雪草挥发油成分分析及其抗抑郁作用研究[J].第二军医大学学报,1998,19(2):87-88.
[8]徐丽丽.积雪草化学成分的分离纯化及结构鉴定[D].大连:辽宁师范大学,2012.
[9]Siddiqui B S,Aslam H,Ali S T,et al. Chemical constituents of Centella asiatica[J]. J Asian Nat Prod Res,2007,9(35):407-414.
[10]Govindan G,Sambandan T G,Govindan M,et al. A bioactive polyacetylene compound isolated from Centella asiatica[J]. Planta Med,2007,73(6):597-599.
[11]张蕾磊,王海生,姚庆强,等.积雪草化学成分研究[J].中草药,2005,36(12):1761-1763.
[12]Robert Azerad. Chemical structures,production and enzymatic transformations of sapogenins and saponins from Centella asiatica(L.)Urban[J]. Fitoterapia,2016,114(1):168-187.
[13] Kaur I,Suthar N,Kaur J,et al. Accelerated Stability Studies on Dried Extracts of Centella asiatica Through Chemical,HPLC,HPTLC,and Biological Activity Analyses[J]. Journal of EvidenceBased Complementary&Alternative Medicine,2016,21(4):127-137.
[14]赵嗣霞,张如松,杨苏蓓.积雪草苷抗大鼠免疫性肝纤维化作用研究[J].中国现代应用药学,2017,34(5):666-670.
[15]张丽娜,郑佳佳,李晓会,等.积雪草苷对小鼠脓毒症致急性肝损伤的保护作用研究[J].时珍国医国药,2010,21(11):2734-2736.
[16]齐志敏.积雪草酸对急性肝损伤的抗炎与抗氧化应激作用及机制的研究[D].长春:吉林大学,2017.
[17]Wei L,Chen Q,Guo A,et al. Asiatic acid attenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/m TOR and Bcl-2/Bax signaling pathways[J]. International Immunopharmacology,2018,60(1):1-8.
[18]周炳杰.积雪草酸对小鼠胆管结扎诱导的肝纤维化的治疗作用及机制的研究[D].镇江:江苏大学,2017.
[19]陈杰,曾令兰,王华,等.积雪草酸对HSC-T6细胞Smad7和PPARγ的mRNA表达的影响[J].临床肝胆病杂志,2011,27(3):251-253,264.
[20]Wang W,Wu L L,Li Q,et al. Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling[J].Biomedicine&Pharmacotherapy,2018,103(1):1137-1145.
[21]斯琴.积雪草醇提物对ZDF大鼠胰岛的保护功能及其机制研究[D].北京:北京中医药大学,2016.
[22]乐佛茂,浦培英,雷颖.复方积雪草浸膏对大白鼠慢性实验性胃溃疡及微循环的影响[J].江苏中医,1992,(3):42.
[23]Abdulla M A,Al Bayaty F H,Younis,L T,et al. Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats[J]. Journal of Medicinal Plants Research,2010,4(13):1253-1259.
[24]陈宝雯,纪宝安,张学智.积雪草提取物对胃粘膜的保护作用及其机制探讨[J].中华消化杂志,1999,19(4):246-248.
[25]Cheng C L,Guo J S,John L,et al. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats[J]. Life Sciences,2004,74(18):2237-2249.
[26]Zheng H M,Choi M J,Kim J M,et al. Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats[J]. J Med Food,2016,19(1):38-46.
[27]施之琪,杜建平,杜铁良.积雪草总苷抗乙酸致大鼠胃溃疡的研究[J].中国实验方剂学杂志,2010,16(12):122-124.
[28]Lahkar M,Pathak A. A study on the effect of Centella asiatica on experimentally induced inflammatory bowel disease in albino rats[J]. Research Journal of Pharmacy&Technology,2011,4(10):1618-1620.
[29]Di P R,Esposito E,Mazzon E,et al. 3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease[J]. Free Radic Res,2010,44(1):74-89.
[30]Xu X,Wang Y,Wei Z,et al. Madecassic acid,the contributor to the anti-colitis effect of madecassoside,enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway[J]. Cell Death and Disease,2017,8(3):1-15.
[31]Guo W,Liu W,Jin B,et al. Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation[J]. Int Immunopharmacol,2015,24(2):232-238.
[32]Hussin F,Eshkoor S A,Rahmat A,et al. The Centella asiatica juice effects on DNA damage,apoptosis and gene expression in hepatocellular carcinoma(HCC)[J]. BMC Complementary and Alternative Medicine,2014,14(1):1-7.
[33]康敏,任美萍,赵磊,等.积雪草苷对人胃癌SGC-7901细胞株转移能力和凋亡影响[J].四川生理科学杂志,2015,37(2):47-49.
[34]Bunpo P,Kataoka K,Arimochi H,et al. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats[J]. Food and Chemical Toxicology,2004,42(12):1987-1997.
[35]Siddique A I,Mani V,Arivalagan S,et al. Asiatic Acid attenuates pre-neoplastic lesions,oxidative stress,biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis[J]. Toxicology Mechanisms and Methods,2016,27(2):136-150.
[36] Alqahtani A,Tongkao-On W,Li K M,et al. Seasonal variation of triterpenes and phenolic compounds in australian Centella asiatica(L.)Urb[J]. Phytochem Anal,2015,26(6),436-443.
[2]闫凯,徐艳梅,徐敬朴,等.UPLC-MS/MS法测定积雪草中7种有效成分的含量[J].中国临床药理学杂志,2017,33(19):1949-1953.
[3]王阳阳.积雪草中活性成分的提取分离[D].杭州:浙江大学,2011.
[4]彭倩,陈有权,曹梓珍,等.溶解介质的性质对积雪草苷溶解度的影响[J].中国新药杂志,2017,26(17):2082-2086.
[5]Weng X X,Shao Y,Chen Y Y,et al. Two new dammarane monodesmosides from Centella asiatica[J].J Asian Nat Prod Res,2011,13(8):749-755.
[6]张伟,张娟娟,尹震花,等.HS-SPME-GC-MS法快速检测积雪草挥发性成分[J].中国药房,2016,27(33):4710-4711.
[7]秦路平,丁如贤,张卫东,等.积雪草挥发油成分分析及其抗抑郁作用研究[J].第二军医大学学报,1998,19(2):87-88.
[8]徐丽丽.积雪草化学成分的分离纯化及结构鉴定[D].大连:辽宁师范大学,2012.
[9]Siddiqui B S,Aslam H,Ali S T,et al. Chemical constituents of Centella asiatica[J]. J Asian Nat Prod Res,2007,9(35):407-414.
[10]Govindan G,Sambandan T G,Govindan M,et al. A bioactive polyacetylene compound isolated from Centella asiatica[J]. Planta Med,2007,73(6):597-599.
[11]张蕾磊,王海生,姚庆强,等.积雪草化学成分研究[J].中草药,2005,36(12):1761-1763.
[12]Robert Azerad. Chemical structures,production and enzymatic transformations of sapogenins and saponins from Centella asiatica(L.)Urban[J]. Fitoterapia,2016,114(1):168-187.
[13] Kaur I,Suthar N,Kaur J,et al. Accelerated Stability Studies on Dried Extracts of Centella asiatica Through Chemical,HPLC,HPTLC,and Biological Activity Analyses[J]. Journal of EvidenceBased Complementary&Alternative Medicine,2016,21(4):127-137.
[14]赵嗣霞,张如松,杨苏蓓.积雪草苷抗大鼠免疫性肝纤维化作用研究[J].中国现代应用药学,2017,34(5):666-670.
[15]张丽娜,郑佳佳,李晓会,等.积雪草苷对小鼠脓毒症致急性肝损伤的保护作用研究[J].时珍国医国药,2010,21(11):2734-2736.
[16]齐志敏.积雪草酸对急性肝损伤的抗炎与抗氧化应激作用及机制的研究[D].长春:吉林大学,2017.
[17]Wei L,Chen Q,Guo A,et al. Asiatic acid attenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/m TOR and Bcl-2/Bax signaling pathways[J]. International Immunopharmacology,2018,60(1):1-8.
[18]周炳杰.积雪草酸对小鼠胆管结扎诱导的肝纤维化的治疗作用及机制的研究[D].镇江:江苏大学,2017.
[19]陈杰,曾令兰,王华,等.积雪草酸对HSC-T6细胞Smad7和PPARγ的mRNA表达的影响[J].临床肝胆病杂志,2011,27(3):251-253,264.
[20]Wang W,Wu L L,Li Q,et al. Madecassoside prevents acute liver failure in LPS/D-GalN-induced mice by inhibiting p38/NF-κB and activating Nrf2/HO-1 signaling[J].Biomedicine&Pharmacotherapy,2018,103(1):1137-1145.
[21]斯琴.积雪草醇提物对ZDF大鼠胰岛的保护功能及其机制研究[D].北京:北京中医药大学,2016.
[22]乐佛茂,浦培英,雷颖.复方积雪草浸膏对大白鼠慢性实验性胃溃疡及微循环的影响[J].江苏中医,1992,(3):42.
[23]Abdulla M A,Al Bayaty F H,Younis,L T,et al. Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats[J]. Journal of Medicinal Plants Research,2010,4(13):1253-1259.
[24]陈宝雯,纪宝安,张学智.积雪草提取物对胃粘膜的保护作用及其机制探讨[J].中华消化杂志,1999,19(4):246-248.
[25]Cheng C L,Guo J S,John L,et al. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats[J]. Life Sciences,2004,74(18):2237-2249.
[26]Zheng H M,Choi M J,Kim J M,et al. Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats[J]. J Med Food,2016,19(1):38-46.
[27]施之琪,杜建平,杜铁良.积雪草总苷抗乙酸致大鼠胃溃疡的研究[J].中国实验方剂学杂志,2010,16(12):122-124.
[28]Lahkar M,Pathak A. A study on the effect of Centella asiatica on experimentally induced inflammatory bowel disease in albino rats[J]. Research Journal of Pharmacy&Technology,2011,4(10):1618-1620.
[29]Di P R,Esposito E,Mazzon E,et al. 3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease[J]. Free Radic Res,2010,44(1):74-89.
[30]Xu X,Wang Y,Wei Z,et al. Madecassic acid,the contributor to the anti-colitis effect of madecassoside,enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway[J]. Cell Death and Disease,2017,8(3):1-15.
[31]Guo W,Liu W,Jin B,et al. Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation[J]. Int Immunopharmacol,2015,24(2):232-238.
[32]Hussin F,Eshkoor S A,Rahmat A,et al. The Centella asiatica juice effects on DNA damage,apoptosis and gene expression in hepatocellular carcinoma(HCC)[J]. BMC Complementary and Alternative Medicine,2014,14(1):1-7.
[33]康敏,任美萍,赵磊,等.积雪草苷对人胃癌SGC-7901细胞株转移能力和凋亡影响[J].四川生理科学杂志,2015,37(2):47-49.
[34]Bunpo P,Kataoka K,Arimochi H,et al. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats[J]. Food and Chemical Toxicology,2004,42(12):1987-1997.
[35]Siddique A I,Mani V,Arivalagan S,et al. Asiatic Acid attenuates pre-neoplastic lesions,oxidative stress,biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis[J]. Toxicology Mechanisms and Methods,2016,27(2):136-150.
[36] Alqahtani A,Tongkao-On W,Li K M,et al. Seasonal variation of triterpenes and phenolic compounds in australian Centella asiatica(L.)Urb[J]. Phytochem Anal,2015,26(6),436-443.