静宁方联合推拿治疗气阴两虚型儿童注意力缺陷多动障碍临床研究
|
摘要
目的:探讨静宁方联合推拿治疗儿童注意力缺陷多动障碍的远期临床疗效及安全性。方法:将儿童注意力缺陷多动障碍50例患儿随机分为两组(A组和B组),采用二阶段交叉设计试验,第一阶段(试验前3个月)A组患者为干预组(静宁方联合推拿组),B组为对照组(静宁方组);第二阶段(试验后3个月)A组为对照组,B组为干预组。于每个阶段开始、结束时应用SNAP-Ⅳ父母等级评定量表评估治疗效果并记录不良反应事件。结果:两组接受静宁方联合推拿干预后,均表现为注意缺陷评分、多动/冲动评分显著降低,差异均有统计学意义(P<0.05)。二阶段交叉设计的方差分析显示,两组患儿注意缺陷评分、多动/冲动评分比较,差异有统计学意义(P<0.05)。无不良反应。结论:静宁方联合推拿治疗儿童注意力缺陷多动障碍具有较好远期临床疗效和安全性。
Objective: To investigate the clinical efficacy and safety of Jingning Prescription combined with massage in treatment of children's attention deficit and hyperactivity disorder( ADHD) with Qi and Yin Deficiency Syndrome. Methods: Fifty ADHD patients were randomly divided into two groups: group A and group B. In the first phase( 3 months before the trial),the patients in group A was the intervention group( Jingning Prescrisption combined with massage group) while group B was the control group( Jingning group); in the second stage( 3 months after the experiment) group A was the control group and group B was the intervention group. At the end of each phase,the SNAP-Ⅳ Parental Rating Scale was used to assess the therapeutic effect and the adverse events were recorded during the process. The scores of attention deficit and hyperactivity/impulse in the two groups( P <0. 05) were significantly lowered after treatment. The variance analysis of the two-stage crossover design suggested that there were significant differences in the scores of attention deficit and hyperactivity/impulse scores after the treatment by using Jingning Prescription combined with massage compared with those before treatment( P < 0. 05). In addition,there were no adverse reactions.Conclusion: Jingning Prescription combined with massage therapy has good long-term clinical efficacy and safety in treatment of children's attention deficit and hyperactivity disorder with Qi and Yin Deficiency Syndrome and massage is an effective and safe method for adjuvant treatment of ADHD.
Objective: To investigate the clinical efficacy and safety of Jingning Prescription combined with massage in treatment of children's attention deficit and hyperactivity disorder( ADHD) with Qi and Yin Deficiency Syndrome. Methods: Fifty ADHD patients were randomly divided into two groups: group A and group B. In the first phase( 3 months before the trial),the patients in group A was the intervention group( Jingning Prescrisption combined with massage group) while group B was the control group( Jingning group); in the second stage( 3 months after the experiment) group A was the control group and group B was the intervention group. At the end of each phase,the SNAP-Ⅳ Parental Rating Scale was used to assess the therapeutic effect and the adverse events were recorded during the process. The scores of attention deficit and hyperactivity/impulse in the two groups( P <0. 05) were significantly lowered after treatment. The variance analysis of the two-stage crossover design suggested that there were significant differences in the scores of attention deficit and hyperactivity/impulse scores after the treatment by using Jingning Prescription combined with massage compared with those before treatment( P < 0. 05). In addition,there were no adverse reactions.Conclusion: Jingning Prescription combined with massage therapy has good long-term clinical efficacy and safety in treatment of children's attention deficit and hyperactivity disorder with Qi and Yin Deficiency Syndrome and massage is an effective and safe method for adjuvant treatment of ADHD.
引文
[1]吴绪旭,方海燕,陶丹红,等.注意缺陷多动障碍的神经电生理研究进展[J].浙江临床医学,2015,17(7):1230-1231.
[2]中华儿科杂志编辑委员会,中华医学会儿科学分会神经学组,中华医学会儿科学分会儿童保健学组.儿童主要缺陷多动障碍诊疗建议[J].中华儿科杂志,2006,44(7):758-759.
[3]陈光福,崔艳丽,陈美清.盐酸哌甲酯控释剂治疗儿童注意缺陷多动障碍的疗效[J].实用儿科临床杂志,2011,26(6):452-454.
[4]刘应科,任昕昕,方琼洁,等.静宁颗粒治疗56例小儿多动症气阴两虚证临床观察[J].湖南中医药大学学报,2016,36(4):49-52.
[5]中华中医药学会.中医儿科常见病诊疗指南[M].北京:中国中医药出版社,2012:69-70.
[6]冷方南.儿童多动症临床治疗学[M].2版.北京:中国医药科技出版社,2012:273-276.
[7]周晋波,郭兰婷,陈颖.中文版注意缺陷多动障碍SNAP-Ⅳ评定量表-父母版的信效度[J].中国心理卫生杂志,2013,27(6):424-428.
[8]Miller AM,Bansal R,Hao X,et al.Enlargement of thalamic nuclei inTouurette syndrome[J].Arch Gen Psychiatry,2010,67(9):955-964.
[9]黎欣,杨昆.以舌象为主要辨证依据分型治疗小儿多动症40例[J].陕西中医,2015,36(3):271-272.
[10]张艳,康传媛,赵兴蓉,等.家长培训合并哌醋甲酯治疗对注意缺陷多动症障碍患儿家庭关系的影响[J].中国当代儿科杂志,2014,16(2):185-189.
[11]方琼杰,王俊宏,姜思竹.从“心肝有余,脾肾不足”及“五神藏”理论辨治儿童多动症[J].中医杂志,2017,57(3):254-256.
[12]王文凯,贾静,丁仁伟,等.太子参近年研究概况[J].中国实验方剂学杂志,2011,17(12):264-267.
[13]夏庆华,路千里.熟地黄药理研究进展[J].江西中医学院学报,2008,20(6):96-97.
[14]任昕昕,王俊宏,方琼杰,等.温胆汤治疗儿科神经精神系统疾病探析[J].环球中医药,2017,10(3):318-320.
[15]Hechtman L.Longterm treatment of children and adolescentswith attention deficit hyper-activity disorder[J].Curr Psychiatry Rep,2006,8(5):398-408.
[16]杨婷,陈丽云.中医治疗儿童多动症与学习障碍的优势[J].中国中医药现代远程教育,2017,15(9):139-141.
[17]张华,陈海丹,陈泽燕.儿童多动症患者发病危险因素及治疗效果分析[J].河北医药,2015,37(5):694-696.
[18]王雅璇,卫利,王素梅.王素梅教授运用加味礞石滚痰汤治疗小儿心肝系疾病验案举隅[J].世界中医药,2016,11(10):2054-2056.
[19]严晓慧,严隽陶.推拿手法分类的规范化研究[J],中医学报,2017,32(5):875-878.
[20]周荣易,韩新民,孙继超,等.近10年中医药治疗儿童注意力缺陷多动障碍文献研究[J],中国中医药信息杂志,2016,23(3):35-27.
[2]中华儿科杂志编辑委员会,中华医学会儿科学分会神经学组,中华医学会儿科学分会儿童保健学组.儿童主要缺陷多动障碍诊疗建议[J].中华儿科杂志,2006,44(7):758-759.
[3]陈光福,崔艳丽,陈美清.盐酸哌甲酯控释剂治疗儿童注意缺陷多动障碍的疗效[J].实用儿科临床杂志,2011,26(6):452-454.
[4]刘应科,任昕昕,方琼洁,等.静宁颗粒治疗56例小儿多动症气阴两虚证临床观察[J].湖南中医药大学学报,2016,36(4):49-52.
[5]中华中医药学会.中医儿科常见病诊疗指南[M].北京:中国中医药出版社,2012:69-70.
[6]冷方南.儿童多动症临床治疗学[M].2版.北京:中国医药科技出版社,2012:273-276.
[7]周晋波,郭兰婷,陈颖.中文版注意缺陷多动障碍SNAP-Ⅳ评定量表-父母版的信效度[J].中国心理卫生杂志,2013,27(6):424-428.
[8]Miller AM,Bansal R,Hao X,et al.Enlargement of thalamic nuclei inTouurette syndrome[J].Arch Gen Psychiatry,2010,67(9):955-964.
[9]黎欣,杨昆.以舌象为主要辨证依据分型治疗小儿多动症40例[J].陕西中医,2015,36(3):271-272.
[10]张艳,康传媛,赵兴蓉,等.家长培训合并哌醋甲酯治疗对注意缺陷多动症障碍患儿家庭关系的影响[J].中国当代儿科杂志,2014,16(2):185-189.
[11]方琼杰,王俊宏,姜思竹.从“心肝有余,脾肾不足”及“五神藏”理论辨治儿童多动症[J].中医杂志,2017,57(3):254-256.
[12]王文凯,贾静,丁仁伟,等.太子参近年研究概况[J].中国实验方剂学杂志,2011,17(12):264-267.
[13]夏庆华,路千里.熟地黄药理研究进展[J].江西中医学院学报,2008,20(6):96-97.
[14]任昕昕,王俊宏,方琼杰,等.温胆汤治疗儿科神经精神系统疾病探析[J].环球中医药,2017,10(3):318-320.
[15]Hechtman L.Longterm treatment of children and adolescentswith attention deficit hyper-activity disorder[J].Curr Psychiatry Rep,2006,8(5):398-408.
[16]杨婷,陈丽云.中医治疗儿童多动症与学习障碍的优势[J].中国中医药现代远程教育,2017,15(9):139-141.
[17]张华,陈海丹,陈泽燕.儿童多动症患者发病危险因素及治疗效果分析[J].河北医药,2015,37(5):694-696.
[18]王雅璇,卫利,王素梅.王素梅教授运用加味礞石滚痰汤治疗小儿心肝系疾病验案举隅[J].世界中医药,2016,11(10):2054-2056.
[19]严晓慧,严隽陶.推拿手法分类的规范化研究[J],中医学报,2017,32(5):875-878.
[20]周荣易,韩新民,孙继超,等.近10年中医药治疗儿童注意力缺陷多动障碍文献研究[J],中国中医药信息杂志,2016,23(3):35-27.