单纯疱疹病毒性角膜炎中西医研究进展
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摘要
单纯疱疹病毒性角膜炎(Herpes simplex keratitis,HSK)是世界致盲眼病之一。关于如何减轻单纯疱疹病毒性角膜炎患者的角膜病损、改善视力、降低复发率,已成为近年来研究的热点。手术与抗病毒药物是西医治疗本病的主要手段,但其在治疗有效率及降低复发率方面疗效有限。中医药治疗因其在改善HSK患者临床症状体征、提高视力、降低复发率及副作用小甚或无等方面有着西医治疗不可比拟的优势,近年来受到大量临床工作者及患者的青睐。许多学者更是将中、西医治疗相结合,优势互补,在提高治疗总有效率、缩短病程、减少复发等方面显著优于单用中医、西医治疗,采用中西医结合将是临床治疗本病的趋向。该文就有关单纯疱疹病毒性角膜炎的现代医学认识、祖国医学认识、西医治疗、中医治疗及中西结合治疗等新进展作一综述,期待为临床治疗本病提供一定的思路。
Herpes simplex viral keratitis is one of the world's leading causes of blindness. How to reduce corneal lesions,improve eyesight and reduce recurrence rate in patients with herpes simplex keratitis has become a hot topic in recent years. Operation and antivirals are the main means of treating this disease in western medicine,but their curative effect in treatment efficiency and reducing recurrence rate is limited. Traditional Chinese medicine treatment has been favored by a large number of clinical workers and patients in recent years due to its incomparable advantages in improving clinical symptoms and signs of HSK patients,improving eyesight,reducing recurrence rate and even the absence of side effects. In addition,many scholars combine Chinese and Western medical treatment with complementary advantages,which is significantly superior to single Chinese and Western medical treatment in terms of improving the total therapeutic efficiency,shortening the course of disease,and reducing recurrence. The combination of Chinese and Western medicine will be the trend of clinical treatment of this disease. This article reviews the new progress of herpes simplex viral keratitis in modern medicine,Chinese medicine,Western medicine treatment,Chinese medicine treatment and combination of Chinese and Western treatment,hoping to provide some ideas for clinical treatment of this disease.
Herpes simplex viral keratitis is one of the world's leading causes of blindness. How to reduce corneal lesions,improve eyesight and reduce recurrence rate in patients with herpes simplex keratitis has become a hot topic in recent years. Operation and antivirals are the main means of treating this disease in western medicine,but their curative effect in treatment efficiency and reducing recurrence rate is limited. Traditional Chinese medicine treatment has been favored by a large number of clinical workers and patients in recent years due to its incomparable advantages in improving clinical symptoms and signs of HSK patients,improving eyesight,reducing recurrence rate and even the absence of side effects. In addition,many scholars combine Chinese and Western medical treatment with complementary advantages,which is significantly superior to single Chinese and Western medical treatment in terms of improving the total therapeutic efficiency,shortening the course of disease,and reducing recurrence. The combination of Chinese and Western medicine will be the trend of clinical treatment of this disease. This article reviews the new progress of herpes simplex viral keratitis in modern medicine,Chinese medicine,Western medicine treatment,Chinese medicine treatment and combination of Chinese and Western treatment,hoping to provide some ideas for clinical treatment of this disease.
引文
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[9]项凯.单纯疱疹病毒性角膜炎采用干扰素联合抗病毒药物治疗的观察[J].临床医药文献电子杂志,2018(27):122-123.
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[13]申爱军,陈晓君,王保贞.角膜清创联合药物治疗上皮型单纯疱疹病毒性角膜炎疗效观察[J].中国实用医药,2014(6):157-158.
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[16]欧阳丽.体外培育牛黄治疗单纯疱疹病毒性角膜炎临床观察[J].湖北中医杂志,2014(6):39.
[17]王勇,詹邶.角膜接触镜联合抗病毒药物在单纯疱疹性病毒性角膜炎治疗中的效果观察[J].亚太传统医药,2012(1):120-121.
[18]刘琳,张波,郭宇燕,等.改良羊膜移植联合角膜接触镜及免疫调节剂治疗复发性上皮型单纯疱疹病毒性角膜炎[J].眼科新进展,2017(12):1150-1152.
[19]彭希.清肝解毒汤联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的疗效观察[J].临床医药文献电子杂志,2018(18):12-14.
[20]巩继平.中药内服联合西医治疗单纯疱疹病毒性角膜炎回顾性分析[J].新中医,2017(9):110-113.
[21]黄俊珺,董学梅.益气养血祛风法治疗复发性单纯疱疹病毒性角膜炎的临床观察[J].国际眼科杂志,2017(12):2318-2320.
[22]张婷,李婧.银翘荆防汤加减治疗单纯疱疹病毒性角膜炎临床观察[J].四川中医,2016(1):171-172.
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[24]韦云昌.辨证论治单纯疱疹毒性角膜炎41例[J].河南中医,2014(7):1341-1342.
[25]张茂荣.中医辨证治疗单纯疱疹病毒性角膜炎临床观察[J].中外医学研究,2013(33):194-195.
[26]黄海东,陈冬,杨月丽,等.炎琥宁联合更昔洛韦对单纯疱疹病毒性角膜炎患者血清和泪液中抗氧化指标的影响[J].解放军预防医学杂志,2018(4):465-468,479.
[27]刘晓霞,孟晶.疏风解毒胶囊联合阿昔洛韦滴眼液治疗单纯疱疹病毒性角膜炎100例临床分析[J].岭南急诊医学杂志,2017(2):185-186.
[28]罗俊.热毒宁注射液联合阿昔洛韦滴眼液治疗单疱病毒性角膜炎的临床观察[J].中外医学研究,2012(2):119.
[29]徐宇明,张焕英,欧国平,等.单纯疱疹病毒性角膜炎患者采取中药离子导入治疗的效果观察[J].中国实用医药,2018(10):141-143.
[30]王齐.抗病毒滴眼液与中药熏眼治疗单纯疱疹性病毒性角膜炎[J].吉林中医药,2017(3):260-262.
[31]赵芳,史桂桃.中药超声雾化眼浴治疗单纯疱疹病毒性角膜炎48例临床观察[J].中医药导报,2015(2):73-74.
[32]鲁士友,宿艳.龙胆泻肝汤加减联合针灸治疗肝火炽盛证单纯疱疹病毒性角膜炎[J].中国实验方剂学杂志,2018(15):216-221.
[33]潘琪琦,邵愚.清肝明目退翳方联合针刺为主治疗复发性上皮型单纯疱疹病毒性角膜炎42例[J].浙江中医杂志,2017(8):595.
[34]秦文广,王艳.清肝泻火法联合针刺治疗单纯疱疹病毒性角膜炎的疗效评价[J].中国处方药,2016(6):107-108.
[35]吕玉林.超声雾化联合中药治疗单纯疱疹病毒性角膜炎[J].光明中医,2018(6):813-815.
[36]熊静,龙辉,周利.祛风明目汤联合雾化熏眼治疗单纯疱疹病毒性角膜炎30例(31眼)疗效观察[J].湖南中医杂志,2017(10):83-85.
[37]张丽芳,关敏,容加勇.加味银翘散配合离子导入治疗单纯疱疹病毒性角膜炎[J].云南中医中药杂志,2013(2):32-33.
[38]陈子燕,李庆生.中药联合无环鸟苷治疗单纯疱疹病毒性角膜炎的临床疗效分析[J].世界中医药,2017(4):825-828,832.
[39]宋晓慧.中西医结合治疗上皮型单纯疱疹病毒性角膜炎40例临床观察[J].浙江中医杂志,2017(9):670-671.
[40]王健,李长生,黄玉琴,等.疏风清热法联合西药治疗上皮型单纯疱疹病毒性角膜炎疗效[J].国际眼科杂志,2015(8):1427-1428.
[2]邹文进,刘祖国.单纯疱疹病毒性角膜炎的发病机制[J].国际眼科杂志,2013(6):1131-1133.
[3]吴甦潜,徐建江.单纯疱疹病毒性角膜炎的发病机制[J].中国眼耳鼻喉科杂志,2014(5):330-332,336.
[4]齐险峰.更昔洛韦胶囊治疗单纯疱疹病毒性角膜炎的临床观察[J].实用医技杂志,2018(4):415-416.
[5]窦丽丽.玻璃酸钠滴眼液联合阿昔洛韦治疗单纯疱疹病毒性角膜炎的效果分析[J].当代医药论丛,2018(3):78-79.
[6]李文俊,张建民,张锐,等.上皮型单纯疱疹病毒性角膜炎治疗中更昔洛韦眼用凝胶应用的效果观察[J].临床医药文献电子杂志,2017(62):12213-12214.
[7]薛红权.更昔洛韦眼用凝胶联合小剂量糖皮质激素治疗单纯疱疹病毒性角膜炎的疗效观察[J].临床合理用药杂志,2016(25):94-95.
[8]马雪燕.更昔洛韦眼用凝胶联合小剂量糖皮质激素治疗单纯疱疹病毒性角膜炎的疗效观察[J].中国现代药物应用,2016(24):87-88.
[9]项凯.单纯疱疹病毒性角膜炎采用干扰素联合抗病毒药物治疗的观察[J].临床医药文献电子杂志,2018(27):122-123.
[10]覃仁勇,谭庆雄,莫优.更昔洛韦眼用凝胶联合干扰素球结膜下注射治疗单纯疱疹病毒性角膜炎疗效分析[J].华夏医学,2015(5):78-79.
[11]万金兰,康斌.重组人干扰素α-2b滴眼液治疗上皮型单纯疱疹病毒性角膜炎[J].国际眼科杂志,2014(2):276-278.
[12]李莉.角膜清创术联合药物治疗上皮型单纯疱疹病毒性角膜炎的效果[J].实用临床医学,2015(8):82,96.
[13]申爱军,陈晓君,王保贞.角膜清创联合药物治疗上皮型单纯疱疹病毒性角膜炎疗效观察[J].中国实用医药,2014(6):157-158.
[14]李爽,田涛.角膜溃疡冷冻清创联合抗病毒药物治疗单纯疱疹病毒性角膜炎的临床分析[J].中国医药指南,2014(30):223-224.
[15]何根杰.自体血清治疗单纯疱疹病毒性角膜炎的疗效观察[J].安徽医药,2014(4):755-756.
[16]欧阳丽.体外培育牛黄治疗单纯疱疹病毒性角膜炎临床观察[J].湖北中医杂志,2014(6):39.
[17]王勇,詹邶.角膜接触镜联合抗病毒药物在单纯疱疹性病毒性角膜炎治疗中的效果观察[J].亚太传统医药,2012(1):120-121.
[18]刘琳,张波,郭宇燕,等.改良羊膜移植联合角膜接触镜及免疫调节剂治疗复发性上皮型单纯疱疹病毒性角膜炎[J].眼科新进展,2017(12):1150-1152.
[19]彭希.清肝解毒汤联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的疗效观察[J].临床医药文献电子杂志,2018(18):12-14.
[20]巩继平.中药内服联合西医治疗单纯疱疹病毒性角膜炎回顾性分析[J].新中医,2017(9):110-113.
[21]黄俊珺,董学梅.益气养血祛风法治疗复发性单纯疱疹病毒性角膜炎的临床观察[J].国际眼科杂志,2017(12):2318-2320.
[22]张婷,李婧.银翘荆防汤加减治疗单纯疱疹病毒性角膜炎临床观察[J].四川中医,2016(1):171-172.
[23]林曦.中医辨证治疗单纯疱疹病毒性角膜炎的临床效果研究[J].齐齐哈尔医学院学报,2017(22):2675-2676.
[24]韦云昌.辨证论治单纯疱疹毒性角膜炎41例[J].河南中医,2014(7):1341-1342.
[25]张茂荣.中医辨证治疗单纯疱疹病毒性角膜炎临床观察[J].中外医学研究,2013(33):194-195.
[26]黄海东,陈冬,杨月丽,等.炎琥宁联合更昔洛韦对单纯疱疹病毒性角膜炎患者血清和泪液中抗氧化指标的影响[J].解放军预防医学杂志,2018(4):465-468,479.
[27]刘晓霞,孟晶.疏风解毒胶囊联合阿昔洛韦滴眼液治疗单纯疱疹病毒性角膜炎100例临床分析[J].岭南急诊医学杂志,2017(2):185-186.
[28]罗俊.热毒宁注射液联合阿昔洛韦滴眼液治疗单疱病毒性角膜炎的临床观察[J].中外医学研究,2012(2):119.
[29]徐宇明,张焕英,欧国平,等.单纯疱疹病毒性角膜炎患者采取中药离子导入治疗的效果观察[J].中国实用医药,2018(10):141-143.
[30]王齐.抗病毒滴眼液与中药熏眼治疗单纯疱疹性病毒性角膜炎[J].吉林中医药,2017(3):260-262.
[31]赵芳,史桂桃.中药超声雾化眼浴治疗单纯疱疹病毒性角膜炎48例临床观察[J].中医药导报,2015(2):73-74.
[32]鲁士友,宿艳.龙胆泻肝汤加减联合针灸治疗肝火炽盛证单纯疱疹病毒性角膜炎[J].中国实验方剂学杂志,2018(15):216-221.
[33]潘琪琦,邵愚.清肝明目退翳方联合针刺为主治疗复发性上皮型单纯疱疹病毒性角膜炎42例[J].浙江中医杂志,2017(8):595.
[34]秦文广,王艳.清肝泻火法联合针刺治疗单纯疱疹病毒性角膜炎的疗效评价[J].中国处方药,2016(6):107-108.
[35]吕玉林.超声雾化联合中药治疗单纯疱疹病毒性角膜炎[J].光明中医,2018(6):813-815.
[36]熊静,龙辉,周利.祛风明目汤联合雾化熏眼治疗单纯疱疹病毒性角膜炎30例(31眼)疗效观察[J].湖南中医杂志,2017(10):83-85.
[37]张丽芳,关敏,容加勇.加味银翘散配合离子导入治疗单纯疱疹病毒性角膜炎[J].云南中医中药杂志,2013(2):32-33.
[38]陈子燕,李庆生.中药联合无环鸟苷治疗单纯疱疹病毒性角膜炎的临床疗效分析[J].世界中医药,2017(4):825-828,832.
[39]宋晓慧.中西医结合治疗上皮型单纯疱疹病毒性角膜炎40例临床观察[J].浙江中医杂志,2017(9):670-671.
[40]王健,李长生,黄玉琴,等.疏风清热法联合西药治疗上皮型单纯疱疹病毒性角膜炎疗效[J].国际眼科杂志,2015(8):1427-1428.