糖皮质激素联合特布他林对AECOPD的临床疗效分析
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摘要
目的观察糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法选取2015年6月～2017年6月在本院就诊的AECOPD患者260例作为研究对象,按照随机数字表法分为观察组及对照组,每组各130例。对照组患者接受特布他林雾化吸入治疗,观察组患者在对照组的治疗基础上联合应用糖皮质激素治疗,观察两组患者疗效。结果治疗完成后,两组患者肺功能、动脉血气指标均较治疗前显著好转(P <0.05),且观察组患者改善更为明显(P <0.05);观察组患者治疗总有效率显著高于对照组(P <0.05),两组患者不良反应总发生情况相比较差异无统计学意义(P> 0.05)。结论糖皮质激素联合特布他林治疗AECOPD的效果显著,安全性高,值得在临床工作中推广。
Objective To observe the clinical efficacy of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods 260 cases patients with AECOPD in our hospital from June 2015 to June 2017 were selected as the research subjects.According to the random number table method,the patients were divided into the observation group and the control group,with 130 cases in each group.The patients in the control group were treated with bubutaline inhalation,and the patients in the observation group were treated with glucocorticoid on the basis of the control group,and the efficacy of the two groups was observed. Results After the treatment,the pulmonary function and arterial blood gas index of the two groups were significantly better than before the treatment(P < 0.05),and the improvement of the patients in the observation group was more obvious(P < 0.05);The total effective rate of the observation group was significantly higher than the control group(P < 0.05).The total adverse reaction of the two groups had no significant difference(P > 0.05). Conclusion Glucocorticoid combined with terbutaline is effective and safe in the treatment of AECOPD.It is worthy of promotion in clinical work.
Objective To observe the clinical efficacy of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods 260 cases patients with AECOPD in our hospital from June 2015 to June 2017 were selected as the research subjects.According to the random number table method,the patients were divided into the observation group and the control group,with 130 cases in each group.The patients in the control group were treated with bubutaline inhalation,and the patients in the observation group were treated with glucocorticoid on the basis of the control group,and the efficacy of the two groups was observed. Results After the treatment,the pulmonary function and arterial blood gas index of the two groups were significantly better than before the treatment(P < 0.05),and the improvement of the patients in the observation group was more obvious(P < 0.05);The total effective rate of the observation group was significantly higher than the control group(P < 0.05).The total adverse reaction of the two groups had no significant difference(P > 0.05). Conclusion Glucocorticoid combined with terbutaline is effective and safe in the treatment of AECOPD.It is worthy of promotion in clinical work.
引文
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[12]金小云.糖皮质激素联合特布他林治疗慢阻肺急性加重期临床疗效观察[J].淮海医药,2017,35(4):402-404.
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[14]翟冠涛.糖皮质激素联合特布他林治疗慢阻肺急性加重期疗效观察[J].中国医学工程,2017,25(11):85-87.
[15]巫治文,谢广渊.特布他林雾化吸入治疗慢性阻塞性肺疾病的效果评价[J].中国当代医药,2017,24(16):39-41.
[2]黄拔威,许能銮.糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].中国现代医生,2017,55(23):33-35.
[3]陈小岚,金珊珊,王兴友.慢性阻塞性肺疾病急性加重期应用糖皮质激素治疗的进展[J].医学综述,2015,21(9):1636-1638.
[4]李艳春.糖皮质激素联合特布他林治疗急性加重期慢阻肺的临床效果[J].河南医学研究,2017,26(6):1036-1037.
[5]慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中国医学前沿杂志(电子版),2014,6(2):67-80.
[6]武翠梅,张美超,代佳,等.慢性阻塞性肺疾病的临床治疗进展[J].吉林医药学院学报,2016,37(4):294-297.
[7]王蕾,杨汀,王辰.2017年版慢性阻塞性肺疾病诊断、处理和预防全球策略解读[J].中国临床医生杂志,2017,45(1):104-108.
[8]Jungho K,Jangyup S,Soogil L,et al.Effects of MgO and MgO/Pd seed-layers on perpendicular magnetic anisotropy of COPD thin films[J].Thin Solid Films,2011,519(23):8252-8255.
[9]王光磊,张春兆.糖皮质激素联合特布他林治疗慢性阻塞性肺疾病急性加重期疗效观察[J].现代医药卫生,2017,33(19):3009-3011.
[10]Yabuhara O,Ohtake M,Tobari K,et al.Structural and magnetic properties of FePd and COPD alloy epitaxial thin films grown on MgO single-crystal substrates with different orientations[J].Thin Solid Films,2011,519(23):8359-8362.
[11]江焰平.糖皮质激素联合特布他林治疗慢阻肺急性加重期的价值[J].当代医学,2017,23(24):161-162.
[12]金小云.糖皮质激素联合特布他林治疗慢阻肺急性加重期临床疗效观察[J].淮海医药,2017,35(4):402-404.
[13]潘琨.糖皮质激素在慢性阻塞性肺疾病治疗中的作用[J].中国慢性病预防与控制,2017,25(4):316-318.
[14]翟冠涛.糖皮质激素联合特布他林治疗慢阻肺急性加重期疗效观察[J].中国医学工程,2017,25(11):85-87.
[15]巫治文,谢广渊.特布他林雾化吸入治疗慢性阻塞性肺疾病的效果评价[J].中国当代医药,2017,24(16):39-41.