中药生物分子信息文献系统的研发与应用
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摘要
随着中医药药理实验和生命科学研究的不断发展,中药从宏观到微观层次已经积累了大量的实验数据以及文献信息,通过整合这些大数据,研发中药生物分子信息文献系统,具有重要意义。中药生物分子信息文献系统可以实现"中药-化学成份-靶蛋白-生物通路-文献信息"的多层次信息检索功能,并且具有蛋白基因关联知识推理发现功能,能够方便研究人员获取中药的所有相关化学成份、靶点、以及生物通路等数据信息,从而有助于分析中药对疾病的分子作用机制,而且系统的推理功能能够分析出两个或多个靶点之间的相互作用关联路径,使研究人员进一步探索多靶点之间的机制作用途径。
With the continuous development of traditional Chinese medicine pharmacology experiments and life science research,Chinese medicine has accumulated a large amount of experimental data and literature information from the macro to the micro level.It is of great significance to integrate the big data and develop the biomolecular information literature system of traditional Chinese medicine.The traditional Chinese medicine biomolecular information literature system can realize the multi-level information retrieval function of "Chinese medicine-chemical composition-target protein-biological pathway-document information",and has the function of protein gene-related knowledge reasoning and discovery,which can facilitate researchers to obtain all relevant chemistry of traditional Chinese medicine.Data information such as components,targets,and biological pathways,which help to analyze the molecular mechanism of Chinese medicine on disease,and the system's reasoning function can analyze the interaction path between two or more targets,making research The personnel further explored the mechanism of action between multiple targets.
With the continuous development of traditional Chinese medicine pharmacology experiments and life science research,Chinese medicine has accumulated a large amount of experimental data and literature information from the macro to the micro level.It is of great significance to integrate the big data and develop the biomolecular information literature system of traditional Chinese medicine.The traditional Chinese medicine biomolecular information literature system can realize the multi-level information retrieval function of "Chinese medicine-chemical composition-target protein-biological pathway-document information",and has the function of protein gene-related knowledge reasoning and discovery,which can facilitate researchers to obtain all relevant chemistry of traditional Chinese medicine.Data information such as components,targets,and biological pathways,which help to analyze the molecular mechanism of Chinese medicine on disease,and the system's reasoning function can analyze the interaction path between two or more targets,making research The personnel further explored the mechanism of action between multiple targets.
引文
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[14]胡双,陆涛,胡建华.文本挖掘技术在药物研究中的应用[J].医学信息学杂志,2013,34(8):49-53.
[15]展俊平,郑光,姜淼等,文本挖掘探索慢性肾小球肾炎“证-症-方-药”相应规律[J].中国实验方剂学杂志,2013,19(3):315-320.
[2]Wang Y,Suzek T,Zhang J,et al.PubChem BioAssay:2014 update[J].Nucleic Acids Res,2014,42(1):1075-1082.
[3]Ye H,Ye L,Kang H,et al.HIT:linking herbal active ingredients to targets[J].Nucleic Acids Res,2011,39(2):1055-1059.
[4]Croft D,Mundo AF,Haw R,etc.The Reactome pathway knowle dgebase[J].Nucleic Acids Res,2014,42(3):472-477.
[5]Ru J,Li P,Wang J,et al.TCMSP:a database of systems pharmacology for drug discovery from herbal medicines[J].J Cheminform,2014,6(1):13.
[6]陈陵,徐燎宇.大数据时代对中医药发展的思考[J].中医文献杂志,2019,37(1):66-69.
[7]陶永鹏,刘朝霞,顼聪.大数据背景下有关中医药现代化思路的探讨[J].中华中医药杂志,2019,34(2):470-473.
[8]刘艳飞,孙明月,姚贺之,等.大数据技术在中医药领域中的应用现状及思考[J].中国循证医学杂志,2018,18(11):1180-115.
[9]刘菊红,曾召,张晓艳,等.中医药文献大数据分析平台的构建[J].中国中医药信息杂志,2018,25(8):4-8.
[10]杨进,罗漫,张启蕊.文本挖掘在中医药文献分析中的应用[J].广东药学院学报,2010,26(2):216-220.
[11]濮正平,夏江明,谢巍,等.基于文献的舒肝解郁胶囊临床应用文本挖掘研究[J].中国中药杂志,2017,42(17):3430-3433.
[12]沈姗姗,姜淼,郑光,等.基于文本挖掘探讨中医外治法和食疗在糖尿病中应用规律[J].中国实验方剂学杂志,2015,21(1):209-212.
[13]吕婷,姜友好.文本挖掘在生物医学领域中的应用及其系统工具[J].中华医学图书情报杂志,2010,19(4):56-64.
[14]胡双,陆涛,胡建华.文本挖掘技术在药物研究中的应用[J].医学信息学杂志,2013,34(8):49-53.
[15]展俊平,郑光,姜淼等,文本挖掘探索慢性肾小球肾炎“证-症-方-药”相应规律[J].中国实验方剂学杂志,2013,19(3):315-320.