儿童哮喘及咳嗽变异性哮喘肺功能检查临床应用价值研究
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摘要
目的研究肺功能检查在儿童哮喘及咳嗽变异性哮喘的诊断及病情评估临床应用价值。方法以48例典型哮喘(CA组)及39例咳嗽变异性哮喘儿童(CVA组)为研究对象,68例健康儿童为对照组,比较哮喘及咳嗽变异性哮喘儿童急性期肺功能检查情况;比较不同阶段哮喘及咳嗽变异性哮喘儿童肺功能检查的变化情况。结果正常对照组、CVA组及CA组FVC、FEV_1、PEF、FEV_1/FVC依次降低,RV、RV/TLC%依次升高,任意组间均有统计学差异(P <0. 05); CA组、CVA组患儿慢性持续期、临床缓解期及正常对照组肺功能检FVC、FEV_1、FEV_1/FVC、PEF、RV、RV/TLC%结果均无统计学差异(P> 0. 05)。结论肺功能检查在支气管哮喘及咳嗽变异性哮喘诊断及病情评估上具有较高的临床应用价值。
Objective To study the clinical value of pulmonary function test in the diagnosis and evaluation of children with asthma and cough variant asthma. Methods 48 children with typical asthma( the CA group) and39 children with cough variant asthma( the CVA group) were selected,and 68 healthy children were taken as the control group. The pulmonary function tests of children with typical asthma and cough variant asthma in acute phase were compared,and the changes of pulmonary function tests of children with typical asthma and cough variant asthma in different stages were compared. Results The levels of FVC,FEV_1,PEF and FEV_1/FVC in the normal control group,the CVA group and the CA group decreased in turn,and the value of RV and RV/TLC% increased in turn,and there were statistical differences among any groups( P < 0. 05). There was no significant difference in FVC,FEV_1/FVC,PEF,RV,or RV/TLC% among the CA group,the CVA group and the normal control group during chronic persistent period and clinical remission period( P > 0. 05). Conclusion Pulmonary function test has high clinical value in the diagnosis and evaluation of bronchial asthma and cough variant asthma.
Objective To study the clinical value of pulmonary function test in the diagnosis and evaluation of children with asthma and cough variant asthma. Methods 48 children with typical asthma( the CA group) and39 children with cough variant asthma( the CVA group) were selected,and 68 healthy children were taken as the control group. The pulmonary function tests of children with typical asthma and cough variant asthma in acute phase were compared,and the changes of pulmonary function tests of children with typical asthma and cough variant asthma in different stages were compared. Results The levels of FVC,FEV_1,PEF and FEV_1/FVC in the normal control group,the CVA group and the CA group decreased in turn,and the value of RV and RV/TLC% increased in turn,and there were statistical differences among any groups( P < 0. 05). There was no significant difference in FVC,FEV_1/FVC,PEF,RV,or RV/TLC% among the CA group,the CVA group and the normal control group during chronic persistent period and clinical remission period( P > 0. 05). Conclusion Pulmonary function test has high clinical value in the diagnosis and evaluation of bronchial asthma and cough variant asthma.
引文
[1]中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版)[S].中华儿科杂志,2016,54(3):167-181.
[2]王浩,邵玉霞.TGF-β1的表达水平与哮喘患者气道重塑的关系[J].哈尔滨医科大学学报,2017,51(4):330-333.
[3]傅鹏.布地奈德联合孟鲁司特钠治疗小儿支气管哮喘的疗效研究[J].基层医学论坛,2017,21(23):3133,3136.
[4]齐力,姜丹.诱导痰查嗜酸粒细胞对支气管哮喘患者调整治疗的指导意义[J].哈尔滨医科大学学报,2017,51(2):180-182.
[5]胡海涛.噻托溴铵对重度支气管哮喘患者肺功能及免疫功能的影响[J].临床医学,2017,37(3):66-67.
[6]吉小军.复方异丙托溴铵与布地奈德联合匹多莫德对儿童支气管哮喘效果及对免疫功能的影响[J].湖南师范大学学报(医学版),2017,14(2):112-116.
[7]张渊源,赵谦,李晓虹,等.潮气呼吸肺功能支气管舒张试验在5岁以内儿童喘息性疾病诊断中的作用[J].中国妇幼健康研究,2017,28(6):656-659.
[8]NIIMI A.Cough and asthma[J].Curr Respir Med Rev,2011,7(1):47-54.
[9]李艳凤,王洪波,高阳,等.支气管哮喘患儿血清骨膜蛋白水平变化及其意义[J].吉林大学学报(医学版),2017,43(1):101-105.
[10]NIIMI A,MATSUMOTO H,MISHIMA M.Eosinophilic airway disorders associated with chronic cough[J].Pulm Pharmacol Ther,2009,22(2):114-120.
[11]缑梦帆,刘娟.呼出气一氧化氮浓度检测对儿童哮喘的诊断价值[J].实用临床医学,2017,18(2):69-71.
[12]高佩琦,孙永法,胡姬婷.高剂量雾化吸入糖皮质激素治疗儿童重度哮喘急性发作的疗效分析[J].现代诊断与治疗,2017,28(10):1810-1811.
[13]李勇,高春彪,盛伟武,等.儿童支气管哮喘患者血浆中miR-NA-125b及miRNA-133b的表达及临床意义[J].现代检验医学杂志,2017,32(3):59-62.
[14]曹明岭.小儿咳嗽变异性哮喘与肺炎支原体感染关系研究[J].河北医学,2013,19(6):919-921.
[15]周焕荣,徐强,陈华,等.慢性咳嗽患儿血清变态反应指标及肺功能特点[J].中华全科医学,2014,12(5):763-764.
[16]陈一芳,考验,忻学英,等.肺功能检测在小儿呼吸道疾病中的临床应用[J].浙江大学学报(医学版),2005,34(4):365-367.
[17]TAMAOKI J,YOKOHORI N,TAGAYA E,et al.Comparable effect of a leukotriene receptor antagonist and long-acting beta2-adrenergic agonist in cough variant asthma[J].Allergy Asthma Proc,2010,31(5):78-84.
[2]王浩,邵玉霞.TGF-β1的表达水平与哮喘患者气道重塑的关系[J].哈尔滨医科大学学报,2017,51(4):330-333.
[3]傅鹏.布地奈德联合孟鲁司特钠治疗小儿支气管哮喘的疗效研究[J].基层医学论坛,2017,21(23):3133,3136.
[4]齐力,姜丹.诱导痰查嗜酸粒细胞对支气管哮喘患者调整治疗的指导意义[J].哈尔滨医科大学学报,2017,51(2):180-182.
[5]胡海涛.噻托溴铵对重度支气管哮喘患者肺功能及免疫功能的影响[J].临床医学,2017,37(3):66-67.
[6]吉小军.复方异丙托溴铵与布地奈德联合匹多莫德对儿童支气管哮喘效果及对免疫功能的影响[J].湖南师范大学学报(医学版),2017,14(2):112-116.
[7]张渊源,赵谦,李晓虹,等.潮气呼吸肺功能支气管舒张试验在5岁以内儿童喘息性疾病诊断中的作用[J].中国妇幼健康研究,2017,28(6):656-659.
[8]NIIMI A.Cough and asthma[J].Curr Respir Med Rev,2011,7(1):47-54.
[9]李艳凤,王洪波,高阳,等.支气管哮喘患儿血清骨膜蛋白水平变化及其意义[J].吉林大学学报(医学版),2017,43(1):101-105.
[10]NIIMI A,MATSUMOTO H,MISHIMA M.Eosinophilic airway disorders associated with chronic cough[J].Pulm Pharmacol Ther,2009,22(2):114-120.
[11]缑梦帆,刘娟.呼出气一氧化氮浓度检测对儿童哮喘的诊断价值[J].实用临床医学,2017,18(2):69-71.
[12]高佩琦,孙永法,胡姬婷.高剂量雾化吸入糖皮质激素治疗儿童重度哮喘急性发作的疗效分析[J].现代诊断与治疗,2017,28(10):1810-1811.
[13]李勇,高春彪,盛伟武,等.儿童支气管哮喘患者血浆中miR-NA-125b及miRNA-133b的表达及临床意义[J].现代检验医学杂志,2017,32(3):59-62.
[14]曹明岭.小儿咳嗽变异性哮喘与肺炎支原体感染关系研究[J].河北医学,2013,19(6):919-921.
[15]周焕荣,徐强,陈华,等.慢性咳嗽患儿血清变态反应指标及肺功能特点[J].中华全科医学,2014,12(5):763-764.
[16]陈一芳,考验,忻学英,等.肺功能检测在小儿呼吸道疾病中的临床应用[J].浙江大学学报(医学版),2005,34(4):365-367.
[17]TAMAOKI J,YOKOHORI N,TAGAYA E,et al.Comparable effect of a leukotriene receptor antagonist and long-acting beta2-adrenergic agonist in cough variant asthma[J].Allergy Asthma Proc,2010,31(5):78-84.