从血瘀“血变”辨析血液病血小板减少并发血栓栓塞
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摘要
目的:从中医血瘀"血变"角度及现代医学血栓理论,对血液病血小板减少并发血栓栓塞进行辨析。方法:回顾10年来江苏省中医院血液科住院患者中血小板减少并发血栓的资料,对其生理特征及血栓高危因素加以分析,并以中医血瘀理论从病名、病因病机、病证特点、治则治法方面进行辨析。结果:高龄、深静脉置管、输血、糖皮质激素、化疗、血液病本病均为血栓栓塞的高危因素。结论:血液病患者在血小板减少时极易并发血栓栓塞,在治疗过程需时刻警惕血栓的风险,中医血瘀与现代医学血栓理论相结合,为血小板减少伴血栓栓塞的诊治提供了理论及实践依据。
Objective: From the perspective of blood stasis "blood change"in TCM and the theory of thrombosis to study the thromboembolism of thrombocytopenia in hematologic patients. Methods: Review the data of in-patients hematologic patients with thromboembolism of thrombocytopenia for 10 years,use the TCM theory of blood stasis and modern medical theory of thrombosis to analyze the clinical biological characteristics and the data of related risk factors of complicating thrombosis from the etiology, pathogenesis, the characteristics of the disease and treatment. Results:Advanced age,deep vein catheter,blood transfusion,glucocorticoids,chemotherapy and hematologic were high risk factors for thrombosis. Conclusion: Patients with thrombocytopenia in hematologic are prone to thromboembolism,so the risk of thrombus should be vigilant in the treatment process. The combination of TCM blood stasis and modern medical thrombus theory,will provide theoretical and practical basis for the diagnosis and treatment of thromboembolism.
Objective: From the perspective of blood stasis "blood change"in TCM and the theory of thrombosis to study the thromboembolism of thrombocytopenia in hematologic patients. Methods: Review the data of in-patients hematologic patients with thromboembolism of thrombocytopenia for 10 years,use the TCM theory of blood stasis and modern medical theory of thrombosis to analyze the clinical biological characteristics and the data of related risk factors of complicating thrombosis from the etiology, pathogenesis, the characteristics of the disease and treatment. Results:Advanced age,deep vein catheter,blood transfusion,glucocorticoids,chemotherapy and hematologic were high risk factors for thrombosis. Conclusion: Patients with thrombocytopenia in hematologic are prone to thromboembolism,so the risk of thrombus should be vigilant in the treatment process. The combination of TCM blood stasis and modern medical thrombus theory,will provide theoretical and practical basis for the diagnosis and treatment of thromboembolism.
引文
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[3]郭艳秋,李文君,高玉娟,等.骨髓增殖性肿瘤血栓形成及出血并发症的风险指标分析[J].血栓与止血学,2017,23(4):718-720.
[4]刘增艳,张国强,于文征,等.多发性骨髓瘤患者高凝状态的实验研究[J].中国实验血液学杂志,2015,23(1):142-145.
[5]吴卿,谢贤如.恶性肿瘤合并静脉血栓栓塞症的临床特点及相关危险因素分析[J].福建医科大学学报,2017,51(4):228-233.
[6]王涛,张立洪,孙思磊,等.下肢静脉曲张术后深静脉血栓形成原因分析及预防性应用低分子肝素的研究[J].实用临床医学,2014,15(10):27-31.
[7]张峰,童若燕,张晓红,等.系统性红斑狼疮合并血栓发生机制的研究进展[J].皮肤病与性病,2014,36(4):207-209.
[8]郑新,邢状杰,赵晖,等.晚期肿瘤患者深静脉血栓发生因素分析[J].中国肿瘤临床与康复,2017,24(2):200-202.
[9]韩聪凡,冯文化.血栓性疾病抗血小板聚集药物研究进展[J].中国新药杂志,2016,25(12):1363-1368.
[10]王海娟,刘小菊,高杰,等.王清任及其五逐瘀汤刍议[J].环球中医药,2016,9(7):848-850.
[11]卢红蓉,胡镜清.“瘀血”与“血瘀”辨析[J].中华中医药杂志,2017,32(2):426-428.
[12]廖桂萍,尹晓林,王丽,等.出血合并血栓形成为表现的获得性维生素K依赖性凝血因子缺乏症1例[J].临床血液学杂志,2014,27(5):432-433.
[13]郭宇飞,申丹,杨洪军.含红花中药组方规律分析[J].中国中药杂志,2014,39(11):2144-2148.
[14]陈文梅,金鸣,吴伟,等.红花黄色素抑制血小板激活因子介导的血小板活化作用的研究[J].中国药学杂志,2000,35(11):4-24.
[15]严常开,刘惟莞,敖英,等.丹参素胶囊活血化瘀作用的实验研究[J].中成药,2003,25(8):637-639.
[16]孔月琼,姚震,云美玲,等.丹参粉针治疗冠心病心绞痛患者的临床疗效及对血小板功能的影响[J].高血压杂志,2002,10(5):56-58.
[17]徐冲,商思阳,刘梅,等.僵蚕化学成分和药理活性的研究进展[J].中国药房,2014,25(39):3732-3734.
[18]程锁明,王航宇,李国玉,等.中药白僵蚕的研究进展[J].农垦医学,2012,34(5):443-448.