去白细胞输血与常规输血的不良反应调查分析
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摘要
目的调查分析去白细胞输血与常规输血的不良反应。方法回顾性分析100例需输血治疗的患者的临床资料,按随机数字表法将患者分为观察组(去白细胞输血)与参考组(常规输血)各50例,比较2组患者输血后不良反应发生情况。结果观察组输血后发热、过敏等不良反应发生率显著低于参考组(P<0.05);输血前,2组间自然杀伤细胞(NK细胞)、T淋巴细胞亚群(CD3+、CD4+、CD4+/CD8+)、白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)及肿瘤坏死因子-ɑ(TNF-ɑ)水平比较无显著差异(P>0.05),输血后,2组以上指标都有所改变,观察组改变程度显著低于参考组(P<0.05)。结论与常规输血比较,去白细胞输血可减少不良反应,减轻输血引起的炎性反应,对机体免疫抑制影响较小。
Objective To investigate the adverse reactions of leukocyte-free transfusion and conventional blood transfusion.Methods The clinical data of 100 patients requiring blood transfusion were retrospectively analyzed.These patients were divided into observation group(leukocyte-free blood transfusion,n=50) and reference group(conventional blood transfusion,n=50) according to the random number table method.The adverse reactions after transfusion were compared between the two groups.Results The incidence of adverse reactions such as fever and allergies in the observation group was significantly lower than that in the reference group(P<0.05).Before transfusion,natural killer cells(NK cells) and T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),interleukin-2(IL-2),interleukin-8(IL-8),interleukin-10(IL-10) and tumor necrosis factor-ɑ(TNF-ɑ) levels between the two groups showed no significant differences(P>0.05).After transfusion,the indicators of two groups all changed,but the observation group had significantly less change than the reference group(P<0.05).Conclusion Compared with conventional blood transfusion,leukocyte-free transfusion can reduce adverse reactions,reduce the inflammatory response caused by blood transfusion,and has less impact on the body's immune suppression.
Objective To investigate the adverse reactions of leukocyte-free transfusion and conventional blood transfusion.Methods The clinical data of 100 patients requiring blood transfusion were retrospectively analyzed.These patients were divided into observation group(leukocyte-free blood transfusion,n=50) and reference group(conventional blood transfusion,n=50) according to the random number table method.The adverse reactions after transfusion were compared between the two groups.Results The incidence of adverse reactions such as fever and allergies in the observation group was significantly lower than that in the reference group(P<0.05).Before transfusion,natural killer cells(NK cells) and T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+),interleukin-2(IL-2),interleukin-8(IL-8),interleukin-10(IL-10) and tumor necrosis factor-ɑ(TNF-ɑ) levels between the two groups showed no significant differences(P>0.05).After transfusion,the indicators of two groups all changed,but the observation group had significantly less change than the reference group(P<0.05).Conclusion Compared with conventional blood transfusion,leukocyte-free transfusion can reduce adverse reactions,reduce the inflammatory response caused by blood transfusion,and has less impact on the body's immune suppression.
引文
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[15]石洁,高琲,杨勇毅,等.围术期去除白细胞的红细胞输注减轻输血对膀胱癌患者的免疫抑制[J].细胞与分子免疫学杂志,2018,34(7):632-636.
[16]董勤敏,李海云,雷福珍,等.去白细胞输血对急性淋巴细胞白血病患者外周血Th1/Th2细胞平衡影响[J].中国实验血液学杂志,2018,26(4):999-1004.
[17]胡成义,勾丽平,王永维,等.保存期内不同时间制备去白细胞混合浓缩血小板制剂的质量研究[J].中国输血杂志,2017,30(10):1189-1192.
[18]马经琼,朱振新.受血者输血中Rh血型E抗原对患者机能免疫功能影响[J].标记免疫分析与临床,2017,24(1):60-63.
[2]古彦铮,汤龙海,黄子逸,等.以LRS滤器获取白细胞作为研究用T细胞的可行性分析[J].中华微生物学和免疫学杂志,2016,36(8):607-614.
[3]贺政新,陈晶,王宪灵,等.流式细胞术检测全血白细胞吞噬白念珠菌方法的建立和应用[J].细胞与分子免疫学杂志,2015,31(4):470-473.
[4]陆亚岚,张欣,汪玉芳,等.去白细胞输血对白血病患者细胞免疫功能的影响[J].中国实验血液学杂志,2016,24(4):1221-1225.
[5]邢莹,闫晓华,普程伟,等.全自动数字图像分析在外周血白细胞形态学复检中的临床应用[J].中华医学杂志,2016,96(8):634-639.
[6]王泰瑞,冯晨晨,吴敏慧,等.大于50%标示量的不足量血红细胞制剂储存期间溶血率调查[J].中国输血杂志,2015,28(12):1502-1504.
[7]王维娜,邢志勇,闫沛云,等. 157例非传染性输血反应相关因素的回顾性调查[J].中国输血杂志,2015,28(7):812-814.
[8]方敏,周群刚,史蓉蓉,等.即采即滤型白细胞滤器对血液质量的影响分析[J].临床输血与检验,2015,17(3):273-274.
[9]马玉媛,贾俊婷,章金刚.血液及血液制品中人细小病毒B19的检测及其意义[J].临床输血与检验,2016,18(3):201-204.
[10]陈会欣,王顺.输血不良反应对输血疗效的影响[J].中国输血杂志,2015,28(8):969-971.
[11]杨丽云,胡飘萍,吴承高,等.输血不良反应智能路径构建与临床应用研究[J].中国输血杂志,2017,30(2):120-124.
[12]田雪,田力,孔玉洁,等. 166例输血不良反应的回顾性评估分级研究[J].中国输血杂志,2017,30(4):371-374.
[13]袁志军,张婧婧,杨志美,等.临床输血不良反应和免疫产生意外抗体的分析[J].现代预防医学,2015,42(12):2296-2298.
[14]郭永建.美国FDA输注血液储存前白细胞减少技术指引及其启示[J].中国输血杂志,2015,28(9):1177-1184.
[15]石洁,高琲,杨勇毅,等.围术期去除白细胞的红细胞输注减轻输血对膀胱癌患者的免疫抑制[J].细胞与分子免疫学杂志,2018,34(7):632-636.
[16]董勤敏,李海云,雷福珍,等.去白细胞输血对急性淋巴细胞白血病患者外周血Th1/Th2细胞平衡影响[J].中国实验血液学杂志,2018,26(4):999-1004.
[17]胡成义,勾丽平,王永维,等.保存期内不同时间制备去白细胞混合浓缩血小板制剂的质量研究[J].中国输血杂志,2017,30(10):1189-1192.
[18]马经琼,朱振新.受血者输血中Rh血型E抗原对患者机能免疫功能影响[J].标记免疫分析与临床,2017,24(1):60-63.