妊娠期糖尿病对子代肺成熟度影响的代谢组学研究进展
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摘要
妊娠糖尿病如果孕妇继续保持高血糖并且控制不理想,会刺激胎儿胰岛素分泌增多,引起孕妇高胰岛素血症。当母亲的胰岛素浓度升高时,会抑制胎儿糖皮质激素的分泌,最终导致胎儿肺泡发育滞后及低血糖症。目前,胎肺成熟度是通过羊水泡沫测试来判断的,行羊膜腔穿刺术属有创操作存在一定弊端,现今临床上存在较大的争议。随着代谢组学在妊娠期糖尿病中的研究越来越多,本文主要就代谢组学在妊娠期糖尿病对子代肺成熟的影响的研究进展进行阐述。
If pregnant women with gestational diabetes mellitus(GDM) maintain hyperglycaemia with bad control,fetal insulin secretion will be stimulated to grow in quantity,thereby causing maternal high insulin hematic disease.When maternal insulin concentration increases,the fetus glucocorticoid secretion will be suppressed,which will finally lead to fetal alveolus development lag and hypoglycemia.At present,fetal lung maturity is judged by amniotic fluid bubble test,and there is a big controversy about line amniotic cavity puncture because it is an invasive operation and has certain disadvantages.With the increasing researches on metabonomics of gestational diabetes,this review will summarize recent progress on the impact of child lung mature from the perspective of metabolomics.
If pregnant women with gestational diabetes mellitus(GDM) maintain hyperglycaemia with bad control,fetal insulin secretion will be stimulated to grow in quantity,thereby causing maternal high insulin hematic disease.When maternal insulin concentration increases,the fetus glucocorticoid secretion will be suppressed,which will finally lead to fetal alveolus development lag and hypoglycemia.At present,fetal lung maturity is judged by amniotic fluid bubble test,and there is a big controversy about line amniotic cavity puncture because it is an invasive operation and has certain disadvantages.With the increasing researches on metabonomics of gestational diabetes,this review will summarize recent progress on the impact of child lung mature from the perspective of metabolomics.
引文
[1] Cheng HR,Walker LO,Brown A,et al.Gestational weight gain and perinatal outcomes of subgroups of Asian-American women,Texas,2009 [J].Women′s Health Issues,2015,25(3):303-311.
[2] Bentleylewis R,Powe C,Ankers E,et al.Effect of race/ethnicity on hypertension risk subsequent to gestational diabetes mellitus[J].Am J Cardiol,2014,113(8):1364-1370.
[3] Yue DK,Molyneaux LM,Ross GP,et a1.Why does ethnicity affect prevalence of gestational diabetes?The underwater volcano theory[J].Diabete Med,2015,13(8):748-752.
[4] 宋耕,杨慧霞.妊娠期糖尿病对其母儿远期转归的影响[J].中华糖尿病杂志,2012,4(4):245-248.
[5] 张振莉.妊娠期糖尿病对母婴结局的影响[J].实用妇科内分泌杂志:电子版,2017,4(6):127-128.
[6] 周玲玲.早期干预对妊娠期糖尿病妊娠结局的影响[J].临床医药文献电子杂志,2015,2(13):2579-2582.
[7] Najim HD.Neonatal complications in infants born to diabetic mothers-a study on iraqi[J].World Journal of Pharmaceutical Research,2016,5(9):257-265.
[8] 周莉,吴连方,范玲.妊娠期糖尿病孕妇足月阴道分娩的时机[J].中华围产医学杂志,2012,15(3) :170-173.
[9] 周秋香,余晓斌,涂国全,等.代谢组学研究进展及其应用[J].生物技术通报,2013,29(1):49-55.
[10] 苗朝霞,刘洪月,郭维,等.高效液相色谱与核磁共振波谱在复杂生物混合物体系代谢物鉴定中的应用[C].杭州:全国波谱学学术年会,2014.
[11] Lauridsen MB,Bliddal H,Christensen R,et al.1H NMR spectroscopy-based interventional metabolic phenotyping:a cohort study of rheumatoid arthritis patients[J].J Proteome Res,2010,9 (9),4545-4553.
[12] Yin P,Zhao X,Li Q,et al.Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS)[J].J Proteome Res,2006,5(9):2135-2143.
[13] Masson P,Alves AC,Ebbels TM,et al.Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS[J].Anal Chem,2010,82 (18):7779-7786.
[14] Want EJ,Coen M,Masson P,et al.Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids:application to experimental toxicology studies[J].Anal Chem,2010,82 (12):5282-5289.
[15] Diaz SO,Barros AS,Good fellow BJ,et a1.Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes[J].J Proteome Res,2013,12(6):2946-2957.
[16] Diaz SO,Pinto J,Graqa G,et a1.Metabolic biomarkers of prenatal disorders:an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma[J].J Proteome Res,2011,10(8):3732-3742.
[17] Scioscia M,Kunjara S,Gumaa K,et a1.Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus[J].Diabet Med,2007,24(11):1300-1304.
[18] Sachse D,Sletner L,Merkrid K,el a1.Metabolic changes in urine during and after pregnancy in a large,multiethnic population-based cohort study of gestational diabetes[J].PLoS One,2012,7(12):e52399.
[19] Dunn WB,Brown M,Worton SA,et a1.The metabolome of human placentl tissue:investigation of first trimester tissue and changes related to preeclampsia in late pregnancy[J].Metabolomics,2012(4):579-597.
[2] Bentleylewis R,Powe C,Ankers E,et al.Effect of race/ethnicity on hypertension risk subsequent to gestational diabetes mellitus[J].Am J Cardiol,2014,113(8):1364-1370.
[3] Yue DK,Molyneaux LM,Ross GP,et a1.Why does ethnicity affect prevalence of gestational diabetes?The underwater volcano theory[J].Diabete Med,2015,13(8):748-752.
[4] 宋耕,杨慧霞.妊娠期糖尿病对其母儿远期转归的影响[J].中华糖尿病杂志,2012,4(4):245-248.
[5] 张振莉.妊娠期糖尿病对母婴结局的影响[J].实用妇科内分泌杂志:电子版,2017,4(6):127-128.
[6] 周玲玲.早期干预对妊娠期糖尿病妊娠结局的影响[J].临床医药文献电子杂志,2015,2(13):2579-2582.
[7] Najim HD.Neonatal complications in infants born to diabetic mothers-a study on iraqi[J].World Journal of Pharmaceutical Research,2016,5(9):257-265.
[8] 周莉,吴连方,范玲.妊娠期糖尿病孕妇足月阴道分娩的时机[J].中华围产医学杂志,2012,15(3) :170-173.
[9] 周秋香,余晓斌,涂国全,等.代谢组学研究进展及其应用[J].生物技术通报,2013,29(1):49-55.
[10] 苗朝霞,刘洪月,郭维,等.高效液相色谱与核磁共振波谱在复杂生物混合物体系代谢物鉴定中的应用[C].杭州:全国波谱学学术年会,2014.
[11] Lauridsen MB,Bliddal H,Christensen R,et al.1H NMR spectroscopy-based interventional metabolic phenotyping:a cohort study of rheumatoid arthritis patients[J].J Proteome Res,2010,9 (9),4545-4553.
[12] Yin P,Zhao X,Li Q,et al.Metabonomics study of intestinal fistulas based on ultraperformance liquid chromatography coupled with Q-TOF mass spectrometry (UPLC/Q-TOF MS)[J].J Proteome Res,2006,5(9):2135-2143.
[13] Masson P,Alves AC,Ebbels TM,et al.Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS[J].Anal Chem,2010,82 (18):7779-7786.
[14] Want EJ,Coen M,Masson P,et al.Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids:application to experimental toxicology studies[J].Anal Chem,2010,82 (12):5282-5289.
[15] Diaz SO,Barros AS,Good fellow BJ,et a1.Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes[J].J Proteome Res,2013,12(6):2946-2957.
[16] Diaz SO,Pinto J,Graqa G,et a1.Metabolic biomarkers of prenatal disorders:an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma[J].J Proteome Res,2011,10(8):3732-3742.
[17] Scioscia M,Kunjara S,Gumaa K,et a1.Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus[J].Diabet Med,2007,24(11):1300-1304.
[18] Sachse D,Sletner L,Merkrid K,el a1.Metabolic changes in urine during and after pregnancy in a large,multiethnic population-based cohort study of gestational diabetes[J].PLoS One,2012,7(12):e52399.
[19] Dunn WB,Brown M,Worton SA,et a1.The metabolome of human placentl tissue:investigation of first trimester tissue and changes related to preeclampsia in late pregnancy[J].Metabolomics,2012(4):579-597.