知柏地黄丸治疗肾阴亏损型精液不液化的临床观察
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摘要
目的观察知柏地黄丸治疗精液不液化的临床疗效。方法采用随机、对照的研究方法,将60例精液不液化的男性患者随机分为治疗组和对照组,各30例,对照组口服维生素E软胶囊,0.1 g/次,3次/d,葡萄糖酸锌片,0.105 g/次,2次/d,治疗组口服知柏地黄丸,1次8丸,3次/d,两组各治疗60 d。比较两组治疗前后的中医证候评分、精液分析及精液液化情况。结果治疗组治疗后的前向运动精子率、精子畸形率、精浆锌及精浆果糖水平较治疗前差异有统计学意义(P<0.05);两组治疗后精液液化情况均有所改善,两组比较差异有统计学意义(P<0.05),治疗组在缩短精液液化时间方面优于对照组;两组治疗后临床症状均有所改善,对照组有效率42.86%,治疗组有效率82.76%,两组比较差异有统计学意义(P<0.05),治疗组在改善临床症状方面优于对照组。结论知柏地黄丸治疗精液不液化疗效确切,值得临床推广应用。
Objective To evaluate the clinical efficacy of Zhibai Dihuang Pill in the treatment of semen non-liquefaction.Methods In a randomized controlled clinical trial, 60 male patients with semen non-liquefaction were randomly and equally divided into treatment group and control group. The control group received oral administration of vitamin E soft capsules0.1 g each time, 3 times daily and zinc gluconate pills 0.105 g each time, 2 times daily. The treatment group received oral administration of Zhibai Dihuang Pill 8 pills each time, 3 times daily. Both groups were treated for 60 days. The scores for traditional Chinese medicine syndrome, semen analysis results, and semen liquefaction were evaluated in the two groups before and after treatment. Results After treatment, the treatment group had significantly improved percentage of forward motile sperm, rate of sperm deformation, and levels of zinc and fructose in seminal plasma(all P<0.05). Both groups showed a significant improvement in semen liquefaction after treatment, and there was a significant difference in semen liquefaction between the two groups(P<0.05).The treatment group was superior to the control group in shortening semen liquefaction time. Both groups had improved clinical symptoms after treatment; the treatment group had a significantly higher response rate than the control group(82.76% vs 42.86%,P<0.05), suggesting that the treatment group was superior to the control group in improving clinical symptoms. Conclusion Zhibai Dihuang Pill is effective in the treatment of semen non-liquefaction, which holds promise for clinical application.
Objective To evaluate the clinical efficacy of Zhibai Dihuang Pill in the treatment of semen non-liquefaction.Methods In a randomized controlled clinical trial, 60 male patients with semen non-liquefaction were randomly and equally divided into treatment group and control group. The control group received oral administration of vitamin E soft capsules0.1 g each time, 3 times daily and zinc gluconate pills 0.105 g each time, 2 times daily. The treatment group received oral administration of Zhibai Dihuang Pill 8 pills each time, 3 times daily. Both groups were treated for 60 days. The scores for traditional Chinese medicine syndrome, semen analysis results, and semen liquefaction were evaluated in the two groups before and after treatment. Results After treatment, the treatment group had significantly improved percentage of forward motile sperm, rate of sperm deformation, and levels of zinc and fructose in seminal plasma(all P<0.05). Both groups showed a significant improvement in semen liquefaction after treatment, and there was a significant difference in semen liquefaction between the two groups(P<0.05).The treatment group was superior to the control group in shortening semen liquefaction time. Both groups had improved clinical symptoms after treatment; the treatment group had a significantly higher response rate than the control group(82.76% vs 42.86%,P<0.05), suggesting that the treatment group was superior to the control group in improving clinical symptoms. Conclusion Zhibai Dihuang Pill is effective in the treatment of semen non-liquefaction, which holds promise for clinical application.
引文
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[6]曾智承.加味二陈汤对痰湿阻滞型精液不液化的临床研究[D].福州:福建中医药大学,2018.
[7] FALLAH A, MOHAMMAD-HASANI A, COLAGAR A H. Zinc is an essential element for male fertility:a review of zn roles in men's health, germination, sperm quality, and fertilization[J].J Reprod Infertil, 2018,19(2):69-81.
[8]李波男,何清湖,周青,等.谭新华教授治疗精液不液化临证经验[J].湖南中医药大学学报,2018,38(10):1143-1145.
[9]李轩,何清湖,刘朝圣,等.知柏地黄丸对解脲脲原体感染性不育患者精子顶体酶影响的临床观察[J].中华中医药杂志,2013,28(6):1731-1733.
[10]李轩,何清湖,王益俊,等.知柏地黄丸对解脲脲原体感染不育患者u PA的影响[J].中国中西医结合杂志,2014,34(12):1449-1452.
[11]卢芳国,何清湖,张波,等.知柏地黄汤对解脲支原体感染大鼠睾丸组织IL-2及TNF-α表达水平的影响[J].中华中医药杂志,2011,26(3):448-450.
[2]何清湖,秦国政.中西医结合男科学[M].北京:人民卫生出版社,2005:279-281.
[3]王琦.王琦男科学[M].2版.郑州:河南科学技术出版社,2007:343-344.
[4]于然,朱春燕,马杰,等.精液不液化症的中医药治疗进展[J].世界中医药,2015,10(8):1276-1279,1283.
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:388-390.
[6]曾智承.加味二陈汤对痰湿阻滞型精液不液化的临床研究[D].福州:福建中医药大学,2018.
[7] FALLAH A, MOHAMMAD-HASANI A, COLAGAR A H. Zinc is an essential element for male fertility:a review of zn roles in men's health, germination, sperm quality, and fertilization[J].J Reprod Infertil, 2018,19(2):69-81.
[8]李波男,何清湖,周青,等.谭新华教授治疗精液不液化临证经验[J].湖南中医药大学学报,2018,38(10):1143-1145.
[9]李轩,何清湖,刘朝圣,等.知柏地黄丸对解脲脲原体感染性不育患者精子顶体酶影响的临床观察[J].中华中医药杂志,2013,28(6):1731-1733.
[10]李轩,何清湖,王益俊,等.知柏地黄丸对解脲脲原体感染不育患者u PA的影响[J].中国中西医结合杂志,2014,34(12):1449-1452.
[11]卢芳国,何清湖,张波,等.知柏地黄汤对解脲支原体感染大鼠睾丸组织IL-2及TNF-α表达水平的影响[J].中华中医药杂志,2011,26(3):448-450.