干扰素α-1b联合布地奈德及特布他林雾化吸入治疗婴幼儿喘息性支气管炎的临床疗效观察
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摘要
目的将干扰素α-1b与布地奈德、特布他林雾化吸入治疗联合用于婴幼儿喘息性支气管炎中,对其临床效果进行观察。方法选取2017年1月至2018年12月期间本院收治的婴幼儿喘息性支气管炎患儿120例,以治疗方式将其分成研究组(n=60)与参照组(n=60),两组患者入院后均行止咳、平喘、抗炎等常规治疗,参照组给予布地奈德+特布他林雾化吸入治疗,研究组在参照组基础上加入干扰素α-1b治疗,对两组患者治疗结果进行评价。结果研究组日间咳嗽评分、夜间咳嗽评分、日间喘息评分、夜间喘息评分与参照组相比,差异有统计学意义(P<0.05);研究组症状缓解时间、住院时间与参照组相比,相对更短,研究组1个月无症状天数与参照组相比,差异有统计学意义(P<0.05);两组治疗前中性粒细胞差异无统计学意义,研究组治疗后中性粒细胞与参照组相比,差异有统计学意义(P<0.05);研究组治疗后总有效率为96.67%,与参照组83.33%相比较,差异有统计学意义(P<0.05)。结论对喘息性支气管炎患儿应用干扰素α-1b+布地奈德+特布他林雾化吸入治疗效果理想,可缓解患儿喘息、咳嗽等症状,缩短住院时间,促进尽快康复,值得在临床中推广及应用。
Objective To observe the clinical effect of interferon alpha-1 b combined with budesonide and terbutaline aerosol inhalation in infants with asthmatic bronchitis. Methods 120 infants with asthmatic bronchitis admitted to our hospital from January 2017 to December 2018 were divided into study group(n=60) and control group(n=60). After admission, the two groups were given routine treatment such as cough relief, asthma relief and anti-inflammation. The reference group was given budesonide + terbutaline aerosol inhalation therapy, and the study group was added interferon alpha-1 b on the basis of the reference group. The treatment results of the two groups were evaluated. Results The day cough score, night cough score, day wheeze score and night wheeze score in the study group were significantly different from those in the control group(P<0.05); the symptoms relief time and hospitalization time in the study group were relatively shorter than those in the control group, and the number of asymptomatic days in the study group was significantly different from those in the control group(P<0.05). There was no significant difference in the number of neutrophils between the study group and the control group(P<0.05). The total effective rate was 96.67% in the study group, and 83.33% in the control group(P<0.05). Conclusion The application of interferon alpha-1 b+budesonide+terbutaline aerosol inhalation in children with asthmatic bronchitis has ideal therapeutic effect. It can alleviate the symptoms of asthma and cough, shorten the hospitalization time and promote the recovery as soon as possible. It is worth popularizing and applying in clinic.
Objective To observe the clinical effect of interferon alpha-1 b combined with budesonide and terbutaline aerosol inhalation in infants with asthmatic bronchitis. Methods 120 infants with asthmatic bronchitis admitted to our hospital from January 2017 to December 2018 were divided into study group(n=60) and control group(n=60). After admission, the two groups were given routine treatment such as cough relief, asthma relief and anti-inflammation. The reference group was given budesonide + terbutaline aerosol inhalation therapy, and the study group was added interferon alpha-1 b on the basis of the reference group. The treatment results of the two groups were evaluated. Results The day cough score, night cough score, day wheeze score and night wheeze score in the study group were significantly different from those in the control group(P<0.05); the symptoms relief time and hospitalization time in the study group were relatively shorter than those in the control group, and the number of asymptomatic days in the study group was significantly different from those in the control group(P<0.05). There was no significant difference in the number of neutrophils between the study group and the control group(P<0.05). The total effective rate was 96.67% in the study group, and 83.33% in the control group(P<0.05). Conclusion The application of interferon alpha-1 b+budesonide+terbutaline aerosol inhalation in children with asthmatic bronchitis has ideal therapeutic effect. It can alleviate the symptoms of asthma and cough, shorten the hospitalization time and promote the recovery as soon as possible. It is worth popularizing and applying in clinic.
引文
[1]魏向阳,滕永华.布地奈德、硫酸特布他林、异丙托溴铵气雾剂三联气泵雾化吸入治疗小儿喘息性支气管炎疗效观察[J].儿科药学杂志,2012,18(6):30-32.
[2]刘华容.布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察[J].中国医药导报,2014,11(1):76-78.
[3]孟连花,白侠,张效东,等.吸入用布地奈德混悬液联合硫酸特布他林雾化吸入加强治疗对喘息性支气管炎反复发作的预防作用[J]临床医学,2012,32(4):111-112.
[4]舒一民,沈群洁,王华英.布地奈德联合特布他林压缩雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].中国现代医生,2018,56(9):115-117.
[5]李晓燕.布地奈德联合硫酸特布他林雾化吸入治疗支气管哮喘的效果[J].河南医学研究,2018,27(7):166-167.
[6]杨丽果,陈伟.布地奈德联合特布他林雾化吸入对哮喘急性发作患者肺功能及临床症状、体征的影响[J].北方药学,2018,15(6):33-34.
[7]何燕,王桂霞,周荷盈,等.布地奈德联合复方异丙托溴铵治疗喘息性慢性支气管炎的临床疗效观察[J].北方药学,2018,15(6):68.
[8]常卫华.布地奈德联合硫酸特布他林雾化吸入治疗老年急性支气管肺炎效果观察[J].河南医学研究,2018,27(4):692-693.
[9]郝凤清.布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效观察[J].中国药物与临床,2018,18(3):451-452.
[10]裴敏.重组人干扰素α1b联合布地奈德、特布他林及异丙托溴铵雾化吸入治疗毛细支气管炎探讨[J].江西医药,2018,53(3):249-250.
[11]陈智芳.联合布地奈德尧特布他林雾化吸入对儿童肺炎支原体肺炎的治疗探讨[J].江西医药,2018,53(3):251-252.
[2]刘华容.布地奈德、硫酸特布他林、异丙托溴铵气雾剂联合雾化吸入治疗小儿喘息性支气管炎的效果观察[J].中国医药导报,2014,11(1):76-78.
[3]孟连花,白侠,张效东,等.吸入用布地奈德混悬液联合硫酸特布他林雾化吸入加强治疗对喘息性支气管炎反复发作的预防作用[J]临床医学,2012,32(4):111-112.
[4]舒一民,沈群洁,王华英.布地奈德联合特布他林压缩雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察[J].中国现代医生,2018,56(9):115-117.
[5]李晓燕.布地奈德联合硫酸特布他林雾化吸入治疗支气管哮喘的效果[J].河南医学研究,2018,27(7):166-167.
[6]杨丽果,陈伟.布地奈德联合特布他林雾化吸入对哮喘急性发作患者肺功能及临床症状、体征的影响[J].北方药学,2018,15(6):33-34.
[7]何燕,王桂霞,周荷盈,等.布地奈德联合复方异丙托溴铵治疗喘息性慢性支气管炎的临床疗效观察[J].北方药学,2018,15(6):68.
[8]常卫华.布地奈德联合硫酸特布他林雾化吸入治疗老年急性支气管肺炎效果观察[J].河南医学研究,2018,27(4):692-693.
[9]郝凤清.布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效观察[J].中国药物与临床,2018,18(3):451-452.
[10]裴敏.重组人干扰素α1b联合布地奈德、特布他林及异丙托溴铵雾化吸入治疗毛细支气管炎探讨[J].江西医药,2018,53(3):249-250.
[11]陈智芳.联合布地奈德尧特布他林雾化吸入对儿童肺炎支原体肺炎的治疗探讨[J].江西医药,2018,53(3):251-252.