摘要
目的系统评价硝苯地平控释片联合依那普利治疗高血压的疗效和安全性。方法检索PubMed、中国知网、维普及万方数据库中2000年至2018年发表的硝苯地平控释片联合依那普利治疗高血压相关文献,使用Jadad量表进行质量评价并通过Review Manager 5.3和Stata 11.0软件对纳入研究进行Meta分析。结果最终入选12篇研究,结果表明联合用药比单用依那普利疗效更好[OR=4.91,95%CI(3.32,7.26),P<0.00001],治疗前后舒张压和收缩压没有显著差异(P>0.05),安全性上联合组的表现也更好[OR=0.43,95%CI(0.26,0.69),P=0.0005]。结论本研究表明两种药物联合使用对高血压的疗效更好,安全性更高。
Objective: To assess the therapy efficacy and safety of enalapril combined with nifedipine for hypertension.Methods: Pubmed, CNKI, VIP and Wanfang Data were searched for combination of enalapril combined with nifedipine on hypertension during 2000-2018.Meta-analysis was performed by RevMan 5.3 and Stata software.Results: Twelve works in the literature were included in this study.Meta-analysis showed that there was a significant difference between experimental group and control group[OR=4.91,95%CI(3.32,7.26),P<0.00001].DBP and SBP had no significant difference between two groups. The difference of adverse effect was statistical between two groups[OR=0.43,95%CI(0.26,0.69),P=0.0005].Conclusion: Enalapril combined with nifedipine shows better efficacy and safety for hypertension.
引文
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