消化性溃疡患者根除HP后发生胃食管反流病的研究
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摘要
目的:观察消化性溃疡患者根除幽门螺杆菌(HP)后发生胃食管反流病的情况,探讨HP与胃食管反流病(GERD的关系。方法:将60例HP阳性消化性溃疡患者随机分为观察组和对照组,各30例,观察两组患者总体疗效,GerdQ评分,HP根除情况及两组患者治疗前、后及停药3个月胃食管反流发生情况。结果:对照组总有效率明显低于观察组(P<0.05);对照组GerdQ评分明显低于观察组(t=2.243,P<0.05);观察组HP根除率高于对照组(χ2=7.2,P<0.05);治疗后,在消化性溃疡患者发生胃食管反流病方面,观察组与对照组差异无统计学意义(χ2=0.3,P>0.05);停药3月后,观察组有3例消化性溃疡患者发生胃食管反流病,对照组有5例,差异无统计学意义(χ2=0.577,P>0.05)。结论:消化性溃疡患者经根除HP后效果显著,HP与胃食管反流病的发生可能不存在相关性。
Objective: To observe the occurrence of gastroesophageal reflux disease(GERD) after HP eradication in patients with peptic ulcer. Methods: 60 patients with helicobacter pylori(HP) positive peptic ulcer were randomly divided into the observation group and the control group, 30 patients each group. The overall efficacy, GerdQ score, HP eradication, and the occurrence of gastroesophageal reflux before, after and after treatment for 3 months were observed. Results: The total effective rate of the control group was significantly lower than that of the observation group(P<0.05). The Gerd Q score of the control group was significantly lower than that of the observation group(t=2.243, P<0.05). The eradication rate of HP in the observation group was higher than that in the control group(χ2=7.2, P<0.05). After treatment, there was no statistically significant difference between the observation group and the control group in the occurrence of gastroesophageal reflux disease in patients with peptic ulcer(χ2=0.3, P>0.05). Three patients with peptic ulcer developed gastroesophageal reflux disease in the observation group and 5 patients in the control group after 3 months of drug withdrawal,with no statistically significant difference(χ2=0.577, P>0.05). Conclusion: The effect of HP eradication on peptic ulcer was significant,and there was no correlation with the occurrence of gastroesophageal reflux.
Objective: To observe the occurrence of gastroesophageal reflux disease(GERD) after HP eradication in patients with peptic ulcer. Methods: 60 patients with helicobacter pylori(HP) positive peptic ulcer were randomly divided into the observation group and the control group, 30 patients each group. The overall efficacy, GerdQ score, HP eradication, and the occurrence of gastroesophageal reflux before, after and after treatment for 3 months were observed. Results: The total effective rate of the control group was significantly lower than that of the observation group(P<0.05). The Gerd Q score of the control group was significantly lower than that of the observation group(t=2.243, P<0.05). The eradication rate of HP in the observation group was higher than that in the control group(χ2=7.2, P<0.05). After treatment, there was no statistically significant difference between the observation group and the control group in the occurrence of gastroesophageal reflux disease in patients with peptic ulcer(χ2=0.3, P>0.05). Three patients with peptic ulcer developed gastroesophageal reflux disease in the observation group and 5 patients in the control group after 3 months of drug withdrawal,with no statistically significant difference(χ2=0.577, P>0.05). Conclusion: The effect of HP eradication on peptic ulcer was significant,and there was no correlation with the occurrence of gastroesophageal reflux.
引文
[1]中华消化杂志编委会.消化性溃疡病诊断与治疗规范建议(2008,黄山)[J].中华消化杂志,2008,28(7):447-450.
[2]Tsugane S,Sasazuki S.Diet and the risk of gastric cancer:review of epidemiological evidence[J].Gastric Cancer,2007,10(2):75-83.
[3]藤原靖弘,後藤英子.幽门螺杆菌(HP)与胃食管反流病[J].日本医学介绍,2002,23(1):10-11.
[4]吴思巧.胃食管反流病与HP感染的相关性分析[J].广州医药,2014,45(3):51-53.
[5]陈波.消化性溃疡根除幽门螺杆菌后对胃食管反流病的影响[J].中国误诊学杂志,2011,11(16):3873.
[6]中华消化杂志编委会.消化性溃疡病诊断与治疗规范(2013年,深圳)[J].中华消化杂志,2014,34(2):73-76.
[7]陈旻湖,侯晓华,肖英莲,等.2014年中国胃食管反流病专家共识意见[J].中华消化杂志,2014(10):155-168.
[8]Fock K M,Poh C H.Gastroesophageal reflux disease[J].Journal of Gastroenterology,2010,45(8):808-815.
[9]王瀛峰,张继全,吴飞,等.胃食管反流病的中西医发病机制及临床治疗的研究进展[J].世界华人消化杂志,2013(34):3821-3827.
[10]江燕,宋澄跃,周亚伯,等.胃食管反流病患者黏膜糜烂与HP感染相关性研究[J].中华全科医学,2013,11(3):401-402.
[11]王霄腾,张梦,陈超英,等.根除幽门螺杆菌与胃食管反流病关系的Meta分析[J].中华内科杂志,2016,55(9):710-716.
[12]李菁.幽门螺杆菌(Hp)感染与胃食管反流病的关系分析[J]中国现代医生,2017(13):82-84.
[13]谢川,吕农华.幽门螺杆菌与胃肠外疾病的关系[J].中华消化杂志,2011,31(12):843-845.
[14]陈吉,王忠,瞿启芬,等.胃食管反流患者夜间酸突破与食管酸暴露及幽门螺杆菌感染的临床研究[J].国际消化病杂志,2008,28(3):250-252.
[2]Tsugane S,Sasazuki S.Diet and the risk of gastric cancer:review of epidemiological evidence[J].Gastric Cancer,2007,10(2):75-83.
[3]藤原靖弘,後藤英子.幽门螺杆菌(HP)与胃食管反流病[J].日本医学介绍,2002,23(1):10-11.
[4]吴思巧.胃食管反流病与HP感染的相关性分析[J].广州医药,2014,45(3):51-53.
[5]陈波.消化性溃疡根除幽门螺杆菌后对胃食管反流病的影响[J].中国误诊学杂志,2011,11(16):3873.
[6]中华消化杂志编委会.消化性溃疡病诊断与治疗规范(2013年,深圳)[J].中华消化杂志,2014,34(2):73-76.
[7]陈旻湖,侯晓华,肖英莲,等.2014年中国胃食管反流病专家共识意见[J].中华消化杂志,2014(10):155-168.
[8]Fock K M,Poh C H.Gastroesophageal reflux disease[J].Journal of Gastroenterology,2010,45(8):808-815.
[9]王瀛峰,张继全,吴飞,等.胃食管反流病的中西医发病机制及临床治疗的研究进展[J].世界华人消化杂志,2013(34):3821-3827.
[10]江燕,宋澄跃,周亚伯,等.胃食管反流病患者黏膜糜烂与HP感染相关性研究[J].中华全科医学,2013,11(3):401-402.
[11]王霄腾,张梦,陈超英,等.根除幽门螺杆菌与胃食管反流病关系的Meta分析[J].中华内科杂志,2016,55(9):710-716.
[12]李菁.幽门螺杆菌(Hp)感染与胃食管反流病的关系分析[J]中国现代医生,2017(13):82-84.
[13]谢川,吕农华.幽门螺杆菌与胃肠外疾病的关系[J].中华消化杂志,2011,31(12):843-845.
[14]陈吉,王忠,瞿启芬,等.胃食管反流患者夜间酸突破与食管酸暴露及幽门螺杆菌感染的临床研究[J].国际消化病杂志,2008,28(3):250-252.