磁性纳米Fe_3O_4颗粒的表面改性及其在肿瘤治疗中的应用
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摘要
磁性纳米Fe3O4颗粒(MNP-Fe3O4)作为药物载体在肿瘤治疗领域受到广泛关注。综述了目前MNP-Fe3O4的研究现状,重点阐述了该材料的表面改性目的与改性途径,介绍了MNP-Fe3O4不同载药系统在肿瘤治疗中的应用,并详细阐述了介孔结构的MNP-Fe3O4颗粒作为药物载体的优势,指出了MNP-Fe3O4在肿瘤治疗中仍需解决的问题和发展趋势。
Magnetic Fe3O4 nanoparticles(MNP-Fe3O4) have many attracted many attentions in cancer therapy.The present paper reviews the research status of MNP-Fe3O4,mainly focusing on the purpose and methods of Fe3O4 surface modification and the application of different MNP-Fe3O4 drug delivery systems in cancer therapy.The great potential application of mesoporous MNP-Fe3O4 is also reviewed and discussed.Finally,the potential problems and trends of MNP-Fe3O4 as drug carrier in cancer therapy are proposed.
Magnetic Fe3O4 nanoparticles(MNP-Fe3O4) have many attracted many attentions in cancer therapy.The present paper reviews the research status of MNP-Fe3O4,mainly focusing on the purpose and methods of Fe3O4 surface modification and the application of different MNP-Fe3O4 drug delivery systems in cancer therapy.The great potential application of mesoporous MNP-Fe3O4 is also reviewed and discussed.Finally,the potential problems and trends of MNP-Fe3O4 as drug carrier in cancer therapy are proposed.
引文
1彭健,刘桦.纳米磁靶向药物载体在肝癌治疗中的研究进展[J].中国现代医学杂志,2008,18(1):80
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5陈汝福,陈积圣.纳米技术在肿瘤诊断与治疗中的应用[J].癌症,2004,23(12):1714
6侯仰龙.磁性纳米材料的化学合成、功能化及其生物医学应用[J].大学化学,2010,25(2):1
7 McCarthy J,Weissleder R.Multifunctional magnetic nano-particles for targeted imaging and therapy[J].Adv DrugDeliv Rev,2008,60(11):1241
8 Kim K Y.Nanotechnology platforms and physiological chal-lenges for cancer therapeutics[J].Nanomedicine,2007,3(2):103
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10 Sandrine Dufort,Lucie Sancey,Jean-Luc Coll.Physico-chemical parameters that govern nanoparticles fate also dic-tate rules for their molecular evolution[J].Adv Drug DelivRev,2012,64(2):179
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14李瑞歌,李鼎,朱春山.β-环糊精/丁二酸酐共聚高分子磁性微球的制备及其体外释药性能研究[J].辽宁化工,2011,40(6):543
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17 Wang Liang,Neoh Koon Gee,Kang En-Tang,et al.Multi-functional polyglycerol-grafted Fe3O4@SiO2nanoparticlesfor targeting ovarian cancer cells[J].Biomaterials,2011,32(8):2166
18王中领,郭亮,李勇刚,等.叶酸靶向超顺磁性氧化铁-多巴胺-叶酸纳米复合物的制备及体外MR成像[J].中国医学影像技术,2011,27(2):251
19 Guo Miao,Que Chailu,et al.Multifunctional super-paramag-netic nanocarriers with folate-mediated and pH-responsivetargeting properties for anticancer drug delivery[J].Bioma-terials,2011,32(1):185
20 Ying Xiaoying,Du Yongzhong,Hong Linghong,et al.Magnetic lipid nanoparticles loading doxorubicin for intra-cellular delivery:Preparation and characteristics[J].JMagn Magn Mater,2011,323(8):1088
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24Ling You,Wei Kun,Luo Yun,et al.Dual docetaxel/super-paramagnetic iron oxide loaded nanoparticles for both targe-ting magnetic resonance imaging and cancer therapy[J].Biomaterials,2011,32(29):7139
25闫润民,梁超,赵明,等.磁性紫杉醇-四氧化三铁-载药脂质体复合体微粒磁靶向脑内分布的实验研究[J].生物医学工程与临床,2011,15(2):103
26Cheng L,Zhou X J.Anti-tumor mechanisms of plant alka-loids[J].Chin Trad Herb Drugs,2004,35(2):216
27Zhu Aiping,Yuan Lanhua,Jin Wenjie,et al.Polysaccha-ride surface modified Fe3O4nanoparticles for camptothecinloading and release[J].Acta Biomater,2009,5(5):1489
28 Taguchi A,Schüth F.Ordered mesoporous materials in ca-talysis[J].Microp Mesop Mater,2005,77(1):1
29Slowing Igor I,Vivero-Escoto Juan L,Wu Chia-Wen,et al.Mesoporous silica nanoparticles as con-trolled release drugdelivery and gene transfection carriers[J].Adv Drug DelivRev,2008,60(11):1278
30Chen Lingyun,Lin Zhen,Zhao Chenglan,et al.Direct syn-thesis and characterization of mesoporous Fe3O4through py-rolysis of ferric nitrate-ethylene glycol gel[J].J AlloysCompd,2011,509(1):L1
31 Mitra Atanu,Vázquez-Vázquez Carlos,Arturo López-Quin-tela M,et al.Soft-templating approach for the synthesis ofhigh surface area and superparamagnetic mesoporous ironoxide materials[J].Microp Mesop Mater,2010,131(1-3):373
32Zhou Weijia,He Wen,Zhong Shide,et al.Biosynthesis andmagnetic properties of mesoporous Fe3O4compo-sites[J].JMagn Magn Mater,2009,321(8):1025
33Xia Yunsheng,Dai Hongxing,Jiang Haiyan,et al.Three-di-mensionally ordered and wormhole-like mesoporous ironoxide catalysts highly active for the oxidation of acetone andmethanol[J].J Hazard Mater,2011,186(1):84
34 Guo Shaojun,Li Dan,Zhang Lixue,et al.Monodisperse me-soporous superparamagnetic single-crystal magnetite nano-particles for drug delivery[J].Biomaterials,2009,30(10):1881
35Luo B,Xu S A,Ma W F,et al.Fabrication of magnetitehollow porous nanocrystal shells as a drug carrier for pacli-taxel[J].J Mater Chem,2010,20(34):7107
36伊希斌,沈晓冬,崔升,等.多孔朵状Fe3O4纳米微球的制备及其性能研究[J].无机化学学报,2010,26(11):2097
37 Huang Chi,Tang Zhaomin,Zhou Yangbo,et al.Magneticmicelles as a potential platform for dual targeted drug deli-very in cancer therapy[J].Int J Pharm,2012,429(1-2):113
38 Kulsheshtra P,Gogoi M,Bahadur D,et al.In vitro applica-tion of paclitaxel loaded magnetoliposomes for combinedchemotherapy and hyperthermia[J].Colloids Surf B:Bioin-terf,2012,96(1):1
2 Gao J H,Xu B.Applications of nanomaterials inside cells[J].Nano Today,2009,4(11):37
3 Polyak B,Friedman G.Magnetic targeting for site-specificdrug delivery:Applications and clinical potential[J].ExpertOpin Drug Deliv,2009,6(1):53
4 Veiseh O,Gunn J W,Zhang M Q.Design and fabrication ofmagnetic nanoparticles for targeted drug delivery and ima-ging[J].Adv Drug Deliv Rev,2010,62(3):284
5陈汝福,陈积圣.纳米技术在肿瘤诊断与治疗中的应用[J].癌症,2004,23(12):1714
6侯仰龙.磁性纳米材料的化学合成、功能化及其生物医学应用[J].大学化学,2010,25(2):1
7 McCarthy J,Weissleder R.Multifunctional magnetic nano-particles for targeted imaging and therapy[J].Adv DrugDeliv Rev,2008,60(11):1241
8 Kim K Y.Nanotechnology platforms and physiological chal-lenges for cancer therapeutics[J].Nanomedicine,2007,3(2):103
9 Zhou Huirui,Tao Ke,Ding Jing,et al.A general approachfor providing nanoparticles water-dispersibility by grindingwith poly(ethylene glycol)[J].Colloids Surf A:Physico-chem Eng Aspects,2011,389(1-3):18
10 Sandrine Dufort,Lucie Sancey,Jean-Luc Coll.Physico-chemical parameters that govern nanoparticles fate also dic-tate rules for their molecular evolution[J].Adv Drug DelivRev,2012,64(2):179
11 Cole Adam J,David Allan E,Wang Jianxin,et al.Magneticbrain tumor targeting and biodistribution of long-circulatingPEG-modified,cross-linked starch-coated iron oxide nano-particles[J].Biomaterials,2011,32(26):6291
12Cheng Gang,Xue Hong,Zhang Zheng,et al.A switchablebiocompatible polymer surface with self-sterilizing and non-fouling capabilities[J].Angew Chem Int Ed,2008,47(46):8831
13 Xu Rui,Sun Guoying,Li Qiuyu,et al.A dual-responsive su-perparamagnetic Fe3O4/silica/PAH/PSS material used forcontrolled release of chemotherapeutic agent,keggin pol-yoxotungstate,PM-19[J].Solid State Sci,2010,12(10):1720
14李瑞歌,李鼎,朱春山.β-环糊精/丁二酸酐共聚高分子磁性微球的制备及其体外释药性能研究[J].辽宁化工,2011,40(6):543
15谭亮,张阳德.温度敏感性脂质体磁性阿霉素纳米粒的制备[J].中国现代医学杂志,2010,20(5):656
16阚思行,王晓文,唐劲天,等.纳米药物控释系统研究进展[J].解放军药学学报,2009,25(2):169
17 Wang Liang,Neoh Koon Gee,Kang En-Tang,et al.Multi-functional polyglycerol-grafted Fe3O4@SiO2nanoparticlesfor targeting ovarian cancer cells[J].Biomaterials,2011,32(8):2166
18王中领,郭亮,李勇刚,等.叶酸靶向超顺磁性氧化铁-多巴胺-叶酸纳米复合物的制备及体外MR成像[J].中国医学影像技术,2011,27(2):251
19 Guo Miao,Que Chailu,et al.Multifunctional super-paramag-netic nanocarriers with folate-mediated and pH-responsivetargeting properties for anticancer drug delivery[J].Bioma-terials,2011,32(1):185
20 Ying Xiaoying,Du Yongzhong,Hong Linghong,et al.Magnetic lipid nanoparticles loading doxorubicin for intra-cellular delivery:Preparation and characteristics[J].JMagn Magn Mater,2011,323(8):1088
21朱荣,罗奎,徐翔晖,等.以磁纳米粒为核的pH敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011(6):679
22杨萍,王晶,景红梅,等.柔红霉素联合磁性纳米铁对Raji细胞株的作用研究[J].中国实验血液学杂志,2011,19(2):385
23Zhang Gen,Lai Binbin,Zhou Yanyan,et al.Fe3O4nanopar-ticles with daunorubicin induce apoptosis through caspase 8-PARP pathway and inhibit K562 leukemia cell-inducedtumor growth in vivo[J].Nanomedicine,2011,7(5):595
24Ling You,Wei Kun,Luo Yun,et al.Dual docetaxel/super-paramagnetic iron oxide loaded nanoparticles for both targe-ting magnetic resonance imaging and cancer therapy[J].Biomaterials,2011,32(29):7139
25闫润民,梁超,赵明,等.磁性紫杉醇-四氧化三铁-载药脂质体复合体微粒磁靶向脑内分布的实验研究[J].生物医学工程与临床,2011,15(2):103
26Cheng L,Zhou X J.Anti-tumor mechanisms of plant alka-loids[J].Chin Trad Herb Drugs,2004,35(2):216
27Zhu Aiping,Yuan Lanhua,Jin Wenjie,et al.Polysaccha-ride surface modified Fe3O4nanoparticles for camptothecinloading and release[J].Acta Biomater,2009,5(5):1489
28 Taguchi A,Schüth F.Ordered mesoporous materials in ca-talysis[J].Microp Mesop Mater,2005,77(1):1
29Slowing Igor I,Vivero-Escoto Juan L,Wu Chia-Wen,et al.Mesoporous silica nanoparticles as con-trolled release drugdelivery and gene transfection carriers[J].Adv Drug DelivRev,2008,60(11):1278
30Chen Lingyun,Lin Zhen,Zhao Chenglan,et al.Direct syn-thesis and characterization of mesoporous Fe3O4through py-rolysis of ferric nitrate-ethylene glycol gel[J].J AlloysCompd,2011,509(1):L1
31 Mitra Atanu,Vázquez-Vázquez Carlos,Arturo López-Quin-tela M,et al.Soft-templating approach for the synthesis ofhigh surface area and superparamagnetic mesoporous ironoxide materials[J].Microp Mesop Mater,2010,131(1-3):373
32Zhou Weijia,He Wen,Zhong Shide,et al.Biosynthesis andmagnetic properties of mesoporous Fe3O4compo-sites[J].JMagn Magn Mater,2009,321(8):1025
33Xia Yunsheng,Dai Hongxing,Jiang Haiyan,et al.Three-di-mensionally ordered and wormhole-like mesoporous ironoxide catalysts highly active for the oxidation of acetone andmethanol[J].J Hazard Mater,2011,186(1):84
34 Guo Shaojun,Li Dan,Zhang Lixue,et al.Monodisperse me-soporous superparamagnetic single-crystal magnetite nano-particles for drug delivery[J].Biomaterials,2009,30(10):1881
35Luo B,Xu S A,Ma W F,et al.Fabrication of magnetitehollow porous nanocrystal shells as a drug carrier for pacli-taxel[J].J Mater Chem,2010,20(34):7107
36伊希斌,沈晓冬,崔升,等.多孔朵状Fe3O4纳米微球的制备及其性能研究[J].无机化学学报,2010,26(11):2097
37 Huang Chi,Tang Zhaomin,Zhou Yangbo,et al.Magneticmicelles as a potential platform for dual targeted drug deli-very in cancer therapy[J].Int J Pharm,2012,429(1-2):113
38 Kulsheshtra P,Gogoi M,Bahadur D,et al.In vitro applica-tion of paclitaxel loaded magnetoliposomes for combinedchemotherapy and hyperthermia[J].Colloids Surf B:Bioin-terf,2012,96(1):1