磁性Fe_3O_4纳米颗粒的制备及其在肿瘤治疗中的应用
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摘要
综述了磁性Fe3O4纳米颗粒的制备方法.目前常用的方法有共沉淀法、水热法及溶剂热法、热分解法、微乳液法、溶胶-凝胶法等,讨论了这些方法的优缺点.介绍了磁性Fe3O4纳米粒子在靶向给药、靶向热疗及栓塞治疗中的应用,最后对磁性Fe3O4纳米粒子的研究前景进行了展望.
This paper reviews the methods of preparation of magnetic Fe3O4 nanoparticles,in which the most commonly used ones are co-precipitation,hydrothermal method and solvothermal method,thermal decomposition method,microemulsion method,sol-gel method,and etc.Besides,the advantages and disadvantages of these methods are discussed as well.In addition,the paper introduces the application of magnetic Fe3O4 nanoparticles in the treatment of targeted drug delivery,targeting hyperthermia and embolization.Finally,the future development in the research of magnetic Fe3O4 nanoparticles is also prospected.
This paper reviews the methods of preparation of magnetic Fe3O4 nanoparticles,in which the most commonly used ones are co-precipitation,hydrothermal method and solvothermal method,thermal decomposition method,microemulsion method,sol-gel method,and etc.Besides,the advantages and disadvantages of these methods are discussed as well.In addition,the paper introduces the application of magnetic Fe3O4 nanoparticles in the treatment of targeted drug delivery,targeting hyperthermia and embolization.Finally,the future development in the research of magnetic Fe3O4 nanoparticles is also prospected.
引文
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[16]Ai Z,Deng K,Wan Q,et al.Facile Microwave-Assisted Synthesis and Magnetic and Gas Sensing Properties of Fe3O4 Nanoroses[J].J Phys Chem C,2010,114(14):6237-6242.
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[18]张鸥,张登宇,徐学东.油酸钠基纳米Fe3O4磁流体制备、表征及应用[J].材料导报,2011(2):185-187.
[19]郭利锋,黄华,罗聪,等.超顺磁性四氧化三铁壳聚糖纳米粒的制备和结构表征[J].重庆医科大学学报,2010(11):1690-1692
[20]Szekeres M,Tóth I Y,Illés E,et al.Chemical and Colloidal Stability of Carboxylated Core-Shell Magnetite Nanoparticles Designed for Biomedical Applications[J].International Journal of Molecular Sciences,2013,14(7):14550-14574.
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[22]Ahmadi R,Masoudi A,Hosseini H R M,et al.Kinetics of magnetite nanoparticles formation in a one step low temperature hydrothermal process[J].Ceramics International,2013,39(5):4999-5005.
[23]Xuan S,Hao L,Jiang W,et al.Preparation of water-soluble magnetite nanocrystals through hydrothermal approach[J].Journal of Magnetism&Magnetic Materials,2007,308(2):210-213.
[24]胡正水,江晨菊.采用水热法制备磁性Fe3O4纳米棒[J].青岛科技大学学报(自然科学版),2012,33(2):149-154.
[25]Xu G,Zhang M,Ou P,et al.Synthesis of Monodispersed Fe3O4 Magnetite Nanoparticles by Ethylene Glycol Solvothermal Method[J].Advances in Chemical Material&Metallurgical Engineering,2013(634/638):2276-2279.
[26]Yan A.Solvothermal synthesis and characterization of size-controlled Fe3O4 nanoparticles[J].Journal of Alloys and Compounds,2010(1/2):487-491.
[27]Gao Jining,Ran Xinze,Shi Chunmeng,et al.One-step solvothermal synthesis of highly water-soluble,negatively charged superparamagnetic Fe3O4 colloidal nanocrystal clusters.[J].Nanoscale,2013,5(15):7026-7033.
[28]涂志江,张宝林,冯凌云,等.聚乙二醇/聚乙烯吡咯烷酮修饰的纳米Fe3O4粒子的制备与表征[J].化工学,2012,63(12):4089-4095.
[29]Belaid S,Laurent S,Vermeersch M,et al.A new approach to follow the formation of iron oxide nanoparticles synthesized by thermal decomposition.[J].Nanotechnology,2013,24(5):1-11.
[30]李文章,李洁,丘克强,等.超顺磁性Fe3O4纳米颗粒的制备及修饰[J].功能材料,2007,38(8):1279-1281.
[31]周孙英,林晨,芮兴.反相微乳液法制备纳米四氧化三铁颗粒[J].福建医科大学学报,2009,43(2):148-152.
[32]Zhang D,Tong Z,Li S,et al.Fabrication and characterization of hollow Fe3O4nanospheres in a microemulsion[J].Materials Letters,2008,62(24):4053-4055.
[33]周长华,李晓民,司红磊,等.相转移方法制备水溶性Fe3O4纳米晶[J].化学学报,2011,69(12):1381-1386.
[34]Lopez R G,Pineda M G,Hurtado G,et al.Chitosan-coated magnetic nanoparticles prepared in one step by reverse microemulsion precipitation.[J].International Journal of Molecular Sciences,2013,14(10):19636-19650.
[35]Xu J,Yang H,Fu W,et al.Preparation and magnetic properties of magnetite nanoparticles by sol-gel method[J].Journal of Magnetism&Magnetic Materials,2007,309(2):307-311.
[36]Worawong A,Jutarosaga T,Onreabroy W.Influence of Calcination Temperature on Synthesis of Magnetite(Fe3O4)Nanoparticles bySol-gel Method[J].Advanced Materials Research,2014,979:208-211.
[37]贾燕燕,潘燕飞,任万忠,等.环氧化物溶胶凝胶路线制备近单分散尺寸可控Fe3O4纳米粒子[J].烟台大学学报(自然科学与工程版),2011,24(1):43-47.
[38]Lemine O M,Omri K,Zhang B,et al.Sol-gel synthesis of 8nm magnetite(Fe3O4)nanoparticles and their magnetic properties[J].Superlattices&Microstructures,2012,52(4):793-799.
[39]Qi H,Yan B,Lu W,et al.A Non-Alkoxide Sol-Gel Method for the Preparation of Magnetite Nanoparticles[J].Current Nanoscience,2011,7(3):381-388.
[40]Lei P,Boies A M,Calder S,et al.Thermal Plasma Synthesis of Superparamagnetic Iron Oxide Nanoparticles[J].Plasma Chemistry and Plasma Processing,2012,32(3):519-531.
[41]Wang L,Ding C X,Zhang L C,et al.A novel carbon-silicon composite nanofiber prepared via electrospinning as anode material for high energy-density lithium ion batteries[J].Journal of Power Sources,2010,195(15):5052-5056.
[42]Wang B,Sun Y,Wang H.Preparation and properties of electrospun PAN/Fe3O4magnetic nanofibers[J].Journal of Applied Polymer Science,2010,115(3):1781-1786.
[43]Dang F,Enomoto N,Hojo J,et al.Sonochemical synthesis of monodispersed magnetite nanoparticles by using an ethanol-water mixed solvent.[J].Ultrasonics Sonochemistry,2009,16(5):649-654.
[44]Okoli C,Sanchez-Dominguez M,Boutonnet M,et al.Comparison and functionalization study of microemulsion-prepared magnetic iron oxide nanoparticles[J].Langmuir,2012,28(22):8479-8485.
[45]Bilalis P,Chatzipavlidis A,Tziveleka L,et al.Nanodesigned magnetic polymer containers for dual stimuli actuated drug controlled release and magnetic hyperthermia mediation[J].J Mater Chem,2012,22(27):13451-13454.
[46]Luo B,Xu S,Ma W,et al.Fabrication of magnetite hollow porous nanocrystal shells as a drug carrier for paclitaxel[J].J Mater Chem,2010,20(34):7107-7113.
[47]朱荣,罗奎,徐翔晖,等.以磁纳米粒为核的pH敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011,25(6):679-686.
[48]Yang F,Fu D,Long J,et al.Magnetic lymphatic targeting drug delivery system using carbon nanotubes[J].Medical Hypotheses,2008,70(4):765-767.
[49]Bae K H,Park M,Min J D,et al.Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia.[J].Acs Nano,2012,6(6):5266-5273.
[50]Jiang B.Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo[J].Quantitative Imaging in Medicine&Surgery,2012,(1).
[51]Sato M,Yamashita T,Ohkura M,et al.N-propionyl-cysteaminylphenol-magnetite conjugate(NPrCAP/M)is a nanoparticle for the targetedgrowth suppression of melanomacells.[J].Journal of Investigative Dermatology,2009,129(9):2233-2241.
[52]游劲松,杨丽,肖萍,等.热疗用四氧化三铁磁性纳米粒子的制备及其性质表征[J].中国药剂学杂志,2008(6):309-316.
[53]赵印敏,粟波,杨晓君,等.靶向血管新生肽修饰的氧化铁纳米粒对荷瘤裸鼠磁热疗的研究[J].肿瘤,2010,30(5):370-375.
[54]信涛,赵妍,张磊,等.磁流体对肝癌细胞的凋亡诱导研究及联合紫杉醇对大鼠肝癌的抑制作用[J].中国肿瘤临床,2011,38(22):1363-1366.
[55]王晓朋,傅相平,李安民,等.顺磁性纳米微粒的磁靶向微血管栓塞研究[J].中国微侵袭神经外科杂志,2014(6):274-276.
[2]Laurent S,Saei A A,Behzadi S,et al.Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents:opportunities and challenges.[J].Expert Opin Drug Deliv,2014,11(9):1449-1470.
[3]Gao L.Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion[J].Biomaterials,2013,34(14):3688-3696.
[4]Wang Y X.Superparamagnetic iron oxide based MRI contrast agents:Current status of clinical application.[J].Quantitative Imaging in Medicine&Surgery,2011,1(1):35-40.
[5]Zhu Y,Stubbs L P,Ho F,et al.Magnetic Nanocomposites:A New Perspective in Catalysis[J].Chemcatchem,2010,2(4):365-374.
[6]González-Alfaro Y,Aranda P,Fernandes F M,et al.Multifunctional porous materials through ferrofluids.[J].Advanced Materials,2011,23(44):5224-5228.
[7]Meyers J D,Doane T,Burda C,et al.Nanoparticles for imaging and treating brain cancer.[J].Nanomedicine,2013,8(1):123-143.
[8]Xu H,Aguilar Z P,Yang L,et al.Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood.[J].Biomaterials,2011,32(36):9758-9765.
[9]Mahmoudi M.Superparamagnetic Iron Oxide Nanoparticles(Spions):Development,Surface Modification And Applications In Chemotherapy[J].Advanced Drug Delivery Reviews,2011,63(1-2):24-46.
[10]Mou X,Ali Z,Li S,et al.Applications of Magnetic Nanoparticles in Targeted Drug Delivery System[J].Journal of Nanoscience&Nanotechnology,2015,15:54-62(9).
[11]Glover A L,Bennett J B,Pritchett J S,et al.Magnetic Heating of Iron Oxide Nanoparticles and Magnetic Micelles for Cancer Therapy[J].IEEE Transactions on Magnetics,2013,49(1):231-235.
[12]Riaz S,Bashir M,Naseem S.Iron Oxide Nanoparticles Prepared by Modified Co-Precipitation Method[J].IEEE Transactions on Magnetics,2014,50(1):277-285.
[13]Welo L A,Baudisch B.The two-staye tranformation of magnetic into hematite[J].Philos,1925,50:399-408.
[14]Linh P,Manh D,Phong P,et al.Magnetic Properties of Fe3O4 Nanoparticles Synthesized by Coprecipitation Method[J].Journal of Superconductivity&Novel Magnetism,2014,27(9):2111-2113.
[15]Yang X,Jiang W,Liu L,et al.One-step hydrothermal synthesis of highly water-soluble secondary structural Fe3O4nanoparticles[J].Journal of Magnetism and Magnetic Materials,2012,324(14):2249-2257.
[16]Ai Z,Deng K,Wan Q,et al.Facile Microwave-Assisted Synthesis and Magnetic and Gas Sensing Properties of Fe3O4 Nanoroses[J].J Phys Chem C,2010,114(14):6237-6242.
[17]Wang N,Zhu L,Wang D,et al.Sono-assisted preparation of highly-efficient peroxidase-like Fe3O4 magnetic nanoparticles for catalytic removal of organic pollutants with H2O2[J].Ultrasonics Sonochemistry,2010,17(3):526-533.
[18]张鸥,张登宇,徐学东.油酸钠基纳米Fe3O4磁流体制备、表征及应用[J].材料导报,2011(2):185-187.
[19]郭利锋,黄华,罗聪,等.超顺磁性四氧化三铁壳聚糖纳米粒的制备和结构表征[J].重庆医科大学学报,2010(11):1690-1692
[20]Szekeres M,Tóth I Y,Illés E,et al.Chemical and Colloidal Stability of Carboxylated Core-Shell Magnetite Nanoparticles Designed for Biomedical Applications[J].International Journal of Molecular Sciences,2013,14(7):14550-14574.
[21]Khodayari F S A.Structural,Compositional,and Biological Characterization of Fe3O4 Nanoparticles Synthesized by Hydrothermal Method[J].Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry,2014,45(3):356-362.
[22]Ahmadi R,Masoudi A,Hosseini H R M,et al.Kinetics of magnetite nanoparticles formation in a one step low temperature hydrothermal process[J].Ceramics International,2013,39(5):4999-5005.
[23]Xuan S,Hao L,Jiang W,et al.Preparation of water-soluble magnetite nanocrystals through hydrothermal approach[J].Journal of Magnetism&Magnetic Materials,2007,308(2):210-213.
[24]胡正水,江晨菊.采用水热法制备磁性Fe3O4纳米棒[J].青岛科技大学学报(自然科学版),2012,33(2):149-154.
[25]Xu G,Zhang M,Ou P,et al.Synthesis of Monodispersed Fe3O4 Magnetite Nanoparticles by Ethylene Glycol Solvothermal Method[J].Advances in Chemical Material&Metallurgical Engineering,2013(634/638):2276-2279.
[26]Yan A.Solvothermal synthesis and characterization of size-controlled Fe3O4 nanoparticles[J].Journal of Alloys and Compounds,2010(1/2):487-491.
[27]Gao Jining,Ran Xinze,Shi Chunmeng,et al.One-step solvothermal synthesis of highly water-soluble,negatively charged superparamagnetic Fe3O4 colloidal nanocrystal clusters.[J].Nanoscale,2013,5(15):7026-7033.
[28]涂志江,张宝林,冯凌云,等.聚乙二醇/聚乙烯吡咯烷酮修饰的纳米Fe3O4粒子的制备与表征[J].化工学,2012,63(12):4089-4095.
[29]Belaid S,Laurent S,Vermeersch M,et al.A new approach to follow the formation of iron oxide nanoparticles synthesized by thermal decomposition.[J].Nanotechnology,2013,24(5):1-11.
[30]李文章,李洁,丘克强,等.超顺磁性Fe3O4纳米颗粒的制备及修饰[J].功能材料,2007,38(8):1279-1281.
[31]周孙英,林晨,芮兴.反相微乳液法制备纳米四氧化三铁颗粒[J].福建医科大学学报,2009,43(2):148-152.
[32]Zhang D,Tong Z,Li S,et al.Fabrication and characterization of hollow Fe3O4nanospheres in a microemulsion[J].Materials Letters,2008,62(24):4053-4055.
[33]周长华,李晓民,司红磊,等.相转移方法制备水溶性Fe3O4纳米晶[J].化学学报,2011,69(12):1381-1386.
[34]Lopez R G,Pineda M G,Hurtado G,et al.Chitosan-coated magnetic nanoparticles prepared in one step by reverse microemulsion precipitation.[J].International Journal of Molecular Sciences,2013,14(10):19636-19650.
[35]Xu J,Yang H,Fu W,et al.Preparation and magnetic properties of magnetite nanoparticles by sol-gel method[J].Journal of Magnetism&Magnetic Materials,2007,309(2):307-311.
[36]Worawong A,Jutarosaga T,Onreabroy W.Influence of Calcination Temperature on Synthesis of Magnetite(Fe3O4)Nanoparticles bySol-gel Method[J].Advanced Materials Research,2014,979:208-211.
[37]贾燕燕,潘燕飞,任万忠,等.环氧化物溶胶凝胶路线制备近单分散尺寸可控Fe3O4纳米粒子[J].烟台大学学报(自然科学与工程版),2011,24(1):43-47.
[38]Lemine O M,Omri K,Zhang B,et al.Sol-gel synthesis of 8nm magnetite(Fe3O4)nanoparticles and their magnetic properties[J].Superlattices&Microstructures,2012,52(4):793-799.
[39]Qi H,Yan B,Lu W,et al.A Non-Alkoxide Sol-Gel Method for the Preparation of Magnetite Nanoparticles[J].Current Nanoscience,2011,7(3):381-388.
[40]Lei P,Boies A M,Calder S,et al.Thermal Plasma Synthesis of Superparamagnetic Iron Oxide Nanoparticles[J].Plasma Chemistry and Plasma Processing,2012,32(3):519-531.
[41]Wang L,Ding C X,Zhang L C,et al.A novel carbon-silicon composite nanofiber prepared via electrospinning as anode material for high energy-density lithium ion batteries[J].Journal of Power Sources,2010,195(15):5052-5056.
[42]Wang B,Sun Y,Wang H.Preparation and properties of electrospun PAN/Fe3O4magnetic nanofibers[J].Journal of Applied Polymer Science,2010,115(3):1781-1786.
[43]Dang F,Enomoto N,Hojo J,et al.Sonochemical synthesis of monodispersed magnetite nanoparticles by using an ethanol-water mixed solvent.[J].Ultrasonics Sonochemistry,2009,16(5):649-654.
[44]Okoli C,Sanchez-Dominguez M,Boutonnet M,et al.Comparison and functionalization study of microemulsion-prepared magnetic iron oxide nanoparticles[J].Langmuir,2012,28(22):8479-8485.
[45]Bilalis P,Chatzipavlidis A,Tziveleka L,et al.Nanodesigned magnetic polymer containers for dual stimuli actuated drug controlled release and magnetic hyperthermia mediation[J].J Mater Chem,2012,22(27):13451-13454.
[46]Luo B,Xu S,Ma W,et al.Fabrication of magnetite hollow porous nanocrystal shells as a drug carrier for paclitaxel[J].J Mater Chem,2010,20(34):7107-7113.
[47]朱荣,罗奎,徐翔晖,等.以磁纳米粒为核的pH敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011,25(6):679-686.
[48]Yang F,Fu D,Long J,et al.Magnetic lymphatic targeting drug delivery system using carbon nanotubes[J].Medical Hypotheses,2008,70(4):765-767.
[49]Bae K H,Park M,Min J D,et al.Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia.[J].Acs Nano,2012,6(6):5266-5273.
[50]Jiang B.Gold nanorods for target selective SPECT/CT imaging and photothermal therapy in vivo[J].Quantitative Imaging in Medicine&Surgery,2012,(1).
[51]Sato M,Yamashita T,Ohkura M,et al.N-propionyl-cysteaminylphenol-magnetite conjugate(NPrCAP/M)is a nanoparticle for the targetedgrowth suppression of melanomacells.[J].Journal of Investigative Dermatology,2009,129(9):2233-2241.
[52]游劲松,杨丽,肖萍,等.热疗用四氧化三铁磁性纳米粒子的制备及其性质表征[J].中国药剂学杂志,2008(6):309-316.
[53]赵印敏,粟波,杨晓君,等.靶向血管新生肽修饰的氧化铁纳米粒对荷瘤裸鼠磁热疗的研究[J].肿瘤,2010,30(5):370-375.
[54]信涛,赵妍,张磊,等.磁流体对肝癌细胞的凋亡诱导研究及联合紫杉醇对大鼠肝癌的抑制作用[J].中国肿瘤临床,2011,38(22):1363-1366.
[55]王晓朋,傅相平,李安民,等.顺磁性纳米微粒的磁靶向微血管栓塞研究[J].中国微侵袭神经外科杂志,2014(6):274-276.