pH敏感型药物载体材料的研究进展
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摘要
近年来,新型智能纳米载体在疾病治疗方面越来越受到人们的关注。pH敏感药物载体材料在智能纳米载体中具有重要的地位。本文简单介绍了pH敏感药物载体材料的作用机理,并从pH敏感型水凝胶、pH敏感型胶束、pH敏感型脂质体、含pH敏感的多重敏感材料四方面入手,综述了pH敏感型材料在药物传递系统中的应用。
In recent years, novel smart nanomaterials have attracted much attention in disease treatment. The mechanism and the recent progress of the application of p H-sensitive materials in drug delivery system was re-viewed from four aspects as the p H-sensitive hydrogels, the p H-sensitive micelles, the p H-sensitive liposomes and the multiple-sensitive materials.
In recent years, novel smart nanomaterials have attracted much attention in disease treatment. The mechanism and the recent progress of the application of p H-sensitive materials in drug delivery system was re-viewed from four aspects as the p H-sensitive hydrogels, the p H-sensitive micelles, the p H-sensitive liposomes and the multiple-sensitive materials.
引文
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[18]Asmarandei I,Fundueanu G,Cristea M,et al.Thermo and p H-sensitive interpenetrating poly N-isopropylacrylamide carboxymethyl pullulan network for drug deliver y[J].J Poly.Res.,2013,20(10):293-306.
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[20]朱荣,罗奎,徐翔晖,等.以磁纳米粒为核的p H敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011,6(6):679-686.
[21]Yuan Q,Venkatasubramanian R,Hein S,et al.A Stimulus-Responsive Magnetic Nanoparticle Drug Carrier:Magnetite Encapsu-lated by Chitosan-Grafted-Copolymer[J].Acta Biomaterialia,2008,4(4):1024-1037.
[2]Yang K N,Zhang C Q,Wang W,et al.PH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment[J].Cancer Biol Med,2014,11(1):34-43.
[3]Iimain F,Tanaka T,Kokufuta E.Volume transition in gel driven by hydrogen bonding[J].Nature,1991,349:400-402.
[4]Nazar M.Ayub R G,Naseem S,et al.Preparation and characterization of hybrid p H-sensitive hydrogels of chitosan-co-acrylic acid for controlled release of verapamil[J].J.Mater.Sci.Mater Med,2010,21:2805-2816.
[5]Wang Huafen,Jia Huizhen,Cheng Sixue.PEG-stabilized micellars system with positively charged polyester core for fast p H-responsive drug release[J].Pharm.Res.,2012,29:1582-1594.
[6]Liu Miaomiao,Wang Lilin,Su Haijia,et al.PH-sensitive IPN hydrogel based on poly(aspartic acid)and poly(vinyl alcohol)for controlled release[J].Polym Bull.2013,70(6):2815-2827.
[7]Oh S T,Kwon O J,Chun B C,et al.The effect of bentonite concentration on the drug delivery efficacy of a p H-sensitive alginate/bentonite hydrogel[J].Fiber Polym,2009,10(1):21-26.
[8]武昊昀,刘志东,李琳,等.p H敏感型黄芩苷眼用原位凝胶剂的体外研究[J].中国新药杂志,2011,20(6):508-513.
[9]李秋,李淼,金义光,等.载紫杉醇p H敏感嵌段共聚物胶束的制备和体外药效[J].国际药学研究杂志.2013,40(4):233-237.
[10]Bagheri M,Pourmoazzen Z,Entezami A A.PH-responsive nanosized micelles based on poly(monomethylitaconate)-co-poly(dim ethylaminoethyl methacrylate)and cholesterol side chains effect on p H change-induced release of piroxicam[J].J Polym Res,2013,20:231.
[11]Luo yanglin,Yu wei,Xu feng.PH-responsive PMAA-b-PEG-bPMAA triblock copolymer micelles for prednisone drug release and release kinetics[J].Polym Bull,2012,69:597-620.
[12]Jin Zhehu,Jin Mingji,Jiang Changgao,et al.Evaluation of doxorubicin-loaded p H-sensitive polymeric micelle release from tumor blood vessels and anticancer efficacy using a dorsal skin-fold window chamber model[J].Acta Pharmacol Sin,2014,35(6):839-845.
[13]Ng L T,Yuba E,Kono K.Modification of liposome surface with p H-responsive polyampholytes for the controlled-release of drugs[J].Res.Chem.Intermed,2009,35:1015-1025.
[14]戎佩佩,宋金春.p H敏感前体阳离子脂质体的制备及瘤内分布研究[J].中国药学杂志.2012,47(3):444-447.
[15]Chen Y,Sun J,Lu Y,et al.Complexes containing cationic and anionic p H-sensitive liposomes:comparative study of factors influencing plasmid DNA gene delivery to tumors[J].Int J Nanomed.2013,8:1573-1593.
[16]Ito A,Shinkai M,Honda H,et al.Medical application of func-tionalized magnetic nanoparticles[J].J Biosci Bioeng,2005,100(1):1-11.
[17]Li Shengfang,Wang Hanlin,Huang Weidong,et al.Facile preparation of p H-sensitive poly(acrylicacid-co-acrylamide)Si O2hybrid hydrogels with high strength by in situ frontal polymerization[J].Colloid.Polym.Sci.,2013,10(8):3050-3056.
[18]Asmarandei I,Fundueanu G,Cristea M,et al.Thermo and p H-sensitive interpenetrating poly N-isopropylacrylamide carboxymethyl pullulan network for drug deliver y[J].J Poly.Res.,2013,20(10):293-306.
[19]Yu Y Y,Tian F,Wei C.Facile synthesis of triple stimuli(photo/PH/thermo)responsive copolymers of 2-Diazo/1-2-naphthoquinon emediated poly(N-isopropylaerylamide-co-N-hydroxymethylacrylamide)[J].J.Polym.Sci.,2009,47(11):2763-2773.
[20]朱荣,罗奎,徐翔晖,等.以磁纳米粒为核的p H敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011,6(6):679-686.
[21]Yuan Q,Venkatasubramanian R,Hein S,et al.A Stimulus-Responsive Magnetic Nanoparticle Drug Carrier:Magnetite Encapsu-lated by Chitosan-Grafted-Copolymer[J].Acta Biomaterialia,2008,4(4):1024-1037.