参麦及丹红注射液治疗急性缺血性脑卒中临床研究
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摘要
目的:观察参麦及丹红注射液治疗急性缺血性脑卒中(AIS)的临床疗效。方法:选取在本院治疗的AIS患者145例,按照随机数字表法分为参麦组43例、丹红组47例及联合组55例。分别使用参麦注射液、丹红注射液及二者联合治疗。对比3组临床疗效,观察3组治疗前后血脂指标及血清炎性因子含量的变化。结果:联合组总有效率高于参麦组及丹红组(P <0.05)。参麦组和丹红组总有效率比较,差异无统计学意义(P> 0.05)。治疗后,3组甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平均较治疗前降低(P <0.05),高密度脂蛋白胆固醇(HDL-C)水平均较治疗前升高(P <0.05);联合组TG、TC及LDL-C水平均低于参麦组和丹红组(P <0.05),HDL-C水平均高于参麦组和丹红组(P <0.05)。治疗后,3组血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6 (IL-6)及白细胞介素-8 (IL-8)水平均较治疗前降低(P <0.05);联合组4项血清炎性因子水平均低于参麦组和丹红组(P <0.05);丹红组CRP、TNF-α及IL-8水平均低于参麦组,IL-6水平高于参麦组(P <0.05)。3组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论:参麦及丹红注射液联用治疗AIS效果优于单独使用,可有效降低患者的血脂指标及血清炎性因子水平,安全性好。
Objective:To observe the clinical effect of Shenmai and Danhong injection for acute ischemic stroke(AIS).Methods:A total of 145 cases of patients with AIS admitted into our hospital were selected,and were divided into the Shenmai group,the Danhong group and the combination group according to the random number table method,43,47 and 55 cases in each group respectively. The three groups were respectively given Shenmai injection,Danhong injection and the combination of Shenmai and Danhong injection for treatment. The clinical effect of the three groups were compared and the changes of the indexes of serum lipid and the content of inflammatory factors in serum in the three groups were observed before and after treatment. Results:The total effective rate in the combination group was higher than that in the Shenmai group and the Danhong group(P < 0.05). There was no significant difference being found in the comparison of the total effective rate between the Shenmai group and the Danhong group(P > 0.05). After treatment,the levels of the triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) in the three groups were decreased compared with those before treatment(P < 0.05),while the level of the low density lipoprotein cholesterol(LDL-C) in the three groups were increased compared with that before treatment(P < 0.05). The levels of TG,TC and LDL-C in the combination groups were lower than those in the Shenmai group and the Danhong group(P < 0.05),while the level of HDL-C was higher than that in the Shenmai group and the Danhong group(P < 0.05). After treatment,the levels of CRP,TNF-α,IL-6 and IL-8 in serum in the three groups were decreased compared with those before treatment(P < 0.05). The levels of four inflammatory factors in serum in the combination group were lower than those in the Shenmai group and the Danhong group(P < 0.05). The levels of CRP,TNF-α,and IL-8 in serum in the Danhong group were lower than those in the Shenmai group;and the level of IL-6 in the Danhong group was higher than that in the Shenmai group(P < 0.05). There was no significant differences being found in the comparisons of the incidence of adverse reactions in the three groups(P > 0.05). Conclusion:The therapy of Shenmai injection combined with Danhong injection for AIS has better effect than the single use of each injection,which can effectively decreased the index of serum lipid and the level of inflammatory factors in serum with good safety.
Objective:To observe the clinical effect of Shenmai and Danhong injection for acute ischemic stroke(AIS).Methods:A total of 145 cases of patients with AIS admitted into our hospital were selected,and were divided into the Shenmai group,the Danhong group and the combination group according to the random number table method,43,47 and 55 cases in each group respectively. The three groups were respectively given Shenmai injection,Danhong injection and the combination of Shenmai and Danhong injection for treatment. The clinical effect of the three groups were compared and the changes of the indexes of serum lipid and the content of inflammatory factors in serum in the three groups were observed before and after treatment. Results:The total effective rate in the combination group was higher than that in the Shenmai group and the Danhong group(P < 0.05). There was no significant difference being found in the comparison of the total effective rate between the Shenmai group and the Danhong group(P > 0.05). After treatment,the levels of the triglyceride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) in the three groups were decreased compared with those before treatment(P < 0.05),while the level of the low density lipoprotein cholesterol(LDL-C) in the three groups were increased compared with that before treatment(P < 0.05). The levels of TG,TC and LDL-C in the combination groups were lower than those in the Shenmai group and the Danhong group(P < 0.05),while the level of HDL-C was higher than that in the Shenmai group and the Danhong group(P < 0.05). After treatment,the levels of CRP,TNF-α,IL-6 and IL-8 in serum in the three groups were decreased compared with those before treatment(P < 0.05). The levels of four inflammatory factors in serum in the combination group were lower than those in the Shenmai group and the Danhong group(P < 0.05). The levels of CRP,TNF-α,and IL-8 in serum in the Danhong group were lower than those in the Shenmai group;and the level of IL-6 in the Danhong group was higher than that in the Shenmai group(P < 0.05). There was no significant differences being found in the comparisons of the incidence of adverse reactions in the three groups(P > 0.05). Conclusion:The therapy of Shenmai injection combined with Danhong injection for AIS has better effect than the single use of each injection,which can effectively decreased the index of serum lipid and the level of inflammatory factors in serum with good safety.
引文
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[10]陈庆友,张艳蕉,于广娜,等.脑卒中肥胖患者发病后血脂、血糖、血尿酸、同型半胱氨酸水平及血流动力学变化[J].中国老年学杂志,2016,36(15):3701-3702.
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[12]张巧红,徐艳玲,杨靖华.人参皂苷干预酒精性脂肪肝形成的实验研究及对小鼠抗氧化应激的影响[J].中华中医药学刊,2016,34(12):2970-2973.
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[2]高维,王嘉麟,邢佳,等.浅谈从气血论治缺血性脑卒中[J].辽宁中医杂志,2017,44(8):1170-1172.
[3]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257.
[4]韩培海,管雪梅,李成君,等.缺血性脑卒中中医辨证分型研究进展[J].中西医结合心脑血管病杂志,2017,15(1):51-52.
[5]戈琦,罗佩仪,李悦斐,等.重组人组织纤溶酶原衍生物用于急性脑梗死溶栓治疗的临床观察[J].实用医学杂志,2018,34(19):3280-3282.
[6]韩敏.参麦注射液治疗急性脑梗塞的临床效果及其对血流动力学和炎症因子的影响[J].临床医学研究与实践,2018,3(14):112-113.
[7]汪蕾,李风军,昌月德.丹红注射液对短暂性脑缺血发作患者脑血流动力学及神经功能的影响[J].现代中西医结合杂志,2016,25(18):2025-2027.
[8]张飞飞,孙妍,张丽,等.参麦注射液联合丁苯酞治疗急性脑梗死的临床研究[J].现代药物与临床,2018,33(7):1635-1639.
[9]樊文萍,黄学莲,马凤英,等.丹红注射液治疗急性脑梗死的临床疗效分析[J].现代生物医学进展,2018,18(9):1772-1775.
[10]陈庆友,张艳蕉,于广娜,等.脑卒中肥胖患者发病后血脂、血糖、血尿酸、同型半胱氨酸水平及血流动力学变化[J].中国老年学杂志,2016,36(15):3701-3702.
[11]侯晨辉,刘雯.老年急性缺血性脑卒中患者神经功能缺损程度与炎症因子、Hcy、NT-pro BNP和D-二聚体的相关性[J].中国老年学杂志,2018,38(19):4631-4633.
[12]张巧红,徐艳玲,杨靖华.人参皂苷干预酒精性脂肪肝形成的实验研究及对小鼠抗氧化应激的影响[J].中华中医药学刊,2016,34(12):2970-2973.
[13]赵彩霞,靳会欣.丹参多酚酸盐的药理作用机制及临床应用研究进展[J].河北医药,2017,39(2):294-299.