基于医用红外热成像技术评价穴位埋线对湿浊内停型非酒精性脂肪性肝病临床疗效观察
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摘要
目的:观察穴位埋线治疗湿浊内停型非酒精性脂肪性肝病的临床疗效,并结合医用红外热成像仪进行疗效分析。方法:应用随机数字表法,将104例非酒精性脂肪性肝病患者随机分为治疗组和对照组,每组各52例。治疗组予穴位埋线治疗,取脾俞、胃俞、肝俞、足三里、中脘、天枢、水分、大横、丰隆、阴陵泉、带脉,7 d埋线1次;对照组予口服多烯磷脂酰胆碱胶囊,232 mg/粒,1粒/次,每日3次。治疗3个月后,观察两组患者治疗前后中医证候评分、肝功能、血脂水平、经络皮温、腹部B超的变化情况。结果:①治疗组总有效率为84.0%,显著高于对照组的68.6%,两组患者总有效率的比较,差异有统计学意义(P<0.05);②治疗组中医证候评分、血清谷草转氨酶(AST)、谷丙转氨酶(ALT)、甘油三酯(TG)、总胆固醇(TC)水平、脂肪肝程度的改善等检测结果优于对照组(P<0.05);③两组非酒精性脂肪性肝病患者治疗后经络及主要穴位的均温显著高于治疗前,且治疗组较对照组的均温改善显著(P<0.05)。结论:穴位埋线治疗非酒精性脂肪性肝病的疗效优于口服多烯磷脂酰胆碱胶囊,值得临床推广应用。
Objective:To observe the efficacy of non-alcoholic fatty liver disease of moisture turbidity stopping type at catgut implantation with infrared thermal imaging technology. Methods:104 patients with non-alcoholic fatty liver disease were randomly divided into treatment group and control group by using random number table method,with 52 cases each group. The treatment group was treated with acupoint embedding therapy,it was applied to Pishu(BL20),Weishu(BL21),Ganshu(ST18),Zusanli(ST36),Zhongwan(RN12),Tianshu(ST25),Shuifen(RN9),Daheng(SP15),Fenglong(ST60),Yinlingquan(SP9),Daimai(GB26),once every seven days;The control group was given polyene phosphatidylcholine capsules(Essentiale),232 mg/capsule,one capsule each time,three times a day. After three months,the changes of TCM syndrome score,liver function,blood lipid level,mesothelial skin temperature and abdominal B-ultrasound were observed and compared before and after treatment between the two group.Results:①The total effective rate of the treatment group was 84.0%,which was significantly better than that of the control group(68.6%). The difference between the two groups was statistically significant(P<0.05).②The test results of treatment group was better than that of control group in the TCM syndrome score,serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),triglyceride(TG),total cholesterol(TC),and fatty liver(P<0.05). ③The average temperature of meridians and main acupoints in the two groups of patients were significantly better than that before treatment,and the mean temperature of the treatment group was significantly improved compared with the control group(P<0.05). Conclusion:The efficacy of acupoint embedding therapy for non-alcoholic fatty liver disease is better than polyene phosphatidylcholine capsule,which is worthy of clinical application.
Objective:To observe the efficacy of non-alcoholic fatty liver disease of moisture turbidity stopping type at catgut implantation with infrared thermal imaging technology. Methods:104 patients with non-alcoholic fatty liver disease were randomly divided into treatment group and control group by using random number table method,with 52 cases each group. The treatment group was treated with acupoint embedding therapy,it was applied to Pishu(BL20),Weishu(BL21),Ganshu(ST18),Zusanli(ST36),Zhongwan(RN12),Tianshu(ST25),Shuifen(RN9),Daheng(SP15),Fenglong(ST60),Yinlingquan(SP9),Daimai(GB26),once every seven days;The control group was given polyene phosphatidylcholine capsules(Essentiale),232 mg/capsule,one capsule each time,three times a day. After three months,the changes of TCM syndrome score,liver function,blood lipid level,mesothelial skin temperature and abdominal B-ultrasound were observed and compared before and after treatment between the two group.Results:①The total effective rate of the treatment group was 84.0%,which was significantly better than that of the control group(68.6%). The difference between the two groups was statistically significant(P<0.05).②The test results of treatment group was better than that of control group in the TCM syndrome score,serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),triglyceride(TG),total cholesterol(TC),and fatty liver(P<0.05). ③The average temperature of meridians and main acupoints in the two groups of patients were significantly better than that before treatment,and the mean temperature of the treatment group was significantly improved compared with the control group(P<0.05). Conclusion:The efficacy of acupoint embedding therapy for non-alcoholic fatty liver disease is better than polyene phosphatidylcholine capsule,which is worthy of clinical application.
引文
[1]中华医学会肝病学分会脂肪肝和酒精性肝病学组,中国医师协会脂肪性肝病专家委员会.非酒精性脂肪性肝病防治指南(2018版)[J].实用肝脏病杂志,2018,21(2):177-186.
[2]Lebeaupin C,Vallee D,Hazari Y,et al. Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease[J]. Journal of hepatology,2018,69(4):927-947.
[3]胡中杰,张晶.我国非酒精性脂肪性肝病的研究现状[J].临床肝胆病杂志,2016,32(3):552-556.
[4]Younossi ZM,Koenig AB,Abdelatif D,et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence,incidence,and outcomes[J]. Hepatology(Baltimore,Md),2016,64(1):73-84.
[5]张声生,李军祥.非酒精性脂肪性肝病中医诊疗专家共识意见(2017)[J].中医杂志,2017,58(19):1706-1710.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:367.
[7]董姝,刘平,孙明瑜.非酒精性脂肪肝的治疗研究进展[J].辽宁中医杂志,2013,40(3):599-602.
[8]李婷,张雪姣,孟祥雯,等.非酒精性脂肪肝病的诊治进展[J].中国老年学杂志,2017,37(12):3114-3116.
[9]王聪庆.从痰论治脂肪肝经验介绍[J].内蒙古中医药,2018,37(5):23-24.
[10]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪肝足三阴经穴位皮温的影响[J].实用临床医药杂志,2011,15(19):40-42.
[11]龚秀杭,陈芝芸,严茂祥.穴位埋线治疗大鼠非酒精性脂肪肝的实验研究[J].中华中医药学刊,2011,29(3):543-544.
[12]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪性肝病大鼠SREBP-1表达的影响[J].中国中医急症,2011,20(6):902-903,908.
[13]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪性肝病患者血清瘦素水平及胰岛素抵抗指数的影响[J].中国中医基础医学杂志,2011,17(11):1254-1255.
[14]周晓玲,谢胜,张丹璇,等.经络红外成像技术在厥阴寒化症患者中的运用及机理探讨[J].时珍国医国药,2015,26(11):2703-2705.
[2]Lebeaupin C,Vallee D,Hazari Y,et al. Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease[J]. Journal of hepatology,2018,69(4):927-947.
[3]胡中杰,张晶.我国非酒精性脂肪性肝病的研究现状[J].临床肝胆病杂志,2016,32(3):552-556.
[4]Younossi ZM,Koenig AB,Abdelatif D,et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence,incidence,and outcomes[J]. Hepatology(Baltimore,Md),2016,64(1):73-84.
[5]张声生,李军祥.非酒精性脂肪性肝病中医诊疗专家共识意见(2017)[J].中医杂志,2017,58(19):1706-1710.
[6]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:367.
[7]董姝,刘平,孙明瑜.非酒精性脂肪肝的治疗研究进展[J].辽宁中医杂志,2013,40(3):599-602.
[8]李婷,张雪姣,孟祥雯,等.非酒精性脂肪肝病的诊治进展[J].中国老年学杂志,2017,37(12):3114-3116.
[9]王聪庆.从痰论治脂肪肝经验介绍[J].内蒙古中医药,2018,37(5):23-24.
[10]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪肝足三阴经穴位皮温的影响[J].实用临床医药杂志,2011,15(19):40-42.
[11]龚秀杭,陈芝芸,严茂祥.穴位埋线治疗大鼠非酒精性脂肪肝的实验研究[J].中华中医药学刊,2011,29(3):543-544.
[12]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪性肝病大鼠SREBP-1表达的影响[J].中国中医急症,2011,20(6):902-903,908.
[13]周晓玲,谢胜,侯秋科.穴位埋线对非酒精性脂肪性肝病患者血清瘦素水平及胰岛素抵抗指数的影响[J].中国中医基础医学杂志,2011,17(11):1254-1255.
[14]周晓玲,谢胜,张丹璇,等.经络红外成像技术在厥阴寒化症患者中的运用及机理探讨[J].时珍国医国药,2015,26(11):2703-2705.