上海市男性同性恋HIV感染者中乙型肝炎、丙型肝炎病毒的合并感染情况横断面研究
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摘要
目的探讨男性同性恋HIV感染者中乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)的合并感染情况。方法选择2016年1月～2018年1月在本区域内进行治疗的男性同性恋HIV感染者157例,以横断面调查的方法进行研究,收集所有入组患者的性别、年龄、文化程度、感染途径等资料。对所有患者HBV抗体、HCV抗体进行检测。结果不同感染途径人群合并感染发生率对比,差异具有统计学意义(P<0.05):同性性行为患者单纯HIV感染发生率最高,吸毒患者HIV+HBV感染率最高,输血患者HIV+HCV感染率最高,HIV+HBV+HCV感染率最高者为吸毒患者。不同学历合并感染发生率对比,差异具有统计学意义(P<0.05):大专及以上的患者以HIV单纯感染为主,高中及中专患者以HIV和HIV+HBV为主,初中及以下的患者则以合并感染为主。不同职业合并感染发生率对比,差异具有统计学意义(P<0.05):单纯HIV感染患者以自由职业及职员为主,职员在HIV+HBV感染发病率高于自由职业者及农民,农民在HIV+HCV及HIV+HBV+HCV的发病率均高于其他职业患者。结论男性同性恋HIV感染者中乙型肝炎病毒、丙型肝炎病毒合并感染发生率均较高,患者感染途径、文化程度及职业的不同,合并感染情况均有显著差异。
Objective To investigate the co-infection of hepatitis B virus(HBV) and hepatitis C virus(HCV) among HIV-infected men. Methods A total of 157 male homosexual HIV-infected patients who were treated in the region from January 2016 to January 2018 were enrolled in this study.The cross-sectional survey was conducted to collect the gender, age, education level, and infection route of all enrolled patients. And other information. All patients were tested for HBV antibodies and HCV antibodies. Results The incidence of co-infection in different infections was statistically significant(P <0.05). The incidence of HIV infection was the highest in patients with homosexual behavior, the highest in HIV +HBV infection among drug users, and the highest in HIV +HCV infection in transfusion patients. The highest rate of HIV +HBV +HCV infection is drug users. The incidence of combined infections in different academic qualifications was statistically significant( P<0.05): patients with college and above were mainly infected with HIV, and high school and secondary school patients were mainly HIV and HIV+HBV. Patients with junior high school and below. Then the main infection is combined. The incidence of concomitant infections in different occupations was statistically significant( P<0.05):Patients with HIV-infected patients were mainly freelancers and staff. The incidence of HIV +HBV infection among staff was higher than that of freelancers and farmers. The incidence of HIV+HCV and HIV+HBV+HCV was higher in farmers than in other occupational patients. Conclusion The incidence of hepatitis B virus and hepatitis C virus co-infection in male homosexual HIV-infected patients is high. The infection route, education level and occupation are different, and the infection status is significantly different.
Objective To investigate the co-infection of hepatitis B virus(HBV) and hepatitis C virus(HCV) among HIV-infected men. Methods A total of 157 male homosexual HIV-infected patients who were treated in the region from January 2016 to January 2018 were enrolled in this study.The cross-sectional survey was conducted to collect the gender, age, education level, and infection route of all enrolled patients. And other information. All patients were tested for HBV antibodies and HCV antibodies. Results The incidence of co-infection in different infections was statistically significant(P <0.05). The incidence of HIV infection was the highest in patients with homosexual behavior, the highest in HIV +HBV infection among drug users, and the highest in HIV +HCV infection in transfusion patients. The highest rate of HIV +HBV +HCV infection is drug users. The incidence of combined infections in different academic qualifications was statistically significant( P<0.05): patients with college and above were mainly infected with HIV, and high school and secondary school patients were mainly HIV and HIV+HBV. Patients with junior high school and below. Then the main infection is combined. The incidence of concomitant infections in different occupations was statistically significant( P<0.05):Patients with HIV-infected patients were mainly freelancers and staff. The incidence of HIV +HBV infection among staff was higher than that of freelancers and farmers. The incidence of HIV+HCV and HIV+HBV+HCV was higher in farmers than in other occupational patients. Conclusion The incidence of hepatitis B virus and hepatitis C virus co-infection in male homosexual HIV-infected patients is high. The infection route, education level and occupation are different, and the infection status is significantly different.
引文
[1]蒋贵英.2001-2014年北京市怀柔区艾滋病流行病学分析[J].职业与健康,2016,32(1):65-68.
[2]淮芬,李效民,李秀兰,等.运城市艾滋病流行病学特征分析[J].山西医药杂志,2017,46(23):2931-2932.
[3]吴杰敏,詹克勤,洪智海,等.74例HIV感染者乙肝,丙肝,戊肝和梅毒螺旋体感染状况分析[J].实验与检验医学,2016,34(6):798-800.
[4]Amiri FB,Mostafavi E,Mirzazadeh A.HIV, HBV and HCV Coinfection Prevalence in Iran-A Systematic Review and Meta-Analysis[J].PLoS One,2016,11(3):e0151946.
[5]Kallas E,Huik K,Türk S,et al.T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use[J].Viral Immunology,2016,29(8):464.
[6]Fuster F,Vargas JI,Jensen D,et al.CD4/CD8 ratio as a predictor of the response to HBV vaccination in HIV-positive patients:A prospective cohort study[J].Vaccine,2016,34(16):1889-1895.
[7]Opaleye OO,Igboama MC,Ojo JA,et al.Seroprevalence of HIV,HBV, HCV, and HTLV among Pregnant Women in Southwestern Nigeria[J].Journal of Immunoassay,2016,37(1):29-42.
[8]Vargas JI,Jensen D,Sarmiento V,et al.Presence of anti-HBc is associated to high rates of HBV resolved infection and low threshold for Occult HBV Infection in HIV patients with negative HBsAg in Chile[J].Journal of Medical Virology,2016,88(4):639-646.
[9]Boyd A,Bottero J,Lacombe K.The I3-glutamyl transpeptidase-to-platelet ratio as a predictor of liver fibrosis in patients co-infected with HBV and HIV[J].Gut,2016,65(4):718-720.
[2]淮芬,李效民,李秀兰,等.运城市艾滋病流行病学特征分析[J].山西医药杂志,2017,46(23):2931-2932.
[3]吴杰敏,詹克勤,洪智海,等.74例HIV感染者乙肝,丙肝,戊肝和梅毒螺旋体感染状况分析[J].实验与检验医学,2016,34(6):798-800.
[4]Amiri FB,Mostafavi E,Mirzazadeh A.HIV, HBV and HCV Coinfection Prevalence in Iran-A Systematic Review and Meta-Analysis[J].PLoS One,2016,11(3):e0151946.
[5]Kallas E,Huik K,Türk S,et al.T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use[J].Viral Immunology,2016,29(8):464.
[6]Fuster F,Vargas JI,Jensen D,et al.CD4/CD8 ratio as a predictor of the response to HBV vaccination in HIV-positive patients:A prospective cohort study[J].Vaccine,2016,34(16):1889-1895.
[7]Opaleye OO,Igboama MC,Ojo JA,et al.Seroprevalence of HIV,HBV, HCV, and HTLV among Pregnant Women in Southwestern Nigeria[J].Journal of Immunoassay,2016,37(1):29-42.
[8]Vargas JI,Jensen D,Sarmiento V,et al.Presence of anti-HBc is associated to high rates of HBV resolved infection and low threshold for Occult HBV Infection in HIV patients with negative HBsAg in Chile[J].Journal of Medical Virology,2016,88(4):639-646.
[9]Boyd A,Bottero J,Lacombe K.The I3-glutamyl transpeptidase-to-platelet ratio as a predictor of liver fibrosis in patients co-infected with HBV and HIV[J].Gut,2016,65(4):718-720.