鸦胆子抗肿瘤作用机制研究进展
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摘要
综述鸦胆子抗肿瘤作用机制研究进展。现代研究发现,鸦胆子具有广泛的抗癌作用,可以抑制细胞增殖、诱导细胞凋亡、抑制肿瘤转移和血管生成以及增强化疗的作用。
To review the research progress of anti-tumor mechanism of Fructus Brucea Modern research has found that Fructus Brucea has a wide range of anti-cancer effects,which can inhibit cell proliferation,induce apoptosis,inhibit tumor metastasis and angiogenesis,and enhance chemotherapy.
To review the research progress of anti-tumor mechanism of Fructus Brucea Modern research has found that Fructus Brucea has a wide range of anti-cancer effects,which can inhibit cell proliferation,induce apoptosis,inhibit tumor metastasis and angiogenesis,and enhance chemotherapy.
引文
[1]国家药典委员会.中华人民共和国药典(一部)[S].北京:中国医药科技出版社,2015:254-255.
[2]DONG S H,LIU J,GE Y Z,et al.Chemical constituents from Brucea javanica[J].Phytochemistry,2013,85(1):175-184.
[3]潘镏镏,郑飞云,诸海燕,等.鸦胆子素D对HPV16感染细胞株的作用及其可能机制[J].温州医科大学学报,2015,45(2):89-94.
[4]孙静莉,任威,杨丽娜,等.鸦胆子素D对高危型HPV 16感染细胞的增殖抑制作用及对HPV16 E6、HPV 16 E7 mRNA表达的影响[J].中国妇幼保健,2017,32(18):4526-4529.
[5]WANG D,QU X,ZHUANG X,et al.Seed Oil of Brucea javanica induces cell cycle arrest and apoptosis via reactive oxygen speciesmediated mitochondrial dysfunction in human lung cancer cells[J].Nutr Cancer,2016,68(8):1394-1403.
[6]耿国军,余海彬,于修义,等.鸦胆子油乳对肺癌细胞的抑制作用[J].中国医院药学杂志,2016,36(4):300-304.
[7]郑颖,王刚阳,陈瑞玲,等.探讨鸦胆子素D对骨肉瘤细胞增殖、凋亡与自噬的作用[J].中国骨与关节杂志,2017,6(6):433-438.
[8]YUE Y,YANG Y,SHI L,et al.Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis[J].Arch Med Sci,2015,11(4):856-862.
[9]冀会方,刘露,李开,等.鸦胆子蛋白质组成分析及其酶解物细胞毒性研究[J].中国中药杂志,2016,41(22):4210-4215.
[10]潘镏镏,万小洁,章圣辉,等.鸦胆子油乳对宫颈永生化细胞体外增殖和凋亡的作用[J].中国妇幼保健,2013,28(5):834-837.
[11]罗琦,杨静.鸦胆子油乳制剂对宫颈癌Hela细胞的抑制效果及作用机制研究[J].现代中西医结合杂志,2015,24(6):574-576.
[12]尹绍成,石文建,赵喜庆,等.鸦胆子油乳注射液对C6胶质瘤细胞增殖影响的实验研究[J].西部医学,2014,26(6):686-688.
[13]张朝晖,金巧智,李志海,等.鸦胆子油乳注射液对喉癌Hep-2细胞抑制作用研究[J].现代实用医学,2015,27(4):518-520.
[14]秦丽娟,贾永森,赵喜庆,等.鸦胆子油乳注射液对胶质瘤细胞侵袭性的影响及其可能机制[J].四川大学学报(医学版),2016,47(3):347-350.
[15]杨利辉,张翡,汪丽珍.替莫唑胺联合鸦胆子油乳对胶质瘤SKMG-4细胞抑制作用研究[J].中国热带医学,2015,15(12):1428-1430.
[16]JIANG L,WANG W,HE Q,et al.Oleic acid induces apoptosis and autophagy in the treatment of tongue squamous cell carcinomas[J].Sci Rep,2017,7(1):11277.
[17]YE Q M,BAI L L,HU S Z,et al.Isolation,chemotaxonomic significance and cytotoxic effects of quassinoids from Brucea javanica[J].Fitoterapia,2015(105):66-72.
[18]ZHANGANG X,SHEUNG C C,CHI H L,et al.Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma[J].Eur J Pharmacol,2014,728(1):141-150.
[19]ZHAO L,WEN Q,YANG G,et al.Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway[J].Phytomedicine,2016,23(2):114-122.
[20]YE H,LIU X,SUN J,et al.Enhanced therapeutic efficacy of LHRHatargeted Brucea javanica oil liposomes for ovarian cancer[J].BMCCancer,2016,16(1):831.
[21]XIANG Y,YE W,HUANG C,et al.Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway[J].Biochem Biophys Res Commun,2017,487(4):820-826.
[22]谭亚芳,李娟,胡树枝,等.鸦胆子苦醇抑制人前列腺癌DU145细胞生长及作用机制[J].广西植物,2015,35(3):431-436.
[23]马斌娟,卫旭东,高江霞,等.鸦胆子油乳对Hep-2细胞增殖与凋亡诱导作用的研究[J].中华肿瘤防治杂志,2013,20(19):10-13.
[24]李义慧,王晓红,郑国红,等.鸦胆子油乳对肺鳞癌细胞增殖的抑制作用[J].中国煤炭工业医学杂志,2015,18(8):1346-1348.
[25]王飞达,王兆洪,张跃,等.鸦胆子素D对人胰腺癌细胞株Panc-1体外增殖的抑制作用[J].浙江医学,2015,37(12):1019-1021.
[26]BAGHERI E,HAJIAGHAALIPOUR F,NYAMATHULLA S,et al.The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation[J].Drug Des Devel Ther,2018(12):657-671.
[27]杨利辉,张颜礼.鸦胆子油乳对胶质瘤U251细胞血管内皮生长因子表达水平的影响[J].蚌埠医学院学报,2017,42(1):34-35.
[28]江波,许东航,徐翔,等.鸦胆子油乳对肺癌A549细胞凋亡及血管内皮生长因子分泌的影响[J].中国药学杂志,2009,44(18):1387-1390.
[29]徐翔,许东航,江波,等.鸦胆子油乳对人肺癌A549细胞血管内皮生长因子表达的影响[J].中国中药杂志,2008,33(21):2517.
[30]乔鹏,俞蕴莉.鸦胆子油乳对体外培养肺癌A549细胞株增殖、迁移能力及血管新生指标影响[J].海南医学院学报,2015,21(4):438-441.
[31]HU B,AN H M,WANG S S,et al.Preventive and therapeutic effects of chinese herbal compounds against hepatocellular carcinoma[J].Molecules,2016,21(2):142.
[32]CHAO C,WANG B.Brucea javanica oil emulsion alleviates cachexia induced by Lewis lung cancer cells in mice[J].J Drug Targ,2017,26(3):1.
[33]张奇峰.鸦胆子油乳剂对人胃癌细胞株HGC-27细胞迁移和侵袭的体外实验研究[J].中国民康医学,2016,28(7):52-54.
[34]陈果,李蔚,李小惠.鸦胆子苦醇抑制人非小细胞肺癌A549细胞转移的机制[J].中国老年学,2016,36(16):3897-3899.
[35]YAN Z,ZHANG B,HUANG Y,et al.Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death[J].Oncol Lett,2015,9(3):1425-1431.
[36]CHEN H M,LAI Z Q,LIAO H J,et al.Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells[J].Int J Mol Med,2018,41(3):1447-1454.
[37]EVANS J P,WINIARSKI B K,SUTTON P A,et al.The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer[J].Oncotarget,2018,43(9):27104-27116.
[38]LU Y,WANG B,SHI Q,et al.Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116cells[J].Sci Rep,2016(6):39123.
[39]OH E T,CHAN W K,KIM H G,et al.Brusatol-Mediated inhibition of c-Myc increases HIF-1αdegradation and causes cell death in colorectal cancer under hypoxia[J].Theranostics,2017,7(14):3415-3431.
[2]DONG S H,LIU J,GE Y Z,et al.Chemical constituents from Brucea javanica[J].Phytochemistry,2013,85(1):175-184.
[3]潘镏镏,郑飞云,诸海燕,等.鸦胆子素D对HPV16感染细胞株的作用及其可能机制[J].温州医科大学学报,2015,45(2):89-94.
[4]孙静莉,任威,杨丽娜,等.鸦胆子素D对高危型HPV 16感染细胞的增殖抑制作用及对HPV16 E6、HPV 16 E7 mRNA表达的影响[J].中国妇幼保健,2017,32(18):4526-4529.
[5]WANG D,QU X,ZHUANG X,et al.Seed Oil of Brucea javanica induces cell cycle arrest and apoptosis via reactive oxygen speciesmediated mitochondrial dysfunction in human lung cancer cells[J].Nutr Cancer,2016,68(8):1394-1403.
[6]耿国军,余海彬,于修义,等.鸦胆子油乳对肺癌细胞的抑制作用[J].中国医院药学杂志,2016,36(4):300-304.
[7]郑颖,王刚阳,陈瑞玲,等.探讨鸦胆子素D对骨肉瘤细胞增殖、凋亡与自噬的作用[J].中国骨与关节杂志,2017,6(6):433-438.
[8]YUE Y,YANG Y,SHI L,et al.Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis[J].Arch Med Sci,2015,11(4):856-862.
[9]冀会方,刘露,李开,等.鸦胆子蛋白质组成分析及其酶解物细胞毒性研究[J].中国中药杂志,2016,41(22):4210-4215.
[10]潘镏镏,万小洁,章圣辉,等.鸦胆子油乳对宫颈永生化细胞体外增殖和凋亡的作用[J].中国妇幼保健,2013,28(5):834-837.
[11]罗琦,杨静.鸦胆子油乳制剂对宫颈癌Hela细胞的抑制效果及作用机制研究[J].现代中西医结合杂志,2015,24(6):574-576.
[12]尹绍成,石文建,赵喜庆,等.鸦胆子油乳注射液对C6胶质瘤细胞增殖影响的实验研究[J].西部医学,2014,26(6):686-688.
[13]张朝晖,金巧智,李志海,等.鸦胆子油乳注射液对喉癌Hep-2细胞抑制作用研究[J].现代实用医学,2015,27(4):518-520.
[14]秦丽娟,贾永森,赵喜庆,等.鸦胆子油乳注射液对胶质瘤细胞侵袭性的影响及其可能机制[J].四川大学学报(医学版),2016,47(3):347-350.
[15]杨利辉,张翡,汪丽珍.替莫唑胺联合鸦胆子油乳对胶质瘤SKMG-4细胞抑制作用研究[J].中国热带医学,2015,15(12):1428-1430.
[16]JIANG L,WANG W,HE Q,et al.Oleic acid induces apoptosis and autophagy in the treatment of tongue squamous cell carcinomas[J].Sci Rep,2017,7(1):11277.
[17]YE Q M,BAI L L,HU S Z,et al.Isolation,chemotaxonomic significance and cytotoxic effects of quassinoids from Brucea javanica[J].Fitoterapia,2015(105):66-72.
[18]ZHANGANG X,SHEUNG C C,CHI H L,et al.Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma[J].Eur J Pharmacol,2014,728(1):141-150.
[19]ZHAO L,WEN Q,YANG G,et al.Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway[J].Phytomedicine,2016,23(2):114-122.
[20]YE H,LIU X,SUN J,et al.Enhanced therapeutic efficacy of LHRHatargeted Brucea javanica oil liposomes for ovarian cancer[J].BMCCancer,2016,16(1):831.
[21]XIANG Y,YE W,HUANG C,et al.Brusatol inhibits growth and induces apoptosis in pancreatic cancer cells via JNK/p38 MAPK/NF-κb/Stat3/Bcl-2 signaling pathway[J].Biochem Biophys Res Commun,2017,487(4):820-826.
[22]谭亚芳,李娟,胡树枝,等.鸦胆子苦醇抑制人前列腺癌DU145细胞生长及作用机制[J].广西植物,2015,35(3):431-436.
[23]马斌娟,卫旭东,高江霞,等.鸦胆子油乳对Hep-2细胞增殖与凋亡诱导作用的研究[J].中华肿瘤防治杂志,2013,20(19):10-13.
[24]李义慧,王晓红,郑国红,等.鸦胆子油乳对肺鳞癌细胞增殖的抑制作用[J].中国煤炭工业医学杂志,2015,18(8):1346-1348.
[25]王飞达,王兆洪,张跃,等.鸦胆子素D对人胰腺癌细胞株Panc-1体外增殖的抑制作用[J].浙江医学,2015,37(12):1019-1021.
[26]BAGHERI E,HAJIAGHAALIPOUR F,NYAMATHULLA S,et al.The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-κB translocation[J].Drug Des Devel Ther,2018(12):657-671.
[27]杨利辉,张颜礼.鸦胆子油乳对胶质瘤U251细胞血管内皮生长因子表达水平的影响[J].蚌埠医学院学报,2017,42(1):34-35.
[28]江波,许东航,徐翔,等.鸦胆子油乳对肺癌A549细胞凋亡及血管内皮生长因子分泌的影响[J].中国药学杂志,2009,44(18):1387-1390.
[29]徐翔,许东航,江波,等.鸦胆子油乳对人肺癌A549细胞血管内皮生长因子表达的影响[J].中国中药杂志,2008,33(21):2517.
[30]乔鹏,俞蕴莉.鸦胆子油乳对体外培养肺癌A549细胞株增殖、迁移能力及血管新生指标影响[J].海南医学院学报,2015,21(4):438-441.
[31]HU B,AN H M,WANG S S,et al.Preventive and therapeutic effects of chinese herbal compounds against hepatocellular carcinoma[J].Molecules,2016,21(2):142.
[32]CHAO C,WANG B.Brucea javanica oil emulsion alleviates cachexia induced by Lewis lung cancer cells in mice[J].J Drug Targ,2017,26(3):1.
[33]张奇峰.鸦胆子油乳剂对人胃癌细胞株HGC-27细胞迁移和侵袭的体外实验研究[J].中国民康医学,2016,28(7):52-54.
[34]陈果,李蔚,李小惠.鸦胆子苦醇抑制人非小细胞肺癌A549细胞转移的机制[J].中国老年学,2016,36(16):3897-3899.
[35]YAN Z,ZHANG B,HUANG Y,et al.Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death[J].Oncol Lett,2015,9(3):1425-1431.
[36]CHEN H M,LAI Z Q,LIAO H J,et al.Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells[J].Int J Mol Med,2018,41(3):1447-1454.
[37]EVANS J P,WINIARSKI B K,SUTTON P A,et al.The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer[J].Oncotarget,2018,43(9):27104-27116.
[38]LU Y,WANG B,SHI Q,et al.Brusatol inhibits HIF-1 signaling pathway and suppresses glucose uptake under hypoxic conditions in HCT116cells[J].Sci Rep,2016(6):39123.
[39]OH E T,CHAN W K,KIM H G,et al.Brusatol-Mediated inhibition of c-Myc increases HIF-1αdegradation and causes cell death in colorectal cancer under hypoxia[J].Theranostics,2017,7(14):3415-3431.