前列腺癌中存活素基因表达的研究
摘要
目的探讨前列腺癌中存活素基因的表达与临床、病理特征的关系,分析其在前列腺癌发生、演变过程中的作用。方法应用RT-PCR方法检测前列腺癌和良性前列腺增生组织中存活素mRNA的表达情况。分析其表达与前列腺癌的临床分期、病理分级的关系。结果存活素mRNA在前列腺癌中总阳性表达率为78.85%(41/52)。在良性前列腺增生中阳性表达率15.00%(3/20),其差异有统计学差异(P<0.05);前列腺癌中低分化和中分化组阳性表达率高于高分化组,其差异有显著意义(P<0.05);存活素mRNA阳性表达在临床分期之间有显著性差异(P<0.05)。结论存活素在前列腺癌组织中广泛表达,并且与前列腺癌的病理分级、临床分期相关。
引文
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[3]Mceleny KR,Watson RW,Coffey RN,et al.Inhibitors of apoptosis proteins in prostate cancer cell Iines[J].Prostate,2002,51(2):133-140.
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