“肾主骨”理论的研究进展
摘要
从理论研究、基础研究及临床研究等方面对"肾主骨"理论研究进展进行综述,以了解近十年"肾主骨"理论的研究现状,从而进一步丰富我国传统中医学提出的"肾主骨"理论的科学内涵。为"肾主骨"理论的深入研究提供思路,增强对临床治疗的指导作用。
引文
[1] 王拥军,卞琴,崔学军,等.“肾主骨”理论研究的思路与方法[J].上海中医药大学学报,2010,24(1):8-12.
[2] 贺县宪,魏春山,陈孝印.“肾主骨”在骨伤临床中的运用[J].安徽中医学院学报,2004,23(1):4-6.
[3] 苏志伟,郑志永,金军.补肾方治疗骨质疏松症临床观察[J].中国中医药信息杂志,2008,17(5):22-24.
[4] 罗卫芳,郭树仁,程士德.中医学肾本质现代研究概述[J].中国中医基础医学杂志,2001,7(4),75.
[5] 朱光楣,张越林,杨宪林,等.中医肾虚与下丘脑-垂体-睾丸轴关系的探讨[J].天津医药,1989(1):37-38.
[6] Kiecker C,Bates T,Bell E.Molecular specification of germ layers in vertebrate embryos[J].Cell Mol Life Sci,2016,73(5):923-947.
[7] Dvorak MM,Siddiqua A,Ward DT,et al.Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones[J].Proc Natl Acad Sci USA,2004,101(14):5140-5145.
[8] Mozar A,Haren N,Chasseraud M,et al.High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclast-like cells[J].J Cell Physiol,2008,215(1):47-54.
[9] 潘振沧,戴鉴之.从肾主骨看钙磷代谢[J].医教研究,1994,22(3):49-51.
[10] 黄满玉,冯峰,朱太咏.从肾与骨代谢的关系探讨中医“肾主骨”现代理论内涵[J].中国临床康复,2005,9(46):128.
[11] St-Arnaud R,Naja RP.Vitamin D metabolism,cartilage and bone fracture repair[J].Mol Cell Endocrinol,2011,347(1):48-54.
[12] Minguell JJ,Erices A,Conget P.Mesenchymal stem cells[J].Exp Bio Med(Maywood),2001,226(6):507-520.
[13] Shiozawa Y,Jung Y,Ziegler AM,et al.Erythropoietin couples hematopoiesis with bone formation[J].PloS One,2010,5(5):e10853.
[14] 谢院生,魏凯,尹智炜.用现代医学诠释中医“肾主骨”的科学内涵[J].中国中西医结合肾病杂志,2016,17(6):472.
[15] Tou L,Quibria N,Alexander JM.Transcriptional regulation of the human Runx2/Cbfa1 gene promoter by bone morphogenetic protein-7[J].Mol Cell Endocrinol,2003,205(1):121-129.
[16] 沈奕,李晓淼,王伟力.骨形态发生蛋白7在骨科的应用[J].中国组织工程研究与临床康复,2011,15(26):4864-4867.
[17] Boon MR,van der Horst G,van der Pluijm G,et al.Bone morphogenetic protein 7:a broad-spectrum growth factor with multiple target therapeutic potency[J].Cytokine Growth Factor Rev,2011,22(4):221-229.
[18] Khosla S,Oursler MJ,Monroe DG.Estrogen and the skeleton[J].Trends Endocrinol Metab,2012,23(11):576-581.
[19] Gao B,Huang Q,Lin YS,et al.Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway[J].PLoS One,2014,9:e99137.
[20] Qiu X,Jin X,Shao Z,et al.17beta-estradiol induces the proliferation of hematopoietic stem cells by promoting the osteogenic differentiation of mesenchymal stem cells[J].Tohoku J Exp Med,2014,233:141-148.
[21] 李金荣,郑少雄.雄激素和骨代[M]//刘忠厚,编.骨矿与临床.北京:中国科技出版社,2006:563-567.
[22] Wei K,Yin Z,Xie Y.Roles of the kidney in the formation,remodeling and repair of bone[J].J Nephrol,2016,29(3):349-357.
[23] Yan J,Sun W,Zhang J,et al.Bone marrow ablation demonstrates that excess endogenous parathyroid hormone plays distinct roles in trabecular and cortical bone[J].Am J Pathol,2012,181(1):234-244.
[24] Li AHardy R,Stoner S,et al.Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure[J].PLoS One,2013,8:e63578.
[25] 张尹娜,王文雅,张柳.降钙素对骨性关节炎关节软骨的作用[J].中国修复重建外科杂志,2008,22(11):1393.
[26] Chesnut CH 3rd,Majumdar S,Newitt DC,et al.Effects of salmon calcitonin on trabecular microarchitecture as determined by magnetic resonance imaging:results from the QUEST study[J].J Bone Miner Res,2005,20(9):1548-1561.
[27] 王长江,王平,王小琴,等.基于Klotho基因的生物学效应探讨“肾藏精”的科学内涵[J].中医杂志,2016,57(24):2078-2082.
[28] 赵洪刚,张遵城.Klotho在肾脏损伤疾病中的作用研究进展[J].重庆医学,2015,4(15),2140.
[29] Clinkenbeard EL,Cass TA,Ni P,et al.Conditional Deletion of Murine Fgf23:Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia[J].J Bone Miner Res,2016,31(6):1247-1257.
[30] 程志安,韩凌,危建安,等.六味地黄丸、金匮肾气丸及健骨二仙丸含药血清对BMSCs成脂、成骨细胞分化相关基因的影响[J].中国中西医结合杂志,2013,33(2):261-265.
[31] 李瑛,邹季,费攀,等.中药验方“补肾强骨汤”含药血清对家兔骨髓干细胞的动员及成骨作用的影响[C].第十九届全国中西医结合骨伤科学术研讨会论文汇编,2012.
[32] 阳晟.补肾健脾活血方含药血清调控p38信号通路促进去卵巢大鼠BMSCs成骨分化研究[J].新中医,2013,45(6):160-162.
[33] 刘梅洁,鞠大宏,赵宏艳,等.“肾主骨”的机理研究—左归丸含药血清对破骨细胞分化调控因子OPG、RANKL蛋白表达的影响[J].中国中医基础医学杂志,2009,15(3):187.
[34] 周乐,崔燎,吴铁.淫羊藿对肾阳虚雄性大鼠肾脏和股骨BMP-7 表达的影响[J].中国骨质疏松杂志,2008,14(2):90-94.
[35] 侯晓峰,李朝旭,刘景生.鹿茸对实验型骨折愈合过程中TGF-β1的表达影响[J].中医药学刊,2005,23(5):890-891.
[36] 张军芳,郭敏,王建华.异补骨脂素加锌对大鼠成骨细胞增殖与分化的影响[J].天然产物研究与开发,2009,21(3):409.
[37]李楠,王和鸣,郭素华,等.巴戟天多糖及其水提取物对体外培养成骨细胞活性的影响[J].中国组织工程研究与临床康复,2007,11(23):4570-4572.
[38]黄丹奇.运用中医肾主骨的理论治疗膝骨性关节炎临床研究[J].中国临床医生,2011,39(5):63-64.
[39]李芙英.中医“肾主骨”指导骨科康复治疗的效果分析[J].中国卫生产业,2012,9(26):172.
[40]苏恩洁.二仙汤治疗绝经妇女骨质疏松症机制[J].辽宁中医药大学学报,2015,17(4):172-174.
[41]黄明炜,廖勇敢,李晓雯,等.联用补肾益骨方治疗绝经后骨质疏松症患者临床观察[J].中国骨质疏松杂志,2014,20(1):53.
[42]段昱方,赵文景,蔡联,等.益肾坚骨汤治疗肾性骨病34例临床观察[J].北京中医药,2010,29(9):682-684.
[2] 贺县宪,魏春山,陈孝印.“肾主骨”在骨伤临床中的运用[J].安徽中医学院学报,2004,23(1):4-6.
[3] 苏志伟,郑志永,金军.补肾方治疗骨质疏松症临床观察[J].中国中医药信息杂志,2008,17(5):22-24.
[4] 罗卫芳,郭树仁,程士德.中医学肾本质现代研究概述[J].中国中医基础医学杂志,2001,7(4),75.
[5] 朱光楣,张越林,杨宪林,等.中医肾虚与下丘脑-垂体-睾丸轴关系的探讨[J].天津医药,1989(1):37-38.
[6] Kiecker C,Bates T,Bell E.Molecular specification of germ layers in vertebrate embryos[J].Cell Mol Life Sci,2016,73(5):923-947.
[7] Dvorak MM,Siddiqua A,Ward DT,et al.Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones[J].Proc Natl Acad Sci USA,2004,101(14):5140-5145.
[8] Mozar A,Haren N,Chasseraud M,et al.High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclast-like cells[J].J Cell Physiol,2008,215(1):47-54.
[9] 潘振沧,戴鉴之.从肾主骨看钙磷代谢[J].医教研究,1994,22(3):49-51.
[10] 黄满玉,冯峰,朱太咏.从肾与骨代谢的关系探讨中医“肾主骨”现代理论内涵[J].中国临床康复,2005,9(46):128.
[11] St-Arnaud R,Naja RP.Vitamin D metabolism,cartilage and bone fracture repair[J].Mol Cell Endocrinol,2011,347(1):48-54.
[12] Minguell JJ,Erices A,Conget P.Mesenchymal stem cells[J].Exp Bio Med(Maywood),2001,226(6):507-520.
[13] Shiozawa Y,Jung Y,Ziegler AM,et al.Erythropoietin couples hematopoiesis with bone formation[J].PloS One,2010,5(5):e10853.
[14] 谢院生,魏凯,尹智炜.用现代医学诠释中医“肾主骨”的科学内涵[J].中国中西医结合肾病杂志,2016,17(6):472.
[15] Tou L,Quibria N,Alexander JM.Transcriptional regulation of the human Runx2/Cbfa1 gene promoter by bone morphogenetic protein-7[J].Mol Cell Endocrinol,2003,205(1):121-129.
[16] 沈奕,李晓淼,王伟力.骨形态发生蛋白7在骨科的应用[J].中国组织工程研究与临床康复,2011,15(26):4864-4867.
[17] Boon MR,van der Horst G,van der Pluijm G,et al.Bone morphogenetic protein 7:a broad-spectrum growth factor with multiple target therapeutic potency[J].Cytokine Growth Factor Rev,2011,22(4):221-229.
[18] Khosla S,Oursler MJ,Monroe DG.Estrogen and the skeleton[J].Trends Endocrinol Metab,2012,23(11):576-581.
[19] Gao B,Huang Q,Lin YS,et al.Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway[J].PLoS One,2014,9:e99137.
[20] Qiu X,Jin X,Shao Z,et al.17beta-estradiol induces the proliferation of hematopoietic stem cells by promoting the osteogenic differentiation of mesenchymal stem cells[J].Tohoku J Exp Med,2014,233:141-148.
[21] 李金荣,郑少雄.雄激素和骨代[M]//刘忠厚,编.骨矿与临床.北京:中国科技出版社,2006:563-567.
[22] Wei K,Yin Z,Xie Y.Roles of the kidney in the formation,remodeling and repair of bone[J].J Nephrol,2016,29(3):349-357.
[23] Yan J,Sun W,Zhang J,et al.Bone marrow ablation demonstrates that excess endogenous parathyroid hormone plays distinct roles in trabecular and cortical bone[J].Am J Pathol,2012,181(1):234-244.
[24] Li AHardy R,Stoner S,et al.Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure[J].PLoS One,2013,8:e63578.
[25] 张尹娜,王文雅,张柳.降钙素对骨性关节炎关节软骨的作用[J].中国修复重建外科杂志,2008,22(11):1393.
[26] Chesnut CH 3rd,Majumdar S,Newitt DC,et al.Effects of salmon calcitonin on trabecular microarchitecture as determined by magnetic resonance imaging:results from the QUEST study[J].J Bone Miner Res,2005,20(9):1548-1561.
[27] 王长江,王平,王小琴,等.基于Klotho基因的生物学效应探讨“肾藏精”的科学内涵[J].中医杂志,2016,57(24):2078-2082.
[28] 赵洪刚,张遵城.Klotho在肾脏损伤疾病中的作用研究进展[J].重庆医学,2015,4(15),2140.
[29] Clinkenbeard EL,Cass TA,Ni P,et al.Conditional Deletion of Murine Fgf23:Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia[J].J Bone Miner Res,2016,31(6):1247-1257.
[30] 程志安,韩凌,危建安,等.六味地黄丸、金匮肾气丸及健骨二仙丸含药血清对BMSCs成脂、成骨细胞分化相关基因的影响[J].中国中西医结合杂志,2013,33(2):261-265.
[31] 李瑛,邹季,费攀,等.中药验方“补肾强骨汤”含药血清对家兔骨髓干细胞的动员及成骨作用的影响[C].第十九届全国中西医结合骨伤科学术研讨会论文汇编,2012.
[32] 阳晟.补肾健脾活血方含药血清调控p38信号通路促进去卵巢大鼠BMSCs成骨分化研究[J].新中医,2013,45(6):160-162.
[33] 刘梅洁,鞠大宏,赵宏艳,等.“肾主骨”的机理研究—左归丸含药血清对破骨细胞分化调控因子OPG、RANKL蛋白表达的影响[J].中国中医基础医学杂志,2009,15(3):187.
[34] 周乐,崔燎,吴铁.淫羊藿对肾阳虚雄性大鼠肾脏和股骨BMP-7 表达的影响[J].中国骨质疏松杂志,2008,14(2):90-94.
[35] 侯晓峰,李朝旭,刘景生.鹿茸对实验型骨折愈合过程中TGF-β1的表达影响[J].中医药学刊,2005,23(5):890-891.
[36] 张军芳,郭敏,王建华.异补骨脂素加锌对大鼠成骨细胞增殖与分化的影响[J].天然产物研究与开发,2009,21(3):409.
[37]李楠,王和鸣,郭素华,等.巴戟天多糖及其水提取物对体外培养成骨细胞活性的影响[J].中国组织工程研究与临床康复,2007,11(23):4570-4572.
[38]黄丹奇.运用中医肾主骨的理论治疗膝骨性关节炎临床研究[J].中国临床医生,2011,39(5):63-64.
[39]李芙英.中医“肾主骨”指导骨科康复治疗的效果分析[J].中国卫生产业,2012,9(26):172.
[40]苏恩洁.二仙汤治疗绝经妇女骨质疏松症机制[J].辽宁中医药大学学报,2015,17(4):172-174.
[41]黄明炜,廖勇敢,李晓雯,等.联用补肾益骨方治疗绝经后骨质疏松症患者临床观察[J].中国骨质疏松杂志,2014,20(1):53.
[42]段昱方,赵文景,蔡联,等.益肾坚骨汤治疗肾性骨病34例临床观察[J].北京中医药,2010,29(9):682-684.