半夏白术天麻汤对后循环缺血性眩晕的临床研究
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摘要
目的观察半夏白术天麻汤对后循环缺血性眩晕的临床疗效。方法患者90例随机分为两组,两组均给予基础治疗,在此基础上对照组给予盐酸氟桂利嗪、拜阿司匹林肠溶片治疗,治疗组在对照组的基础上予以半夏白术天麻汤治疗。一个疗程(14 d)后比较两组临床疗效情况,同时观察两组治疗前及治疗后第3、7、14天的椎基底动脉TCD指标、血液流变学指标的变化。结果治疗组临床疗效明显高于对照组,差异有统计学意义(P <0.05);治疗组在第3、7、14天的椎基底动脉平均血流速度、血流变学指标改善程度明显高于对照组(P <0.05)。结论半夏白术天麻汤对后循环缺血性眩晕疗效确切,可明显改善患者临床症状,提高椎基底动脉平均血流速度,降低血液流变学指标。
Objective: To observe the clinical effect of Banxia Baizhu Tianma Decoction on posterior circulation ischemic vertigo. Methods: 90 patients were randomly divided into two groups. The two groups were given basic treatment. On this basis,the control group was given flunarizine hydrochloride and aspirin enteric-coated tablets.The treatment group was given Banxia Baizhu Tianma Decoction on the basis. After one course of treatment,the clinical effects of the two groups were compared. Meanwhile,the changes of mean blood flow velocity and hemorheological indexes of vertebrobasilar artery were observed before treatment and 3,7 and 14 days after treatment. Results: The clinical efficacy of the treatment group was significantly higher than that of the control group(P < 0.05). On the 3 rd,7 th and 14 th day,the average blood flow velocity and hemorheological indexes of vertebrobasilar artery in the treatment group were significantly higher than those in the control group(P < 0.05). Conclusion: Banxia Baizhu Tianma Decoction is effective on posterior circulation ischemic vertigo. It can improve the clinical symptoms,increase the average blood flow velocity of vertebrobasilar artery and reduce the hemorheological indexes.
Objective: To observe the clinical effect of Banxia Baizhu Tianma Decoction on posterior circulation ischemic vertigo. Methods: 90 patients were randomly divided into two groups. The two groups were given basic treatment. On this basis,the control group was given flunarizine hydrochloride and aspirin enteric-coated tablets.The treatment group was given Banxia Baizhu Tianma Decoction on the basis. After one course of treatment,the clinical effects of the two groups were compared. Meanwhile,the changes of mean blood flow velocity and hemorheological indexes of vertebrobasilar artery were observed before treatment and 3,7 and 14 days after treatment. Results: The clinical efficacy of the treatment group was significantly higher than that of the control group(P < 0.05). On the 3 rd,7 th and 14 th day,the average blood flow velocity and hemorheological indexes of vertebrobasilar artery in the treatment group were significantly higher than those in the control group(P < 0.05). Conclusion: Banxia Baizhu Tianma Decoction is effective on posterior circulation ischemic vertigo. It can improve the clinical symptoms,increase the average blood flow velocity of vertebrobasilar artery and reduce the hemorheological indexes.
引文
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[2]郭琳佳.后循环缺血的研究进展[J].中华老年心脑血管病杂志,2015,17(12):1332-1336.
[3]姜伟,赵晓峰,孟智宏.后循环缺血的名称演变及治疗进展[J].中国卒中杂志,2013,8(6):496-500.
[4]李焰生.中国后循环缺血的专家共识[J].中华内科杂志,2006,45(9):786-787.
[5]国家中医药管理局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2005.
[6]眩晕的诊断依据、证候分类、疗效评定———中华人民共和国中医药行业标准《中医内科病证诊断疗效标准》(ZY/T001.1-94)[J].辽宁中医药大学报,2016,18(9):167.
[7]周路,邱全,贺启荣.中医药治疗后循环缺血性眩晕的临床应用近况[J].广西中医药大学学报,2015,18(1):59-60.
[8]邵义泽,王会民,赵文莉.中西医结合优化治疗眩晕症的临床观察[J].中草药,2014,45(7):982-984.
[9]李燕,谢淼,王世军,等.近10年来天麻的药理作用及化学成分研究进展[J].中华中医药学刊,2017,35(12):2987-2993.
[10]孙进华,秦霞,倪艳,等.半夏白术天麻汤的组方规律研究[J].中国实验方剂学杂志,2010,16(5):89-91.
[11]钟凌云.半夏刺激性毒性成分、炮制减毒机理及工艺研究[D].南京:南京中医药大学,2007.
[12]王涵,杨娜,刘金平,等.白术化学成分、药理作用及临床应用的研究进展[J].甘肃医药,2018,37(1):23-26.
[13]范荣.中药治疗椎动脉型颈椎病的研究进展和机理分析[J].中医药导报,2009,15(7):98-100.
[14]王宇.半夏白术天麻汤治疗椎基底动脉供血不足痰浊中阻型眩晕的临床研究[D].沈阳:辽宁中医药大学,2017.
[15]徐硕,姜文清,金鹏飞,等.茯苓的化学成分及生物活性研究进展[J].西北药学杂志,2016,31(3):327-330.