microRNA-378与肿瘤血管生成的研究进展
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摘要
微小RNA(MicroRNAs,mi RNAs)是真核生物中一类长度约为21到23个核苷酸的非编码小分子单链RNA。mi RNA通过与靶m RNA 3′UTR(3′-untranslated region,3′非编码区)完全或不完全结合,抑制翻译或直接诱导其降解,发挥转录后负调控作用。mi RNA参与机体多种生理和病理过程,且可通过调控其靶标基因参与各种信号通路,影响血管生成。mi R-378属于诸多mi RNAs中的一种。目前已知mi R-378的研究主要集中在肿瘤发生及血管生成、心血管疾病和脑缺血等病理过程,其中与肿瘤发生及血管生成相关研究居多。mi R-378在不同肿瘤中的发挥的作用也不一样,在脑胶质瘤,肺癌,横纹肌肉瘤等肿瘤中发挥促癌基因的作用,在卵巢癌,胃癌,大肠癌等肿瘤中发挥抑癌基因的作用。但是,mi R-378调节肿瘤血管生成的作用机制还有待于深入研究。本文主要对mi R-378在四种肿瘤(脑胶质瘤、肺腺癌、卵巢癌和横纹肌肉瘤)中调控血管生成的相关性研究进展进行综述,以期为这些疾病的治疗和预防提供一种新的思路。
MicroRNAs(mi RNAs) are non-coding small-molecule single-stranded RNAs of approximately 21 to 23 nucleotides in length in eukaryotes. The mi RNA inhibits translation or directly induces degradation by completely or incompletely binding to the target m RNA 3'UTR(3'-untranslated region, 3' non-coding region), and exerts a negative post-transcriptional regulation. Numerous studies have shown that mi RNAs participate in a variety of physiological and pathological processes in the body, and can affect angiogenesis by regulating their target genes to participate in signaling pathways. MiR-378 is one of the families of mi RNAs. At present,mi R-378 is mainly studied in the pathogenesis of tumorigenesis and angiogenesis, cardiovascular disease and cerebral ischemia, and most of the studies related to tumorigenesis and angiogenesis. MiR-378 plays a different role in different tumor tissues, and plays a role as a tumor-promoting gene in glioma, lung cancer, rhabdomyosarcoma, etc., and acts as a tumor suppressor gene in tumors such as ovarian cancer, gastric cancer, colorectal cancer. However, the mechanism by which miR-378 regulates tumor angiogenesis remains to be further studied. This study mainly introduces the progress of miR-378 in the regulation of angiogenesis in four tumors(glioma, lung adenocarcinoma, ovarian cancer and rhabdomyosarcoma), providing a new idea for the treatment and prevention of these diseases.
MicroRNAs(mi RNAs) are non-coding small-molecule single-stranded RNAs of approximately 21 to 23 nucleotides in length in eukaryotes. The mi RNA inhibits translation or directly induces degradation by completely or incompletely binding to the target m RNA 3'UTR(3'-untranslated region, 3' non-coding region), and exerts a negative post-transcriptional regulation. Numerous studies have shown that mi RNAs participate in a variety of physiological and pathological processes in the body, and can affect angiogenesis by regulating their target genes to participate in signaling pathways. MiR-378 is one of the families of mi RNAs. At present,mi R-378 is mainly studied in the pathogenesis of tumorigenesis and angiogenesis, cardiovascular disease and cerebral ischemia, and most of the studies related to tumorigenesis and angiogenesis. MiR-378 plays a different role in different tumor tissues, and plays a role as a tumor-promoting gene in glioma, lung cancer, rhabdomyosarcoma, etc., and acts as a tumor suppressor gene in tumors such as ovarian cancer, gastric cancer, colorectal cancer. However, the mechanism by which miR-378 regulates tumor angiogenesis remains to be further studied. This study mainly introduces the progress of miR-378 in the regulation of angiogenesis in four tumors(glioma, lung adenocarcinoma, ovarian cancer and rhabdomyosarcoma), providing a new idea for the treatment and prevention of these diseases.
引文
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[27]张秀敏,于波,李学渊.过表达miR-378骨髓间充质干细胞移植治疗心肌梗死[J].中国组织工程研究,2017,21(9):1390-1396
[28]Yuan J,Liu H,Gao W,et al.MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress[J].Theranostics,2018,8(9):2565-2582
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[33]Zielaksteciwko AE,Browne JA.How to explore the function and importance of microRNAs:microRNAs expression profile and their target/pathway prediction in bovine ovarian cells[J].Methods in Molecular Biology,2018,1733:93
[34]Zhang Y,Yun Z,Gong L,et al.Comparison of miRNA evolution and function in plants and animals[J].Microrna,2018,7(1):4
[35]Fabbri M.MicroRNAs and mi-rceptors:a new mechanism of action for intercellular communication[J].Philos Trans R Soc Lond B Biol Sci,2018,373(1737):20160486
[36]Xu Y,Yuan FE,Chen QX,et al.Molecular mechanisms involved in angiogenesis and potential target of antiangiogenesis in human glioblastomas[J].Glioma,2018,1(2):35-42
[37]Li LY.Targeting tumor vasculature for anti-cancer therapy[J].Clinical Journal of Cancer Biotherm,2001,8(3):163-3167
[38]Folkman J.Angiogenesis in cancer,vascular,rheumatoid and other disease[J].Nature Medicine,1995,1(1):27-31
[39]Bauer AJ,Terrell R,Doniparthi NK,et al.Vascular endothelial growth factor monoclonal antibody inhibits growth of anaplastic thyroid cancer xenografts in nude mice[J].Thyroid Official Journal of the American Thyroid Association,2002,12(11):953
[40]Yaguang Hu,Xi Lu,Yue Xu,et al.Salubrinal attenuated retinal neovascularization by inhibiting CHOP-HIF-1α-VEGF pathways[J].Oncotarget,2017,8(44):77219-77232
[41]Tang J,Xia J,Zhang X.The relationship between the level of serum HIF-1α,MMP-2 and VEGF and clinical features in patients with non-small cell lung cancer[J].Chinese Journal of Clinical Rational Drug Use,2018
[42]Ai P,Shen B,Pan H,et al.MiR-411 suppressed vein wall fibrosis by downregulating MMP-2 via targeting HIF-1α[J].Journal of Thrombosis&Thrombolysis,2018,45(2):264-273
[43]Liu G,Liu L,Pathology DO.Expression of HIF-1αand MMP-2 in gastric cancer and their clinicopathological significance[J].Contemporary Medicine,2018
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