双环醇联合异甘草酸镁治疗甲亢性肝损害的疗效观察
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摘要
目的探讨双环醇联合异甘草酸镁治疗甲亢性肝损害的疗效观察。方法 60例甲亢性肝损害患者随机分为观察组和对照组,每组30例,观察组应用异甘草酸镁联合双环醇,治疗组单用异甘草酸镁,治疗1周后进行疗效及不良反应评价。结果两组治疗前总胆红素(TBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)组间比较差异均无统计学意义(P>0.05),治疗后两组肝功能指标(TBIL、ALT、AST)均较治疗前显著下降(P<0.05),且两组间比较观察组疗效优于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论采用双环醇联合异甘草酸镁的治疗方案安全、有效,应进行临床推广。
Objective To abserve effects of combination of Bicyclol tablets and magnesium isoglycyrrhizinate injection on liver function abnormality induced by hyperthyroidism.Methods 60 cases of liver function abnormality induced by hyperthyroidism were randomly divided into the observation group and the control group,with 30 cases in each group.Both groups were administered with magnesium isoglycyrrhizinate injection,bicyclol tablets were given to the observation group in addition.The therapeutic efficacy and adverse reactions were evaluated after 1-week therapy.Results There is no statistics significance among factors such as TBIL,ALT and AST before treatment between the two groups(P>0.05).The level of liver function indexes such as TBIL,ALT and AST decreased in both groups(P<0.05).The decreases of these factors of the observation group were better than those in the control group and there was statistical significance between the two groups(P<0.05).There was no statistical significance in adverse reactions between the two groups(P >0.05).Conclusion The combined therapy of bicyclol tablets and magnesium Isoglycyrrhizinate injection was safe and effective and can be promoted in clinical practice.
Objective To abserve effects of combination of Bicyclol tablets and magnesium isoglycyrrhizinate injection on liver function abnormality induced by hyperthyroidism.Methods 60 cases of liver function abnormality induced by hyperthyroidism were randomly divided into the observation group and the control group,with 30 cases in each group.Both groups were administered with magnesium isoglycyrrhizinate injection,bicyclol tablets were given to the observation group in addition.The therapeutic efficacy and adverse reactions were evaluated after 1-week therapy.Results There is no statistics significance among factors such as TBIL,ALT and AST before treatment between the two groups(P>0.05).The level of liver function indexes such as TBIL,ALT and AST decreased in both groups(P<0.05).The decreases of these factors of the observation group were better than those in the control group and there was statistical significance between the two groups(P<0.05).There was no statistical significance in adverse reactions between the two groups(P >0.05).Conclusion The combined therapy of bicyclol tablets and magnesium Isoglycyrrhizinate injection was safe and effective and can be promoted in clinical practice.
引文
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[8]曾乌查,林学德,张志锋,等.双环醇片防治肿瘤化疗药物性肝损害的研究[J].中国当代医药,2011,18(17):5-6.
[9]廖绪强,赵端壁,张奕贤.替比夫定联合多烯磷脂酰胆碱及双环醇治疗慢性乙型肝炎合并脂肪性肝病的疗效分析[J].中国医药指南,2014,12(20):267-268.
[10]李志宏,郝磊,孔佩艳,等.异甘草酸镁治疗化疗药物性肝损害的临床疗效观察[J].实用临床医药杂志,2011,15(1):88-89.
[2] Kubota S,Amino N,Matsumoto Y,et al. Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves'disease and painless thyroiditis[J]. Thyroid,2008,18(3):283-287.
[3] Woeber KA. Methimazole-induced hepatotoxicity[J]. Endocr Pract,2002,8(3):222-224.
[4] Malik R,Hodgson H. The relationship between the thyroid gland and liver[J]. QJM,2002,95(9):559-569.
[5]任留梅,刘萍,卫红艳,等. Graves病甲亢肝损害与免疫因素关系的探讨[J].实用医学杂志,2011,27(3):436-438.
[6]赵家军.甲状腺疾病与肝脏[J].中华肝脏病杂志,2014,22(3):165-167.
[7]姜曼蕾,许飞,唐长玖.双环醇治疗酒精性肝炎的临床疗效观察[J].江西医药,2014,49(11):1255-1257.
[8]曾乌查,林学德,张志锋,等.双环醇片防治肿瘤化疗药物性肝损害的研究[J].中国当代医药,2011,18(17):5-6.
[9]廖绪强,赵端壁,张奕贤.替比夫定联合多烯磷脂酰胆碱及双环醇治疗慢性乙型肝炎合并脂肪性肝病的疗效分析[J].中国医药指南,2014,12(20):267-268.
[10]李志宏,郝磊,孔佩艳,等.异甘草酸镁治疗化疗药物性肝损害的临床疗效观察[J].实用临床医药杂志,2011,15(1):88-89.