蒲地蓝联合他克莫司对口腔糜烂型扁平苔癣的疗效分析
|
摘要
目的:探讨口服蒲地蓝与局部他克莫司的联合应用对糜烂型扁平苔藓(erosive oral lichen planus, eOLP)的治疗效果。方法:采用随机数字表法,将160例糜烂型扁平苔藓患者分为两组,每组各80例。试验组采用蒲地蓝与他克莫司联合给药;对照组他克莫司单独给药治疗。对治疗后第1周及第2周,患者病变范围、糜烂程度以及总体病情进行评估,同时分析治疗前后,外周血T淋巴细胞亚群的变化。结果:治疗后两组体征评分以及VAS评分均较同组治疗前降低(P<0.05);试验组治疗后第2周体征评分低于对照组(P<0.05);病情总体改善情况,试验组显著高于对照组(P<0.05)。试验组治疗后,CD3、CD4和CD4/CD8显著升高,CD8显著降低(P<0.05)。结论:运用蒲地蓝口服液全身用药糜烂型扁平苔藓辅以他克莫司局部辅助治疗,能提高治疗效果,是一种临床上可行的治疗方案。
Objective:To explore the effect of combined application of Pudilan and Tacrolimus on erosive lichen(erosive oral lichen planus, eOLP). Methods:A total of 160 patients with eOLP were divided into two groups. 80 cases were given Pudilan and Tacrolimus in the experimental group and 80 cases were only given Tacrolimus. The range of disease, the degree of erosion and the overall condition were evaluated at the first week and two weeks after treatment. Meanwhile, the changes of T lymphocyte subsets in peripheral blood were analyzed before and after treatment. Results: After treatment, the physical score and VAS score of two groups were lower than those in the same group before(P<0.05), and the score in the experimental group was lower than that in the control group at the second week(P<0.05).The overall improvement of the condition was significantly higher in the experimental group than that in the control group(P<0.05). CD3 and CD4/CD8 were significantly increasedand CD8 significantly decreased after treatment in the experimental group(P<0.05). Conclusion: Pudilan in the treatment of erosive lichen planus combined with Tacrolimus has topical therapy and can improve the therapeutic effect. It is a clinically feasible treatment scheme.
Objective:To explore the effect of combined application of Pudilan and Tacrolimus on erosive lichen(erosive oral lichen planus, eOLP). Methods:A total of 160 patients with eOLP were divided into two groups. 80 cases were given Pudilan and Tacrolimus in the experimental group and 80 cases were only given Tacrolimus. The range of disease, the degree of erosion and the overall condition were evaluated at the first week and two weeks after treatment. Meanwhile, the changes of T lymphocyte subsets in peripheral blood were analyzed before and after treatment. Results: After treatment, the physical score and VAS score of two groups were lower than those in the same group before(P<0.05), and the score in the experimental group was lower than that in the control group at the second week(P<0.05).The overall improvement of the condition was significantly higher in the experimental group than that in the control group(P<0.05). CD3 and CD4/CD8 were significantly increasedand CD8 significantly decreased after treatment in the experimental group(P<0.05). Conclusion: Pudilan in the treatment of erosive lichen planus combined with Tacrolimus has topical therapy and can improve the therapeutic effect. It is a clinically feasible treatment scheme.
引文
[1] 刘东娟,陈谦明. 口腔扁平苔藓的诊断与治疗[J]. 中国实用口腔科杂志, 2017, 10(9):518-521.
[2] 董俊平.Toll样受体9基因多态性与口腔扁平苔藓治疗及预后的关系研究[J].中国药物与临床, 2016, 16(12):1798-1800.
[3] 李梅. 他克莫司软膏与白芍总苷治疗口腔扁平苔藓的临床疗效分析[J].实用临床医药杂志,2016,20(19):152-153.
[4] 李昭萍. 杞菊地黄汤加二仙汤加减对口腔扁平苔藓患者炎症因子及HSP27表达水平的影响[J]. 四川中医,2017,35(9):145-148.
[5] 王秀.他克莫司软膏配合308 nm准分子激光治疗面部白癜风临床研究[J].中国现代药物应用,2018,12(1): 116-117.
[6] 李璐璐,张耕.他克莫司致肾病综合征患者药物性肝损伤[J].中国医院药学杂志,2017, 37(14):1419-1420.
[7] 石娴,邹爱玲,付曼妮,等. 卡泊三醇软膏联合转移因子治疗扁平苔癣的临床研究[J]. 现代药物与临床,2018,33(1):105-109.
[8] 王劲超.外用他克莫司软膏治疗扁平苔藓的疗效观察[J].全科口腔医学电子杂志, 2016, 3(9):46-49.
[9] 梁桂丽.蒲地蓝联合利巴韦林喷雾剂治疗小儿普通型手足口病疗效观察[J].临床合理用药杂志, 2017, 10(1):95-96.
[10] 王腾宇,白根本. 基于生物信息学预测蒲公英干预炎症的“药效网络”及机制研究[J]. 江苏中医药, 2018,50(2): 73-75.
[11] 王倩,别玉龙,王豆,等. 蒲公英多糖对溃疡性结肠炎大鼠IL-6/STAT3信号通路的影响[J].中国应用生理学杂志,2017,33(5):422-425.
[12] 陈捷,费立龙,郜罕,等. 羟氯喹联合复方倍他米松注射液治疗口腔扁平苔藓的临床研究[J]. 现代药物与临床,2018,33(1):110-113.
[13] 黄志波. 板蓝根药理作用、临床应用及不良反应分析[J].医药前沿,2017,7(5):63-64.
[14] 李生柏.他克莫司软膏治疗糜烂型口腔扁平苔癣的效果评价[J].临床合理用药杂志,2018,11(11):42-43.
[15] 王秋玲,蒋小玲,黄妮娜,等. 凋亡蛋白Bcl-2、Bax表达检测在口腔扁平苔藓诊治中的临床意义[J]. 现代医学,2018,46(2):101-105.
[16] 罗晓平,于之伦,邓超,等. 黄芩素对2,4,6-三硝基苯磺酸诱导的小鼠实验性肠炎的作用和机制[J]. 中国药理学与毒理学杂志, 2017, 31(6):541-546.
[17] 赵军. 中药材黄芩对幽门螺杆菌体外抗菌活性的作用分析[J].中国现代药物应用, 2017, 11(8):195-196.
[18] 辛明,王加众,刘卿,等.地丁豆根白术汤抗肿瘤作用的实验研究[J].中国现代医生,2015,53(33):25-27.
[19] 陈福稳,相顺利,曹伟,等. 补中益气汤对口腔扁平苔藓患者炎症因子、T细胞亚群、疼痛症状的影响[J]. 四川中医,2017,35(12):165-167.
[20] 毛其芬,上官醉飞. 细胞免疫功能及辅助型T细胞因子在口腔扁平苔藓中的作用[J]. 中国微生态学杂志,2017,29(2):162-165.
[21] 王翠杰,李言君,薛江南,等. 调节性T细胞和白介素15在口腔扁平苔藓中的表达及意义[J].上海口腔医学,2016,25(4):438-442.
[22] 朱丽芳,余淼,潘璐,等. CD3+、CD8+T细胞与口腔扁平苔藓糜烂的关系[J].口腔生物医学, 2017, 8(4):195-198.
[23] 段红云.曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓(EOLP)的疗效及安全性[J].全科口腔医学电子杂志,2018,5(9):35-37.
[24] 于乐斌,于珺,宋永海,等.口腔扁平苔藓患者CD4+T细胞中miR-155功能调控对CD4+T细胞和角质形成细胞的影响[J].北京口腔医学,2017,25(5):266-270.
[2] 董俊平.Toll样受体9基因多态性与口腔扁平苔藓治疗及预后的关系研究[J].中国药物与临床, 2016, 16(12):1798-1800.
[3] 李梅. 他克莫司软膏与白芍总苷治疗口腔扁平苔藓的临床疗效分析[J].实用临床医药杂志,2016,20(19):152-153.
[4] 李昭萍. 杞菊地黄汤加二仙汤加减对口腔扁平苔藓患者炎症因子及HSP27表达水平的影响[J]. 四川中医,2017,35(9):145-148.
[5] 王秀.他克莫司软膏配合308 nm准分子激光治疗面部白癜风临床研究[J].中国现代药物应用,2018,12(1): 116-117.
[6] 李璐璐,张耕.他克莫司致肾病综合征患者药物性肝损伤[J].中国医院药学杂志,2017, 37(14):1419-1420.
[7] 石娴,邹爱玲,付曼妮,等. 卡泊三醇软膏联合转移因子治疗扁平苔癣的临床研究[J]. 现代药物与临床,2018,33(1):105-109.
[8] 王劲超.外用他克莫司软膏治疗扁平苔藓的疗效观察[J].全科口腔医学电子杂志, 2016, 3(9):46-49.
[9] 梁桂丽.蒲地蓝联合利巴韦林喷雾剂治疗小儿普通型手足口病疗效观察[J].临床合理用药杂志, 2017, 10(1):95-96.
[10] 王腾宇,白根本. 基于生物信息学预测蒲公英干预炎症的“药效网络”及机制研究[J]. 江苏中医药, 2018,50(2): 73-75.
[11] 王倩,别玉龙,王豆,等. 蒲公英多糖对溃疡性结肠炎大鼠IL-6/STAT3信号通路的影响[J].中国应用生理学杂志,2017,33(5):422-425.
[12] 陈捷,费立龙,郜罕,等. 羟氯喹联合复方倍他米松注射液治疗口腔扁平苔藓的临床研究[J]. 现代药物与临床,2018,33(1):110-113.
[13] 黄志波. 板蓝根药理作用、临床应用及不良反应分析[J].医药前沿,2017,7(5):63-64.
[14] 李生柏.他克莫司软膏治疗糜烂型口腔扁平苔癣的效果评价[J].临床合理用药杂志,2018,11(11):42-43.
[15] 王秋玲,蒋小玲,黄妮娜,等. 凋亡蛋白Bcl-2、Bax表达检测在口腔扁平苔藓诊治中的临床意义[J]. 现代医学,2018,46(2):101-105.
[16] 罗晓平,于之伦,邓超,等. 黄芩素对2,4,6-三硝基苯磺酸诱导的小鼠实验性肠炎的作用和机制[J]. 中国药理学与毒理学杂志, 2017, 31(6):541-546.
[17] 赵军. 中药材黄芩对幽门螺杆菌体外抗菌活性的作用分析[J].中国现代药物应用, 2017, 11(8):195-196.
[18] 辛明,王加众,刘卿,等.地丁豆根白术汤抗肿瘤作用的实验研究[J].中国现代医生,2015,53(33):25-27.
[19] 陈福稳,相顺利,曹伟,等. 补中益气汤对口腔扁平苔藓患者炎症因子、T细胞亚群、疼痛症状的影响[J]. 四川中医,2017,35(12):165-167.
[20] 毛其芬,上官醉飞. 细胞免疫功能及辅助型T细胞因子在口腔扁平苔藓中的作用[J]. 中国微生态学杂志,2017,29(2):162-165.
[21] 王翠杰,李言君,薛江南,等. 调节性T细胞和白介素15在口腔扁平苔藓中的表达及意义[J].上海口腔医学,2016,25(4):438-442.
[22] 朱丽芳,余淼,潘璐,等. CD3+、CD8+T细胞与口腔扁平苔藓糜烂的关系[J].口腔生物医学, 2017, 8(4):195-198.
[23] 段红云.曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓(EOLP)的疗效及安全性[J].全科口腔医学电子杂志,2018,5(9):35-37.
[24] 于乐斌,于珺,宋永海,等.口腔扁平苔藓患者CD4+T细胞中miR-155功能调控对CD4+T细胞和角质形成细胞的影响[J].北京口腔医学,2017,25(5):266-270.