2014–2017年云南省大理州囊尾蚴病新发病例流行病学分析
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摘要
目的了解云南省大理州囊尾蚴病新发病例流行病学特征,为制定该病防治策略提供科学依据。方法以大理州寄生虫病防治中心为数据采集点,采用回顾性调查方法,收集2014–2017年该中心所有囊尾蚴病住院病例资料,并对符合条件的囊尾蚴病新发病例进行流行病学分析。结果 2014–2017年大理州寄生虫病防治中心共收治囊尾蚴病住院病例1 552人·次,其中新发囊尾蚴病病例549例。新发囊尾蚴病病例以神经系统囊尾蚴病为主,占88.16%(484/549);症状以癫痫为主(51.37%),其次为头痛(40.98%)和头晕(18.76%)。患者以白族中年男性农民为主,病例在大理州各县(市)均有分布,但以洱源县(26.78%)和大理市(19.49%)为主。2014–2017年新发囊尾蚴病发病率分别为4.423/10万、3.837/10万、3.765/10万和3.442/10万,各年间发病率差异无统计学意义(χ~2=4.595,P> 0.05)。结论大理州仍为囊尾蚴病流行区,今后应加强对当地囊尾蚴病的监测与防治工作。
Objective To understand the basic information and epidemic characteristics of new cases of cysticercosis in Dali Prefecture, Yunnan Province, so as to provide the evidence for formulating the prevention and control strategy of cysticercosis.Methods The data of inpatients in the Dali Parasitic Disease Prevention and Control Center from 2014 to 2017 were collected and the eligible data of new cases of cysticercosis were analyzed by the epidemiological method. Results There were 1 552 patients with cysticercosis, including 549 new cases of cysticercosis. Among the new cysticercosis patients, most were neurocysticercosis cases(484/549, 88.16%). The symptoms included epilepsy and headache(51.73%), headache(40.98%), and dizziness(18.76%). The new cysticercosis patients were mainly middle-aged male farmers of Bai nationality, and they were distributed in all counties(cities) of Dali Prefecture, especially in Eryuan County(26.78%), and Dali City(19.49%). The annual incidence rate was 4.423/10~5 in 2014, 3.837/10~5 in 2015, 3.765/10~5 in 2016, and 3.442/10~5 in 2017, and there was no significance among the different years' incidence(χ~2= 4.595, P > 0.05). Conclusion Dali Prefecture is still an endemic area of cysticercosis. Therefore, the monitoring, prevention and control of the disease should be strengthened.
Objective To understand the basic information and epidemic characteristics of new cases of cysticercosis in Dali Prefecture, Yunnan Province, so as to provide the evidence for formulating the prevention and control strategy of cysticercosis.Methods The data of inpatients in the Dali Parasitic Disease Prevention and Control Center from 2014 to 2017 were collected and the eligible data of new cases of cysticercosis were analyzed by the epidemiological method. Results There were 1 552 patients with cysticercosis, including 549 new cases of cysticercosis. Among the new cysticercosis patients, most were neurocysticercosis cases(484/549, 88.16%). The symptoms included epilepsy and headache(51.73%), headache(40.98%), and dizziness(18.76%). The new cysticercosis patients were mainly middle-aged male farmers of Bai nationality, and they were distributed in all counties(cities) of Dali Prefecture, especially in Eryuan County(26.78%), and Dali City(19.49%). The annual incidence rate was 4.423/10~5 in 2014, 3.837/10~5 in 2015, 3.765/10~5 in 2016, and 3.442/10~5 in 2017, and there was no significance among the different years' incidence(χ~2= 4.595, P > 0.05). Conclusion Dali Prefecture is still an endemic area of cysticercosis. Therefore, the monitoring, prevention and control of the disease should be strengthened.
引文
[1]Aung AK,Spelman DW.Taenia solium taeniasis and cysticercosis in Southeast Asia[J].Am J Trop Med Hyg,2016,94(5):947-954.
[2]李焕璋,臧新中,钱门宝,等.囊尾蚴病流行现况及研究进展[J].中国血吸虫病防治杂志,2018,30(1):99-103.
[3]Gonzales I,Rivera JT,Garcia HH,et al.Pathogenesis of Taenia solium taeniasis and cysticercosis[J].Parasite Immunol,2016,38(3):136-146.
[4]Garcia HH,Gonzalez AE,Evans CA,et al.Taenia solium cysticercosis.[J].Lancet,2003,362(9383):547-556.
[5]Carabin H,Ndimubanzi PC,Budke CM,et al.Clinical manifestations associated with neurocysticercosis:a systematic review[J].PLoS Negl Trop Dis,2011,5(5):e1152.
[6]Rizvi SA,Saleh AM,Frimpong H,et al.Neurocysticercosis:a case report and brief review[J].Asian Pac J Trop Med,2016,9(1):98-100.
[7]汤林华,许隆祺,陈颖丹.中国寄生虫病防治与研究[M].北京:北京科学技术出版社,2012:347-352.
[8]李焕璋,薛靖波,钱门宝,等.绦虫病/囊尾蚴病现场问卷调查管Chin J Schisto Control 2019Vol.31No.2理系统的设计与应用[J].中国血吸虫病防治杂志,2018,30(2):211-214,225.
[9]官亚宜,周晓俊,熊彦红.规范诊断依据避免误诊漏诊——《囊尾蚴病的诊断》标准解读[J].中国卫生标准管理,2012,3(5):36-40.
[10]张懋功.云南年鉴[M].昆明:云南年鉴社,2017:152-154.
[11]方文,陈凤,王月一.1999~2006年大理州囊虫病住院病例流行病学特征分析[J].中国病原生物学杂志,2009,4(4):298-300.
[12]陈凤,陈绍荣,方文,等.大理州1991~2001年囊虫病住院病例回顾性调查[J].中国病原生物学杂志,2007,2(5):380-382.
[13]方文.1986~1998年大理州人群猪带绦/囊虫病流行病学分析[J].中国寄生虫病防治杂志,2001,14(2):39-41.
[14]Tellez-Zenteno JF,Hernandez-Ronquillo L.Epidemiology of neurocysticercosis and epilepsy,is everything described?[J].Epilepsy Behav,2017,76:146-150.
[15]Garcia HH,Nash TE,Del Brutto OH.Clinical symptoms,diagnosis,and treatment of neurocysticercosis[J].Lancet Neurol,2014,13(12):1202-1215.
[16]Garcia HH,Rodriguez S,Friedland JS,et al.Immunology of Taenia solium taeniasis and human cysticercosis[J].Parasite Immunol,2014,36(8):388-396.
[17]Liu GZ,Li YS,Cui Y,et al.Cysticercosis in Shandong province,eastern China[J].Emerg Infect Dis,2018,24(2):384-385.
[18]Schantz PM,Moore AC,Mu?oz JL,et al.Neurocysticercosis in an orthodox Jewish community in New York city[J].N Engl J Med,1992,327(10):692-695.
[2]李焕璋,臧新中,钱门宝,等.囊尾蚴病流行现况及研究进展[J].中国血吸虫病防治杂志,2018,30(1):99-103.
[3]Gonzales I,Rivera JT,Garcia HH,et al.Pathogenesis of Taenia solium taeniasis and cysticercosis[J].Parasite Immunol,2016,38(3):136-146.
[4]Garcia HH,Gonzalez AE,Evans CA,et al.Taenia solium cysticercosis.[J].Lancet,2003,362(9383):547-556.
[5]Carabin H,Ndimubanzi PC,Budke CM,et al.Clinical manifestations associated with neurocysticercosis:a systematic review[J].PLoS Negl Trop Dis,2011,5(5):e1152.
[6]Rizvi SA,Saleh AM,Frimpong H,et al.Neurocysticercosis:a case report and brief review[J].Asian Pac J Trop Med,2016,9(1):98-100.
[7]汤林华,许隆祺,陈颖丹.中国寄生虫病防治与研究[M].北京:北京科学技术出版社,2012:347-352.
[8]李焕璋,薛靖波,钱门宝,等.绦虫病/囊尾蚴病现场问卷调查管Chin J Schisto Control 2019Vol.31No.2理系统的设计与应用[J].中国血吸虫病防治杂志,2018,30(2):211-214,225.
[9]官亚宜,周晓俊,熊彦红.规范诊断依据避免误诊漏诊——《囊尾蚴病的诊断》标准解读[J].中国卫生标准管理,2012,3(5):36-40.
[10]张懋功.云南年鉴[M].昆明:云南年鉴社,2017:152-154.
[11]方文,陈凤,王月一.1999~2006年大理州囊虫病住院病例流行病学特征分析[J].中国病原生物学杂志,2009,4(4):298-300.
[12]陈凤,陈绍荣,方文,等.大理州1991~2001年囊虫病住院病例回顾性调查[J].中国病原生物学杂志,2007,2(5):380-382.
[13]方文.1986~1998年大理州人群猪带绦/囊虫病流行病学分析[J].中国寄生虫病防治杂志,2001,14(2):39-41.
[14]Tellez-Zenteno JF,Hernandez-Ronquillo L.Epidemiology of neurocysticercosis and epilepsy,is everything described?[J].Epilepsy Behav,2017,76:146-150.
[15]Garcia HH,Nash TE,Del Brutto OH.Clinical symptoms,diagnosis,and treatment of neurocysticercosis[J].Lancet Neurol,2014,13(12):1202-1215.
[16]Garcia HH,Rodriguez S,Friedland JS,et al.Immunology of Taenia solium taeniasis and human cysticercosis[J].Parasite Immunol,2014,36(8):388-396.
[17]Liu GZ,Li YS,Cui Y,et al.Cysticercosis in Shandong province,eastern China[J].Emerg Infect Dis,2018,24(2):384-385.
[18]Schantz PM,Moore AC,Mu?oz JL,et al.Neurocysticercosis in an orthodox Jewish community in New York city[J].N Engl J Med,1992,327(10):692-695.