塞来昔布结合卡马西平对癫痫患者疗效及血清炎症因子的影响
|
摘要
目的:探讨塞来昔布结合卡马西平治疗癫痫的疗效及其机制。方法:选取癫痫患者60例随机分为对照组和观察组,每组30例。对照组口服卡马西平,观察组患者在对照组药物治疗的基础上加服塞来昔布,两组患者连续治疗3个月。观察两组患者临床疗效,同时比较治疗前与治疗后以及对照组与观察组血清炎症因子TNF-α、IL-6和CRP水平。结果:观察组临床总有效率96.7%与对照组总有效率60.0%比较差异有统计学意义(P<0.01)。观察组治疗前与治疗后TNF-α、IL-6、CRP比较差异有统计学意义(P<0.01),且治疗后观察组TNF-α、IL-6和CRP含量明显低于对照组(P<0.01)。结论:塞来昔布结合卡马西平治疗癫痫患者疗效显著,其机制可能是通过降低癫痫患者体内的炎症反应。
Objective: To explore the efficacy and mechanism of Celecoxib combined with Carbamazepine for the treatment of epilepsy.Methods: 60 epilepsy patients were randomly divided into control group(30 cases) and observation group(30 cases).The control group was given Carbamazepine orally,and the observation group was given Celecoxib combined with Carbamazepine.The two groups of patients were being treated for three months.The clinical efficacy of two groups was observed and the levels of TNF-α、IL-6 and CRP in serum were tested before and after treatment.Results: The total effective rate of the observation group was 96.7%,significant higher than that of the control group(60.0%),the difference was statistically significant(P<0.01).The TNF-α、IL-6 and CRP in the observation group before treatment were significantly lower than after treatment with statistical difference(P<0.01),and the levels of TNF-α、IL-6 and CRP in the observation group were significantly lower than those in the control group after treatment with statistical difference(P<0.01).Conclusion: Celecoxib combined with Carbamazepine in treatment of epilepsy has significant clinical effect,and the mechanism may be to reduce the inflammatory reaction in epilepsy.
Objective: To explore the efficacy and mechanism of Celecoxib combined with Carbamazepine for the treatment of epilepsy.Methods: 60 epilepsy patients were randomly divided into control group(30 cases) and observation group(30 cases).The control group was given Carbamazepine orally,and the observation group was given Celecoxib combined with Carbamazepine.The two groups of patients were being treated for three months.The clinical efficacy of two groups was observed and the levels of TNF-α、IL-6 and CRP in serum were tested before and after treatment.Results: The total effective rate of the observation group was 96.7%,significant higher than that of the control group(60.0%),the difference was statistically significant(P<0.01).The TNF-α、IL-6 and CRP in the observation group before treatment were significantly lower than after treatment with statistical difference(P<0.01),and the levels of TNF-α、IL-6 and CRP in the observation group were significantly lower than those in the control group after treatment with statistical difference(P<0.01).Conclusion: Celecoxib combined with Carbamazepine in treatment of epilepsy has significant clinical effect,and the mechanism may be to reduce the inflammatory reaction in epilepsy.
引文
[1]FABENE P F,BRAMANTI P,CONSTANTIN G.The emerging role for chemokines in epilepsy[J].Neuroimmunol,2010,224(1/2):22-27.
[2]秦文艳,齐越,韦丹,等.塞来昔布对海人藻酸致痫大鼠Iba-1及GFAP表达的影响[J].实验动物科学,2016,33(6):31-34.
[3]中华医学会.临床诊疗指南:癫痫病分册[M].北京:人民卫生出版社,2007:25-29.
[4]胡婷婷.癫痫康胶囊联合奥卡西平治疗癫痫的临床研究[J].现代药物临床,2018,33(7):1640-1643.
[5]叶冰,金瑞峰,田广燕.多耐药基因1C3435T和C1236T多态性与癫痫患者苯巴比妥血清药物浓度的关系[J].脑与神经疾病杂志,2015,2(23):94-98.
[6]杨志刚,李巷,刘人凯,等.托吡酯、卡马西平与丙戊酸钠治疗脑炎继发癫痫效果分析[J].西北药学杂志,2015,3(5):295-297.
[7]耿虹,张佳,马俊兵.塞来昔布在大鼠痫性发作中的作用及对大鼠认知功能的影响[J].包头医学院学报,2013,29(4):14-16.
[8]ALI C,NICOL O,DOCAGNE F,et al.Jschemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain[J].J Cere Blood Flow Metab,2000,20(6):956.
[9]蔡发良.复方丹参滴丸联合抗癫痫药物治疗外伤性癫痫的临床效果及对炎症因子和生化指标的影响[J].中华临床医师杂志(电子版),2015,9(15):2969-2972.
[2]秦文艳,齐越,韦丹,等.塞来昔布对海人藻酸致痫大鼠Iba-1及GFAP表达的影响[J].实验动物科学,2016,33(6):31-34.
[3]中华医学会.临床诊疗指南:癫痫病分册[M].北京:人民卫生出版社,2007:25-29.
[4]胡婷婷.癫痫康胶囊联合奥卡西平治疗癫痫的临床研究[J].现代药物临床,2018,33(7):1640-1643.
[5]叶冰,金瑞峰,田广燕.多耐药基因1C3435T和C1236T多态性与癫痫患者苯巴比妥血清药物浓度的关系[J].脑与神经疾病杂志,2015,2(23):94-98.
[6]杨志刚,李巷,刘人凯,等.托吡酯、卡马西平与丙戊酸钠治疗脑炎继发癫痫效果分析[J].西北药学杂志,2015,3(5):295-297.
[7]耿虹,张佳,马俊兵.塞来昔布在大鼠痫性发作中的作用及对大鼠认知功能的影响[J].包头医学院学报,2013,29(4):14-16.
[8]ALI C,NICOL O,DOCAGNE F,et al.Jschemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain[J].J Cere Blood Flow Metab,2000,20(6):956.
[9]蔡发良.复方丹参滴丸联合抗癫痫药物治疗外伤性癫痫的临床效果及对炎症因子和生化指标的影响[J].中华临床医师杂志(电子版),2015,9(15):2969-2972.