脂类激素应用于脊髓损伤的研究进展
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摘要
脊髓损伤(Spinal cord injury,SCI)是中枢神经系统严重损伤性疾病,具有高死亡率和高致残率等特点。随着医疗及护理技术的不断进步,SCI的患者生存率得到明显提高。目前,SCI除手术治疗外,药物治疗也具有不可替代的作用。近年来,研究人员关于脂类激素治疗SCI的实验性研究不断深入,逐步了解了脂类激素潜在的神经保护功能,这为将来脂类激素作为神经保护剂应用于SCI的治疗提供了可能。
Spinal cord injury(SCI)with high mortality and high morbidity,is a serious injury to the central nervous system.With the continuous improvement in medical and nursing techniques,the survival rate of patients with SCI has been significantly improved.At present,In addition to surgical treatment of SCI,the drug treatment also has an irreplaceable role.In recent years,with the deepening research on the experimental study of lipid hormones in SCI,and gradually understand the potential neuroprotective function in lipid hormones,which means that the lipid hormones may be used as neuroprotective agents in the treatment of SCI in the future.
Spinal cord injury(SCI)with high mortality and high morbidity,is a serious injury to the central nervous system.With the continuous improvement in medical and nursing techniques,the survival rate of patients with SCI has been significantly improved.At present,In addition to surgical treatment of SCI,the drug treatment also has an irreplaceable role.In recent years,with the deepening research on the experimental study of lipid hormones in SCI,and gradually understand the potential neuroprotective function in lipid hormones,which means that the lipid hormones may be used as neuroprotective agents in the treatment of SCI in the future.
引文
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[4]Bracken M B.Methylprednisolone and acute spinal cord injury-An update of the randomized evidence[J].Spine,2001,26(24):S47-S54.
[5]Libro R,Giacoppo S,Bramanti P,et al.Is the Wnt/betacatenin pathway involved in the anti-inflammatory activity of glucocorticoids in spinal cord injury[J].Neuroreport,2016,27(14):1086-1094.
[6]Ito Y,Sugimoto Y,Tomioka M,et al.Does High Dose Methylprednisolone Sodium Succinate Really Improve Neurological Status in Patient With Acute Cervical Cord Injury?A Prospective Study About Neurological Recovery and Early Complications[J].Spine,2009,34(20):2121-2124.
[7]Qian T,Guo X,Levi A D,et al.High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients[J].Spinal Cord,2005,43(4):199-203.
[8]Verhovshek T,Rudolph L M,Sengelaub D R.Brainderived neurotrophic factor and androgen interactions in spinal neuromuscular systems[J].Neuroscience,2013,239:103-114.
[9]Gray K M,Derosa A.Subcutaneous pellet testosterone replacement therapy:the"first steps"in treating men with spinal cord injuries[J].J Am Osteopath Assoc,2013,113(12):921-925.
[10]Byers J S,Huguenard A L,Kuruppu D,et al.Neuroprotective effects of testosterone on motoneuron and muscle morphology following spinal cord injury[J].J Comp Neurol,2012,520(12):2683-2696.
[11]Alexander C J,Sipski M L,Findley T.Sexual activities,desire,and satisfaction in males pre-spinal and post-spinal cord injury[J].Archives of Sexual Behavior,1993,22(3):217-228.
[12]Beggs L A,Ye F,Ghosh P,et al.Sclerostin inhibition prevents spinal cord injury-induced cancellous bone loss[J].J Bone Miner Res,2015,30(4):681-689.
[13]Arbo B D,Bennetti F,Ribeiro M F.Astrocytes as a target for neuroprotection:Modulation by progesterone and dehydroepiandrosterone[J].Prog Neurobiol,2016,144:27-47.
[14]Schumacher M,Mattern C,Ghoumari A,et al.Revisiting the roles of progesterone and allopregnanolone in the nervous system:resurgence of the progesterone receptors[J].Prog Neurobiol,2014,113:6-39.
[15]Zukor K,Belin S,Wang C,et al.Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury[J].J Neurosci,2013,33(39):15350-15361.
[16]Williams R R,Henao M,Pearse D D,et al.Permissive Schwann cell graft/spinal cord interfaces for axon regeneration[J].Cell Transplant,2015,24(1):115-131.
[17]Alizadeh A,Karimi-Abdolrezaee S.Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury[J].Journal of Physiology London,2016,594(13):3539-3552.
[18]Alizadeh A,Dyck S M,Karimi-Abdolrezaee S.Myelin damage and repair in pathologic CNS:challenges and prospects[J].Frontiers in Molecular Neuroscience,2015,8:27.
[19]Lee J Y,Choi S Y,Oh T H,et al.17beta-Estradiol inhibits apoptotic cell death of oligodendrocytes by inhibiting RhoA-JNK3activation after spinal cord injury[J].Endocrinology,2012,153(8):3815-3827.
[20]Acaz-Fonseca E,Sanchez-Gonzalez R,Azcoitia I,et al.Role of astrocytes in the neuroprotective actions of 17 beta-estradiol and selective estrogen receptor modulators[J].Molecular and Cellular Endocrinology,2014,389(1-2):48-57.
[21]Lee J Y,Choi H Y,Na W H,et al.17 beta-Estradiol Inhibits MMP-9 and SUR1/TrpM4 Expression and Activation and Thereby Attenuates BSCB Disruption/Hemorrhage After Spinal Cord Injury in Male Rats[J].Endocrinology,2015,156(5):1838-1850.
[22]Na W,Lee J Y,Kim W S,et al.17 beta-Estradiol Ameliorates Tight Junction Disruption via Repression of MMP Transcription[J].Molecular Endocrinology,2015,29(9):1347-1361.
[23]Letaif O B,Cristante A F,de Barros T E,et al.Effects of estrogen on functional and neurological recovery after spinal cord injury:An experimental study with rats[J].Clinics,2015,70(10):700-705.
[24]Forman B M,Tontonoz P,Chen J,et al.15-Deoxy-delta 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma[J].Cell,1995,83(5):803-812.
[25]Straus D S,Glass C K.Cyclopentenone prostaglandins:new insights on biological activities and cellular targets[J].Med Res Rev,2001,21(3):185-210.
[26]Haskew-Layton R E,Payappilly J B,Xu H B,et al.15-Deoxy-Delta 12,14-prostaglandin J2(15d-PGJ2)protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPAR gamma[J].Journal of Neurochemistry,2013,124(4):536-547.