聚乳酸材料在3D打印中的研究与应用进展
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摘要
综述了最近PLA材料在3D打印中的研究和应用进展。介绍了PLA的结构性质和合成方法,以及熔融沉积成型3D打印PLA材料的特性。重点介绍了最近3D打印PLA材料的改性和成型工艺研究。最后详细描述了3D打印PLA材料在生物医学领域中的应用进展,并对未来的发展方向和应用前景进行了展望。
The recent research and application of 3D printing PLA materials are reviewed. The structure and synthesis of PLA,and the characteristic of 3D printing PLA materials through fused deposition modeling( FDM) are introduced. The recent investigations of modification and process of 3D printing PLA materials are emphatically discussed. The application of 3D printing PLA materials in biomedicine is briefly described. The future development and application prospect are analyzed and forecasted.
The recent research and application of 3D printing PLA materials are reviewed. The structure and synthesis of PLA,and the characteristic of 3D printing PLA materials through fused deposition modeling( FDM) are introduced. The recent investigations of modification and process of 3D printing PLA materials are emphatically discussed. The application of 3D printing PLA materials in biomedicine is briefly described. The future development and application prospect are analyzed and forecasted.
引文
[1]王雪莹. 3D打印技术与产业的发展及前景分析[J].中国高新技术企业,2012(26):3-5.
[2]李小丽,马剑雄,李萍,等. 3D打印技术及应用趋势[J].自动化仪表,2014,35(1):1-5.
[3]闵玉勤,王浩仁,黄伟,等.适应3D打印技术的聚合物材料研究进展[J].粘接,2016(1):36-41.
[4]刘洋子健,夏春蕾,张均,等.熔融沉积成型3D打印技术应用进展及展望[J].工程塑料应用,2017,45(3):130-133.
[5]姜辉.无卤阻燃增韧聚乳酸3D打印材料的制备及性能研究[D].沈阳:沈阳工业大学,2016.
[6]杨波.聚乳酸/改性微原纤纤维素复合材料制备及性能研究[D].大连:大连理工大学,2015.
[7]李鹏,刘磊力,路庆辉,等.聚乳酸合成工艺研究[J].应用化工,2008,37(4):352-354.
[8] Zhao Y,Wang Z,Wang J,et al. Direct synthesis of poly(D,L-lactic acid)by melt polycondensation and its application in drug delivery[J]. Journal of Applied Polymer Science,2004,91(4):2143-2150.
[9]潘鑫龙.基于聚乳酸的熔融沉积成型系统研究[D].桂林:桂林电子科技大学,2014.
[10] Ling X,Spruiell J E. Analysis of the complex thermal behavior of poly(L-lactic acid)film. I. Samples crystallized from the glassy state[J]. Journal of Polymer Science Part B:Polymer Physics,2006,44(22):3200-3214.
[11] Appuhamillage G,Reagan J,Khorsandi S,et al. 3D printed remendable polylactic acid blends with uniform mechanical strength enabled by a dynamic Diels-Alder reaction[J]. Polymer Chemistry,2017,8(13):2087-2092.
[12]燕丰. JSR推出3D打印用高韧聚乳酸[J].橡塑技术与装备,2015(10):43.
[13]何军亮,孙东成,曹艳霞,等.用于FDM的PLA共混改性[J].工程塑料应用,2017,45(6):7-11.
[14]范东风,费旭,徐龙权. 3D打印聚乳酸材料的改性[J].大连工业大学学报,2017,36(3):198-200.
[15]姚禹国,徐美娜,周刚明.可生物降解PLA/PBAT/PHBV共混3D打印复合材料开发[J].浙江纺织服装职业技术学院学报,2017,9(3):15-18.
[16]陈卫,汪艳,傅轶.用于3D打印的改性聚乳酸丝材的制备与研究[J].工程塑料应用,2015,43(8):21-24.
[17] Xu W,Pranovich A,Uppstu P,et al. Novel biorenewable composite of wood polysaccharide and polylactic acid for three dimensional printing[J]. Carbohydrate Polymers,2018,187:51-58.
[18] Esposito Corcione C,Gervaso F,Scalera F,et al. The feasibility of printing polylactic acid&ash-nanohydroxyapatite composites using a low-cost fused deposition modeling 3D printer[J]. Journal of Applied Polymer Science,2017,134(13):44656.
[19] Chen Q,Mangadlao J D,Wallat J,et al. 3D Printing biocompatible polyurethane/poly(lactic acid)/graphene oxide nanocomposites:Anisotropic properties[J]. Acs Applied Materials&Interfaces,2017,9(4):4015-4023.
[20] Wang Z,Xu J,Lu Y,et al. Preparation of 3D printable micro/nanocellulose-polylactic acid(MNC/PLA)composite wire rods with high MNC constitution[J]. Industrial Crops&Products,2017,109:889-896.
[21]李天才. 3D打印用聚乳酸复合材料的研究[J].铸造,2017,66(8):806-809.
[22]王莹,梁硕,孙百威,等.聚乳酸/木粉3D打印复合材料的制备与性能研究[J].塑料科技,2017,45(10):80-85.
[23]肖苏华,张静娴,张文华.应用于3D打印的聚乳酸/纳米Ti O2复合材料制备及力学性能研究[J].塑料工程学报,2017,24(3):219-224.
[24]毕永豹,杨兆哲,许民. 3D打印PLA/麦秸粉复合材料的力学性能优化[J].工程塑料应用,2017,45(4):24-28.
[25] Kao C T,Lin C C,Chen Y W,et al. Poly(dopamine)coating of 3D printed poly(lactic acid)scaffolds for bone tissue engineering[J]. Materials Science&Engineering C,2015,56:165-173.
[26] Gao Y,Yan L,Xiaoran H,et al. Preparation and properties of novel thermoplastic vulcanizate based on bio-based polyester/polylactic acid,and its application in 3D printing[J]. Polymers,2017,9:694.
[27] Gramlich,William M. Toughening polylactide with phaseseparating complex copolymer architectures[J]. Macromolecular Chemistry and Physics,2015,216(2):145-155.
[28]黄凯兵,姚异渊,杨秀文.二醋酸纤维素酯接枝聚乳酸的制备及性能研究[J].湖南大学学报:自然科学版,2016,43(12):104-109.
[29] Wu W,Ye W,Wu Z,et al. Influence of layer thickness,raster angle,deformation temperature and recovery temperature on the shape-memory effect of 3D-Printed polylactic acid samples[J]. Materials,2017,10(8):970.
[30] Chacón J M,Caminero M A,García-Plaza E,et al. Additive manufacturing of PLA structures using fused deposition modelling:Effect of process parameters on mechanical properties andtheir optimal selection[J]. Materials&Design,2017,124:143-157.
[31]蔡冯杰,祝成炎,田伟,等. 3D打印成型的玻璃纤维增强聚乳酸基复合材料[J].纺织学报,2017,38(10):13-18.
[32]闫丽静,李真真,冯婧,等.聚乳酸(PLA)3D打印工艺研究[J].塑料工业,2017,45(2):71-74.
[33]徐运祺,潘永红,王万卷,等. 3D打印参数对聚乳酸力学性能的影响[J].塑料工业,2017,45(12):67-69.
[34] Wurm M C,Mst T,Bergauer B,et al. In-vitro evaluation of polylactic acid(PLA)manufactured by fused deposition modeling[J]. Journal of Biological Engineering,2017,11(29):1-9.
[35] Wang M,Favi P,Cheng X,et al. Cold atmospheric plasma(CAP)surface nanomodified 3D printed polylactic acid(PLA)scaffolds for bone regeneration[J]. Acta Biomater,2016,46:256-265.
[36] Tao Z,Ahn H J,Lian C,et al. Design and optimization of prosthetic foot by using polylactic acid 3D printing[J].Journal of Mechanical Science&Technology,2017,31(5):2393-2398.
[37] Flores R L,Liss H,Raffaelli S,et al. The technique for 3D printing patient-specific models for auricular reconstruction[J]. J Craniomaxillofac Surg,2017,45(6):937-943.
[38]张登央,张英,张丽君,等. 3D技术制备骨修复生物材料的功能和安全性评价[J].中国生物工程杂志,2015,35(7):55-61.
[39]张海峰,杜子婧,毛曦媛,等. 3D打印PLA-HA复合材料构建组织工程骨的实验研究[J].国际骨科学杂志,2016,37(1):57-63.
[40] Water J J,Bohr A,Boetker J,et al. Three-dimensional printing of drug-eluting implants:preparation of an antimicrobial polylactide feedstock material[J]. Journal of Pharmaceutical Sciences,2015,104(3):1099-1107.
[41] Weisman J A,Nicholson J C,Tappa K,et al. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications[J].International Journal of Nanomedicine, 2015, 10:357-370.
[42]黄从云,朱剑华,刘欣,等. 3D打印技术在肝脏切除术中的应用[J].中国普外基础与临床杂志,2015,11:1351-1353.
[43]郑锋,余正希,陈宣煌,等.基于数字化设计和3D打印胫骨近端骨折内固定的关键技术[J].中国组织工程研究,2016,20(26):3837-3842.
[2]李小丽,马剑雄,李萍,等. 3D打印技术及应用趋势[J].自动化仪表,2014,35(1):1-5.
[3]闵玉勤,王浩仁,黄伟,等.适应3D打印技术的聚合物材料研究进展[J].粘接,2016(1):36-41.
[4]刘洋子健,夏春蕾,张均,等.熔融沉积成型3D打印技术应用进展及展望[J].工程塑料应用,2017,45(3):130-133.
[5]姜辉.无卤阻燃增韧聚乳酸3D打印材料的制备及性能研究[D].沈阳:沈阳工业大学,2016.
[6]杨波.聚乳酸/改性微原纤纤维素复合材料制备及性能研究[D].大连:大连理工大学,2015.
[7]李鹏,刘磊力,路庆辉,等.聚乳酸合成工艺研究[J].应用化工,2008,37(4):352-354.
[8] Zhao Y,Wang Z,Wang J,et al. Direct synthesis of poly(D,L-lactic acid)by melt polycondensation and its application in drug delivery[J]. Journal of Applied Polymer Science,2004,91(4):2143-2150.
[9]潘鑫龙.基于聚乳酸的熔融沉积成型系统研究[D].桂林:桂林电子科技大学,2014.
[10] Ling X,Spruiell J E. Analysis of the complex thermal behavior of poly(L-lactic acid)film. I. Samples crystallized from the glassy state[J]. Journal of Polymer Science Part B:Polymer Physics,2006,44(22):3200-3214.
[11] Appuhamillage G,Reagan J,Khorsandi S,et al. 3D printed remendable polylactic acid blends with uniform mechanical strength enabled by a dynamic Diels-Alder reaction[J]. Polymer Chemistry,2017,8(13):2087-2092.
[12]燕丰. JSR推出3D打印用高韧聚乳酸[J].橡塑技术与装备,2015(10):43.
[13]何军亮,孙东成,曹艳霞,等.用于FDM的PLA共混改性[J].工程塑料应用,2017,45(6):7-11.
[14]范东风,费旭,徐龙权. 3D打印聚乳酸材料的改性[J].大连工业大学学报,2017,36(3):198-200.
[15]姚禹国,徐美娜,周刚明.可生物降解PLA/PBAT/PHBV共混3D打印复合材料开发[J].浙江纺织服装职业技术学院学报,2017,9(3):15-18.
[16]陈卫,汪艳,傅轶.用于3D打印的改性聚乳酸丝材的制备与研究[J].工程塑料应用,2015,43(8):21-24.
[17] Xu W,Pranovich A,Uppstu P,et al. Novel biorenewable composite of wood polysaccharide and polylactic acid for three dimensional printing[J]. Carbohydrate Polymers,2018,187:51-58.
[18] Esposito Corcione C,Gervaso F,Scalera F,et al. The feasibility of printing polylactic acid&ash-nanohydroxyapatite composites using a low-cost fused deposition modeling 3D printer[J]. Journal of Applied Polymer Science,2017,134(13):44656.
[19] Chen Q,Mangadlao J D,Wallat J,et al. 3D Printing biocompatible polyurethane/poly(lactic acid)/graphene oxide nanocomposites:Anisotropic properties[J]. Acs Applied Materials&Interfaces,2017,9(4):4015-4023.
[20] Wang Z,Xu J,Lu Y,et al. Preparation of 3D printable micro/nanocellulose-polylactic acid(MNC/PLA)composite wire rods with high MNC constitution[J]. Industrial Crops&Products,2017,109:889-896.
[21]李天才. 3D打印用聚乳酸复合材料的研究[J].铸造,2017,66(8):806-809.
[22]王莹,梁硕,孙百威,等.聚乳酸/木粉3D打印复合材料的制备与性能研究[J].塑料科技,2017,45(10):80-85.
[23]肖苏华,张静娴,张文华.应用于3D打印的聚乳酸/纳米Ti O2复合材料制备及力学性能研究[J].塑料工程学报,2017,24(3):219-224.
[24]毕永豹,杨兆哲,许民. 3D打印PLA/麦秸粉复合材料的力学性能优化[J].工程塑料应用,2017,45(4):24-28.
[25] Kao C T,Lin C C,Chen Y W,et al. Poly(dopamine)coating of 3D printed poly(lactic acid)scaffolds for bone tissue engineering[J]. Materials Science&Engineering C,2015,56:165-173.
[26] Gao Y,Yan L,Xiaoran H,et al. Preparation and properties of novel thermoplastic vulcanizate based on bio-based polyester/polylactic acid,and its application in 3D printing[J]. Polymers,2017,9:694.
[27] Gramlich,William M. Toughening polylactide with phaseseparating complex copolymer architectures[J]. Macromolecular Chemistry and Physics,2015,216(2):145-155.
[28]黄凯兵,姚异渊,杨秀文.二醋酸纤维素酯接枝聚乳酸的制备及性能研究[J].湖南大学学报:自然科学版,2016,43(12):104-109.
[29] Wu W,Ye W,Wu Z,et al. Influence of layer thickness,raster angle,deformation temperature and recovery temperature on the shape-memory effect of 3D-Printed polylactic acid samples[J]. Materials,2017,10(8):970.
[30] Chacón J M,Caminero M A,García-Plaza E,et al. Additive manufacturing of PLA structures using fused deposition modelling:Effect of process parameters on mechanical properties andtheir optimal selection[J]. Materials&Design,2017,124:143-157.
[31]蔡冯杰,祝成炎,田伟,等. 3D打印成型的玻璃纤维增强聚乳酸基复合材料[J].纺织学报,2017,38(10):13-18.
[32]闫丽静,李真真,冯婧,等.聚乳酸(PLA)3D打印工艺研究[J].塑料工业,2017,45(2):71-74.
[33]徐运祺,潘永红,王万卷,等. 3D打印参数对聚乳酸力学性能的影响[J].塑料工业,2017,45(12):67-69.
[34] Wurm M C,Mst T,Bergauer B,et al. In-vitro evaluation of polylactic acid(PLA)manufactured by fused deposition modeling[J]. Journal of Biological Engineering,2017,11(29):1-9.
[35] Wang M,Favi P,Cheng X,et al. Cold atmospheric plasma(CAP)surface nanomodified 3D printed polylactic acid(PLA)scaffolds for bone regeneration[J]. Acta Biomater,2016,46:256-265.
[36] Tao Z,Ahn H J,Lian C,et al. Design and optimization of prosthetic foot by using polylactic acid 3D printing[J].Journal of Mechanical Science&Technology,2017,31(5):2393-2398.
[37] Flores R L,Liss H,Raffaelli S,et al. The technique for 3D printing patient-specific models for auricular reconstruction[J]. J Craniomaxillofac Surg,2017,45(6):937-943.
[38]张登央,张英,张丽君,等. 3D技术制备骨修复生物材料的功能和安全性评价[J].中国生物工程杂志,2015,35(7):55-61.
[39]张海峰,杜子婧,毛曦媛,等. 3D打印PLA-HA复合材料构建组织工程骨的实验研究[J].国际骨科学杂志,2016,37(1):57-63.
[40] Water J J,Bohr A,Boetker J,et al. Three-dimensional printing of drug-eluting implants:preparation of an antimicrobial polylactide feedstock material[J]. Journal of Pharmaceutical Sciences,2015,104(3):1099-1107.
[41] Weisman J A,Nicholson J C,Tappa K,et al. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications[J].International Journal of Nanomedicine, 2015, 10:357-370.
[42]黄从云,朱剑华,刘欣,等. 3D打印技术在肝脏切除术中的应用[J].中国普外基础与临床杂志,2015,11:1351-1353.
[43]郑锋,余正希,陈宣煌,等.基于数字化设计和3D打印胫骨近端骨折内固定的关键技术[J].中国组织工程研究,2016,20(26):3837-3842.