补肾祛邪疗法治疗慢性乙型肝炎概述
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摘要
综述近年来补肾祛邪法治疗慢性乙型肝炎的疗效机制。认为肾虚邪伏、正虚邪恋与正气胶着导致慢性乙型肝炎持续进展、迁延不愈;补肾(兼以益气、养阴、健脾、疏肝等)与祛邪(清热解毒、祛湿化痰、活血化瘀等)双管齐下,可整体调节患者气血脏腑功能,抵御甚至清除体内邪毒;补肾祛邪治疗慢性乙型肝炎具有抗乙肝病毒、保肝、抗肝纤维化及降低乙肝病毒变异的作用。
The therapeutic mechanism of kidney-tonifying and pathogen-eliminating therapy in treating chronichepatitis B was reviewed. It is indicated that kidney deficiency with hidden pathogen and lingering pathogens dueto deficient healthy Qi result into the sustained development and difficulty in the healing of chronic hepatitis B;thecombination of therapy for tonifying kidney assistant by strengthening Qi,nourishing yin,invigorating spleen,orsoothing liver, and eliminating pathogens(clearing heating and removing toxicity, dispelling dampness andresolving phlegm,activating blood and removing stasis) can regulate the function of Zang-fu organs and Qi andblood,prevent the attack of hepatitis B virus or even eliminate hepatitis B virus;kidney-tonifying and pathogen-eliminating therapy has the actions of counteracting hepatitis B virus,protecting liver,anti-hepatic fibrosis andreducing hepatitis B virus mutation in treating chronic hepatitis B.
The therapeutic mechanism of kidney-tonifying and pathogen-eliminating therapy in treating chronichepatitis B was reviewed. It is indicated that kidney deficiency with hidden pathogen and lingering pathogens dueto deficient healthy Qi result into the sustained development and difficulty in the healing of chronic hepatitis B;thecombination of therapy for tonifying kidney assistant by strengthening Qi,nourishing yin,invigorating spleen,orsoothing liver, and eliminating pathogens(clearing heating and removing toxicity, dispelling dampness andresolving phlegm,activating blood and removing stasis) can regulate the function of Zang-fu organs and Qi andblood,prevent the attack of hepatitis B virus or even eliminate hepatitis B virus;kidney-tonifying and pathogen-eliminating therapy has the actions of counteracting hepatitis B virus,protecting liver,anti-hepatic fibrosis andreducing hepatitis B virus mutation in treating chronic hepatitis B.
引文
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[25]田桂珍.五灵丸与联苯双酯治疗慢性乙型肝炎的疗效比较[J].中国中医药信息杂志,2002,9(11):6.
[26]杨海燕.垂盆草冲剂治疗慢性乙肝200例临床观察[J].邯郸医学高等专科学校学报,2005,18(1):44.
[27]张俊富,崔丽安,苑淑芳,等.肝炎灵治疗慢性乙型肝炎的疗效分析[J].天津中医,1995,12(4):10.
[28]陈淼生,周庭雄,左建华.猪苓多糖与重组干扰素治疗慢性乙肝对比观察[J].时珍国医国药,2000,11(10):942.
[29] Zeng M D,Lu LG,Mao Y M,et al. Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model[J]. World J Gastroenterol,2005,42(6):1437.
[30]李慧贞.补肾清透治疗慢性乙型肝炎病毒携带者随机对照研究[D].广州:广州中医药大学,2012.
[31]徐春军.乙肝病毒基因变异与中医药治疗策略探讨[J].中国中医药信息杂志,2002,9(11):24.
[2]李保良,高月求.王灵台从肾虚邪伏论治轻度慢性乙肝经验[J].辽宁中医杂志,2011,38(1):1964.
[3]王琦,姚实林,董静,等.阳虚体质者内分泌及免疫功能变化[J].中西医结合学报,2008,6(12):1226.
[4]李子征,裴振安,林青梅,等.中医体质分型与乙肝病毒感染的相关性研究[J].中国中医基础医学杂志,2011,17(2):189.
[5]郭新新,车念聪,王志强,等. 125例慢性乙肝病毒携带者中医体质类型分布特征研究[J].中西医结合肝病杂志,2013,23(1):47.
[6]邢宇锋,张晓晖,陈英杰,等.慢性乙肝病毒携带者中医证候分布规律调查及病机探讨[J].中西医结合肝病杂志,2012,22(4):196.
[7]吴继勇.彭胜权教授治疗肝病经验[J].新中医,2002,32(11):8.
[8]赵汉鸣.吴德光诊治“乙肝”经验[J].江西中医药,2002,31(4):3.
[9]孙钧.试论乙型肝炎的辨病与辨证[J].中西医结合肝病杂志,2002,12(1):52.
[10]廖宇,宋翊.中医对慢性乙型肝炎论治的重新认识[J].四川中医,2015,12(33):30.
[11]中华中医药学会内科肝胆病学组.慢性乙型肝炎中医诊疗专家共识[J].临床肝胆病杂志,2012,28(3):164.
[12]尹常健.病毒性肝炎中医临床研究的思路和方法[J].中医杂志,1994,35(2):109.
[13] McCulloch M,Broffman M,Gao J,et al. Chinese herbal medicine and interferon in the treatment of chronic hepatitis B:a metaanalysis of randomized, controlled trials[J]. Am J Public Health,2002,92(10):1619.
[14]李小科,叶永安.中药治疗慢性乙型肝炎的免疫评价指标探讨[J].中国中医基础医学杂志,2013,19(2):191.
[15]彭皓均,沈强,刘亚敏,等.补肾清毒法对慢性乙型肝炎患者外周血树突状细胞表型和功能的影响[J].中西医结合肝病杂志,2012,22(6):348.
[16]王灵台,陈建杰,高月求,等.补肾法为主治疗慢性肝病的临床研究[J].中医药通报,2005,4(2):26.
[17]周飞,王灵台,陈建杰,等.拉米夫定和补肾方联合应用治疗慢性乙型肝炎的疗效及对YMDD区域的影响[J].中国中西医结合杂志,2003,23(6):417.
[18]王丽佳,杨志云,王宪波.中药单体成分对慢性乙型肝炎免疫调节机制的研究策略及进展[J].中国实验方剂学杂志,2013,19(7):358.
[19]陆伦根,曾民德,茅益民,等.氧化苦参碱胶囊治疗慢性乙型病毒性肝炎的随机、双盲、安慰剂对照多中心临床研究(I)[J].肝脏,2002,7(4):218.
[20]陈明,杨慧芳,陈锵,等.八宝丹胶囊治疗慢性乙型肝炎顽固性黄疸50例[J].陕西中医学院学报,2009,32(3):28.
[21] Chen F P,Kung Y Y,Chen Y C,et al. Frequency and pattern of Chinese herbal medicine prescriptions for chronic hepatitis in Taiwan[J]. J Ethnopharmacol,2008,117(1):84.
[22] Chang J S,Wang K C,Liu H W,et al. Sho-saiko-to(XiaoChai-Hu-Tang)and crude Saikosaponins inhibit hepatitis B virus in a stable HBV producing cell line[J]. Am J Chin Med,2007,35(2):341.
[23]徐春军,刘燕玲,李秀惠,等.益气凉血解毒类中药对拉米夫定诱发乙肝病毒YMDD变异的干预作用[J].中华中医药杂志,2008,23(12):1079.
[24] Zhang L, Wang G, Hou W, et al. Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China:an analytical review[J]. Hepatology,2010,51(2):690.
[25]田桂珍.五灵丸与联苯双酯治疗慢性乙型肝炎的疗效比较[J].中国中医药信息杂志,2002,9(11):6.
[26]杨海燕.垂盆草冲剂治疗慢性乙肝200例临床观察[J].邯郸医学高等专科学校学报,2005,18(1):44.
[27]张俊富,崔丽安,苑淑芳,等.肝炎灵治疗慢性乙型肝炎的疗效分析[J].天津中医,1995,12(4):10.
[28]陈淼生,周庭雄,左建华.猪苓多糖与重组干扰素治疗慢性乙肝对比观察[J].时珍国医国药,2000,11(10):942.
[29] Zeng M D,Lu LG,Mao Y M,et al. Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model[J]. World J Gastroenterol,2005,42(6):1437.
[30]李慧贞.补肾清透治疗慢性乙型肝炎病毒携带者随机对照研究[D].广州:广州中医药大学,2012.
[31]徐春军.乙肝病毒基因变异与中医药治疗策略探讨[J].中国中医药信息杂志,2002,9(11):24.