多焦视网膜电流图在不同程度近视眼视网膜功能状态分析中的应用
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摘要
目的利用多焦视网膜电流图探讨不同程度近视眼黄斑部的视网膜功能状态,为今后的临床眼科工作提供有价值的参考信息。方法选择2015年6月—2017年6月间郑州市第二人民医院眼科门诊所收治的18～32岁近视眼患者76例(113眼)作为研究对象,将其按照近视程度分成中低度近视组,高度近视组,另取同期健康人群做对照组,对所有受试者均进行多焦视网膜电流图进行检测,并对检测结果进行对比分析。结果经对比发现,三组患者N_1波、P_1波的振幅密度在第1环最大,随离心度的不断增加振幅密度逐渐降低;潜伏期在第1环最小,随离心度的不断增加逐渐延迟。高度近视组N_1波和P_1波各环的振幅密度较中低度近视组、正常对照组比较发生显著降低(P<0.05),而中低度组与正常对照组比较无差异(P>0.05)。结论经多焦视网膜电流图可发现,高度近视mERG各环振幅密度较正常对照组发生明显降低,1环潜伏期较正常对照组延长;中低度近视mERG各环振幅密度及潜伏期与正常组无明显差别,这对于眼科临床诊治具有重要意义,值得关注。
Objective Multifocal electroretinogram(mf-ERG) was used to investigate the retinal function of macula of myopia with different degrees.Methods Chose patients aged 18-32 years with myopia were selected from the department of ophthalmology of our hospital from June 2015 to June 2017, 76 cases(113 eyes) as the research object, according to the degree of myopia it into moderate myopia groups, high myopia group, the other healthy people do take the same period the control group, of all the subjects are more focal electroretinogram for testing, and the testing results were analyzed.Results By comparison, the amplitude density of N_1 wave and P_1 wave was the largest in the first ring, and the amplitude density decreased gradually as the degree of centrifugation increased. The incubation period was minimal in the first ring and was delayed gradually with increasing degrees of eccentricity. The amplitude density of the rings of N_1 and P_1 waves in the high myopia group was significantly lower than that of the medium and low myopia group and the normal control group(P<0.05), while there was no difference between the medium and low myopia group and the normal control group(P>0.05).Conclusion The multi-focal electroretinogram can be found that the amplitude density of each ring of high myopia mERG is significantly lower than that of the normal control group. The latency of 1-ring is prolonged compared with the normal control group. The amplitude density and latency of mERG in the middle and low myopia are not obvious with the normal group.
Objective Multifocal electroretinogram(mf-ERG) was used to investigate the retinal function of macula of myopia with different degrees.Methods Chose patients aged 18-32 years with myopia were selected from the department of ophthalmology of our hospital from June 2015 to June 2017, 76 cases(113 eyes) as the research object, according to the degree of myopia it into moderate myopia groups, high myopia group, the other healthy people do take the same period the control group, of all the subjects are more focal electroretinogram for testing, and the testing results were analyzed.Results By comparison, the amplitude density of N_1 wave and P_1 wave was the largest in the first ring, and the amplitude density decreased gradually as the degree of centrifugation increased. The incubation period was minimal in the first ring and was delayed gradually with increasing degrees of eccentricity. The amplitude density of the rings of N_1 and P_1 waves in the high myopia group was significantly lower than that of the medium and low myopia group and the normal control group(P<0.05), while there was no difference between the medium and low myopia group and the normal control group(P>0.05).Conclusion The multi-focal electroretinogram can be found that the amplitude density of each ring of high myopia mERG is significantly lower than that of the normal control group. The latency of 1-ring is prolonged compared with the normal control group. The amplitude density and latency of mERG in the middle and low myopia are not obvious with the normal group.
引文
[1] 罗俊,刘双珍,吴小影.高度近视患者多焦视网膜电流图的评估[J].国际眼科杂志,2009,6(6):1339-1341.
[2] Holden, BA, Fricke TR, Wilson DA, et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology.2016,123(5):1036-1042.
[3] Ohno-Matsui, K. What Is the Fundamental Nature of Pathologic Myopia Retina.2017,37(16):1043-1048.
[4] Silva, R. Myopic maculopathy: A review. Ophthalmologica 2012,228:197-213.
[5] Shimada N, Tanaka Y, Tokoro T, et al. Natural course of myopic traction maculopathy and factors associated with progression or resolution. Am J Ophthalmol. 2013,156(5):948-957.
[6] 刘卫,徐格致,姜春晖.高度近视眼底后极血管弓旁的光相干断层扫描观察[J].中华眼底病杂志,2010,26(1):75-77.
[7] Kawabata H1, Adachi-Usami E. Multifocal electroretinogram in myopia. Invest Ophthalmol Vis Sci 1997,38(13):2844-2851.
[8] Luu CD Foulds WS Tan DT. Features of the multifocal electroretinogram may predict the rate of myopia progression in children. Ophthalmology 2007,114(8):1433-1438.
[9] Kader MA. Electrophysiological study of myopia.Saudi J Ophthalmol 2012,26(1): 91-99.
[10] Mo Y, Wang MF, Zho uLL. Risk facto r analysis o f 167 patients with high myopia[J].Int Ophthalmol,2010,34(4):218-221.
[2] Holden, BA, Fricke TR, Wilson DA, et al. Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology.2016,123(5):1036-1042.
[3] Ohno-Matsui, K. What Is the Fundamental Nature of Pathologic Myopia Retina.2017,37(16):1043-1048.
[4] Silva, R. Myopic maculopathy: A review. Ophthalmologica 2012,228:197-213.
[5] Shimada N, Tanaka Y, Tokoro T, et al. Natural course of myopic traction maculopathy and factors associated with progression or resolution. Am J Ophthalmol. 2013,156(5):948-957.
[6] 刘卫,徐格致,姜春晖.高度近视眼底后极血管弓旁的光相干断层扫描观察[J].中华眼底病杂志,2010,26(1):75-77.
[7] Kawabata H1, Adachi-Usami E. Multifocal electroretinogram in myopia. Invest Ophthalmol Vis Sci 1997,38(13):2844-2851.
[8] Luu CD Foulds WS Tan DT. Features of the multifocal electroretinogram may predict the rate of myopia progression in children. Ophthalmology 2007,114(8):1433-1438.
[9] Kader MA. Electrophysiological study of myopia.Saudi J Ophthalmol 2012,26(1): 91-99.
[10] Mo Y, Wang MF, Zho uLL. Risk facto r analysis o f 167 patients with high myopia[J].Int Ophthalmol,2010,34(4):218-221.