不同剂量注射用心肌肽在重度子痫前期心功能异常产妇剖宫产术后应用的有效性及安全性观察
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摘要
目的探讨20mg和40mg剂量注射用心肌肽在重度子痫前期心功能异常产妇剖宫产术后应用对心脏功能的影响及安全性。方法选取2014年8月至2017年6月本院收治的126例重度子痫前期心功能异常剖宫产产妇,随机分为A组(术后给予20mg/d剂量注射用心肌肽治疗,63例)和B组(术后给予40mg/d剂量注射用心肌肽治疗,63例),比较两组患者心功能、心电活动、肌钙蛋白水平及不良反应发生率。结果术后第0d,两组患者cTnT、LVEF、LEVDD水平比较差异无统计学意义(P> 0.05);术后第3d,两组患者cTnT、LEVDD水平较术后第0d显著下降,LVEF水平较术后第0d显著升高,但B组患者改善程度更显著(P <0.05)。两组患者恶心、呕吐、皮疹、头晕及肝肾损伤发生率比较差异无统计学意义(P> 0.05)。结论注射用心肌肽在重度子痫前期心功能异常产妇剖宫产术后应用可有效提高对心脏功能保护作用,给予40mg/d剂量治疗效果更为显著,且不提高药物不良反应发生率。
Objective To investigate the cardiac effects and safety of 20 mg and 40 mg injection of myocardial peptide for post-cesarean section in patients with severe preeclampsia. Methods Select 126 case of severe preeclampsia cardiac dysfunction cesarean section patients in our hospital from August 2014 to June 2017 as studying object, the patients were randomly divided into group A(63 cases treated with 20 mg/d injection of myocardial peptide after operation) and group B(63 cases treated with 40 mg/d injection of myocardial peptide after operation, the cardiac function, electrocardiogram activities, troponin levels and incidence of adverse reactions were compared.Results At the 0 th day after operation, the levels of cTnT, LVEF and LEVDD in the two groups were not statistically significant(P> 0.05); At the 3 th day after operation, the levels of cTnT and LEVDD in the two groups were significantly lower than those on the 0 th day after operation, the levels of LVEF was significant increased than that of at day 0 th, but the improvement in group B was more significant(P <0.05). Nausea, vomiting, rash, dizziness and the incidence of liver and kidney injury in both groups were not statistically significant(P> 0.05). Conclusion Cardiomyocyte injection of myocardial dysfunction in patients with severe preeclampsia maternal cesarean section can effectively improve the protection of cardiac function, given 40 mg/d dose of the treatment effect is more significant, and does not increase the incidence of adverse drug reactions.
Objective To investigate the cardiac effects and safety of 20 mg and 40 mg injection of myocardial peptide for post-cesarean section in patients with severe preeclampsia. Methods Select 126 case of severe preeclampsia cardiac dysfunction cesarean section patients in our hospital from August 2014 to June 2017 as studying object, the patients were randomly divided into group A(63 cases treated with 20 mg/d injection of myocardial peptide after operation) and group B(63 cases treated with 40 mg/d injection of myocardial peptide after operation, the cardiac function, electrocardiogram activities, troponin levels and incidence of adverse reactions were compared.Results At the 0 th day after operation, the levels of cTnT, LVEF and LEVDD in the two groups were not statistically significant(P> 0.05); At the 3 th day after operation, the levels of cTnT and LEVDD in the two groups were significantly lower than those on the 0 th day after operation, the levels of LVEF was significant increased than that of at day 0 th, but the improvement in group B was more significant(P <0.05). Nausea, vomiting, rash, dizziness and the incidence of liver and kidney injury in both groups were not statistically significant(P> 0.05). Conclusion Cardiomyocyte injection of myocardial dysfunction in patients with severe preeclampsia maternal cesarean section can effectively improve the protection of cardiac function, given 40 mg/d dose of the treatment effect is more significant, and does not increase the incidence of adverse drug reactions.
引文
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[2]魏素洁.重度子痫前期并发胎盘早剥的临床分析[J].世界最新医学信息文摘,2017,17(53):53-53.
[3]关健,陈小燕.子痫前期孕妇动态血压与异常心电图特点分析[J].中国临床新医学,2017(5):747-750.
[4]谢幸,苟文丽.《妇产科学》第8版[M].人民卫生出版社,2013:126-129.
[5]叶望莲,胡小玲.不同孕周早发型重度子痫前期对母婴的影响及围产结局分析[J].中国妇幼保健,2015,30(16):2506-2508.
[6]刘晋荣.早发型重度子痫前期126例临床分析[J].中华医学杂志,2014,94(37):2945-2947.
[7]李元成,沈伶,黄菊,等.重度子痫前期孕妇不良妊娠结局的危险因素分析[J].中国实验诊断学,2014,18(3):403-405.
[8]臧皓,李晓东,李丽,等.肌肽药理活性研究新进展[J].吉林中医药,2014,34(3):274-278.
[9]Song,Y.,Huang,Z.,Xu,J.,et al.Multimodal SPION-CREKA peptide based agents for molecular imaging of microthrombus in a rat myocardial ischemia-reperfusion model[J].Biomaterials,2014,35(9):2961-2970.
[10]Song,M.,Jang,H.,Lee,J.,et al.Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP[J].Biomaterials,2014,35(8):2436-2445.
[11]Teraguchi,I.,Imanishi,T.,Ozaki,Y.,et al.Acute-phase glucose fluctuation is negatively correlated with myocardial salvage after acute myocardial infarction-Involvement of monocyte subsets[J].Circulation journal,2014,78(1):170-179.
[12]Ng,L.L.,Sandhu,J.K.,Narayan,H.,et al.Proenkephalin and prognosis after acute myocardial infarction[J].Journal of the American College of Cardiology,2014,63(3):280-289.