miRNA与复发性流产的相关性研究
摘要
复发性流产因其病因和发病机制复杂,目前尚没有明确的临床诊疗方案,在遗传特性、发病机制、预防等方面有待探索。miRNA是一类内源性非编码RNA,参与调节人胎盘滋养细胞的增殖、凋亡、侵袭及血管生成。因此,本文通过介绍miRNA与复发性流产的相关性研究进展,以期为复发性流产的诊断和治疗提供新思路。
引文
[1] 谢幸.妇产科学[M].9版.北京:人民卫生出版社,2018:72.
[2] McQueen DB,Bernardi LA,Stephenson MD.Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise[J].Fertil Steril,2014,101(4):1026-1030.
[3] Li M,Marin-Muller C,Bharadwaj U,et al.MicroRNAs:control and loss of control in human physiology and disease[J].World J Surg,2009,33(4):667-684.
[4] Tomasetti M,Lee W,Santarelli L,et al.Exosome-derived microRNAs in cancer metabolism:possible implications in cancer diagnostics and therapy[J].Exp Mol Med,2017,49(1):e285.
[5] Burchard J,Zhang C,Liu AM,et al.microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma[J].Mol Syst Biol,2010,6:402.
[6] Callis TE,Pandya K,Seok HY,et al.MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice[J].J Clin Invest,2009,119(9):2772-2786.
[7] Bai Y,Yang W,Yang HX,et al.Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRⅡA expression[J].PLoS One,2012,7(6),e38875.
[8] Fu G,Ye G,Nadeem L,et al.MicroRNA-376c impairs transforming growth factor -β and nodal signaling to promote trophoblast cell proliferation and invasion[J].Hypertension,2013,61(4),864-872.
[9] Liu M,Wang Y,Lu H,et al.miR-518b enhances human trophoblast cell proliferation through targeting Rap1b and activating Ras-MAPK signal[J].Front Endocrinol(Lausanne),2018,9:100.
[10] Jiang L,Long A,Tan L,et al.Elevated microRNA-520g in pre-eclampsia inhibits migration and invasion of trophoblasts[J].Placenta,2017,51:70-75.
[11] Wu L,Song WY,Xie Y,et al.miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2[J].Cell Death Dis,2018,9(2),16.
[12] Zou AX,Chen B,Li Q,et al.MiR-134 inhibits infiltration of trophoblast cells in placenta of patients with preeclampsia by decreasing ITGB1 expression[J].Eur Rev Med Pharmacol Sci,2018,22(8):2199-2206.
[13] Williams PJ,Bulmer JN,Innes BA,et al.Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy[J].Biol Reprod 2011,84(6):1148-1153.
[14] Carmeliet P.Angiogenesis in life,disease and medicine[J].Nature,2005,438(7070):932-936.
[15] Gourvas V,Dalpa E,Konstantinidou A,et al.Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review) [J].Mol Med Rep,2012,6(1):23-27.
[16] Wang W,Feng L,Zhang H,et al.Preeclampsia up-regulates angiogenesis-associated microRNA (i.e.,miR-17,-20a,and-20b) that target ephrin-B2 and EPHB4 in human placenta [J].J Clin Endocrinol Metab,2012,97(6):E1051-E1059.
[17] Zhu Y,Lu H,Huo Z,et al.MicroRNA-16 inhibits feto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor [J].Sci Rep,2016,6:35536.
[18] Liu F,Wu W,Wu K,et al.MiR-203 participates in human placental angiogenesis by inhibiting VEGFA and VEGFR2 expression [J].Reprod Sci,2018,25(3):358-365.
[19] Hong F,Li Y,Xu Y.Decreased placental miR-126 expression and vascular endothelial growth factor levels in patients with pre-eclampsia [J].J Int Med Res,2014,42(6):1243-1251.
[20] Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2),261-271.
[21] Kuehbacher A,Urbich C,Zeiher AM,et al.Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis[J].Circ Rese,2007,101(1):59-68.
[22] Luo SS,Ishibashi O,Ishikawa G,et al.Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes[J].Biol Reprod,81(4),717-729.
[23] Qin W,Tang Y,Yang N,et al.Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion[J].Fertil Steril,2016,105(5):1247-1254.
[24] Zhang Y,Zhou J,Li MQ,et al.MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion[J].Cell Death Dis,2019,10(3):223.
[25] Zhao W,Shen WW,Cao XM,et al.Novel mechanism of miRNA-365-regulated trophoblast apoptosis in recurrent miscarriage[J].J Cell Mol Med,2017,21(10):2412-2425.
[26] Amin-Beidokhti M,Mirfakhraie R,Zare-Karizi S,et al.The role of parental microRNA alleles in recurrent pregnancy loss:an association study[J].Reprod Biomed Online,2017,34(3):325-330.
[2] McQueen DB,Bernardi LA,Stephenson MD.Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise[J].Fertil Steril,2014,101(4):1026-1030.
[3] Li M,Marin-Muller C,Bharadwaj U,et al.MicroRNAs:control and loss of control in human physiology and disease[J].World J Surg,2009,33(4):667-684.
[4] Tomasetti M,Lee W,Santarelli L,et al.Exosome-derived microRNAs in cancer metabolism:possible implications in cancer diagnostics and therapy[J].Exp Mol Med,2017,49(1):e285.
[5] Burchard J,Zhang C,Liu AM,et al.microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma[J].Mol Syst Biol,2010,6:402.
[6] Callis TE,Pandya K,Seok HY,et al.MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice[J].J Clin Invest,2009,119(9):2772-2786.
[7] Bai Y,Yang W,Yang HX,et al.Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRⅡA expression[J].PLoS One,2012,7(6),e38875.
[8] Fu G,Ye G,Nadeem L,et al.MicroRNA-376c impairs transforming growth factor -β and nodal signaling to promote trophoblast cell proliferation and invasion[J].Hypertension,2013,61(4),864-872.
[9] Liu M,Wang Y,Lu H,et al.miR-518b enhances human trophoblast cell proliferation through targeting Rap1b and activating Ras-MAPK signal[J].Front Endocrinol(Lausanne),2018,9:100.
[10] Jiang L,Long A,Tan L,et al.Elevated microRNA-520g in pre-eclampsia inhibits migration and invasion of trophoblasts[J].Placenta,2017,51:70-75.
[11] Wu L,Song WY,Xie Y,et al.miR-181a-5p suppresses invasion and migration of HTR-8/SVneo cells by directly targeting IGF2BP2[J].Cell Death Dis,2018,9(2),16.
[12] Zou AX,Chen B,Li Q,et al.MiR-134 inhibits infiltration of trophoblast cells in placenta of patients with preeclampsia by decreasing ITGB1 expression[J].Eur Rev Med Pharmacol Sci,2018,22(8):2199-2206.
[13] Williams PJ,Bulmer JN,Innes BA,et al.Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy[J].Biol Reprod 2011,84(6):1148-1153.
[14] Carmeliet P.Angiogenesis in life,disease and medicine[J].Nature,2005,438(7070):932-936.
[15] Gourvas V,Dalpa E,Konstantinidou A,et al.Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (review) [J].Mol Med Rep,2012,6(1):23-27.
[16] Wang W,Feng L,Zhang H,et al.Preeclampsia up-regulates angiogenesis-associated microRNA (i.e.,miR-17,-20a,and-20b) that target ephrin-B2 and EPHB4 in human placenta [J].J Clin Endocrinol Metab,2012,97(6):E1051-E1059.
[17] Zhu Y,Lu H,Huo Z,et al.MicroRNA-16 inhibits feto-maternal angiogenesis and causes recurrent spontaneous abortion by targeting vascular endothelial growth factor [J].Sci Rep,2016,6:35536.
[18] Liu F,Wu W,Wu K,et al.MiR-203 participates in human placental angiogenesis by inhibiting VEGFA and VEGFR2 expression [J].Reprod Sci,2018,25(3):358-365.
[19] Hong F,Li Y,Xu Y.Decreased placental miR-126 expression and vascular endothelial growth factor levels in patients with pre-eclampsia [J].J Int Med Res,2014,42(6):1243-1251.
[20] Wang S,Aurora AB,Johnson BA,et al.The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis[J].Dev Cell,2008,15(2),261-271.
[21] Kuehbacher A,Urbich C,Zeiher AM,et al.Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis[J].Circ Rese,2007,101(1):59-68.
[22] Luo SS,Ishibashi O,Ishikawa G,et al.Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes[J].Biol Reprod,81(4),717-729.
[23] Qin W,Tang Y,Yang N,et al.Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion[J].Fertil Steril,2016,105(5):1247-1254.
[24] Zhang Y,Zhou J,Li MQ,et al.MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion[J].Cell Death Dis,2019,10(3):223.
[25] Zhao W,Shen WW,Cao XM,et al.Novel mechanism of miRNA-365-regulated trophoblast apoptosis in recurrent miscarriage[J].J Cell Mol Med,2017,21(10):2412-2425.
[26] Amin-Beidokhti M,Mirfakhraie R,Zare-Karizi S,et al.The role of parental microRNA alleles in recurrent pregnancy loss:an association study[J].Reprod Biomed Online,2017,34(3):325-330.