热敏灸配合质子泵抑制剂治疗胃食管反流性咳嗽疗效观察
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摘要
目的观察热敏灸配合质子泵抑制剂治疗胃食管反流性咳嗽的临床疗效。方法将78例胃食管反流性咳嗽患者随机分为治疗组和对照组,每组39例。对照组采用口服奥美拉唑肠溶胶囊和莫沙比利分散片治疗,治疗组在对照组基础上采用热敏灸治疗。观察两组治疗前后咳嗽严重程度(cough severity score, CSS)评分、反流性疾病问卷(reflux diagnostic questionnaire, RDQ)评分及莱塞斯特咳嗽问卷(the Leicester cough questionnaire, LCQ)各项评分的变化情况,并比较两组临床疗效。结果治疗组总有效率为89.5%,对照组为78.4%,两组比较差异具有统计学意义(P<0.05)。两组治疗后CSS评分、RDQ评分及LCQ各项评分(生理、心理、社会)与同组治疗前比较差异均具有统计学意义(P<0.05)。治疗组治疗后CSS评分、RDQ评分及LCQ中生理、心理领域评分与对照组比较差异均具有统计学意义(P<0.05)。结论热敏灸配合质子泵抑制剂是一种治疗胃食管反流性咳嗽的有效方法。
Objective To observe the clinical efficacy of heat-sensitive point moxibustion plus proton pump inhibitors(PPI) in treating gastroesophageal reflux-related chronic cough(GERC). Method Seventy-eight patients with GERC were randomized into treatment and control groups, with 39 cases in each group. The control group was intervened by taking omeprazole enteric-coated capsules and Mosa Billy dispersible tablets, while the treatment group was additionally given heat-sensitive point moxibustion. Cough severity score(CSS), reflux diagnostic questionnaire(RDQ) score and the Leicester cough questionnaire(LCQ) score in the two groups were observed before and at the end of the treatment, and the clinical efficacies of the two groups were compared. Result The total efficacy rate was 89.5% in the treatment group and 78.4% in the control group, and there was a statistically significant difference between the two groups(P<0.05).The CSS score, RDQ score and LCQ score all showed a significant change after the treatment in the two groups(P<0.05). After the treatment, The CSS score, RDQ score and LCQ score in the treatment group were significantly different from those in the control group(P<0.05). Conclusion Heat-sensitive point moxibustion plus PPI is an effective method in treating GERC.
Objective To observe the clinical efficacy of heat-sensitive point moxibustion plus proton pump inhibitors(PPI) in treating gastroesophageal reflux-related chronic cough(GERC). Method Seventy-eight patients with GERC were randomized into treatment and control groups, with 39 cases in each group. The control group was intervened by taking omeprazole enteric-coated capsules and Mosa Billy dispersible tablets, while the treatment group was additionally given heat-sensitive point moxibustion. Cough severity score(CSS), reflux diagnostic questionnaire(RDQ) score and the Leicester cough questionnaire(LCQ) score in the two groups were observed before and at the end of the treatment, and the clinical efficacies of the two groups were compared. Result The total efficacy rate was 89.5% in the treatment group and 78.4% in the control group, and there was a statistically significant difference between the two groups(P<0.05).The CSS score, RDQ score and LCQ score all showed a significant change after the treatment in the two groups(P<0.05). After the treatment, The CSS score, RDQ score and LCQ score in the treatment group were significantly different from those in the control group(P<0.05). Conclusion Heat-sensitive point moxibustion plus PPI is an effective method in treating GERC.
引文
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[12]冯业全.奥美拉唑联合莫沙比利治疗94例胃食管反流性咳嗽的效果分析[J].检验医学与临床,2011,8(22):2746,2748.
[13]黄迪,张伟.从“聚于胃,关于肺”论治胃食管反流性咳嗽[J].四川中医,2015,33(8):34-35.
[14]陈日新,熊俊,谢丁一.热敏灸疗法[M].北京:人民卫生出版社,2014:1-21.
[15]蔡国伟,李静,陈玉婷,等.热敏灸热敏化大椎穴治疗神经根型颈椎病临床观察[J].上海针灸杂志,2015,34(6):559-561.
[16]江月霞.热敏灸治疗脊髓损伤性尿潴留的临床疗效观察[J].中华中医药杂志,2016,31(1):324-326.
[17]赵帅,苏懿,万鸣,等.热敏灸治疗原发性高血压病患者34例疗效观察[J].新中医,2011,43(8):131-133.
[18]付宁,曲怡,张立德.热敏灸干预高血压前期的思路探讨[J].辽宁中医药大学学报,2016,18(2):81-83.
[19]于航,霍建民.慢性咳嗽评估工具的系统评价[J].医学综述,2016,22(3):523-526.
[2]吴萍,李莹杰,宣丽倩,等.慢性胃食管反流性咳嗽患者的生活质量评估[J].同济大学学报(医学版),2016,37(2):69-73.
[3]Laheij RJ,Sturkenboom MC,Hassing RJ,et al.Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs[J].JAMA,2004,292(16):1955-1960.
[4]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2009版)[J].中华结核和呼吸杂志,2009,32(6):407-413.
[5]Hsu JY,Stone RA,Logan-Sinclair RB,et al.Coughing frequency in patients with persistent cough:assessment using a 24 hour ambulatory recorder[J].Eur Respir J,1994,7(7):1246-1253.
[6]刘文忠.2013年美国胃肠病学院胃食管反流病诊断和处理指南解读[J].胃肠病学,2013,18(4):193-199.
[7]Birring SS,Prudon B,Carr AJ,et al.Development of a symptom specific health status measure for patients with chronic cough:Leicester Cough Questionnaire(LCQ)[J].Thorax,2003,58(4):339-343.
[8]中华中医药学会脾胃病分会.胃食管反流病中医诊疗共识意见(2009,深圳)[J].中医杂志,2010,51(9):844-847.
[9]Dicpinigaitis PV,Tso R,Banauch G.Prevalence of depressive symptoms among patients with chronic cough[J].Chest,2006,130(6):1839-1843.
[10]McGarvey LP,Carton C,Gamble LA,et al.Prevalence of psychomorbidity among patients with chronic cough[J].Cough,2006,(2):4.
[11]Woodland P,Amarasinghe G,Sifrim D.Emerging therapeutic options in GERD[J].Best Pract Res Clin Gastroenterol,2013,27(3):455-467.
[12]冯业全.奥美拉唑联合莫沙比利治疗94例胃食管反流性咳嗽的效果分析[J].检验医学与临床,2011,8(22):2746,2748.
[13]黄迪,张伟.从“聚于胃,关于肺”论治胃食管反流性咳嗽[J].四川中医,2015,33(8):34-35.
[14]陈日新,熊俊,谢丁一.热敏灸疗法[M].北京:人民卫生出版社,2014:1-21.
[15]蔡国伟,李静,陈玉婷,等.热敏灸热敏化大椎穴治疗神经根型颈椎病临床观察[J].上海针灸杂志,2015,34(6):559-561.
[16]江月霞.热敏灸治疗脊髓损伤性尿潴留的临床疗效观察[J].中华中医药杂志,2016,31(1):324-326.
[17]赵帅,苏懿,万鸣,等.热敏灸治疗原发性高血压病患者34例疗效观察[J].新中医,2011,43(8):131-133.
[18]付宁,曲怡,张立德.热敏灸干预高血压前期的思路探讨[J].辽宁中医药大学学报,2016,18(2):81-83.
[19]于航,霍建民.慢性咳嗽评估工具的系统评价[J].医学综述,2016,22(3):523-526.