高胆红素血症与新生儿脑干听觉诱发电位的关系探究
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摘要
目的:探究高胆红素血症与新生儿脑干听觉诱发电位的关系。方法:选取2016年4月-2017年10月本院收治的高胆红素血症新生儿60例。根据胆红素水平的不同将其分为A组(221~280μmol/L)、B组(281~342μmol/L)及C组(>342μmol/L),各20例;并选取同期正常新生儿20例为D组。四组均进行脑干听觉诱发电位的检测,A、B、C组于治疗后3个月再检测1次,比较四组检测结果,并比较A、B、C组治疗后3个月的检测结果。结果:A、B、C组的脑干听觉诱发电位检测指标异常率与检测值均高于D组,B、C组均高于A组,C组均高于B组,比较差异均有统计学意义(P<0.05);A、B、C组治疗后3个月的脑干听觉诱发电位检测指标异常率与检测值比较,差异均有统计学意义(P<0.05)。结论:高胆红素血症新生儿脑干听觉诱发电位状态明显异常,且不同胆红素水平者的状态存在明显差异,应注意对高胆红素血症新生儿进行脑干听觉诱发电位的监测与干预。
Objective:To investigate the relationship between hyperbilirubinemia and brainstem auditory evoked potential of newborns.Method:A total of 60 newborns with hyperbilirubinemia in our hospital from April 2016 to October 2017 were selected,according to the level of bilirubin,they were divided into A group(221-280 μmol/L),B group(281-342 μmol/L) and C group(>342 μmol/L),20 cases in each group,and 20 cases of normal newborn were selected as D group at the same time.Brainstem auditory evoked potentials were detected in four groups,and A,B and C groups were tested for one time after treatment 3 months.The results of four groups were compared,and the results of after treatment 3 months in A,B and C groups were compared.Result:The abnormal rate and detection value of brainstem auditory evoked potential in A,B and C groups were higher than those in D group,and those in B and C groups were higher than those of A group,and all of C group were higher than those of B group,the difference were statistically significant(P<0.05).After treatment 3 months,the abnormal rate and detection value of brainstem auditory evoked potential in A,B and C groups were compared,the difference were statistically significant(P<0.05).Conclusion:The state of brainstem auditory evoked potential in newborns with hyperbilirubinemia is obviously abnormal,and there are significant differences in the status of different bilirubin levels,so the brainstem auditory evoked potential of newborns with hyperbilirubinemia should be paid to more monitoring and intervention.
Objective:To investigate the relationship between hyperbilirubinemia and brainstem auditory evoked potential of newborns.Method:A total of 60 newborns with hyperbilirubinemia in our hospital from April 2016 to October 2017 were selected,according to the level of bilirubin,they were divided into A group(221-280 μmol/L),B group(281-342 μmol/L) and C group(>342 μmol/L),20 cases in each group,and 20 cases of normal newborn were selected as D group at the same time.Brainstem auditory evoked potentials were detected in four groups,and A,B and C groups were tested for one time after treatment 3 months.The results of four groups were compared,and the results of after treatment 3 months in A,B and C groups were compared.Result:The abnormal rate and detection value of brainstem auditory evoked potential in A,B and C groups were higher than those in D group,and those in B and C groups were higher than those of A group,and all of C group were higher than those of B group,the difference were statistically significant(P<0.05).After treatment 3 months,the abnormal rate and detection value of brainstem auditory evoked potential in A,B and C groups were compared,the difference were statistically significant(P<0.05).Conclusion:The state of brainstem auditory evoked potential in newborns with hyperbilirubinemia is obviously abnormal,and there are significant differences in the status of different bilirubin levels,so the brainstem auditory evoked potential of newborns with hyperbilirubinemia should be paid to more monitoring and intervention.
引文
[1]江莲英,唐渊,陈若珊,等.脑干听觉诱发电位测定在新生儿重度高胆红素血症中的意义[J].广东医学院学报,2014,32(3):363-364.
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[4]Gardner Berry K,Chang H,Ching T Y,et al.Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder[J].Semin Hear,2016,37(1):53-61.
[5]凌秀明,唐海燕,凌日宣,等.不同浓度高胆红素血症患儿脑干听觉诱发电位对比分析[J].现代电生理学杂志,2015,22(4):199-202.
[6]金宏娟.血清总胆红素与白蛋白比值对新生儿脑干听觉诱发电位影响分析[J].中国医药科学,2015,5(22):20-23.
[7]Salehi N,Bagheri F,Farkhani H R.Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy[J].Iran J Otorhinolaryngol,2016,28(84):23-29.
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[9]叶同生,张健,胡克非,等.磁共振波谱技术及脑干听觉诱发电位在新生儿早期胆红素脑损伤中的评估作用[J].安徽医学,2017,38(5):552-555.
[10]李先红,张健,查萍,等.新生儿胆红素脑病脑脊液胆红素及脑干听觉诱发电位检测的临床意义[J].安徽医学,2014,35(4):414-416.
[11]侯德红,彭久君.脑干听觉诱发电位在新生儿高胆红素血症诊断中的应用[J].中国继续医学教育,2016,8(36):91-93.
[12]陈瑜毅,王金秋,黄英肖,等.不同程度胆红素水平对脑干听觉诱发电位影响的探讨[J].中国现代药物应用,2017,11(16):36-37.
[13]赵赛,程怀平,田兆方.脑干听觉诱发电位对高胆红素血症新生儿的早期诊断效果[J].中国实用神经疾病杂志,2015,18(24):86.
[14]赵丹,蒙丹华,韦秋芬,等.ROC曲线评价血清总胆红素、振幅整合脑电图和脑干听觉诱发电位对新生儿急性胆红素脑病的早期诊断价值[J].中国小儿急救医学,2017,24(9):686-690.
[15]Abdollahi F Z,Ahmadi T,Manchaiah V,et al.Auditory Brainstem Response Improvements in Hyperbillirubinemic Infants[J].J Audiol Otol,2016,20(1):13-16.
[16]张莹,艾雪梅,梁庆红.早产儿高胆红素血症患儿血清UCB等检测指标水平对BAEP的影响[J].中国妇幼保健,2015,30(27):4636-4638.
[17]廖继研,李木兰,张桂花.新生儿高胆红素血症对脑干听觉诱发电位影响的相关性研究[J].中国医药科学,2017,7(16):54-57.
[18]王乐,傅燕娜,郑洪,等.不同程度高胆红素血症患儿脑干听觉诱发电位及神经行为的预后研究[J].中国全科医学,2015,18(20):2413-2417.
[19]刘冬丽,侯书杨,余凤娟,等.脑干听觉诱发电位检测在新生儿高胆红素血症中的应用[J].中国实用神经疾病杂志,2016,19(4):109-110.
[20]柳秋菊,岳嗣凤.不同日龄足月病理性黄疸新生儿听觉诱发电位结果分析[J].华夏医学,2017,30(5):24-28.
[2]吴玫瑰,黄志坚,李坚,等.新生儿高胆红素血症脑干听觉诱发电位的临床应用分析[J].北京医学,2014,36(4):272-274.
[3]叶丹妮,葛令清,俞生林.脑干听觉诱发电位联合MRI在新生儿胆红素脑病早期诊断中的意义[J].中国儿童保健杂志,2017,25(7):737-740.
[4]Gardner Berry K,Chang H,Ching T Y,et al.Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder[J].Semin Hear,2016,37(1):53-61.
[5]凌秀明,唐海燕,凌日宣,等.不同浓度高胆红素血症患儿脑干听觉诱发电位对比分析[J].现代电生理学杂志,2015,22(4):199-202.
[6]金宏娟.血清总胆红素与白蛋白比值对新生儿脑干听觉诱发电位影响分析[J].中国医药科学,2015,5(22):20-23.
[7]Salehi N,Bagheri F,Farkhani H R.Effects of Hyperbilirubinemia on Auditory Brainstem Response of Neonates Treated with Phototherapy[J].Iran J Otorhinolaryngol,2016,28(84):23-29.
[8]Silva D D,Lopez P,Mantovani J C.Auditory Brainstem Response in Term and Preterm Infants with Neonatal Complications:The Importance of the Sequential Evaluation[J].Int Arch Otorhinolaryngol,2015,19(2):161-165.
[9]叶同生,张健,胡克非,等.磁共振波谱技术及脑干听觉诱发电位在新生儿早期胆红素脑损伤中的评估作用[J].安徽医学,2017,38(5):552-555.
[10]李先红,张健,查萍,等.新生儿胆红素脑病脑脊液胆红素及脑干听觉诱发电位检测的临床意义[J].安徽医学,2014,35(4):414-416.
[11]侯德红,彭久君.脑干听觉诱发电位在新生儿高胆红素血症诊断中的应用[J].中国继续医学教育,2016,8(36):91-93.
[12]陈瑜毅,王金秋,黄英肖,等.不同程度胆红素水平对脑干听觉诱发电位影响的探讨[J].中国现代药物应用,2017,11(16):36-37.
[13]赵赛,程怀平,田兆方.脑干听觉诱发电位对高胆红素血症新生儿的早期诊断效果[J].中国实用神经疾病杂志,2015,18(24):86.
[14]赵丹,蒙丹华,韦秋芬,等.ROC曲线评价血清总胆红素、振幅整合脑电图和脑干听觉诱发电位对新生儿急性胆红素脑病的早期诊断价值[J].中国小儿急救医学,2017,24(9):686-690.
[15]Abdollahi F Z,Ahmadi T,Manchaiah V,et al.Auditory Brainstem Response Improvements in Hyperbillirubinemic Infants[J].J Audiol Otol,2016,20(1):13-16.
[16]张莹,艾雪梅,梁庆红.早产儿高胆红素血症患儿血清UCB等检测指标水平对BAEP的影响[J].中国妇幼保健,2015,30(27):4636-4638.
[17]廖继研,李木兰,张桂花.新生儿高胆红素血症对脑干听觉诱发电位影响的相关性研究[J].中国医药科学,2017,7(16):54-57.
[18]王乐,傅燕娜,郑洪,等.不同程度高胆红素血症患儿脑干听觉诱发电位及神经行为的预后研究[J].中国全科医学,2015,18(20):2413-2417.
[19]刘冬丽,侯书杨,余凤娟,等.脑干听觉诱发电位检测在新生儿高胆红素血症中的应用[J].中国实用神经疾病杂志,2016,19(4):109-110.
[20]柳秋菊,岳嗣凤.不同日龄足月病理性黄疸新生儿听觉诱发电位结果分析[J].华夏医学,2017,30(5):24-28.