清润养目口服液与揿针埋针治疗干眼性视疲劳的临床疗效比较
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摘要
目的:观察清润养目口服液、揿针埋针治疗对干眼性视疲劳患者的治疗效果。方法:将90例(180眼)干眼性视疲劳患者采用多中心、分层随机分为3组,即人工泪液组、清润养目组和揿针埋针组,每组30例(60眼)。人工泪液组仅予0.1%玻璃酸钠滴眼液点眼治疗,清润养目组同时给予清润养目口服液治疗,揿针埋针组同时给予揿针埋针治疗。疗程为2周。于治疗前,治疗后第1周、第2周及1个月时观察并记录患者主观症状积分、泪液分泌量(SIT)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)评分以及明视持久度(PD)等变化情况,观察结束后进行数据统计及疗效评估。结果:治疗后各观察时间点揿针埋针组、清润养目组均能降低主观症状积分、CFS评分,增加SIT及延长BUT,提高PD。而人工泪液组治疗后各时间点能降低CFS评分,提高PD,延长BUT(P<0.05),主观症状积分及SIT在治疗后第1周改善较好(P<0.05),随着观察时间延长疗效降低。三组疗效比较:人工泪液组总有效率为63.3%,清润养目组为73.3%,揿针埋针组为76.7%;清润养目组、揿针埋针组疗效明显优于与人工泪液组(P<0.05)。结论:3种治疗方法均有治疗干眼及缓解视疲劳症状作用,但联合治疗更能促进泪液分泌,延长BUT,缓解患者眼干涩、不耐久视等症状。
Objective: To observe the therapeutic effect of Qingrun Yangmu Oral Liquid and needle-buried needle in dry eye patients with visual fatigue. Methods: Ninety patients(180 eyes) with dry eye visual fatigue diagnosed were randomly divided into three groups: artificial tear group, Qingrun Yangmu group, and needle-buried needle group, with 30 cases(60 eyes) in each group. Artificial tear group was only given 0.1% sodium hyaluronate eye drops treatment, Qingrun Yangmu group was also given Qingrun Yangmu Oral Liquid, and needle-buried needle group was also given needle buried needle treatment. The course of treatment was 2 weeks. The changes of subjective symptom score, tear secretion(SIT), tear film rupture time(BUT), corneal fluorescein staining(CFS) score and bright-viewing duration(PD) were observed and recorded before treatment, 1 week, 2 weeks and 1 month after treatment. After the observation, data statistics and efficacy evaluation were conducted. Results: After treatment,needle-buried needle group and Qingrun Yangmu group both reduced the subjective symptom score, CFS score, promoted SIT and prolonged BUT, improved PD. The artificial tear group could reduce subjective symptom score, CFS score, prolong the BUT(P<0.05). It found that in the first week after treatment, the observed effect of each patient improved the best(P<0.05), and the efficacy of each index decreased with the observation time. Comparison of three groups: the total effective rate was 63.3% in artificial tear group, 73.3% in Qingrun Yangmu group, and 76.7% in needle-buried needle group. Qingrun Yangmu group and needle-buried needle group were significantly better than the efficacy of artificial tear group(P<0.05). Conclusion: Three kinds of treatment on patients with dry eye could relieve the symptoms of visual fatigue. Combination therapy can better promote tear secretion, prolong BUT, relieve symptoms such as dry eyes and long-term vision.
Objective: To observe the therapeutic effect of Qingrun Yangmu Oral Liquid and needle-buried needle in dry eye patients with visual fatigue. Methods: Ninety patients(180 eyes) with dry eye visual fatigue diagnosed were randomly divided into three groups: artificial tear group, Qingrun Yangmu group, and needle-buried needle group, with 30 cases(60 eyes) in each group. Artificial tear group was only given 0.1% sodium hyaluronate eye drops treatment, Qingrun Yangmu group was also given Qingrun Yangmu Oral Liquid, and needle-buried needle group was also given needle buried needle treatment. The course of treatment was 2 weeks. The changes of subjective symptom score, tear secretion(SIT), tear film rupture time(BUT), corneal fluorescein staining(CFS) score and bright-viewing duration(PD) were observed and recorded before treatment, 1 week, 2 weeks and 1 month after treatment. After the observation, data statistics and efficacy evaluation were conducted. Results: After treatment,needle-buried needle group and Qingrun Yangmu group both reduced the subjective symptom score, CFS score, promoted SIT and prolonged BUT, improved PD. The artificial tear group could reduce subjective symptom score, CFS score, prolong the BUT(P<0.05). It found that in the first week after treatment, the observed effect of each patient improved the best(P<0.05), and the efficacy of each index decreased with the observation time. Comparison of three groups: the total effective rate was 63.3% in artificial tear group, 73.3% in Qingrun Yangmu group, and 76.7% in needle-buried needle group. Qingrun Yangmu group and needle-buried needle group were significantly better than the efficacy of artificial tear group(P<0.05). Conclusion: Three kinds of treatment on patients with dry eye could relieve the symptoms of visual fatigue. Combination therapy can better promote tear secretion, prolong BUT, relieve symptoms such as dry eyes and long-term vision.
引文
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[12]田莉,吴永红.玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究.中国全科医学,2017,20:164-166
[13]陈文东,付涛,潘思佳,等.贞杞口服液抗视疲劳实验研究.中华中医药学刊,2013,31(4):911-913
[14]庞龙.视疲劳中医古籍探源及其证治.中国中医基础医学杂志,2007,13(9):669-670
[15]刘畅,姚靖.干眼的中医论治思路探讨.中医药学报,2016,44(2):111-114
[16]赵艳青,项敏泓,王雪菲,等.基于因子分析与关联规则挖掘干眼症的用药规律.中华中医药杂志,2017,32(10):4708-4712
[17]Decanini A,Nordgaard C L,Feng X,et al.Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration.American Journal of Ophthalmology,2007,143(4):607-615
[18]刘春民,王抗美,邹玲.花青素对近视青少年视疲劳症状及视力的影响.中国实用眼科杂志,2005,23(6):607-609
[19]解正高,陈放,庄朝荣,等.银杏叶提取物增强大鼠视网膜光损伤模型抗氧化应激能力.眼科新进展,2012,32(1):24-26
[20]Kaarniranta K,Sinha D,Blasiak J,et al.Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration.Autophagy,2013,9(7):973-984
[21]苏国辉,米雪松.中药材枸杞子药食同源的机理.生命科学,2015,27(8):1070-1074
[22]王婷婷,王少康,黄桂玲,等.菊花主要活性成分含量及其抗氧化活性测定.食品科学,2013,34(15):95-98
[23]瞿璐,王涛,董勇喆,等.菊花化学成分与药理作用的研究进展.食品科学,2015,38(1):98-102
[24]文珠,肖移生,唐宁,等.黄精多糖对神经细胞的毒性及抗缺氧性坏死和凋亡作用研究.中药药理与临床,2006,22(22)29-31
[25]刘伟,李中燕,田艳,等.北沙参的化学成分及药理作用研究进展.国际药学研究杂志,2013,40(3):291-294
[26]庞荣,马军玲,张彬,等.药物联合针刺治疗视疲劳疗效观察.临床合理用药,2015,8(5):139-140
[27]闻慧.揿针疗法的临床应用.上海医药,2014,35(22):34-35
[28]武静,马晓昀,何琳萍.揿针埋针治疗干眼症临床疗效.长春中医药大学学报,2016,32(5):1033-1036
[29]厉越.清肝养阴汤熏蒸联合玻璃酸钠滴眼液治疗干眼症疗效观察.新中医,2015,47(2):129-130
[30]王佳娣,姚靖.中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼疗效观察.中医药学报,2016,44(4):130-132
[2]中华医学会眼科学分会眼视光学组.视疲劳诊疗专家共识.中华眼视光学与视觉科学杂志,2014,16(7):385-387
[3]中华医学会眼科学分会眼角膜病学组.干眼临床诊疗专家共识.中华眼科杂志,2013,49(1):73-75
[4]郑燕林,姚曼,彭晓丽,等.清润养目口服液对干眼兔模型结膜炎性细胞表达的影响.中国中医眼科杂志,2016,26(1):1-5
[5]朱文增,朱莉莉,倪金霞,等.针刺内睛明穴为主治疗干眼27例.中国针灸,2017,37(1):107-108
[6]谢汶璋,曾亮,陶颖,等.导气针刺法治疗干眼症临床疗效观察.中国针灸,2018,38(2):153-157
[7]杨雪艳,何锦贤,梁先军,等.杞菊地黄汤内服联合超声雾化治疗肝肾阴虚型干眼症临床观察.新中医,2015,2(15):211-213
[8]马越,王丹,张超,等.花青素饮料缓解视疲劳作用的人体试验观察.中国食品学报,2015,15(8):42-46
[9]陈玮琳,黄蓉,刘敦华.缓解视疲劳枸杞饮料的毒理学试验及安全性评价.现代食品科技,2013,29(5):1112-11135
[10]马宏杰,李月灵,曹双胜,等.杞菊地黄丸治疗不同角膜屈光术后干眼的临床研究.中国中医眼科杂志,2017,27(3):34-37
[11]王咏丽,体欣,张晓莉,等.玻璃酸钠联合0.1%氟米龙治疗干眼症的临床观察.中国药房,2016,27(2):258-260
[12]田莉,吴永红.玻璃酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对干眼症患者症状改善情况的影响研究.中国全科医学,2017,20:164-166
[13]陈文东,付涛,潘思佳,等.贞杞口服液抗视疲劳实验研究.中华中医药学刊,2013,31(4):911-913
[14]庞龙.视疲劳中医古籍探源及其证治.中国中医基础医学杂志,2007,13(9):669-670
[15]刘畅,姚靖.干眼的中医论治思路探讨.中医药学报,2016,44(2):111-114
[16]赵艳青,项敏泓,王雪菲,等.基于因子分析与关联规则挖掘干眼症的用药规律.中华中医药杂志,2017,32(10):4708-4712
[17]Decanini A,Nordgaard C L,Feng X,et al.Changes in select redox proteins of the retinal pigment epithelium in age-related macular degeneration.American Journal of Ophthalmology,2007,143(4):607-615
[18]刘春民,王抗美,邹玲.花青素对近视青少年视疲劳症状及视力的影响.中国实用眼科杂志,2005,23(6):607-609
[19]解正高,陈放,庄朝荣,等.银杏叶提取物增强大鼠视网膜光损伤模型抗氧化应激能力.眼科新进展,2012,32(1):24-26
[20]Kaarniranta K,Sinha D,Blasiak J,et al.Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration.Autophagy,2013,9(7):973-984
[21]苏国辉,米雪松.中药材枸杞子药食同源的机理.生命科学,2015,27(8):1070-1074
[22]王婷婷,王少康,黄桂玲,等.菊花主要活性成分含量及其抗氧化活性测定.食品科学,2013,34(15):95-98
[23]瞿璐,王涛,董勇喆,等.菊花化学成分与药理作用的研究进展.食品科学,2015,38(1):98-102
[24]文珠,肖移生,唐宁,等.黄精多糖对神经细胞的毒性及抗缺氧性坏死和凋亡作用研究.中药药理与临床,2006,22(22)29-31
[25]刘伟,李中燕,田艳,等.北沙参的化学成分及药理作用研究进展.国际药学研究杂志,2013,40(3):291-294
[26]庞荣,马军玲,张彬,等.药物联合针刺治疗视疲劳疗效观察.临床合理用药,2015,8(5):139-140
[27]闻慧.揿针疗法的临床应用.上海医药,2014,35(22):34-35
[28]武静,马晓昀,何琳萍.揿针埋针治疗干眼症临床疗效.长春中医药大学学报,2016,32(5):1033-1036
[29]厉越.清肝养阴汤熏蒸联合玻璃酸钠滴眼液治疗干眼症疗效观察.新中医,2015,47(2):129-130
[30]王佳娣,姚靖.中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼疗效观察.中医药学报,2016,44(4):130-132