血管性认知功能障碍的研究进展
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摘要
<正>随着全球人口老龄化的日益加剧,痴呆已成为亟待解决的严重健康问题~([1]),预计到2030年全球痴呆患者将达6600万人,而2050年将增至1.15亿人~([2])。研究表明,血管性痴呆(vascular dement ia,Va D)已成为仅次于阿尔茨海默病(Alzheimer’s disease,AD)之后导致痴呆的第二大病因,而我国
引文
[1]Dichgans M,Leys D.Vascular cognitive impairment[J].Circ Res,2017,120(3):573-591.
[2]Wortmann M.Dementia:a global health priority-highlights from an ADI and World Health Organization report[J].Alzheimers Res Ther,2012,4(5):40.
[3]Jia J,Wang F,Wei C,et al.The prevalence of dementia in urban and rural areas of China[J].Alzheimers Dement,2014,10(1):1-9.
[4]Loeb C,Gandolfo C.Diagnostic evaluation of degenerative and vascular dementia[J].Stroke,1983,14(3):399-401.
[5]BowIer JV,Hachinski V.Vascular cognitive impairment:a new approach to vascular dementia[J].Baillieres Clin Neurol,1995,4(2):357-376.
[6]Hachinski V,Iadecola C,Petersen RC,et al.National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards[J].Stroke,2006,37(9):2220-2241.
[7]Gorelick PB,Scuteri A,Black SE,et al.Vascular contributions to cognitive impairment and dementia:a statement for healthcare professionals from the american heart association/american stroke association[J].Stroke,2011,42(9):2672-2713.
[8]中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011,44(2):142-147.
[9]贾建平.中国痴呆与认知障碍诊治指南(2015年版)[M].2版.北京:人民卫生出版社,2015.
[10]Roberts RO,Cha RH,Mielke MM,et al.Risk and protective factors for cognitive impairment in persons aged 85 years and older[J].Neurology,2015,84(18):1854-1861.
[11]方珉,刘学源.血管性认知功能障碍及其早期识别与干预的研究进展[J].上海医药,2016,37(15):5-11.
[12]朱穆峰,邓丽影,龚黎民,等.非痴呆型血管性认知障碍的睡眠结构分析[J].南方医科大学学报,2011,31(2):295-298.
[13]Gorelick PB.William M Feinberg Lecture:Cognitive vitality and the role of stroke and cardiovascular disease risk factors[J].Stroke,2005,36(4):875-879.
[14]O’Brien JT,Erkinjuntti T,Reisberg B,et al.Vascular cognitive impairment[J].Lancet Neurol,2003,2(2):89-98.
[15]Hachjnski V,Bowler JV.Vascular dementia[J].Neurology,1993,43(10):2159-2160.
[16]Rockwood K,Ebly E,Hachinski V,et al.Presence and treatment of vascular risk factors in patients with vasculaI cognitive impairment[J].Arch Neurol,1997,54(1):33-39.
[17]Moorhouse P,Rockwood K.Vascular cognitive impairnent:current concepts and clinical developments[J].Lancet Neurol,2008,7(3):246-255.
[18]Stephan BC,Matthews FE,Khaw KT,et al.Beyond mild cognitive impairment:vascular cognitive impairment,no dementia(VCIND)[J].Alzheimers Res Ther,2009,1(1):4.
[19]Elias MF,Sullivan LM,D'Agostino RB,et al.Framingham stroke risk profile and lowered cognitive performance[J].Stroke,2004,35(2):404-409.
[20]Seshadri S,Wolf PA,Beiser A,et al.Stroke risk profile,brain volume,and cognitive function:the Framingham Offspring Study[J].Neurology,2004,63(9):1591-1599.
[21]Pendlebury ST,Rothwell PM.Prevalence,incidence,and factors associated with pre-stroke and post-stroke dementia:a systematic review and meta-analysis[J].Lancet Neurol,2009,8(11):1006-1018.
[22]Magot A,Desal H,Wiertlewski S,et al.[Dural arteriovenous fi stula.A rare cause of treatable dementia][J].Rev Neurol(Paris),2004,160(4 Pt 1):425-433.
[23]Zekry D,Hauw JJ,Gold G.Mixed dementia:epidemiology,diagnosis,and treatment[J].J Am Geriatr Soc,2002,50(8):143l-1438.
[24]Snowdon DA,Greiner LH,Mortimer JA,et al.Brain infarction and the clinical expression of Alzheimer disease.The Nun Study[J].JAMA,1997,277(10):813-817.
[25]Esiri MM,Nagy Z,Smith MZ,et al.Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease[J].Lancet,1999,354(9182):919-920.
[26]刘学源.血管性认知功能障碍的诊断与治疗进展[J].临床内科杂志,2014,31(12):797-800.
[27]Jorge RE,Acion L,Moser D,et al.Escitalopram and enhancement of cognitive recovery following stroke[J].Arch Gen Psychiatry,2010,67(2):187-196.
[28]Royall DR,Cordes JA,Román G,et al.Sertraline improves executive function in patients with vascular cognitive impairment[J].J Neuropsychiatry Clin Neurosci,2009,21(4):445-454.
[29]Liu X,Zhang J,Sun D,et al.Effects of fluoxetine on brainderived neurotrophic factor serum concentration and cognition in patients with vascular dementia[J/OL].Clin Interv Aging,2014,9:411-418.
[2]Wortmann M.Dementia:a global health priority-highlights from an ADI and World Health Organization report[J].Alzheimers Res Ther,2012,4(5):40.
[3]Jia J,Wang F,Wei C,et al.The prevalence of dementia in urban and rural areas of China[J].Alzheimers Dement,2014,10(1):1-9.
[4]Loeb C,Gandolfo C.Diagnostic evaluation of degenerative and vascular dementia[J].Stroke,1983,14(3):399-401.
[5]BowIer JV,Hachinski V.Vascular cognitive impairment:a new approach to vascular dementia[J].Baillieres Clin Neurol,1995,4(2):357-376.
[6]Hachinski V,Iadecola C,Petersen RC,et al.National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards[J].Stroke,2006,37(9):2220-2241.
[7]Gorelick PB,Scuteri A,Black SE,et al.Vascular contributions to cognitive impairment and dementia:a statement for healthcare professionals from the american heart association/american stroke association[J].Stroke,2011,42(9):2672-2713.
[8]中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011,44(2):142-147.
[9]贾建平.中国痴呆与认知障碍诊治指南(2015年版)[M].2版.北京:人民卫生出版社,2015.
[10]Roberts RO,Cha RH,Mielke MM,et al.Risk and protective factors for cognitive impairment in persons aged 85 years and older[J].Neurology,2015,84(18):1854-1861.
[11]方珉,刘学源.血管性认知功能障碍及其早期识别与干预的研究进展[J].上海医药,2016,37(15):5-11.
[12]朱穆峰,邓丽影,龚黎民,等.非痴呆型血管性认知障碍的睡眠结构分析[J].南方医科大学学报,2011,31(2):295-298.
[13]Gorelick PB.William M Feinberg Lecture:Cognitive vitality and the role of stroke and cardiovascular disease risk factors[J].Stroke,2005,36(4):875-879.
[14]O’Brien JT,Erkinjuntti T,Reisberg B,et al.Vascular cognitive impairment[J].Lancet Neurol,2003,2(2):89-98.
[15]Hachjnski V,Bowler JV.Vascular dementia[J].Neurology,1993,43(10):2159-2160.
[16]Rockwood K,Ebly E,Hachinski V,et al.Presence and treatment of vascular risk factors in patients with vasculaI cognitive impairment[J].Arch Neurol,1997,54(1):33-39.
[17]Moorhouse P,Rockwood K.Vascular cognitive impairnent:current concepts and clinical developments[J].Lancet Neurol,2008,7(3):246-255.
[18]Stephan BC,Matthews FE,Khaw KT,et al.Beyond mild cognitive impairment:vascular cognitive impairment,no dementia(VCIND)[J].Alzheimers Res Ther,2009,1(1):4.
[19]Elias MF,Sullivan LM,D'Agostino RB,et al.Framingham stroke risk profile and lowered cognitive performance[J].Stroke,2004,35(2):404-409.
[20]Seshadri S,Wolf PA,Beiser A,et al.Stroke risk profile,brain volume,and cognitive function:the Framingham Offspring Study[J].Neurology,2004,63(9):1591-1599.
[21]Pendlebury ST,Rothwell PM.Prevalence,incidence,and factors associated with pre-stroke and post-stroke dementia:a systematic review and meta-analysis[J].Lancet Neurol,2009,8(11):1006-1018.
[22]Magot A,Desal H,Wiertlewski S,et al.[Dural arteriovenous fi stula.A rare cause of treatable dementia][J].Rev Neurol(Paris),2004,160(4 Pt 1):425-433.
[23]Zekry D,Hauw JJ,Gold G.Mixed dementia:epidemiology,diagnosis,and treatment[J].J Am Geriatr Soc,2002,50(8):143l-1438.
[24]Snowdon DA,Greiner LH,Mortimer JA,et al.Brain infarction and the clinical expression of Alzheimer disease.The Nun Study[J].JAMA,1997,277(10):813-817.
[25]Esiri MM,Nagy Z,Smith MZ,et al.Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease[J].Lancet,1999,354(9182):919-920.
[26]刘学源.血管性认知功能障碍的诊断与治疗进展[J].临床内科杂志,2014,31(12):797-800.
[27]Jorge RE,Acion L,Moser D,et al.Escitalopram and enhancement of cognitive recovery following stroke[J].Arch Gen Psychiatry,2010,67(2):187-196.
[28]Royall DR,Cordes JA,Román G,et al.Sertraline improves executive function in patients with vascular cognitive impairment[J].J Neuropsychiatry Clin Neurosci,2009,21(4):445-454.
[29]Liu X,Zhang J,Sun D,et al.Effects of fluoxetine on brainderived neurotrophic factor serum concentration and cognition in patients with vascular dementia[J/OL].Clin Interv Aging,2014,9:411-418.