银屑病与PRINS lncRNA相关性研究进展
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摘要
银屑病是一种常见免疫介导的,与遗传、代谢等多种因素相关的疾病,目前病因尚未清晰。近年来越来越多的研究表明,PRINS lncRNA作为一种新型长链非编码RNA在银屑病无损伤的表皮中呈高反应性,参与了G1P3之间的信号传递以及NPM蛋白的调控,其可调节炎症介质产生,在慢性炎症中发挥重要作用。本文就银屑病发病机制与PRINS lncRNA相关性的研究进展作一综述。
Psoriasis is a common immune-mediated disease associated with genetic, metabolic and other factors, and its cause is not clear yet. In recent years, there is a growing number of studies shown that PRINS lncRNA, as a new type of long chain non-coding RNA, has high reactivity in psoriasis skin without damage. What's more, it participates in the signal transmission of G1P3 and the regulation of NPM protein, which can adjust inflammatory mediators and plays an important role in chronic inflammation. This review mainly discusses PRINS lncRNA and its functions in the pathogenesis of psoriasis and its research progress.
Psoriasis is a common immune-mediated disease associated with genetic, metabolic and other factors, and its cause is not clear yet. In recent years, there is a growing number of studies shown that PRINS lncRNA, as a new type of long chain non-coding RNA, has high reactivity in psoriasis skin without damage. What's more, it participates in the signal transmission of G1P3 and the regulation of NPM protein, which can adjust inflammatory mediators and plays an important role in chronic inflammation. This review mainly discusses PRINS lncRNA and its functions in the pathogenesis of psoriasis and its research progress.
引文
[1]秦思,温炬,郑荣昌,等.T细胞在银屑病与特应性皮炎发病机制中的研究进展[J].广东医学,2013,34(7):1126-1129.
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[3]魏娟.银屑病的发病机制与临床诊断进展[J].黑龙江医学,2005,29(5):344-46.
[4]Sonkoly E,Bata-Csorgo Z,Pivarcsi A,et al.Identification and characterization of a novel,psoriasis susceptibility-related noncoding RNAgene,PRINS[J].JBiol Chem,2005,280(25):24159-24167.
[5]Suda H,Lee KJ,Semba K,et al.The Skt gene,required for anorectal development,is a candidate for a molecular marker of the cloacal plate[J].Pediatr Surg Int,2011,27(3):269-273.
[6]St Laurent G,Wahlestedt C,Kapranov P.The landscape of long noncoding RNA classification[J].Trends Genet,2015,31(5):239-251.
[7]Schmidt LH,Spieker T,Koschmieder S,et al.The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth[J].J Thorac Oncol,2011,6(12):1984-1992.
[8]Necsulea A,Soumillon M,Warnefors M,et al.The evolution of lncRNA repertoires and expression patterns in tetrapods[J].Nature,2014,505(7485):635-640.
[9]Kapusta A,Feschotte C.Volatile evolution of long noncoding.RNArepertoires:mechanisms and biological implications[[J].Trends Genet,2014,30(10):439-452.
[10]Miyagawa R,Tano K,Mizuno R,et al.Identification of cis-and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles[J].RNA,2012,(18):738-751.
[11]]Kelley D,Rinn J.Transposable elements reveal a stem cellspecific class of long noncoding RNAs[J].Genome Biol,2012,(13):R107.
[12]Johnsson P,Lipovich L,Grander D,et al.Evolutionary conservation of long non-coding RNAs;sequence,structure,function[J].Biochim Biophys Acta,2014,1840(3):1063-1071.
[13]Hirsch GE,Parisi MM,Martins LA,et al.gamma-Oryzanol reduces caveolin-1 and PCGEM1 expression,markers of aggressiveness in prostate cancer cell lines[J].Prostate,2015,75(8):783-797.
[14]Danis J,G?bl?s A,Bata-Cs?rg ZS,et al.PRINS the psoriasis susceptibility related non-coding RNA is involved in stress response of cells,but not in inflammasome activation[J].Immunol Szle,2015,8(3):12.
[15]Costa V,Aprile M,Esposito R,et al.RNA-Seq and human complex diseases:recent accomplishments and future perspectives[J].Eur JHum Genet,2013,21(2):134-142.
[16]Beylot-Barry M,Lamant L,Vergier B,et al.Detection of t(2;5)(p23;q35)translocation by reverse transcriptase polymerase chain reaction and in situ hybridization in CD30-positive primary cutaneous lymphoma and lymphomatoid papulosis[J].Am J Pathol,1996,149(2):483-492.
[2]Nestle FO,Kaplan DH.Barker J.Psoriasis[J].N Engl J Med,2009,361(5):496-509.
[3]魏娟.银屑病的发病机制与临床诊断进展[J].黑龙江医学,2005,29(5):344-46.
[4]Sonkoly E,Bata-Csorgo Z,Pivarcsi A,et al.Identification and characterization of a novel,psoriasis susceptibility-related noncoding RNAgene,PRINS[J].JBiol Chem,2005,280(25):24159-24167.
[5]Suda H,Lee KJ,Semba K,et al.The Skt gene,required for anorectal development,is a candidate for a molecular marker of the cloacal plate[J].Pediatr Surg Int,2011,27(3):269-273.
[6]St Laurent G,Wahlestedt C,Kapranov P.The landscape of long noncoding RNA classification[J].Trends Genet,2015,31(5):239-251.
[7]Schmidt LH,Spieker T,Koschmieder S,et al.The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth[J].J Thorac Oncol,2011,6(12):1984-1992.
[8]Necsulea A,Soumillon M,Warnefors M,et al.The evolution of lncRNA repertoires and expression patterns in tetrapods[J].Nature,2014,505(7485):635-640.
[9]Kapusta A,Feschotte C.Volatile evolution of long noncoding.RNArepertoires:mechanisms and biological implications[[J].Trends Genet,2014,30(10):439-452.
[10]Miyagawa R,Tano K,Mizuno R,et al.Identification of cis-and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles[J].RNA,2012,(18):738-751.
[11]]Kelley D,Rinn J.Transposable elements reveal a stem cellspecific class of long noncoding RNAs[J].Genome Biol,2012,(13):R107.
[12]Johnsson P,Lipovich L,Grander D,et al.Evolutionary conservation of long non-coding RNAs;sequence,structure,function[J].Biochim Biophys Acta,2014,1840(3):1063-1071.
[13]Hirsch GE,Parisi MM,Martins LA,et al.gamma-Oryzanol reduces caveolin-1 and PCGEM1 expression,markers of aggressiveness in prostate cancer cell lines[J].Prostate,2015,75(8):783-797.
[14]Danis J,G?bl?s A,Bata-Cs?rg ZS,et al.PRINS the psoriasis susceptibility related non-coding RNA is involved in stress response of cells,but not in inflammasome activation[J].Immunol Szle,2015,8(3):12.
[15]Costa V,Aprile M,Esposito R,et al.RNA-Seq and human complex diseases:recent accomplishments and future perspectives[J].Eur JHum Genet,2013,21(2):134-142.
[16]Beylot-Barry M,Lamant L,Vergier B,et al.Detection of t(2;5)(p23;q35)translocation by reverse transcriptase polymerase chain reaction and in situ hybridization in CD30-positive primary cutaneous lymphoma and lymphomatoid papulosis[J].Am J Pathol,1996,149(2):483-492.