百令胶囊联合呼吸康复训练治疗慢性阻塞性肺疾病及对血气指标、肺功能研究
|
摘要
目的:探究百令胶囊与呼吸康复训练联合治疗慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Diseases,COPD)患者的临床效果、血气指标及肺功能的影响。方法:COPD患者212例,按数字表法随机分为对照组(n=104)与观察组(n=108)。两组患者入院后均给予常规药物治疗,包括祛痰、控制感染、解痉平喘等,在此基础上,予以对照组百令胶囊进行治疗,而观察组采用百令胶囊联合呼吸康复训练进行治疗,分析两组患者肺功能情况、各项血气分析指标、6MWD、生存质量及临床总有效率。结果:经过治疗后,观察组FEV_1(2.12±0.89)L、FVC(2.55±0.82)L、FEV_1/FVC(80.69±10.32)%、FEV(42.38±6.42)%等均明显高于对照组FEV_1(1.87±0.85)L、FVC(2.33±0.84)L、FEV_1/FVC(76.27±7.65)%、FEV(38.17±4.23)%;经治疗1～3个月,两组患者的6MWD均呈上升趋势,且治疗后1～3个月观察组的6MWD值均明显高于对照组;观察组PaO_2(70.21±5.27)mmHg、SaO_2(88.96±4.19)mmHg值均明显高于对照组PaO_2(65.29±5.14)mmHg、SaO_2(84.25±4.62)mmHg值,观察组PaCO_2(40.05±3.11)mmHg明显低于对照组的(43.28±6.43);观察组整体生存质量均明显优于对照组;观察组临床总有效率(92.59%)明显高于对照组的(71.15%),差异均有统计学意义(P<0.05)。结论:COPD患者在常规治疗基础上加用百令胶囊联合呼吸康复训练治疗后,患者肺通气换气功能有了显著改善,呼吸困难等不适症状得到有效缓解,整体治疗效果较优。
Objective: To explore the effect of Bailing Capsule combined with respiratory rehabilitation training on the clinical effect, blood gas index and pulmonary function of the patients with chronic obstructive pulmonary disease(COPD). Methods: Totally 212 cases of COPD were selected and randomly divided into the control group(n=104) and the observation group(n=108) according to the number table method. The two groups of patients were given routine drug treatment, including infection control, expectorant, antispasmodic drugs. On this basis the control group was given Bailing Capsule treatment and the observation group were given Bailing Capsule combined with respiratory rehabilitation training treatment. The two groups' pulmonary function and the blood gas analysis index, 6 MWD, survival quality and clinical total efficiency were compared. Results: After treatment, the observation group's FEV1(2.12±0.89) L, FVC(2.55±0.82) L, FEV1/FVC(80.69±10.32)%, and FEV(42.38±6.42)% were significantly higher than the control group's FEV1(1.87±0.85) L, FVC(2.33±0.84) L, FEV1/FVC(76.27±7.65)% and FEV(38.17±4.23)%. After 1～3 months treatment, two groups' 6 MWD showed an upward trend, and after 1～3 months treatment the observation group's 6 MWD values were significantly higher than the control group's. The observation group's PaO_2(70.21±5.27) mmHg and SaO_2(88.96±4.19) mmHg were significantly higher than the control group's PaO_2(65.29±5.14) mmHg and SaO_2(84.25±4.62) mmHg. The observation group's PaCO2(40.05±3.11) mmHg was significantly lower than the control group's(43.28±6.43)mmHg. The observation group's overall quality of life was significantly better than that of the control group. The total efficiency of the observation group(92.59%) was significantly higher than the control group's(71.15%), and the difference was statistically significant(P<0.05). Conclusion: On the basis of routine treatment,adding Bailing Capsule combined with respiratory rehabilitation training for the patients with chronic obstructive pulmonary disease can significantly improve lung ventilation and ventilation function, and dyspnea has been relieved effectively, and the overall treatment effect is excellent.
Objective: To explore the effect of Bailing Capsule combined with respiratory rehabilitation training on the clinical effect, blood gas index and pulmonary function of the patients with chronic obstructive pulmonary disease(COPD). Methods: Totally 212 cases of COPD were selected and randomly divided into the control group(n=104) and the observation group(n=108) according to the number table method. The two groups of patients were given routine drug treatment, including infection control, expectorant, antispasmodic drugs. On this basis the control group was given Bailing Capsule treatment and the observation group were given Bailing Capsule combined with respiratory rehabilitation training treatment. The two groups' pulmonary function and the blood gas analysis index, 6 MWD, survival quality and clinical total efficiency were compared. Results: After treatment, the observation group's FEV1(2.12±0.89) L, FVC(2.55±0.82) L, FEV1/FVC(80.69±10.32)%, and FEV(42.38±6.42)% were significantly higher than the control group's FEV1(1.87±0.85) L, FVC(2.33±0.84) L, FEV1/FVC(76.27±7.65)% and FEV(38.17±4.23)%. After 1～3 months treatment, two groups' 6 MWD showed an upward trend, and after 1～3 months treatment the observation group's 6 MWD values were significantly higher than the control group's. The observation group's PaO_2(70.21±5.27) mmHg and SaO_2(88.96±4.19) mmHg were significantly higher than the control group's PaO_2(65.29±5.14) mmHg and SaO_2(84.25±4.62) mmHg. The observation group's PaCO2(40.05±3.11) mmHg was significantly lower than the control group's(43.28±6.43)mmHg. The observation group's overall quality of life was significantly better than that of the control group. The total efficiency of the observation group(92.59%) was significantly higher than the control group's(71.15%), and the difference was statistically significant(P<0.05). Conclusion: On the basis of routine treatment,adding Bailing Capsule combined with respiratory rehabilitation training for the patients with chronic obstructive pulmonary disease can significantly improve lung ventilation and ventilation function, and dyspnea has been relieved effectively, and the overall treatment effect is excellent.
引文
[1] 孙楷,聂洪玉.慢性阻塞性肺疾病肺康复1例病案报告[J].中国实用内科杂志,2016,36(2):189-190.
[2] 陈敏,朱慕云.振动PEP排痰法在慢阻肺患者肺康复中的应用研究进展[J].临床肺科杂志,2017,22(7):1323-1326.
[3] 韩国敬,许菡苡,胡红,等.哮喘-慢阻肺重叠综合征、哮喘及慢阻肺患者的肺功能及临床特征比较[J].解放军医学院学报,2017,37(11):1122-1125,1189.
[4] Hardinge M.British Thoracic Society guidelines for home oxygen use in adults[J].Thorax,2015,70(Suppl):41-43.
[5] Fitting JW.The challenge of personalized care for all in chronic obstructive pulmonary disease[J].Int J Tuberc Lung Dis,2016,20(3):289-290.
[6] 周露茜,黎晓莹,李允,等.呼吸肌锻炼联合无创正压通气在稳定期重度慢性阻塞性肺疾病患者中的应用[J].中国实用内科杂志,2017,37(4):330-333.
[7] 田德禄.中医内科学[M].7版.北京:人民卫生出版社,2001:94.
[8] 李大亮,黄雪敏,岑树坤,等.早期康复治疗对老年重症肺炎机械通气患者并发症及预后的影响[J].中国呼吸与危重监护杂志,2018,17(1):46-50.
[9] 李红,朱明华,刘燕,等.肺康复运动训练对稳定期COPD合并肺心病患者的辅助治疗作用观察[J].中国医刊,2018,53(1):29-32.
[10] Fagevik Olsen M,Lannefors L,Westerdahl E.Positive expiratory pressure-Common clinical applications and physiological effects[J].Respir Med,2015,109(3):297-307.
[11] 李洁,王艳红.综合运动康复训练对慢性阻塞性肺疾病稳定期病人肺功能及运动耐力的影响[J].护理研究,2016,30(6):2271-2272.
[12] 郝艳芳,孙文英,赵永芳,等.联合肺康复训练对慢性阻塞性肺疾病缓解期康复的疗效分析[J].中国医药导刊,2017,19(12):1253-1256.
[13] Chow L,Parulekar AD,Hanania NA.Hospital management of acute exacerbations of chronic obstructive pulmonary disease[J].J Hosp Med,2015,10(5):328-339.
[14] Svenningsen S,Paulin GA,Sheikh K,et al.Oscillatory Positive Expiratory Pressure in Chronic Obstructive Pulmonary Disease[J].COPD,2016,13(1):66-74.
[15] 王丽丽,冯轩,崔婷婷.百令胶囊联合呼吸康复训练治疗慢阻肺的疗效及对患者血气指标、肺功能的影响[J].世界中医药,2017,12(12):2949-2952.
[16] Calzetta L,Rogliani P,Matera MG,et al.A Systematic Review With Meta-Analysis of Dual Bronchodilation With LAMA/LABA for the Treatment of Stable COPD[J].Chest,2016,149(5):1181-1196.
[17] 张满云.多学科诊疗模式对老年慢阻肺患者病情康复及生活质量的影响[J].临床肺科杂志,2017,22(8):1456-1459.
[18] 蒋胜华,李岷,秦茂华,等.从慢性病自我管理、自我效能的角度对慢性阻塞性肺疾病综合性肺康复的评价[J].中国康复医学杂志,2017,32(9):1030-1034.
[19] 李芳,邢静文,张何琴,等.运动训练在慢性阻塞性肺疾病患者康复中应用及影响的研究进展[J].中国老年学杂志,2017,37(5):1270-1272.
[20] Rochester CL.An Official American Thoracic Society/European Respiratory Society Policy Statement:Enhancing Implementation Use and Delivery of Pulmonary Rehabilitation[J].Am J Respir Crit Care Med,2015,192(11):1373-1386.
[21] 游明元,李群,陈锋,等.肺康复训练对极重度稳定期慢性阻塞性肺疾病的影响[J].西部医学,2016,28(5):702-704,708.
[22] 谢斌,鲍晓,李伟玲,等.康复训练对稳定期慢阻肺患者生活质量和运动功能的影响[J].中国康复,2016,31(4):277-279.
[23] 尹辉明,禹斌,代友华,等.无创正压通气辅助踏车运动在稳定期重度慢性阻塞性肺疾病患者的实施与疗效观察[J].中国呼吸与危重监护杂志,2017,16(5):432-435.
[2] 陈敏,朱慕云.振动PEP排痰法在慢阻肺患者肺康复中的应用研究进展[J].临床肺科杂志,2017,22(7):1323-1326.
[3] 韩国敬,许菡苡,胡红,等.哮喘-慢阻肺重叠综合征、哮喘及慢阻肺患者的肺功能及临床特征比较[J].解放军医学院学报,2017,37(11):1122-1125,1189.
[4] Hardinge M.British Thoracic Society guidelines for home oxygen use in adults[J].Thorax,2015,70(Suppl):41-43.
[5] Fitting JW.The challenge of personalized care for all in chronic obstructive pulmonary disease[J].Int J Tuberc Lung Dis,2016,20(3):289-290.
[6] 周露茜,黎晓莹,李允,等.呼吸肌锻炼联合无创正压通气在稳定期重度慢性阻塞性肺疾病患者中的应用[J].中国实用内科杂志,2017,37(4):330-333.
[7] 田德禄.中医内科学[M].7版.北京:人民卫生出版社,2001:94.
[8] 李大亮,黄雪敏,岑树坤,等.早期康复治疗对老年重症肺炎机械通气患者并发症及预后的影响[J].中国呼吸与危重监护杂志,2018,17(1):46-50.
[9] 李红,朱明华,刘燕,等.肺康复运动训练对稳定期COPD合并肺心病患者的辅助治疗作用观察[J].中国医刊,2018,53(1):29-32.
[10] Fagevik Olsen M,Lannefors L,Westerdahl E.Positive expiratory pressure-Common clinical applications and physiological effects[J].Respir Med,2015,109(3):297-307.
[11] 李洁,王艳红.综合运动康复训练对慢性阻塞性肺疾病稳定期病人肺功能及运动耐力的影响[J].护理研究,2016,30(6):2271-2272.
[12] 郝艳芳,孙文英,赵永芳,等.联合肺康复训练对慢性阻塞性肺疾病缓解期康复的疗效分析[J].中国医药导刊,2017,19(12):1253-1256.
[13] Chow L,Parulekar AD,Hanania NA.Hospital management of acute exacerbations of chronic obstructive pulmonary disease[J].J Hosp Med,2015,10(5):328-339.
[14] Svenningsen S,Paulin GA,Sheikh K,et al.Oscillatory Positive Expiratory Pressure in Chronic Obstructive Pulmonary Disease[J].COPD,2016,13(1):66-74.
[15] 王丽丽,冯轩,崔婷婷.百令胶囊联合呼吸康复训练治疗慢阻肺的疗效及对患者血气指标、肺功能的影响[J].世界中医药,2017,12(12):2949-2952.
[16] Calzetta L,Rogliani P,Matera MG,et al.A Systematic Review With Meta-Analysis of Dual Bronchodilation With LAMA/LABA for the Treatment of Stable COPD[J].Chest,2016,149(5):1181-1196.
[17] 张满云.多学科诊疗模式对老年慢阻肺患者病情康复及生活质量的影响[J].临床肺科杂志,2017,22(8):1456-1459.
[18] 蒋胜华,李岷,秦茂华,等.从慢性病自我管理、自我效能的角度对慢性阻塞性肺疾病综合性肺康复的评价[J].中国康复医学杂志,2017,32(9):1030-1034.
[19] 李芳,邢静文,张何琴,等.运动训练在慢性阻塞性肺疾病患者康复中应用及影响的研究进展[J].中国老年学杂志,2017,37(5):1270-1272.
[20] Rochester CL.An Official American Thoracic Society/European Respiratory Society Policy Statement:Enhancing Implementation Use and Delivery of Pulmonary Rehabilitation[J].Am J Respir Crit Care Med,2015,192(11):1373-1386.
[21] 游明元,李群,陈锋,等.肺康复训练对极重度稳定期慢性阻塞性肺疾病的影响[J].西部医学,2016,28(5):702-704,708.
[22] 谢斌,鲍晓,李伟玲,等.康复训练对稳定期慢阻肺患者生活质量和运动功能的影响[J].中国康复,2016,31(4):277-279.
[23] 尹辉明,禹斌,代友华,等.无创正压通气辅助踏车运动在稳定期重度慢性阻塞性肺疾病患者的实施与疗效观察[J].中国呼吸与危重监护杂志,2017,16(5):432-435.