血必净注射液治疗老年重症肺炎疗效及对患者肠黏膜屏障与氧供状态的影响
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摘要
目的:探讨血必净注射液对老年重症肺炎患者肠黏膜屏障与氧供状态的影响。方法:选取老年重症肺炎患者80例,依据随机分配的原则分为对照组和观察组各40例。对照组进行常规重症肺炎治疗,观察组则在对照组的基础上加用血必净注射液治疗。对比两组临床治疗效果、治疗前后的临床肺部感染评分、炎症反应指标、肠黏膜屏障与氧供状态指标。结果:观察组治疗3 d、7 d后临床总有效率分别为75.00%及97.50%,显著高于对照组的52.50%及80.00%,差异有统计学意义(P<0.05)。治疗前两组的临床肺部感染评分、炎症反应指标、肠黏膜屏障与氧供状态指标比较,差异无统计学意义(P>0.05)。治疗后3 d、7 d两组的上述指标均明显改善,且观察组的临床肺部感染评分、炎症反应指标、肠黏膜屏障与氧供状态指标优于对照组,差异有统计学意义(P<0.05)。结论:血必净注射液对老年重症肺炎患者肠黏膜屏障与氧供状态的影响更为积极,有助于此类老年患者疾病状态的改善。
Objective:To investigate the influence of Xuebijing injection for the intestinal mucosal barrier and oxygen supply state of elderly patients with severe pneumonia.Methods:80 elderly patients with severe pneumonia were chosen as the study object,and they were divided into control group and observation group according to the principle of random distribution,each group respectively included 40 cases.The control group were routine treatment of severe pneumonia,the observation group were treated with Xuebijing injection on the treatment of control group.Clinical effect,clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes before and after the treatment of two groups were compared.Results:The total effective rates of observation group at third and seventh day after the treatment were respectively 75.00% and 97.50%,and they were significantly higher than 52.50% and 80.00% of control group,the difference between control group and observation group was statistically significant(P<0.05).The clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes of two groups before the treatment were compared,the differences between control group and observation group were not statistically significant(P>0.05).Those indexes of two groups at third and seventh day after the treatment were all obviously improved,and the clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes of observation group were all better than those of control group,the differences between control group and observation group were all statistically significant(P<0.05).Conclusion:The influence of Xuebijing injection for the intestinal mucosal barrier and oxygen supply state of elderly patients with severe pneumonia are more active. It is helpful for the improvement of disease state of these elderly patients.
Objective:To investigate the influence of Xuebijing injection for the intestinal mucosal barrier and oxygen supply state of elderly patients with severe pneumonia.Methods:80 elderly patients with severe pneumonia were chosen as the study object,and they were divided into control group and observation group according to the principle of random distribution,each group respectively included 40 cases.The control group were routine treatment of severe pneumonia,the observation group were treated with Xuebijing injection on the treatment of control group.Clinical effect,clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes before and after the treatment of two groups were compared.Results:The total effective rates of observation group at third and seventh day after the treatment were respectively 75.00% and 97.50%,and they were significantly higher than 52.50% and 80.00% of control group,the difference between control group and observation group was statistically significant(P<0.05).The clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes of two groups before the treatment were compared,the differences between control group and observation group were not statistically significant(P>0.05).Those indexes of two groups at third and seventh day after the treatment were all obviously improved,and the clinical pulmonary infection score,inflammatory reaction indexes,intestinal mucosal barrier and oxygen supply state indexes of observation group were all better than those of control group,the differences between control group and observation group were all statistically significant(P<0.05).Conclusion:The influence of Xuebijing injection for the intestinal mucosal barrier and oxygen supply state of elderly patients with severe pneumonia are more active. It is helpful for the improvement of disease state of these elderly patients.
引文
[1] 蒙素丹,谢斌 .血必净注射液联合利奈唑胺治疗重症肺炎的疗效观察[J].现代药物与临床,2018,33(3):518-522.
[2] 李桂仙,程连房,张尧.血必净注射液联合常规西药治疗重症肺炎的临床疗效[J].湖南中医药大学学报,2018,38(3):342-344.
[3] 李燕明,王玉霞,孙铁英.正确的诊断是规范治疗的前提——《肺炎诊断》标准解读[J].中国卫生标准管理,2012,3(12):56-58.
[4] 杨东明,许东风.血必净辅助治疗重症肺炎的疗效及对患者肾功能和血清Th1/Th2细胞因子的影响[J].药物评价研究,2018,41(1):118-121.
[5] Starr ME,Saito M,Evers BM ,et al.Age-associated increase in cytokine production during systemic inflammation-ii:the role of il-1β in age-dependent il-6 upregulation in adipose tissue[J].J Gerontol A Biol Sci Med Sci,2015,70(12):1508–1515.
[6] Marion CR,Wang J,Sharma L,et al.Chitinase 3-like 1 (chil1) regulates survival and macrophage-mediated interleukin-1β and tumor necrosis factor alpha during pseudomonas aeruginosa pneumonia[J].Infect Immun,2016,84(7):2094-2104.
[7] 姚兰,刘亚男,侯果,等.血必净注射液在重症肺炎中对机体免疫功能的调控研究[J].湖北中医药大学学报,2017,19(5):35-38.
[8] 牛丽丽,夏建鸿,赵建荣,等.血必净治疗老年重症肺炎伴呼吸衰竭的疗效观察以及对患者机体炎症介质的影响[J].山西医药杂志,2017,36(12):1440-1443.
[9] 霍晋,王蕾,鹿育萨,等.血清炎性因子水平与老年人重症肺炎预后的相关性研究[J].中国基层医药,2018,25(17):2233-2235.
[10] 张雷,马云杰,乔梁,等.3项炎性指标检测在重症肺炎患者病情变化及预后评估中的应用研究[J].检验医学与临床,2015,12(20):3065-3067.
[11] 宋歌,吕月涛 .早期免疫肠内营养对重症肺炎患者营养状态及肠黏膜屏障功能的影响[J].中国社区医师,2017,33(6):29-30,33.
[12] 韩正贵,陆江涛,王文静,等.肺通腑汤辅助治疗中老年重症肺炎合并胃肠功能障碍的临床观察[J].中国实验方剂学杂志,2018,24(16):188-193.
[13] Khailova L,Baird CH,Rush AA,et al.Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of pseudomonas aeruginosa pneumonia[J].Clin Nutr,2017,36(6):1549-1557.
[14] 张妍,苏晓蕾,赵睿,等.替加环素治疗多重耐药菌所致重症肺炎的效果及对氧代谢状态的影响[J].中国医药导报,2018,15(27):106-109.
[15] 周华忠,李娜,白梦蝶.血必净联合小剂量氢化可的松治疗老年重症肺炎临床疗效及对患者免疫功能的影响[J].中国煤炭工业医学杂志,2018,21(6):588-592.
[16] 蒋一雅,仇铁峰,庄志方.血必净联合胸腺五肽辅助抗生素治疗老年重症肺炎对免疫功能及炎症因子的影响[J].海南医学院学报,2017,23(11):1471-1473,1477.
[17] 薛静.血必净注射液对伴心肌损害重症肺炎患者sICAM-1、hs-CRP、IL-17及心肌损伤指标的影响[J].现代中西医结合杂志,2016,25(35):3909-3912.
[18] 吴静华.血必净注射液佐治老年重症肺炎并呼吸衰竭的临床疗效及对炎性因子的影响[J].医学综述,2015,21(22):4166-4168.
[19] 季华庆,杨平.血必净注射液联合乌司他丁对重症急性胰腺炎患者临床疗效及对血清炎症因子水平的影响[J].陕西中医,2017,38(7):909-910.
[2] 李桂仙,程连房,张尧.血必净注射液联合常规西药治疗重症肺炎的临床疗效[J].湖南中医药大学学报,2018,38(3):342-344.
[3] 李燕明,王玉霞,孙铁英.正确的诊断是规范治疗的前提——《肺炎诊断》标准解读[J].中国卫生标准管理,2012,3(12):56-58.
[4] 杨东明,许东风.血必净辅助治疗重症肺炎的疗效及对患者肾功能和血清Th1/Th2细胞因子的影响[J].药物评价研究,2018,41(1):118-121.
[5] Starr ME,Saito M,Evers BM ,et al.Age-associated increase in cytokine production during systemic inflammation-ii:the role of il-1β in age-dependent il-6 upregulation in adipose tissue[J].J Gerontol A Biol Sci Med Sci,2015,70(12):1508–1515.
[6] Marion CR,Wang J,Sharma L,et al.Chitinase 3-like 1 (chil1) regulates survival and macrophage-mediated interleukin-1β and tumor necrosis factor alpha during pseudomonas aeruginosa pneumonia[J].Infect Immun,2016,84(7):2094-2104.
[7] 姚兰,刘亚男,侯果,等.血必净注射液在重症肺炎中对机体免疫功能的调控研究[J].湖北中医药大学学报,2017,19(5):35-38.
[8] 牛丽丽,夏建鸿,赵建荣,等.血必净治疗老年重症肺炎伴呼吸衰竭的疗效观察以及对患者机体炎症介质的影响[J].山西医药杂志,2017,36(12):1440-1443.
[9] 霍晋,王蕾,鹿育萨,等.血清炎性因子水平与老年人重症肺炎预后的相关性研究[J].中国基层医药,2018,25(17):2233-2235.
[10] 张雷,马云杰,乔梁,等.3项炎性指标检测在重症肺炎患者病情变化及预后评估中的应用研究[J].检验医学与临床,2015,12(20):3065-3067.
[11] 宋歌,吕月涛 .早期免疫肠内营养对重症肺炎患者营养状态及肠黏膜屏障功能的影响[J].中国社区医师,2017,33(6):29-30,33.
[12] 韩正贵,陆江涛,王文静,等.肺通腑汤辅助治疗中老年重症肺炎合并胃肠功能障碍的临床观察[J].中国实验方剂学杂志,2018,24(16):188-193.
[13] Khailova L,Baird CH,Rush AA,et al.Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of pseudomonas aeruginosa pneumonia[J].Clin Nutr,2017,36(6):1549-1557.
[14] 张妍,苏晓蕾,赵睿,等.替加环素治疗多重耐药菌所致重症肺炎的效果及对氧代谢状态的影响[J].中国医药导报,2018,15(27):106-109.
[15] 周华忠,李娜,白梦蝶.血必净联合小剂量氢化可的松治疗老年重症肺炎临床疗效及对患者免疫功能的影响[J].中国煤炭工业医学杂志,2018,21(6):588-592.
[16] 蒋一雅,仇铁峰,庄志方.血必净联合胸腺五肽辅助抗生素治疗老年重症肺炎对免疫功能及炎症因子的影响[J].海南医学院学报,2017,23(11):1471-1473,1477.
[17] 薛静.血必净注射液对伴心肌损害重症肺炎患者sICAM-1、hs-CRP、IL-17及心肌损伤指标的影响[J].现代中西医结合杂志,2016,25(35):3909-3912.
[18] 吴静华.血必净注射液佐治老年重症肺炎并呼吸衰竭的临床疗效及对炎性因子的影响[J].医学综述,2015,21(22):4166-4168.
[19] 季华庆,杨平.血必净注射液联合乌司他丁对重症急性胰腺炎患者临床疗效及对血清炎症因子水平的影响[J].陕西中医,2017,38(7):909-910.